Sony Pixel Power calrec Sony

November 18, 2019

19/11/2019

Experimental HIV vaccine successfully elicits broadly neutralizing antibodies to the virus Vaccinated rabbits produce antibodies to at least two vulnerable sites on HIV.

November 18, 2019

LA JOLLA, CA An experimental HIV vaccine developed by scientists at Scripps Research and the nonprofit vaccine research organization IAVI has reached an important milestone by eliciting antibodies that can neutralize a wide variety of HIV strains.

The tests, in rabbits, showed that these broadly neutralizing antibodies, or bnAbs, targeted at least two critical sites on the virus. Researchers widely assume that a vaccine must elicit bnAbs to multiple sites on HIV if it is to provide robust protection against this ever-changing virus.

The promising results, which appear in Immunity, suggest that researchers are one step closer to developing an effective HIV vaccine a major goal of medical science ever since the virus was identified in 1983.

It's an initial proof of principle but an important one, and we're now working to optimize this vaccine design, says the study's senior author Richard Wyatt, PhD, a professor in the Department of Immunology and Microbiology at Scripps Research.

According to UNAIDS, about 35 million people worldwide have died of the immunodeficiency syndrome, AIDS, which is caused by HIV infection. About 38 million others are now living with HIV infection. Antiviral drugs can keep HIV-infected people alive and reduce their ability to transmit the virus to others, but these drugs do not clear the infection and must be taken indefinitely. Researchers have long recognized that a preventive vaccine, available at a low cost to uninfected people, will be needed to eliminate HIV as a major public health threat.

HIV's rapid mutation rate and other mechanisms for evading immune attack have made it an extremely difficult target for vaccine designers. But the test conducted by Wyatt and his team confirms that vaccination can elicit the kinds of antibodies that are needed to provide broad protection against HIV. These bnAbs, as vaccine experts call them, can neutralize multiple HIV strains because they bind to critical sites on the virus that do not vary much from strain to strain. People who are infected with HIV sometimes produce bnAbs as part of their antibody response, but infrequently and usually after infection has been long established. The chief challenge for HIV vaccine designers has been to find ways to stimulate the immune system in most or all individuals into making bnAbs that hit multiple vulnerable sites on the virus, in order to protect against a high proportion of HIV strains.

At the heart of the vaccine design by Wyatt and colleagues is a virus-mimicking protein based on HIV's Env protein. Normally, multiple copies of bush-like Env proteins are spread out on the surface of each spherical HIV particle. Each Env protein contains a molecular mechanism that allows it to bind to a receptor on immune cells known as CD4, and use that receptor as a portal to break into the cell. The researchers engineered a version of Env that models the essential structures on the real Env while being stable enough to use as a vaccine. To present it in a way that would resemble a real HIV virus particle, they created virus-sized synthetic spheres of fat-related molecules, liposomes, which are studded densely with the engineered Env proteins.

On a natural HIV Env protein, thickets of sugar-related molecules called glycans normally help shield the all-important CD4 binding site from immune attack. As an initial priming immunization, the researchers used versions of Env in which this glycan shield around the CD4 binding site had been partly removed.

The idea was to better expose this site and thereby stimulate a broad antibody reaction to it at the start, Wyatt says.

Subsequent booster immunizations over 48 weeks used Env proteins with restored glycans, to select for antibodies that target the CD4 binding site but can also get through this shield. The Env proteins in the booster shots also were mixes based on different strains of HIV, to generally promote antibody responses against Env structures that do not vary among these strains.

The team inoculated 12 rabbits following their vaccine strategy and compared the results with a control group that received only a single, glycan-shielded version of Env. They found that their vaccine strategy had a much better response, with five of the rabbits developing antibodies that could neutralize multiple HIV isolates.

The researchers analyzed the antibodies of the rabbit that had responded most strongly, and identified two distinct types of bnAb. One, which they called E70, blocks the CD4 binding site as expected, though in an unusual way partly by grabbing one of the shielding glycans. The other, 1C2, hits a different but well known vulnerable spot on Env, at the interface between two key segments of the complex protein. The binding of antibody 1C2 apparently destabilizes Env so that it can no longer mediate HIV's entry into host cells. That antibody also turned out to have an unusual breadth of neutralization, blocking 87 percent of a panel of 208 distinct HIV isolates.

The finding is an important demonstration that vaccination against HIV, if done in the right way, can achieve the goal of inducing bnAbs to multiple sites on the virus, Wyatt says.

The team of scientists are continuing to test and improve their vaccine strategy in small animal models and hope eventually to test it in monkeys and then humans.

The co-lead authors of the study, Vaccination with Glycan-Modified HIV NFL Envelope Trimer-Liposomes Elicits Broadly Neutralizing Antibodies to Multiple Sites of Vulnerability, were Viktoriya Dubrovskaya, PhD, and Gabriel Ozorowski, PhD, of Scripps Research and Karen Tran, PhD, of the IAVI Neutralizing Antibod
LINK: https://www.scripps.edu/news-and-events/press-room/2019/20191118-wyatt...
See more stories from scripps

North America Stories

12/05/2026

CNN Pushes Into Lifestyle Products with CNN Weather' App Launch

Share Copy link Facebook X Linkedin Bluesky Email...

12/05/2026

Marshall Electronics Cameras Elevate Elite Equestrian Com...

Tyrell Corporation, specialists in high-end live sports and entertainment broadcasts, was tasked with delivering compelling broadcast coverage of premier equest...

12/05/2026

IBC2026 registration opens as international media industr...

Registration is now open for IBC2026 as the global media, entertainment and technology community prepares to converge on the RAI Amsterdam from 11 14 September ...

12/05/2026

Ross Video Showcases Unified Production Workflows at Broa...

Ross Video, a global leader in live video production technology, will present its latest innovations and integrated production workflows at BroadcastAsia 2026, ...

12/05/2026

With over 50bn euros in assets under management and recor...

500 selected leaders from around the world across start-ups, corporates, and venture capital. Over 50bn in assets under management among attending investors, a...

12/05/2026

Randy Koeman Joins CVP as Part of Continued European Expa...

CVP, one of Europe's leading suppliers of professional video and broadcast solutions, has appointed Randy Koeman as Sales Manager, Netherlands, marking anot...

12/05/2026

Taiwan Television selects PlayBox Neo Suite multi-channel...

Taiwan Television has expanded its HD content ingest workflow capabilities by investing in the PlayBox Neo Suite - a leading multi-channel multi-server UHD/HD/S...

12/05/2026

Jigsaw24 Appoints Tom Laker and Ashish Chauhan to Support...

Jigsaw24 is strengthening its media team with the appointment of Tom Laker as Client Director and Ashish Chauhan as Project Manager. These strategic hires bring...

12/05/2026

Pebble brings future-ready playout innovation to Broadcas...

Broadcast playout leader showcases hybrid IP infrastructure and workflow automation with Videoland deployment as regional benchmark...

12/05/2026

dzjinius to Showcase All-in-one Production Management Pla...

dzjinius, the all-in-one production management platform for the media and entertainment industry, will showcase its centralised approach to production workflows...

12/05/2026

G&D and CT Square Launch New Joint Venture in India

Share Copy link Facebook X Linkedin Bluesky Email...

12/05/2026

Congress Urged to Protect Live Sports on Broadcast TV

Share Copy link Facebook X Linkedin Bluesky Email...

12/05/2026

Roku to Stream Inaugural Enhanced Games in North America

Share Copy link Facebook X Linkedin Bluesky Email...

12/05/2026

Austrian Broadcaster Selects Lawo, SLG Broadcast for Studio Upgrade

Share Copy link Facebook X Linkedin Bluesky Email...

12/05/2026

NUGEN Audio Debuts Enhanced DialogCheck at MPTS 2026

NUGEN Audio will debut Version 1.1 of DialogCheck, its intelligent dialog intelligibility and compliance tool, at the 2026 Media Production & Technology Show (S...

12/05/2026

Disguise Powers Interactive LED Castle for Laura Pausini

The reactive visuals can adapt to any stage or screen setup and comprise 50 layers of Notch content Today, Disguise announced that its high performance GX 3 m...

12/05/2026

DoPchoice Intros Light-Shaping Accessories for ARRI Omnib...

Snapgrid , Snapbag & Airglow Expand Creative Control for the ARRI Modular LED BarFollowing the launch of the ARRI Omnibar, DoPchoice introduces a dedicated li...

12/05/2026

Macarena Garca and Carlos Cuevas star in 'El Acercamiento de la Mujer Cactus y el Hombre Globo'

Back to All News Macarena Garc a and Carlos Cuevas star in El Acercamiento de l...

12/05/2026

Netflix Unveils Documentary on Norway's 26-Year Journey to This Year's World Cup

Back to All News Netflix Unveils Documentary on Norway's 26-Year Journey to...

12/05/2026

The Netflix Effect

Back to All News The Netflix Effect Ted Sarandos co-CEO Social Impact 12 May 2026 Global Link copied to clipboard Download all assets Ten years ago, Ne...

12/05/2026

News Test

This is my news content...

12/05/2026

NVIDIA and SAP Bring Trust to Specialized Agents

From finance and procurement to supply chain and manufacturing, specialized AI agents are moving into the enterprise systems where business decisions are made, ...

11/05/2026

Ross Production Services 48-Foot HyperMax-1 Truck Quickly in Demand

New production unit features not only wealth of Ross gear but also Sony cameras, Canon lenses, and a Calrec Argo S audio board...

11/05/2026

Solid State Logic Launches TCA Tour Portable Audio Production System

Solid State Logic (SSL) has announced TCA Tour, a portable fly-away audio production system built from System T components for broadcast, touring, and live prod...

11/05/2026

Riedel Communications Named Official Connectivity Integration Provider for Glasgow 2026 Commonwealth Games

Riedel Communications has announced it will serve as Official Connectivity Integ...

11/05/2026

G&D and NETGEAR AV Launch KVM-over-IP Plugin for Automated Network Configuration

Guntermann and Drunck (G&D) and NETGEAR AV have announced a plugin that automates network configuration for G&D KVM-over-IP deployments on NETGEAR AV Line infra...

11/05/2026

The Famous Group and Elite Edge Announce Unified Ownership

The Famous Group (TFG) and Elite Edge, a production studio specializing in live-action production, show opens, set design, and fabrication for sports and live e...

11/05/2026

SVG All-Stars: Odair Auger, Tech Project Manager, NBCUniversal Telemundo Enterprises

The native of S o Paulo, Brazil, will play a crucial role in the broadcaster'...

11/05/2026

Cobalt Digital to Showcase IPMX/ST 2110 Ecosystem at BroadcastAsia 2026

Cobalt Digital will exhibit its IPMX/ST 2110 product lineup at BroadcastAsia 2026 (Stand 5D2-4), anchored by the COBALT blueCORE family of standalone signal pro...

11/05/2026

Interra Systems to Demonstrate QC, Monitoring, and Captioning Solutions at BroadcastAsia 2026

Interra Systems will exhibit at BroadcastAsia 2026 (Stand 5C1-10), demonstrating...

11/05/2026

T-Mobile Deploys 5G and AI Tools Across 2026 PGA Championship

T-Mobile is serving as a technology partner for the 2026 PGA Championship at Aronimink Golf Club in Newtown Square, Pennsylvania, deploying 5G connectivity and ...

11/05/2026

Vizrt Named Official Technical Supplier of Eurovision Song Contest 2026

Vizrt has announced it has been named an Official Technical Supplier of the Eurovision Song Contest 2026, in partnership with host broadcaster ORF. The 70th edi...

11/05/2026

WNBA and AWS Announce Multi-Year Partnership

The WNBA and Amazon Web Services (AWS) have announced a multi-year partnership making AWS the Official Cloud and Cloud AI Partner of the WNBA. AWS is also joini...

11/05/2026

NAB 2026: kronehit Awards Lawo and SLG Broadcast Contract for Full Studio Modernization

Austrian private broadcaster kronehit publicly awarded SLG Broadcast AG and Lawo...

11/05/2026

Behind The Mic: PGA Championship Changing Weekday Announcer Lineup for 2026 Tournament

Behind The Mic provides a roundup of recent news regarding on-air talent, includ...

11/05/2026

L3Harris Reaches Over 50% in FAA Telecommunications Modernization

L3Harris has completed more than 50% of a nationwide effort to rebuild the invisible backbone of America's airspace....

11/05/2026

CBS Sacramento Debuts New AR/VR Studio

Share Copy link Facebook X Linkedin Bluesky Email...

11/05/2026

Gray Media Advances James Fitch to Senior VP, News Services

Share Copy link Facebook X Linkedin Bluesky Email...

11/05/2026

Smarter Monetization Stronger Retention and PurposeDriven...

As Asia Pacific's streaming market continues to evolve, operators across the region are rebalancing their strategies and shifting their focus from subscribe...

11/05/2026

QuickLink to Highlight Latest StudioEdge Models StudioPr...

QuickLink, a leading provider of award-winning video production and remote guest contribution solutions, will showcase its latest innovations at MPTS (Media Pro...

11/05/2026

Cobalt Digitals BroadcastAsia Line up Highlights Flexible...

Cobalt Digital's BroadcastAsia Line-up Highlights Flexible End-to-End IPMX/ST 2110 Ecosystem Award-winning blueCORE standalone signal processors at the he...

11/05/2026

Encompass and VideoMagic Launch Altitude Intelligence to...

Encompass Digital Media, in partnership with VideoMagic International, announced at NAB 2026 the launch of Altitude Intelligence, an AI-powered platform designe...

11/05/2026

Louis Libin Preps for the World Cup's Spectrum Crunch

Share Copy link Facebook X Linkedin Bluesky Email...

11/05/2026

Report: Broadcast Employment Hard Hit by AI

Share Copy link Facebook X Linkedin Bluesky Email...

11/05/2026

Alfalite installs 150 LED panels in Torre Iberdrola audit...

Alfalite, the only European manufacturer of LED screens, has completed a major new corporate installation in Spain with the upgrade of the auditorium at Torre I...

10/05/2026

Berklee Honors Jacob Collier, Jill Scott, and Vinnie Colaiuta at 2026 Commencement

Berklee Honors Jacob Collier, Jill Scott, and Vinnie Colaiuta at 2026 Commenceme...

09/05/2026

New SoundApp ARA Plugin Transforms Boris FX CrumplePop

New SoundApp ARA Plugin Transforms Boris FX CrumplePop Jessie Electa Petrov May 9, 2026 0 Comments CrumplePop 2026.5 streamlines music, voice, and cin...

09/05/2026

Celebrating a TV Legend: Sir David Attenborough

Share Copy link Facebook X Linkedin Bluesky Email...

09/05/2026

Playmetrics Acquires SportsEngine From Versant

Share Copy link Facebook X Linkedin Bluesky Email...

08/05/2026

NBC Sports, Peacock Scale Vertical-Video Production Across Sports - and Beyond - Ahead of FIFA World Cup 2026

NBC's 9:16 live-production workflows power Courtside Live, Rinkside Live, Vi...