Advancements in whole genome sequencing have ignited a revolution in digital biology.
Genomics programs across the world are gaining momentum as the cost of high-throughput, next-generation sequencing has declined.
Whether used for sequencing critical-care patients with rare diseases or in population-scale genetics research, whole genome sequencing is becoming a fundamental step in clinical workflows and drug discovery.
But genome sequencing is just the first step. Analyzing genome sequencing data requires accelerated compute, data science and AI to read and understand the genome. With the end of Moore's law, the observation that there's a doubling every two years in the number of transistors in an integrated circuit, new computing approaches are necessary to lower the cost of data analysis, increase the throughput and accuracy of reads, and ultimately unlock the full potential of the human genome.
An Explosion in Bioinformatics Data Sequencing an individual's whole genome generates roughly 100 gigabytes of raw data. That more than doubles after the genome is sequenced using complex algorithms and applications such as deep learning and natural language processing.
As the cost of sequencing a human genome continues to decrease, volumes of sequencing data are exponentially increasing.
An estimated 40 exabytes will be required to store all human genome data by 2025. As a reference, that's 8x more storage than would be required to store every word spoken in history.
Many genome analysis pipelines are struggling to keep up with the expansive levels of raw data being generated.
Accelerated Genome Sequencing Analysis Workflows Sequencing analysis is complicated and computationally intensive, with numerous steps required to identify genetic variants in a human genome.
Deep learning is becoming important for base calling right within the genomic instrument using RNN- and convolutional neural network (CNN)-based models. Neural networks interpret image and signal data generated by instruments and infer the 3 billion nucleotide pairs of the human genome. This is improving the accuracy of the reads and ensuring that base calling occurs closer to real time, further hastening the entire genomics workflow, from sample to variant call format to final report.
For secondary genomic analysis, alignment technologies use a reference genome to assist with piecing a genome back together after the sequencing of DNA fragments.
BWA-MEM, a leading algorithm for alignment, is helping researchers rapidly map DNA sequence reads to a reference genome. STAR is another gold-standard alignment algorithm used for RNA-seq data that delivers accurate, ultrafast alignment to better understand gene expressions.
The dynamic programming algorithm Smith-Waterman is also widely used for alignment, a step that's accelerated 35x on the NVIDIA H100 Tensor Core GPU, which includes a dynamic programming accelerator.
Uncovering Genetic Variants One of the most critical stages of sequencing projects is variant calling, where researchers identify differences between a patient's sample and the reference genome. This helps clinicians determine what genetic disease a critically ill patient might have, or helps researchers look across a population to discover new drug targets. These variants can be single-nucleotide changes, small insertions and deletions, or complex rearrangements.
GPU-optimized and -accelerated callers such as the Broad Institute's GATK - a genome analysis toolkit for germline variant calling - increase speed of analysis. To help researchers remove false positives in GATK results, NVIDIA collaborated with the Broad Institute to introduce NVScoreVariants, a deep learning tool for filtering variants using CNNs.
Deep learning-based variant callers such as Google's DeepVariant increase accuracy of calls, without the need for a separate filtering step. DeepVariant uses a CNN architecture to call variants. It can be retrained to fine-tune for enhanced accuracy with each genomic platform's outputs.
Secondary analysis software in the NVIDIA Clara Parabricks suite of tools has accelerated these variant callers up to 80x. For example, germline HaplotypeCaller's runtime is reduced from 16 hours in a CPU-based environment to less than five minutes with GPU-accelerated Clara Parabricks.
Accelerating the Next Wave of Genomics NVIDIA is helping to enable the next wave of genomics by powering both short- and long-read sequencing platforms with accelerated AI base calling and variant calling. Industry leaders and startups are working with NVIDIA to push the boundaries of whole genome sequencing.
For example, biotech company PacBio recently announced the Revio system, a new long-read sequencing system featuring NVIDIA Tensor Core GPUs. Enabled by a 20x increase in computing power relative to prior systems, Revio is designed to sequence human genomes with high-accuracy long reads at scale for under $1,000.
Oxford Nanopore Technologies offers the only single technology that can sequence any-length DNA or RNA fragments in real time. These features allow the rapid discovery of more genetic variation. Seattle Children's Hospital recently used the high-throughput nanopore sequencing instrument PromethION to understand a genetic disorder in the first few hours of a newborn's life.
Ultima Genomics is offering high-throughput whole genome sequencing at just $100 per sample, and Singular Genomics' G4 is the most powerful benchtop system.
Learn More At NVIDIA GTC, a free AI conference taking place online March 20-23, speakers from PacBio, Oxford Nanopore, Genomic England, KAUST, Stanford, Argonne National Labs and other leading institutions will share the latest AI advances in genomic sequencing, analysis and genomic large language models for understanding gene expression.
The conf
Most recent headlines
06/10/2025
France T l visions, France's leading broadcaster, has received the 2025 EBU ...
04/09/2025
Monumental Sports & Entertainment (MSE), in collaboration with Dalet, has been a...
30/08/2025
WASHINGTON The Federal Communications Commission has adopted its FY 2025 Regulatory Fees Order that establishes the regulatory fee rates for the broadcast stati...
29/08/2025
Australian Red Cross and SBS launch training to help workplaces in the fight aga...
29/08/2025
The National Film and Video Foundation (NFVF), an agency of the Department of Sp...
29/08/2025
L3Harris Technologies has concentrated decades of expertise across the entire enterprise to develop affordable and reliable best-of-breed solutions to rapidly c...
29/08/2025
BURBANK, Calif. The CW Network and the Pac-12 Conference have announced a new media rights deal that will extend their broadcast partnership beginning with the ...
29/08/2025
NEW YORK Gracenote has released a new analysis of its global video dataset showing that the number of FAST channels grew nearly 14% from Q1 2025 and 76% since 2...
29/08/2025
SAN JOSE, Calif. Harmonic has announced a series of improvements to its live sports streaming solution that the company said will improve fan engagement, protec...
29/08/2025
NEW YORK and LOS ANGELES Fox Corp. and YouTube TV last night announced a renewal of the full portfolio of Fox networks, including Fox News Channel, Fox Business...
29/08/2025
Budapest, Hungary, August 2025 - The integration of Microsoft Teams Rooms (MTR) with Lightware's Taurus universal matrix switchers delivers a new level of f...
29/08/2025
Frequency, the engine behind many of the world's best-known streaming television channels, today announced it will launch Studio Live, a next-generation uni...
29/08/2025
In an era when AI and cyber resilience are essential, Scality will mark the 10th anniversary of Scality Day on October 16, 2025 in Paris. This flagship global e...
29/08/2025
Disguise's In-House Creative and Technical Teams Pre-Visualised, Programmed and Delivered Content for the Experience, All Powered by EX 3+
Technology solu...
29/08/2025
Disguise will be demonstrating the latest workflows for TV, film and live events on a number of partner booths at the show
Disguise, the industry-leading tech...
29/08/2025
STOCKHOLM, Sweden Accedo will showcase Accedo Compose, its AI agent-powered modular orchestration layer that assists streaming providers in transitioning client...
29/08/2025
LOS ANGELES Cineverse has announced that it is working with Xperi to bring four of its streaming channels to automobiles for the first time as part of the DTS A...
29/08/2025
DALLAS & ATLANTA Gray Media has announced an agreement with the sports streaming service Victory+ to simulcast 17 Dallas Stars NHL games in 15 television market...
29/08/2025
NEW YORK AND CULVER CITY Comcast NBCUniversal and Amazon have announced new and extended distribution agreements that will expand the content available on their...
29/08/2025
FOOTHILL RANCH, Calif. RED Digital Cinema will feature its Cine-Broadcast Module supporting live broadcast workflows during IBC2025, Sept. 12-15, at the RAI Ams...
29/08/2025
29 Aug 2025
Kyivstar Rings Opening Bell at Nasdaq Marking Landmark Listing and ...
29/08/2025
More than half of all NFL games live on Sky for the first timeFriday 29 August 2025
Sky Sports has announced a new three-year deal with the NFL, extending its ...
29/08/2025
Back to All News
RIV4LRIES: The Trailer of the New Series With Samuele Carrino ...
29/08/2025
Get ready for an inspiring and emotional insight into the world of competitive Irish dancing with My Story: Tomi Champion of the World airing on RT 2 this monda...
29/08/2025
RT has today announced that David McCullagh is to be the new presenter of RT Radio 1's flagship Today programme, which airs every weekday at 10am, replaci...
28/08/2025
By Kristin Feeley, Director, Documentary Film & Artist Programs
If you want to tell untold stories, if you want to give voice to the voiceless, you've got ...
28/08/2025
Directed by Steven Bognar and Julia Reichert, Sundance Institute-supported Amer...
28/08/2025
Corridos have been a cornerstone of M sica Mexicana for generations, telling stories rooted in everyday life. Now, a new chapter is taking shape: motivational c...
28/08/2025
Los corridos han sido un pilar de la M sica Mexicana durante generaciones, contando historias enraizadas en la vida cotidiana. Ahora, un nuevo cap tulo est tom...
28/08/2025
Earlier this month, we promised our Verano Forever party would bring the heat, a...
28/08/2025
L3Harris will provide the Polish F-16V fleet with the Viper Shield electronic warfare system as part of an upgrade program....
28/08/2025
Bilbao, August 26, 2025 - AgileTV, an international television and video technol...
28/08/2025
Ken Wilkinson is an Emmy Awards nominated New York audio engineer who specialises in production sound mixing for film, commercial, episodic and documentary work...
28/08/2025
NEW YORK FuboTV today announced that it will launch Fubo Sports, a skinny bundle that focuses on sports with a subscription price of $56 monthly....
28/08/2025
NEVADA City, Calif. At IBC2025, Sept. 12-15 at the RAI Amsterdam, Telestream will debut its new Global Ingest strategy, introducing a next-generation ingest arc...
28/08/2025
Dr. Rhoda Bernard Releases Groundbreaking Debut Book on Accessible Arts Educatio...
28/08/2025
TAG Video Systems, the leader in software-based IP end-to-end workflow monitoring, deep probing, and real-time visualization, has named Oliver Gappa as Sales Di...
28/08/2025
AI-based voice enhancement will be among a series of innovations making their IBC 2025 debut on the DHD stand B46 in Hall 8 at the RAI Amsterdam Convention Cent...
28/08/2025
Telef nica Servicios Audiovisuales (TSA), the leading system integrator and service provider in the media sector in Spain, with the support of Appear, the globa...
28/08/2025
To fully immerse sailing fans in the world's biggest offshore yacht race, production company, Optical Media turned to LiveU's On-site Production solutio...
28/08/2025
Working with Calrec on its most recent overhaul, radio and television broadcaster, WNED has migrated to a fully IP infrastructure with multiple Type R consoles,...
28/08/2025
Cleeng, the Subscriber Retention Management (SRM ) inventor, has unveiled Cleeng Pro, the first-ever direct-to-consumer (D2C) subscription management platform t...
28/08/2025
Zixi, the industry leader in live broadcast-quality video over IP, today announced that French media distribution platform OKAST has selected Zixi to enable rel...
28/08/2025
Solution offers a streamlined, speaker-free architecture to optimize integration with premium external loudspeakers and advanced loudness metering
Nixer Pro Au...
28/08/2025
Cinegy, the premier provider of software-defined television technology, has announced a strategic partnership with Vision One Touch Film Production Services L.L...
28/08/2025
Telestream, a global leader in media workflow technologies, will debut its new Global Ingest strategy at IBC2025, introducing a next-generation ingest architect...
28/08/2025
Tier 1 operator selects Broadpeak to power high-performance, unified CDN solution across Norway, Sweden and Finland
Broadpeak, a leader in streaming and moneti...
28/08/2025
Leading video software provider, Synamedia, today announced that 24 Frames Digital, one of India's leading live event streaming service providers, has chose...
28/08/2025
Meet VisualOn at IBC2025: See What's Next in AI-Powered Video Streaming Join VisualOn at IBC2025 and discover how our AI-driven Optimizer and advanced media...
Advancements in whole genome sequencing have ignited a revolution in digital biology.
