St. Jude and Scripps Research Institute Scientists Help Launch Human Dark Proteome Initiative Group to focus on advancing research on intrinsically disordered proteins to better understand catastrophic diseases
Memphis, TN and La Jolla, CA - November 9, 2015 - Scientists at St. Jude Children's Research Hospital, The Scripps Research Institute (TSRI) and other institutions today announced the launch of the Human Dark Proteome Initiative (HDPI). The initiative aims to accelerate research into biology's invisible mass to provide novel insights into cell function and a new frontier in drug discovery.
The term dark proteome describes the large portion of the proteome the complete collection of proteins in an organism that do not adopt defined 3D structures. These little-studied proteins make up about one third of the human proteome and control many aspects of cellular behavior. Recent developments in technology, including advances in nuclear magnetic resonance (NMR) spectroscopy methods, now make it possible to look in detail at these intrinsically disordered proteins (IDPs) and the intrinsically disordered regions (IDRs) of these molecules.
Our goal is to raise awareness about the potential societal impacts of a broad-based research infrastructure for these understudied proteins, said Richard Kriwacki, Ph.D., a member of the St. Jude Department of Structural Biology and of the HDPI. We also want to develop educational programs that will address the origins and potential cures of devastating diseases affected by these proteins that afflict large numbers of patients across the world.
IDPs are involved in heart disease, infectious disease, type 2 diabetes, cancer and many neurodegenerative diseases, such as Parkinson's disease and Alzheimer's disease, said Peter Wright, Ph.D., who is Cecil H. and Ida M. Green Investigator at TSRI and chair of the HDPI. We need to advance our understanding of the functions and molecular mechanisms of these proteins so we can work toward better therapies for these debilitating diseases.
Wright and Kriwacki emphasized that dramatically expanded investment in basic and translational research into the dark proteome is needed to achieve the full potential for understanding and developing cures for many devastating diseases.
Many of the members of the new Human Dark Proteome Initiative were in Memphis last week for the Intrinsically Disordered Proteins session at the Southeastern/Southwestern Regional Meeting of the American Chemical Society.
Joining Kriwacki and Wright in spearheading the initiative are researchers from Columbia University (Arthur G. Palmer III), Rutgers University (Jean Baum), UConn Health (Jeffrey Hoch), University of California, San Francisco (Steven Finkbeiner) and Washington University in St. Louis (Rohit V. Pappu).
Additional information about the Human Dark Proteome Initiative can found at https://darkproteome.wordpress.com
St. Jude Children's Research Hospital
St. Jude Children's Research Hospital is leading the way the world understands, treats and defeats childhood cancer and other life-threatening diseases. It is the only National Cancer Institute-designated Comprehensive Cancer Center devoted solely to children. Treatments developed at St. Jude have helped push the overall childhood cancer survival rate from 20 percent to 80 percent since the hospital opened more than 50 years ago. St. Jude freely shares the breakthroughs it makes, and every child saved at St. Jude means doctors and scientists worldwide can use that knowledge to save thousands more children. Families never receive a bill from St. Jude for treatment, travel, housing and food because all a family should worry about is helping their child live. To learn more, visit stjude.org or follow St. Jude at @stjuderesearch.
About The Scripps Research Institute
The Scripps Research Institute (TSRI) is one of the worlds largest independent, not-for-profit organizations focusing on research in the biomedical sciences. TSRI is internationally recognized for its contributions to science and health, including its role in laying the foundation for new treatments for cancer, rheumatoid arthritis, hemophilia, and other diseases. An institution that evolved from the Scripps Metabolic Clinic founded by philanthropist Ellen Browning Scripps in 1924, the institute now employs about 2,700 people on its campuses in La Jolla, CA, and Jupiter, FL, where its renowned scientists including two Nobel laureates work toward their next discoveries. The institutes graduate program, which awards PhD degrees in biology and chemistry, ranks among the top ten of its kind in the nation. For more information, see www.scripps.edu.
# # #
For information:
Media Relations Contacts
St. Jude:
Frannie Marmorstein
Tel: 901-595-0221
Cell: 901-379-6072
frannie.marmorstein@stjude.org
The Scripps Research Institute:
Madeline McCurry-Schmidt
Tel: 858-784-9254
madms@scripps.edu
Most recent headlines
04/08/2024
Dalet, a leading technology and service provider for media-rich organizations, is excited to announce Santiago Solanas as its new Chief Executive Officer (CEO)....
03/06/2024
Dalet, a leading technology and service provider for media-rich organizations, a...
30/04/2024
By Adam Piron
In anticipation of this edition of the Indigenous Program's Native Lab, it actually dawned on me that this will be our lab's tenth year i...
30/04/2024
Launch of SBS South Asian channel and SBS Spice, a new English language offering...
30/04/2024
LOS ANGELES (April 30, 2024) Light Iron, the post-production creative-services division of Panavision, is excited to announce that lodie Ichter has joined th...
30/04/2024
Now streaming on Netflix, Good Grief marks the feature-film directorial debut of Daniel Levy, well known as the co-creator and costar of the series Schitt's...
30/04/2024
The Forsyte Saga, John Galsworthy's sweeping portrait of a wealthy British family in 1880s London, is getting its third TV adaptation in less than 60 years....
30/04/2024
eds3_5_jq(document).ready(function($) { $(#eds_sliderM519).chameleonSlider_2_1({...
30/04/2024
CAMPBELL, Calif. Streaming media company Plex and T-Mobile will work together to expand T-Mobile's connected TV (CTV) inventory and advance the connection b...
30/04/2024
SAN JOSE, Calif. & BELLEVUE, Wash. Roku, Inc. has announced an expanded measurement partnership with iSpot.tv, the cross-platform TV measurement company....
30/04/2024
NEW YORK As Paramount Global wrestled with management turmoil and ongoing negotiations for a proposed merger with Skydance, the company managed to report improv...
30/04/2024
Cobalt Digital Receives Trifecta of Awards at NAB 2024
Company adds two 2024 NAB Show Product of the Year awards and one Best of Show from TV Tech to long list...
30/04/2024
arkona technologies GmbH, provider of IP core infrastructure solutions for top-tier broadcast productions, has announced that its BLADE//runner IP Audio Engine ...
30/04/2024
OpenDrives, Inc., the global provider of software-defined media workflow solutions and data management capabilities, announced today that it has joined the glob...
30/04/2024
The first norm conform sustainability service dedicated to the needs of the events industry
Easy-to-use, intuitive platform for venues, event organisers and su...
30/04/2024
Dejero GateWay enables Stream7 to create independent internet connectivity at any venue or location, including UK teaching hospital for live streaming of surgic...
30/04/2024
Excitement is building as farmerswife, a leading software provider for resource scheduling, project management, and team collaboration in the media industry, ha...
30/04/2024
XL8, a leading deep-tech startup specializing in AI-powered machine translation technology, proudly announces the successful completion of a System and Organiza...
30/04/2024
Test & measurement innovator, Leader Electronics of Europe, has announced that it will exhibit at CABSAT, which takes place this year from 21-23 May 2024 at the...
30/04/2024
MRMC Debuts Cinebot Max Camera Robot at NAB 2024
Brie Clayton April 30, 2024
0 Comments
Expands its range of live-action, motion-control camera robots...
30/04/2024
Next Jazz Legacy Announces 2024 Cohort of Women and Nonbinary Awardees The program was created by New Music USA and the Berklee Institute of Jazz and Gender J...
30/04/2024
European telecom satellite company SES announced today that it is acquiring rival Intelsat for $3.1 billion. The deal, unanimously approved by both companies...
30/04/2024
Bob Bakish, chief executive of Paramount stepped down on Monday, effective immediately. Bakish, who was a staunch ally of Shari Redstone, controlling shareholde...
30/04/2024
Hotspring said the breakthrough had been achieved through the acceleration of machine learning technology
By Matthew Corrigan
Published: April 30, 2024
Ho...
30/04/2024
Speaking about the deal, Adel Al-Saleh, CEO of SES, said: it will bring value-added, efficient, and reliable offerings for both companies media customers
By Je...
30/04/2024
Paramount said the Office of the CEO is working with its board to develop a comp...
30/04/2024
LOUISVILLE, Ky. In another sign that broadcasters are finally using NextGen TV broadcasts to offer viewers new features instead of simply simulcasting existing ...
30/04/2024
OKLAHOMA CITY The Oklahoma Journalism Hall of Fame will induct Blaise Labbe, a group news director for Sinclair Broadcast Group, May 2 at the 54th Anniversary I...
30/04/2024
ATLANTA and ENGLEWOOD, Colo. Cox Media Group and Dish have ended a dispute over retransmission fees that lasted nearly a year and a half with a new multi-year ...
30/04/2024
Video transport solution provider LTN has announced that it is working with TelevisaUnivision to help the Spanish-language media giant migrate to IP-based video...
30/04/2024
ALAMEDA, Calif. Clear-Com has released details about how it played a pivotal role in the seamless coverage of the recent solar eclipse on April 8, 2024 by NBC K...
30/04/2024
CINCINNATI The E.W. Scripps Company is adding Seth Walters to its sales leadership team as head of CTV sales, effective April 29....
30/04/2024
The force was strong at the Durham Bulls Athletic Park on Saturday night, April 27, 2024, as the night netted the ballpark's first official sellout crowd of...
30/04/2024
Revry, a network celebrating queer culture. said its second annual NewFront presentation will be a cabaret-type spectacle showcasing the spirit of the LGBTQ+ co...
30/04/2024
Family Entertainment Television (FETV) said that the Western series The Life and Legend of Wyatt Earp will be joining the network's afternoon lineup startin...
30/04/2024
Bob Bakish, president and CEO of Paramount Global, will depart the company as Paramount explores a merger, according to numerous published reports. The reports ...
30/04/2024
6 minute read
Share
alt=Alternative descriptive text class=lazyload main main-lazyloaded responsive-image data-v-1a5ebb10>
Telenor showed good momentum...
30/04/2024
SES Acquiring Intelsat to Create New Satellite Giant; Will Offer Improved Reach ...
30/04/2024
Wuppertal April 30, 2024
WDR Filmhaus to Implement Riedel Infrastructure Award-Winning MediorNet HorizoN Hybrid Processing Platform Serves as Bridge to IP
Ri...
30/04/2024
Back to All News
Tilda Swinton Joins Colin Farrell in Edward Bergers The Ballad...
30/04/2024
Back to All News
Netflix Reveals First Look Images and Teaser from Senna, Inspi...
30/04/2024
Back to All News
Top 10 Week of Apr. 22: Baby Reindeer' and Rebel Moon - ...
30/04/2024
Dr. Nicola Hodson, Chief Executive, IBM UK & Ireland introduces the UK findings of an IBM study on female leadership in the age of AI
Advances in Artificial In...
30/04/2024
Channel Expansion, and New Codecs, Compression and Transport Technology Among Latest Updates...
30/04/2024
Accel-KKR Credit Partners today announced that it has provided debt financing to support Dalet in its next chapter of innovation and growth. Accel-KKR Credit Pa...
30/04/2024
Skeem Saam: Monday's episode, 29 April 2024 [video]Missed an episode of Skeem Saam? No problem! Watch the latest episode of your favourite South African soa...
30/04/2024
Tonight on Skeem Saam: Lewatle witnesses an explosive fight between Sthoko and B...
30/04/2024
RT News is pleased to announce the appointment of David Murphy as its new Economics & Public Affairs Correspondent. David is currently RT 's Political Cove...
30/04/2024
Concerts in Limerick, Dublin, Carlow and Cork, including Marty in the Evening, Morricone and May the Fourth Be With You, celebrating the remarkable decade of th...
St. Jude and Scripps Research Institute Scientists Help Launch Human Dark Proteome Initiative Group to focus on advancing research on intrinsically disordered proteins to better understand catastrophic diseases
