Muscle protein abundant in the heart plays key role in blood clotting during heart attack The surprise finding from a Scripps Research team reveals a potential new approach for treating cardiovascular diseases.
April 02, 2020
LA JOLLA, CA A prevalent heart protein known as cardiac myosin, which is released into the body when a person suffers a heart attack, can cause blood to thicken or clot worsening damage to heart tissue, a new study shows.
A team led by John H. Griffin, PhD, a professor in the Department of Molecular Medicine at Scripps Research, made the unexpected finding after a series of experiments spanning three years and involving researchers from multiple collaborating institutions.
Though blood clotting is the root cause of many life-threatening cardiac events, including heart attack and stroke, scientists didn't know until now that cardiac myosin was implicated in that process. The protein's primary job is to provide the muscle-motor action that pumps blood.
The real breakthrough of this study is that we've discovered another major biologic activity of cardiac myosin. No one had suspected it was acting as a procoagulant factor, Griffin says. Our findings bridge research in hematology and cardiology, showing there's another potentially very important factor influencing the health outcomes of people with cardiac disease.
Blood coagulation is essential to prevent bleeding after an injury. The most abundant procoagulant protein in the human body is collagen, but it's not usually exposed to blood. Upon blood vessel and tissue damage, many procoagulant factors, including collagens, cause blood to turn from a liquid into a gel, forming a blood clot and reducing blood loss. However, procoagulants must strike the right balance between stopping bleeding and preventing excessive clotting, as occurs in conditions such as deep vein thrombosis or when a blood clot causes a stoke.
Just as with inflammation, a little coagulation is good, but too much is dangerous, Griffin says. While a small amount of cardiac myosin might help reduce bleeding in the heart, an excess of the protein may worsen the injury by promoting blood clots that cut off oxygen and exacerbate damage to heart tissue.
Indeed, Griffin and his collaborators, including Tobias Eckle, MD, PhD, of the University of Colorado, found that excess cardiac myosin doubled heart damage when administered to mice who experienced controlled heart attacks.
The study appears in the April 2020 issue of the American Heart Association journal Arteriosclerosis, Thrombosis, and Vascular Biology.
Griffin and his team are now working with scientists at Calibr, the drug discovery and development division of Scripps Research, to create a therapeutic compound that would target the procoagulant activity of cardiac myosin, reducing tissue damage caused by a heart attack.
Anticoagulant drugs already exist, ranging from over-the-counter medications like aspirin to widely prescribed drugs such as coumadin and warfarin. A newer class of drugs, known as direct oral anticoagulants (commonly referred to as DOACs), also have emerged to address the great need for blood clotting medications. But many of these existing drugs can cause excessive bleeding or other side effects because they act on the entire body's coagulation system, not just blood clotting in the heart.
Griffin envisions an anticoagulant medicine that targets only cardiac myosin-driven coagulation. Such a drug could theoretically be administered to patients in the hospital immediately after an acute cardiac event.
Cardiovascular disease is the leading cause of death for men, women and people of most racial and ethnic groups in the United States, Griffin says. New and better medicines are needed for those at risk of disease, and cardiac myosin gives us a promising avenue to pursue.
Authors of the study, Cardiac Myosin Promotes Thrombin Generation and Coagulation In Vitro and In Vivo, include Jevgenia Zilberman-Rudenko, Hiroshi Deguchi, Meenal Shukla, Yoshimasa Oyama, Jennifer N. Orje, Zihan Guo, Tine Wyseure, Laurent O. Mosnier, Owen J.T. McCarty, Zaverio M. Ruggeri, Tobias Eckle and John H. Griffin.
The work was supported by the American Heart Association and multiple grants from the National Institutes of Health.
Heart Disease Griffin, John
North America Stories
16/07/2026
This recent graduate and Georgia native has turned an early fascination with live production into a growing passion for camera work
In the live-sports-video in...
16/07/2026
TNDV is marking the first anniversary of Aspiration 35, a mobile production truck built around ARRI Alexa 35 Live camera systems. Over its first year, the truck...
16/07/2026
ATSC has completed a major revision to its A/85 Recommended Practice: Techniques...
16/07/2026
FloSports has announced an exclusive global media partnership with CrossFit for the 2026 CrossFit Games, presented by Air National Guard, beginning July 21 in S...
16/07/2026
Sennheiser has released firmware version 1.4 for its Spectera wireless system and announced the Spectera Command Button (Cat. No. 701014). The update adds comma...
16/07/2026
ESPN and the Southwestern Athletic Conference (SWAC) have announced a multi-year...
16/07/2026
Audio-Technica has announced the 20 Series Control Application, a Stream Deck plug-in for compatible Audio-Technica USB microphones. The application is compatib...
16/07/2026
The fifteenth season of The Voice - La plus belle voix on TF1 used four Solid St...
16/07/2026
Gray Media and the Atlanta Hawks have announced a broadcast partnership that wil...
16/07/2026
Season 3 of Netflix's docuseries, which dropped this week, follows Jayden Da...
16/07/2026
The Texas Rangers and Rangers Sports Network presented by Progressive (RSN) have announced BZZR as the new direct-to-consumer distributor for Rangers game broad...
16/07/2026
With England's FIFA World Cup 2026 team getting ready to fly home after losi...
16/07/2026
In a return to Royal Birkdale, the team enjoys partnering with ETP and Gravity M...
16/07/2026
Along with a new studio at Ball Arena, the Colorado-based RSN is working with XR...
16/07/2026
Austria was back at the World Cup for the first time in 28 years, and the team d...
16/07/2026
With 42 RF cameras and high-power radio mics deployed, the spectrum environment ...
16/07/2026
June brought stabilization to the television market. Poles spent an average of 3 hours and 36 minutes a day in front of their TV screens exactly the same as i...
16/07/2026
Glensound returns to IBC with a major new addition to its intelligent loudspeaker range, the Greater Divine Supernal studio monitor, alongside recent developmen...
16/07/2026
33 leading exhibitors are taking part in the GREAT Britain and Northern Ireland Pavilions and linked locations across IBC2026 (Amsterdam RAI, 11 14 September)...
16/07/2026
Hitomi Broadcast will introduce Spectra, a new HDR colour verification solution measured in picture, not using VPID, at IBC2026 (Hall 10, Stand A40). Expanding ...
16/07/2026
Share
Copy link
Facebook
X
Linkedin
Bluesky
Email...
16/07/2026
Share
Copy link
Facebook
X
Linkedin
Bluesky
Email...
16/07/2026
Share
Copy link
Facebook
X
Linkedin
Bluesky
Email...
16/07/2026
Share
Copy link
Facebook
X
Linkedin
Bluesky
Email...
16/07/2026
Share
Copy link
Facebook
X
Linkedin
Bluesky
Email...
16/07/2026
Zixi, a leader in live video delivery and workflow orchestration, and Comcast Technology Solutions (CTS) today announced a strategic new integration to deliver ...
16/07/2026
Blackmagic Design Cameras Capture Immersive Flight for New Cirrus App
Brie Clayton July 15, 2026
0 Comments
Leader in Personal Aviation taps URSA Cin...
16/07/2026
XenData Announces LTO Archive Appliances with both File and S3 Object Storage In...
16/07/2026
Onimusha: Way of the Sword is coming to GeForce NOW at launch, with the playable...
15/07/2026
The 2026 FIFA World Cup is a big deal for DAZN, which has distribution rights in three markets: Italy, Spain, and Japan. Each requires a different editorial app...
15/07/2026
As sports-media organizations manage rapidly growing content libraries and incre...
15/07/2026
HBS director of digital Johannes Franken talks SVG Europe through the operation built to serve FIFA World Cup 2026 rights holders remotely from Stratford, east ...
15/07/2026
IBC has unveiled the conference program for IBC2026, with this year's event ...
15/07/2026
Software-defined wideband RF platform supports 96-kHz monitoring, streamlined fr...
15/07/2026
New AI-powered module enables broadcasters and content owners to extract dialogu...
15/07/2026
Weeklong gathering at EBU headquarters will test new IPMX capabilities and expand certified product ecosystem...
15/07/2026
Force Tech has announced the appointment of Bryan Adams, CTS, as Vice President of Integration. Adams will oversee AV and broadcast integration project delivery...
15/07/2026
USA Sports has announced an exclusive English-language agreement with the Bundes...
15/07/2026
ITV Sport's FIFA World Cup 2026 coverage has been produced from one of the m...
15/07/2026
Program will provide professional camera kits, training, and technical support to participating local newsrooms...
15/07/2026
San Francisco church becomes first U.S. deployment of the 2 M/E production switcher...
15/07/2026
Former ESPN and NFL Network executive to advise startup league on media, distribution, technology, and fan engagement...
15/07/2026
The Houston-based RSN is the live-game home of the Astros and Rockets...
15/07/2026
Share
Copy link
Facebook
X
Linkedin
Bluesky
Email...
15/07/2026
Share
Copy link
Facebook
X
Linkedin
Bluesky
Email...
15/07/2026
GigaCloud, a leading Ukrainian cloud service provider, and Cubbit, the first geo-distributed cloud storage enabler, today announced a new Business Alliance Part...
15/07/2026
SMPTE, the global society for media professionals, technologists, and engineers, has announced the launch of the SMPTE 110th Anniversary Campaign, a fundraising...
15/07/2026
Studio Technologies, a leading manufacturer of high-quality audio, video, and fiber-optic solutions, unveils the new StudioComm Model 762 Stereo Level Control, ...
15/07/2026
COW Jobs: Producer, Virtual Events - Hybrid, Full Time, Salaried
Brie Clayton July 15, 2026
0 Comments
Producer, Virtual Events (Hybrid | Full-time | ...
Muscle protein abundant in the heart plays key role in blood clotting during heart attack The surprise finding from a Scripps Research team reveals a potential new approach for treating cardiovascular diseases.
