Scripps Research scientists receive $1.1 million to advance AI modeling for HIV vaccine development New AI system helps scientists rapidly pinpoint the most promising paths to an HIV vaccine.
November 18, 2025
LA JOLLA, CA As of 2024, over 40 million people in the world are diagnosed with human immunodeficiency virus (HIV) a chronic, life-threatening infection that remains one of the leading global causes of death. Even decades after its discovery, HIV continues to take lives and challenge global health systems, in part because scientists haven't been able to quickly determine which experimental vaccine approaches are working due to significant volumes of data.
Scripps Research scientists recently received $1.1 million from the Scripps Consortium for HIV/AIDS Vaccine Development (CHAVD) to purchase high-performance computing equipment to address this global health challenge. The equipment will be used to accelerate the identification of more effective HIV vaccine candidates through enhanced computational infrastructure, reduced data-processing bottlenecks, and state-of-the-art artificial intelligence (AI) technology. Support for CHAVD is provided by the National Institutes of Health.
Scripps Research Scientific Associate Terrence Messmer Jr. (left) and Staff Scientist Charles Bowman (right) led the procurement and installation of the three new NVIDIA DGX B200 servers. The new equipment allows researchers to rapidly identify promising HIV vaccine candidates and reduces data-processing bottlenecks.
Credit: Scripps Research
Click here for a high-resolution image. Over the last 10 years, we've been able to accelerate data generation, but we don't have a good way of analyzing that data to understand if these vaccines are working well, says Bryan Briney, associate professor at Scripps Research and co-principal investigator on the project. This new AI technology will supercharge our ability to evaluate up to millions of potential vaccine designs in the time it used to take to study a few dozen bringing us closer to finding more promising vaccine approaches.
Developing an effective HIV vaccine remains extraordinarily difficult. To work, it must train the immune system to produce antibodies protective proteins capable of neutralizing more than 90% of HIV strains in more than 90% of people. In other words, it's an exceptionally high bar that no vaccine has yet achieved. The challenge is driven by HIV's remarkable ability to mutate, constantly changing its form and making it difficult for the immune system to recognize and destroy the virus.
The Scripps Research team hopes to eventually develop a long-lasting vaccine that adapts to mutations of the virus and can be delivered in a single dose. In the meantime, however, Briney and the collaborators aim to develop a series of multiple vaccines that adapt to the virus' changes over time. To meet the challenge of protecting against more than 90% of HIV strains, the team needs real-time feedback from clinical trials data that reveals how the vaccine is performing and informs the design of the next version in the series.
We're shifting from trial-and-error to smart prediction, says Andrew Ward, professor in the Department of Integrative Structural and Computational Biology and co-principal investigator on the project. Instead of spending months testing every design idea in the laboratory, we can screen hundreds of thousands of possibilities computationally, identify the best candidates and focus our experimental work where it matters most.
Supercharging science with AI
Ward, Briney and their labs will use the funds to purchase new AI technology that doubles the computational power available at Scripps Research and operates at speeds four-to-five times faster than existing systems. This new computational bandwidth will allow the team to rapidly analyze the antibodies produced by people who receive experimental vaccines in clinical trials and determine if they are on the right track with molecular precision.
This new resource leverages a ton of hard work and creativity from the scientists in our labs and I am excited to see how far they can extend the technology, says Ward.
When a vaccine is administered, it can train the immune system to produce antibodies that neutralize a broad range of HIV strains also known as broadly neutralizing antibodies. The team will then evaluate these vaccine-induced antibodies, test multiple scenarios simultaneously, and model how they interact with the virus at the molecular level, all while reducing analysis time from weeks to days. The antibodies identified to work exceptionally well against the virus are known as antibody candidates, which make up the next iteration of the vaccine. This added processing power will also support the work of other Scripps Research teams working on different aspects of HIV, such as protein engineering helping drive discovery from multiple angles.
The teams will first train the AI system on historical clinical trial data from previous vaccines to develop a comprehensive computational model that can quickly identify the best antibody candidates. In the lab, researchers often sift through data manually and apply their own thinking to determine which antibody may work best. The AI model, however, has proven to identify promising candidates that the researchers had initially dismissed.
To further develop this AI framework, the group will leverage a method called StepwiseDesign which, like its name implies, mimics how the immune system gradually learns to develop more efficient antibodies through small, optimized iterations.
The approach has already proven remarkably successful: the team used their AI system to analyze about 2,000 antibodies from people who had never been infected with HIV, searching for rare candidates that might have the pote
Most recent headlines
05/01/2027
Worlds first 802.15.4ab-UWB chip verified by Calterah and Rohde & Schwarz to be ...
06/09/2026
June 9 2026, 23:00 (PDT) Dolby and MagentaTV Bring Fans Closer to the FIFA Worl...
04/08/2026
Dalet, a leading technology and service provider for media-rich organizations, t...
04/07/2026
April 7 2026, 19:00 (PDT) Detective Conan: Fallen Angel of the Highway Opens in...
15/06/2026
Detach from Direct-Attached: How Remote Editing with EVO Keeps Creative Teams Mo...
14/06/2026
Library captures 1960s R&B/pop drum sound
Following on from their recent wave of plug-in effects, Iconic Instruments have just launched an all-new virtual d...
14/06/2026
HBO Comedy Rooster Shot with URSA Cine 17K 65
Brie Clayton June 14, 2026
0 Comments
Large format brings viewers intimately close to characters.
Black...
13/06/2026
Latest expansion pack includes 252 presets
Devious Machines have recently introduced another expansion for their powerful multi-effects plug-in, Infiltrator...
13/06/2026
Create custom DAW/plug-in controllers using prompts
MetaGrid have recently introduced an all-new AI Builder function to their touchscreen-based control surf...
13/06/2026
Share
Copy link
Facebook
X
Linkedin
Bluesky
Email...
13/06/2026
Share
Copy link
Facebook
X
Linkedin
Bluesky
Email...
12/06/2026
YES Network and The Gotham Sports App will air seven Athletes Unlimited Softball...
12/06/2026
The United Football League will host its FAST Innovation Suite at the 2026 United Bowl presented by Credit One Bank on Saturday, June 13 at 3:00 p.m. ET at Audi...
12/06/2026
PTZOptics and LayerJot will present live demonstrations at InfoComm 2026 showing how natural-language AI prompting, robotic camera control, and on-device comput...
12/06/2026
MultiDyne Video and Fiber Optic Systems will exhibit at InfoComm 2026, featuring...
12/06/2026
Ateme has announced that Eurovision Services is using Ateme's software-based frame-rate conversion technology for international live event workflows. The de...
12/06/2026
Bitmovin and Simplestream have announced a partnership with Xperi to simplify the launch of OTT streaming services on TiVo OS smart TVs and devices. The collabo...
12/06/2026
Net Insight has announced that a multinational technology company is deploying a...
12/06/2026
MLB Players Inc., the business arm of the MLB Players Association, has announced a partnership with Athletes First to develop and sell brand partnerships across...
12/06/2026
Guntermann and Drunck (G&D) and VuWall have announced the CommandKeyboard-Advanc...
12/06/2026
Comcast Smart Solutions announces a new smart technology deployment with Major L...
12/06/2026
Elevation Worship completed the initial leg of its Elevation Nights 2026 tour ...
12/06/2026
AJA Video Systems has announced KONA IP25 support for Colorfront Transkoder and ...
12/06/2026
Audinate Group Limited (ASX: AD8) will exhibit at InfoComm 2026 (Booth C7321, Ce...
12/06/2026
Pac-12 Commissioner Teresa Gould has announced the appointment of Scott Adametz as Chief Technology Officer. The Pac-12 describes the hire as the first CTO appo...
12/06/2026
Grass Valley has announced AMPP Edge Live, a production system combining Grass Valley hardware, NVIDIA Blackwell GPU acceleration, and AMPP OS in a single platf...
12/06/2026
At one time a trailblazer with the launch of the Longhorn Network, the Universit...
12/06/2026
Ratings Roundup is a rundown of recent rating news and is derived from press rel...
12/06/2026
Chyron has announced PAINT 10.4, an update to its illustrated replay and sports ...
12/06/2026
SVP, Production, Mark Gross: With the new schedule, with not having every Sunday night, it has given us an opportunity to take a step back and reimagine what o...
12/06/2026
For Televisa Technical Engineering Manager Roberto N nez Ibarra and the small team of 12 technicians and two production personnel at the IBC things are already ...
12/06/2026
Simple Steps to Better Acoustics - Taming The Small Room
Most of us mix in spare rooms and small spaces, where the acoustics fight us at every turn. At Gear...
12/06/2026
Latest addition expands vintage-inspired effects palette
Meris' Ottobit pedal range draws its inspiration from vintage gaming consoles, and the latest a...
12/06/2026
Soundbox-based chamber strings series expanded
Sonora Cinematic have just announced the launch of the second instalment in their Soundbox-based chamber stri...
12/06/2026
Share
Copy link
Facebook
X
Linkedin
Bluesky
Email...
12/06/2026
Share
Copy link
Facebook
X
Linkedin
Bluesky
Email...
12/06/2026
AJA Announces KONA IP25 Integration with Colorfront Software
Brie Clayton June 12, 2026
0 Comments
Collaboration enables uncompressed SMPTE ST 2110 I/O ...
12/06/2026
URSA Cine 12K LF Used to Create Visuals for STUTS' K-Arena Concert
Brie Clayton June 12, 2026
0 Comments
Organic visuals projected on a giant scre...
12/06/2026
MTI FILM Acquires Mango New Edit, Expanding its Global Post-Production Services ...
12/06/2026
AI Point Tracking Speeds Up Complex VFX Tracks in Mocha Pro
Jessie Electa Petrov June 12, 2026
0 Comments
The 2026.5 release adds automatic point trac...
12/06/2026
Bitmovin, a provider of video streaming solutions, has partnered with Simplestream, a provider of OTT and broadcast solutions, and technology provider Xperi, to...
12/06/2026
Leostream Corporation, creator of the world-leading Leostream Remote Desktop Access Platform, today announced Jigsaw24, a leading B2B IT solutions provider wit...
12/06/2026
Share
Copy link
Facebook
X
Linkedin
Bluesky
Email...
12/06/2026
Share
Copy link
Facebook
X
Linkedin
Bluesky
Email...
12/06/2026
Share
Copy link
Facebook
X
Linkedin
Bluesky
Email...
12/06/2026
Share
Copy link
Facebook
X
Linkedin
Bluesky
Email...
12/06/2026
Share
Copy link
Facebook
X
Linkedin
Bluesky
Email...
12/06/2026
How Aussie indie games and screen are levelling up with IP 11 June 2026
Ari Harrison, Pro Jank Footy
Head of Games Joey Egger and Ari Harrison of Umbrella sha...
12/06/2026
AgentPerf from Artificial Analysis, the industry's first agentic AI benchmark, gives developers, enterprises and infrastructure providers a clear way to com...
Scripps Research scientists receive $1.1 million to advance AI modeling for HIV vaccine development New AI system helps scientists rapidly pinpoint the most promising paths to an HIV vaccine.
