A better way to predict a patient's risk of coronary artery disease Scripps Research scientists developed a model that more accurately identifies patients at risk of coronary artery disease and can inform tailored treatment.
April 16, 2025
LA JOLLA, CA Coronary artery disease (CAD) is the leading cause of death in the United States. Although effective preventative treatments exist, these measures are often underutilized, in part because people don't know they're at risk of CAD until it's too late.
Now, scientists at the Scripps Research Translational Institute have developed a machine learning model that more accurately estimates a patient's risk of CAD compared to the standard clinical practice, which is based primarily on age. The findings, published in Nature Medicine on April 16, 2025, leveraged data that spanned 10 years. Their new model is personalized and integrates factors including genetics, lifestyle and medical history, enabling clinicians to provide patients with advice and preventative treatment tailored to their individual needs.
I think more precise and personalized risk prediction could motivate patients to engage in early prevention, says senior author Ali Torkamani, PhD, professor and director of Genomics and Genome Informatics at the Scripps Research Translational Institute. Our model first predicts the risk that a person will develop CAD, and then it provides information to allow personalized intervention.
CAD is caused by a buildup of plaque in the heart's arteries, which then blocks blood supply. Many people don't realize they have CAD until they experience a heart attack, but the disease is cumulative the earlier treatment begins, the more effective it will be.
We tend to observe bad outcomes for CAD in patients who are in their mid-50s and older, but the disease actually begins to develop much earlier, sometimes even while people are teenagers. Theres a lot of room for us to take action, says first author Shang-Fu Shaun' Chen, a former doctoral student in Torkamani's group.
To enable more accurate CAD risk prediction, Torkamani's team set out to create a model that incorporates factors beyond age, including genetic predisposition, lifestyle and medical history. They used data from the UK Biobank to train a machine learning model to recognize factors associated with CAD. Then, they tested the model on longitudinal data from a different cohort of individuals within the Biobank to see whether it could predict their risk of developing CAD over the course of 10 years based on their baseline data.
The model started with around 2,000 predictive features that could factor into CAD risk, but the team eventually whittled this list down to 53 risk factors. These included physical measurements, blood biomarkers, family medical history, mental illness, sleep duration and the presence of specific gene variants.
The new model outperformed the standard clinical model and enabled the prediction of two times as many CAD events. After 10 years of follow-up, 62.9% of individuals that the model categorized as being at highest risk had developed CAD, compared to only 0.3% of individuals in the lowest risk group.
The new model is personalized and integrates factors including genetics, lifestyle and medical history, enabling clinicians to provide patients with advice and preventative treatment tailored to their individual needs. Credit: Scripps Research Compared to traditional clinical tools, the new model improved risk classification for approximately one in four individuals helping to better identify those truly at risk while avoiding unnecessary concern for those who are not, said Chen.
The model's accuracy was partially due to its better ability to predict CAD in groups of people who are usually categorized as low risk, such as younger individuals and women.
Our model can pick up individuals who would be considered at low risk of CAD due to their age, but who are actually high risk due to their underlying genetics, says Torkamani.
Though the model's accuracy depended on the inclusion of multiple factors, the team showed that genetic predisposition was by far the strongest predictor of CAD risk. This included not only genetic predisposition for CAD itself, but also for related conditions such as high blood pressure, high cholesterol and diabetes.
The higher your genetic risk for one of those traits high cholesterol levels or high blood pressure levels or high diabetes risk the greater benefit you get from intervening on that particular aspect through medication or lifestyle changes, says Torkamani.
When the team validated the model using the National Institutes of Health All of Us dataset which includes more diverse populations than the UK Biobank they showed it was able to predict CAD risk equally well for people with European, African and Hispanic ancestries.
Now, the researchers are planning a long-term clinical trial to test whether informing patients of their risk of CAD can help prevent the disease.
We think the most important thing is for patients to be aware of their individual risks so that they can receive the appropriate treatments and make lifestyle changes, says Chen.
In addition to Torkamani and Chen, authors of the study, Meta-Prediction of Coronary Artery Disease Risk, include Hossein J. Sadaei, Ahmed Khattab, Corneliu Henegar, Nathan E. Wineinger and Evan D. Muse of Scripps Research; Sang Eun Lee of University of Ulsan College of Medicine; Jun-Bean Park of Seoul National University Hospital; and Jei-Fu Chen of Memorial Sloan Kettering Cancer Center.
This work was supported by funding from the National Institutes of Health (R01HG010881 and UM1TR004407) and the Scripps Research HPC team, including JC Ducom and Lisa Dong.
Heart Disease Torkamani, Ali
North America Stories
19/05/2026
Share
Copy link
Facebook
X
Linkedin
Bluesky
Email...
19/05/2026
Share
Copy link
Facebook
X
Linkedin
Bluesky
Email...
19/05/2026
Grass Valley has entered into a three-year enterprise agreement with Phoenix Broadcast Solutions as the Singapore-based company expands its live production oper...
19/05/2026
Clear-Com supported Musikal Perahu Kertas, a large-scale musical theater production in Indonesia adapted from the acclaimed novel by Dee Lestari, through the d...
19/05/2026
Actus Digital, a LiveU company, and a leading provider of intelligent media monitoring and broadcast compliance platforms, announced today that METEO CONSULT ha...
19/05/2026
Globecast, a leading provider of managed services for the broadcast and media industry, today announced the completion of a major renovation of its Singapore fa...
19/05/2026
Following a major upgrade to its Connecticut remote production centre with the installation of three 60-fader Argo S consoles in 2023, RPS has switched one of t...
19/05/2026
PlayBox Technology today announced the launch of Celebro Play, a browser-based media orchestration platform designed specifically for broadcast facilities and p...
19/05/2026
Share
Copy link
Facebook
X
Linkedin
Bluesky
Email...
19/05/2026
Share
Copy link
Facebook
X
Linkedin
Bluesky
Email...
19/05/2026
Share
Copy link
Facebook
X
Linkedin
Bluesky
Email...
19/05/2026
Share
Copy link
Facebook
X
Linkedin
Bluesky
Email...
19/05/2026
LYNX Technik, provider of modular signal processing solutions for broadcast, post, and professional AV will showcase its latest signal processing solutions at B...
19/05/2026
Media Links, a leading developer and manufacturer of IP media transport solutions, has announced the integration of its Xscend platform with Skyline Communicat...
19/05/2026
Collaboration expands regional partner ecosystem as Media Links showcases IP media transport solutions on stand 4M4-4 and alongside Clearcast Asia on stand
Me...
19/05/2026
Company Highlights Labor-Saving Control and Custom Branding Opportunities Designed to Increase Integrator Profitability
LynTec, a leading manufacturer of ele...
19/05/2026
Mago Studio Moves AI Video Beyond Prompts with New Production-Focused Tools
Brie Clayton May 18, 2026
0 Comments
New Capabilities Bring Controllable, ...
19/05/2026
It May be Time to Stop and Take an AI Breather
Brie Clayton May 19, 2026
0 Comments
If the rock you stay on starts to roll, jump clean. Or you'll...
18/05/2026
Despite a bumpy start to the year, the provider of event-production support and ...
18/05/2026
Daktronics has partnered with the University of North Carolina to manufacture and install 11 LED displays totaling more than 10,000 square feet and more than 14...
18/05/2026
CBS LA has announced a multi-year partnership with the Los Angeles Rams, covering exclusive local broadcasts of Rams preseason games, weekly year-round programm...
18/05/2026
Skyline Communications has announced an integration between its DataMiner xOps p...
18/05/2026
eCLUTCH, the hybrid esports platform powered by iKOMG, has announced an expansion of its distribution across Europe, MENA, Africa, and Asia, along with new cont...
18/05/2026
Behind The Mic provides a roundup of recent news regarding on-air talent, includ...
18/05/2026
With 22 games this season, the production team looks forward to tweaking and enhancing the coverage
After 8,660 days off the air, the WNBA returned to NBC yest...
18/05/2026
(L-R) Midori Francis and Natalie Erika James attend the Saccharine premiere during the 2026 Sundance Film Festival at The Ray Theatre on January 22, 2026, in ...
18/05/2026
The Australian Defence Force uses L3Harris T4 and T7 robots for explosive ordnan...
18/05/2026
Continued investment across Europe and Germany is expanding local teams and improving access to stock, regional expertise, and specialist broadcast support.
CV...
18/05/2026
Agentic AI inference at one-tenth the cost per token with NVIDIA Vera Rubin NVL7...
17/05/2026
Back to All News
Oasis Premieres on Netflix June 19
Entertainment
17 May 2026
GlobalSpain
Link copied to clipboard
Summer, sunshine, the beach, parties. T...
16/05/2026
Boris FX Continuum Pairs AI Precision and Advanced Creative Controls
Jessie Electa Petrov May 16, 2026
0 Comments
The 2026.5 release adds automatic de...
16/05/2026
Share
Copy link
Facebook
X
Linkedin
Bluesky
Email...
16/05/2026
Share
Copy link
Facebook
X
Linkedin
Bluesky
Email...
16/05/2026
Share
Copy link
Facebook
X
Linkedin
Bluesky
Email...
16/05/2026
Share
Copy link
Facebook
X
Linkedin
Bluesky
Email...
15/05/2026
Seattle Sounders FC and Seattle Reign FC, in partnership with RAVE Foundation an...
15/05/2026
Dan Brumm has served as sound designer on Bluey, the Australian children's t...
15/05/2026
The Professional Audio Manufacturers Alliance (PAMA) and Shure Incorporated are accepting applications for the 6th annual Mark Brunner Professional Audio Schola...
15/05/2026
Netflix has announced an expanded NFL schedule for 2026 and beyond under a four-year partnership extension with the NFL through the 2029-30 season. Each season,...
15/05/2026
Ateme is supporting TVRI (Televisi Republik Indonesia) with a contribution and d...
15/05/2026
Concacaf has announced the launch of a new website and mobile app built on Deltatre's FORGE platform. Concacaf.com and the mobile app, available on iOS and ...
15/05/2026
Eutelsat has announced the launch of QBC Business Economic Channel by Qatar Media Corporation, broadcasting in 4K/UHD via Eutelsat's 7/8 West video neighbo...
15/05/2026
Major League Soccer has announced four original content series timed to the 2026...
15/05/2026
The Alliance for IP Media Solutions (AIMS) has announced it will exhibit and present at InfoComm 2026, taking place June 13-19 at the Las Vegas Convention Cente...
15/05/2026
InfoComm 2026 will take place June 13-19 (exhibits June 17-19) at the Las Vegas Convention Center. The show will include sessions and exhibits covering broadcas...
15/05/2026
Tracy McGrady's Ones Basketball League (OBL) and FuboTV Inc. have announced ...
15/05/2026
Disguise has partnered with Creative Technology (CT) to deliver visual playback ...
15/05/2026
Sony Electronics has announced two new products for professional imaging: the Alpha 7R VI full-frame mirrorless camera and the FE 100-400mm F4.5 GM OSS super-te...
15/05/2026
In-venue and creative video staffers at the professional and collegiate level ha...
A better way to predict a patient's risk of coronary artery disease Scripps Research scientists developed a model that more accurately identifies patients at risk of coronary artery disease and can inform tailored treatment. 
