June 05, 2019
06/06/2019
June 05, 2019
When is a mutated virus a good thing? When the mutation could make flu shots more powerful.
Scientists at Scripps Research have found that a mutation called G186V could be a useful addition to the H3N2 influenza vaccine. As they reported in Cell Host & Microbe, preparing a seasonal flu vaccine with the G186V mutation may prevent a vexing problem that commonly occurs during the vaccine manufacturing process.
This study gives us a roadmap to suggest how to improve the vaccine, says Ian Wilson, D.Phil., Hansen Professor of Structural Biology at Scripps Research.
Wilson co-led the study with Chris K.P. Mok, PhD, of The University of Hong Kong and the First Affiliated Hospital of Guangzhou Medical University. Their work builds on a 2017 study that revealed that the common practice of growing the flu vaccine in eggs leads to a mutation called L194P, which keeps the vaccine from working as well as it should in humans.
For decades, vaccine manufacturers have made the flu vaccine by injecting influenza into chicken eggs. This is a relatively cheap way to allow the virus to replicate. Manufacturers then purify the fluid from the eggs to get enough of the virus to use in vaccines.
But this method comes with drawbacks.
These are human viruses, and you're growing them in an avian species, says Wilson. Putting the virus in this challenging environment forces the virus to mutate to adapt and survive. They're acquiring mutations in order to grow better.
As the virus mutates inside eggs, it becomes less like the viral strains circulating among the human population. A vaccine containing the L194P mutation is less likely to prompt the human immune system to recognize and attack the real virus. Wilson and his colleagues say this is one factor behind the low effectiveness of some seasonal flu vaccines in recent years.
For the new study, the researchers looked at other mutations that cropped up near the same site on the surface of the virus. Nicholas Wu, PhD, a research associate at Scripps Research, led the work to analyze mutations that appeared in the specific H3N2 strains selected for use in flu vaccines going back through the years.
Wu saw that the L194P and G186V mutations were very common in the egg-grown virus. Both of these mutations are well-known in the field for helping the virus grow in eggs, but Wu realized that the two mutations never showed up in the same virus.
The scientists then tested a theory that the two mutations were in opposition. The team studied influenza's structure and showed that L194P and G186V functionally compete around the receptor binding site on the virus surface. Whichever mutation occurred at that site first was there to stay and would prevent the other mutation from occurring.
These two mutations are incompatible with each other, says Wu.
But while L194P harmed the flu shot's effectiveness, G186V did not. The scientists found that the immune system treats the G186V virus as if it were similar to the circulating human virus.
Wilson and Wu say it will be important for vaccine manufacturers to test for these two mutations and select for H3N2 strains that contain G186V, before growing up the vaccine strains into eggs.
Going forward, the team hopes to screen influenza for more mutations that occur during the egg manufacturing process and better understand how these mutations interact.
It's important to try to figure out how we can make the seasonal flu vaccine better, especially for H3N2 viruses, says Wilson.
In addition to Wilson, Mok and Wu, authors of the study, Preventing an Antigenically Disruptive Mutation in Egg-Based H3N2 Seasonal Influenza Vaccines by Mutational Incompatibility, were Huibin Lv and Wilson W.S. Ng of The University of Hong Kong and the First Affiliated Hospital of Guangzhou Medical University; Andrew J. Thompson, Rameshwar U. Kadam, Chih-Wei Lin, Corwin M. Nycholat, Ryan McBride and James C. Paulson of Scripps Research; Douglas C. Wu of the University of Texas at Austin; and Weiwen Liang of the First Affiliated Hospital of Guangzhou Medical University.
The study was supported by the National Institutes of Health (grants R56 AI127371 and R01 AI114730); the Bill and Melinda Gates Foundation (grant OPP1170236 and a Post-Doctoral Fellowship in Global Health); the Research Grants Council of the Hong Kong Special Administrative Region, China (Ref: T11-705/14N); and Guangzhou Medical University High Level University Construction Project Funding.
Infectious Diseases Immunology & Microbiology Wilson, Ian
LINK: | https://www.scripps.edu/news-and-events/press-room/2019/20190605-ward-... |
See more stories from scripps |
Most recent headlines
04/08/2024
Dalet Appoints Santiago Solanas as CEO to Lead Next Era of Growth and Innovation
Dalet, a leading technology and service provider for media-rich organizations, is excited to announce Santiago Solanas as its new Chief Executive Officer (CEO)....
03/06/2024
Dalet and Veritone Reach Agreement to Distribute, Transact and Monetize Media Archives
Dalet, a leading technology and service provider for media-rich organizations, a...
30/04/2024
SES Announces Acqusition of Intelsat for $3.1B
European telecom satellite company SES announced today that it is acquiring rival Intelsat for $3.1 billion. The deal, unanimously approved by both companies...
30/04/2024
Bakish Out at Paramount
Bob Bakish, chief executive of Paramount stepped down on Monday, effective immediately. Bakish, who was a staunch ally of Shari Redstone, controlling shareholde...
30/04/2024
Hotspring unveils Slapshot ML-driven rotoscoping solution
Hotspring said the breakthrough had been achieved through the acceleration of machine learning technology By Matthew Corrigan Published: April 30, 2024 Ho...
30/04/2024
SES to acquire Intelsat in $3.1 billion deal
Speaking about the deal, Adel Al-Saleh, CEO of SES, said: it will bring value-added, efficient, and reliable offerings for both companies media customers By Je...
30/04/2024
Bob Bakish officially out at Paramount, new Office of the CEO finalising long-term plan'
Paramount said the Office of the CEO is working with its board to develop a comp...
30/04/2024
Gray Television Using NextGen TV to Roll Out Advanced Features Like HDR
LOUISVILLE, Ky. In another sign that broadcasters are finally using NextGen TV broadcasts to offer viewers new features instead of simply simulcasting existing ...
30/04/2024
Oklahoma Journalism Hall of Fame To Honor Blaise Labbe
OKLAHOMA CITY The Oklahoma Journalism Hall of Fame will induct Blaise Labbe, a group news director for Sinclair Broadcast Group, May 2 at the 54th Anniversary I...
30/04/2024
Cox Media Group, Dish Ink New Multi-Year Agreement
ATLANTA and ENGLEWOOD, Colo. Cox Media Group and Dish have ended a dispute over retransmission fees that lasted nearly a year and a half with a new multi-year ...
30/04/2024
TelevisaUnivision Taps LTN for IP-Based Distribution
Video transport solution provider LTN has announced that it is working with TelevisaUnivision to help the Spanish-language media giant migrate to IP-based video...
30/04/2024
NBC KXAS and Telemundo KXTX Used Clear-Com Solutions for Eclipse Coverage
ALAMEDA, Calif. Clear-Com has released details about how it played a pivotal role in the seamless coverage of the recent solar eclipse on April 8, 2024 by NBC K...
30/04/2024
Scripps Appoints Seth Walters To Steer CTV Sales Strategy
CINCINNATI The E.W. Scripps Company is adding Seth Walters to its sales leadership team as head of CTV sales, effective April 29....
30/04/2024
Durham Bulls Saturday Game, First Sellout of 2024 Season
The force was strong at the Durham Bulls Athletic Park on Saturday night, April 27, 2024, as the night netted the ballpark's first official sellout crowd of...
30/04/2024
NewFront Life Is a Cabaret for LGBTQ+ Network Revry
Revry, a network celebrating queer culture. said its second annual NewFront presentation will be a cabaret-type spectacle showcasing the spirit of the LGBTQ+ co...
30/04/2024
FETV Viewers Say Howdy' as Wyatt Earp' Joins Lineup
Family Entertainment Television (FETV) said that the Western series The Life and Legend of Wyatt Earp will be joining the network's afternoon lineup startin...
30/04/2024
Bob Bakish Departing Paramount, According to Reports
Bob Bakish, president and CEO of Paramount Global, will depart the company as Paramount explores a merger, according to numerous published reports. The reports ...
30/04/2024
SES to acquire Intelsat in compelling transaction focused on the future
Value accretive transaction underpinned by 2.4 billion (NPV) of readily executable synergies. Creating a stronger multi-orbit operator with 60% of revenue in...
30/04/2024
Thales reports its order intake and sales for the first quarter of 2024
Facebook Twitter LinkedIn Order intake: 5.0 billion, up 47% ( 46% on an organic basis1 ) Sales: 4.4 billion, up 9.8% ( 7.9% on an organic basis) All f...
29/04/2024
Filming begins and further cast confirmed in Mark Gatiss drama Bookish for Alibi
(L-R) Mark Gatiss and Polly Walker on set Monday 29 April 2024 Further casting is now confirmed for Bookish (6x70), a brand-new drama created by Emmy Award-wi...
29/04/2024
She Speaks Sudan': Thomson launches programme to empower women journalists and civil society actors in exile
A groundbreaking initiative offering training and mentoring to 30 women journali...
29/04/2024
Meet the 2024 Sundance Institute Directors, Screenwriters, and Native Lab Fellows
Even though we've been doing this for over 40 years, a spark of excitement r...
29/04/2024
The AN/PRC-158: A Resilient Communications Bridge Between Air and Ground
L3Harris is delivering manpack radios to U.S. Army CH-47 Chinooks as part of the Air-to-Ground Networking Radio program, providing seamless, resilient communica...
29/04/2024
CS President Sam Mehta: Resilient Communications are Critical to Realizing JADC2
He writes in Defense One: Despite the near-universal acknowledgement throughout the U.S. government and defense industrial base of the criticality of resilient ...
29/04/2024
Clear-Com Enhances The Kennedy Center with Seamless Communication Solutions
eds3_5_jq(document).ready(function($) { $(#eds_sliderM519).chameleonSlider_2_1({ content_source:......
29/04/2024
Optimising audio loudness & normalisation across the Media Supply Chain
Codemill aims to revolutionize media workflow efficiency at this years NAB Show by introducing Just-In-Time (JIT) playback technology in Accurate.Video Validate...
29/04/2024
TF1 Chooses Broadpeak to Power Targeted Advertising for New Video Streaming Service
April 29, 2024 -- TF1 Chooses Broadpeak to Power Targeted Advertising for New...
29/04/2024
LG Adds Allen Media Group's Local Now FAST Channel in 223 Markets
LOS ANGELES Allen Media Group (AMG) has partnered with LG Electronics to bring 223 Local Now FAST channels to LG's free streaming service, LG Channels, avai...
29/04/2024
Ross Video Unveils Raiden Weather Graphics System
OTTAWA Ross Video has announced the introduction of Raiden, a data-driven weather graphics software that combines data gathering, processing, and visualization ...
29/04/2024
Melanie Georgieva Joins Panalux as Long Form Sales Direct...
Panalux, a leading rental provider of lighting and power solutions for the motion-picture industry and part of Panavision's end-to-end service offerings for...
29/04/2024
Cobalt Iron Earns Patent on Analytics-Based Dynamic Autho...
Cobalt Iron Inc., a leading provider of SaaS-based enterprise data protection, today announced that it has received a patent on its technology for dynamic autho...
29/04/2024
SDVI Rally Access Workstation Earns Two Top Awards at 202...
SDVI, the leading platform provider for cloud-native media supply chains, today announced that Rally Access Workstation, a fully managed solution for editing in...
29/04/2024
Premier Sports selects QuickLink Remote Commentary soluti...
Premier Sports, a premium sports broadcaster, has selected QuickLink's Remote Commentary solution for introducing professional, high-quality remote commenta...
29/04/2024
Glookast picks Jigsaw24 Media as exclusive UK channel par...
Glookast has chosen Jigsaw24 Media as the only UK channel partner to represent their portfolio of ingest and workflow optimisation products. The agreement, sign...
29/04/2024
Clear-Coms Eclipse HX and Agent-IC Technology Illuminate...
Clear-Com played a pivotal role in the seamless coverage of the recent solar eclipse on April 8, 2024. Leveraging its cutting-edge Eclipse HX Digital Matrix i...
29/04/2024
PlayBox Neo to Promote Latest Smart Media Playout Innovat...
PlayBox Neo will promote its complete range of television channel management, graphic branding and playout solutions to EMEA region media content owners and bro...
29/04/2024
RuPaul Game Show Lingo' Returns to CBS May 24
Lingo, RuPaul's word-twisting game show, returns for season two on CBS Friday, May 24. Two episodes air that night, and stream on Paramount Plus, too....
29/04/2024
ESPN, Amazon Prime Video Reportedly Close To New Deals With the NBA
ESPN and Amazon Prime Video are reportedly close to scoring television rights to the National Basketball Association, according to published reports....
29/04/2024
Judge Judy,' Hot Bench' Renewed for 2 More Years
Judge Judy and Hot Bench, CBS Media Ventures' genre-leading court shows, have been renewed through the 2025-26 TV season in more than 95% of the country, Gr...
29/04/2024
Irish Sports Broadcaster Premier Sports Taps QuickLink for Remote Commentary
Premier Sports, an Irish-based premium sports broadcaster, has selected QuickLink's Remote Commentary solution for introducing professional, high-quality re...
29/04/2024
BAFTA Television Craft Awards winners announced
The awards celebrate the craft of behind-the-scenes TV talent and the best programmes of 2023 By Matthew Corrigan Published: April 29, 2024 The awards cel...
29/04/2024
Watch: How Milk VFX helped create 259 shots for Netflix's Scoop
The team at Milk had to create and deliver the VFX and environment work for the royal residences featured in the drama from scratch By Jenny Priestley Publis...
29/04/2024
What's going on at Paramount Global?
CEO Bob Bakish is expected to leave the company as early as today, with a new leadership committee likely to run the company on an interim basis By Jenny Pries...
29/04/2024
Meet the director of media and entertainment and strategic products
Albena Ivanova, director, media and entertainment and strategic products at CHAOS talks to TVBEurope about her route into the industry By TVBEurope Staff Pub...
29/04/2024
Anna Valley brand name acquired by AV company Grand Technix
The acquisition gives Grand Technix the opportunity to expand its footprint in the audio visual and broadcast technology sectors By Jenny Priestley Published...
29/04/2024
Screen Australia announces James J. Robinson's debut feature First Light
29 04 2024 - Media release Screen Australia announces James J. Robinson's debut feature First Light First Light Principal Photography is underway on Firs...
29/04/2024
Capitol Broadcasting Becomes First Company Inducted into NC Media and Journalism Hall of Fame
Capitol Broadcasting recently became the inaugural company honored with inductio...
29/04/2024
Tonight on House of Zwide: Zanele tells a surprised Zola that Faith fully supports her dropping charges against him
Tonight on House of Zwide: Zanele tells a surprised Zola that Faith fully suppor...
29/04/2024
Tonight on Scandal: Nhlamulo's request has Mdala reeling
Tonight on Scandal: A line is crossed and a mother starts to lose focusDon't miss Friday, 26 April's riveting episode of South African soapie Scandal! o...