Transforming pregnancy research with a smartphone app
September 05, 2018
For years, pregnant women have been underrepresented in biomedical research. Current treatments, interventions and guidelines do a poor job of taking into consideration the diverse characteristics of all pregnant women.
For example, the guidelines for recommended weight gain during pregnancy are very general, and don't take into consideration factors such as race, height, age or number of previous pregnancies, says Jennifer Radin, PhD, an epidemiologist and digital medicine expert at the Scripps Research Translational Institute.
This lack of representation in research has jarring consequences. Rates of maternal morbidity and mortality in the United States are among the highest in developed countries.
Radin and her colleagues seek to apply a digital approach to addressing the many knowledge gaps that exist for pregnancy. In an article published in npj Digital Medicine describing their early experience, the team demonstrate how scientists can use a smartphone-based research platform to recruit a large and diverse population of pregnant women to participate in a research study: in this case, a study that uses surveys and sensor collected data to better understand individual pregnancy health.
To implement the study, Radin and colleagues partnered with WebMD, a leading provider of health information services. The highly trafficked WebMD Pregnancy app has been downloaded by over 1.6 million people since 2013. The study platform, built using Apple's ResearchKit technology, was embedded into this popular app and connected the researchers with a highly engaged audience of potential study participants.
Over the course of the first nine months of the planned multi-decade program, 2,058 participants from 50 states (who matched the inclusion criteria) were enrolled into the study. These participants completed a total of more than 14,000 surveys, and shared over 107,000 daily measurements of activity, heart rate, sleep and blood pressure.
Pregnant women are curious about their health. They want to understand what is normal for women like them and how they can keep themselves and their developing baby healthy, Radin explains. Increasingly, they turn to apps to search for information and to ask other women about their pregnancy experiences. They are also using sensors to track and monitor their individual health.
A large burden of pregnancy morbidity and mortality impacts African American women, women living in rural areas, and women with co-morbidities, such as diabetes and cardiovascular disease. Radin and her colleagues believe that a mobile research app platform, combined with sensors that enable the collection of frequent and more detailed data, will eliminate many of the barriers that exist for traditional clinic-based studies (e.g. lack of access to care centers, time constraints, transportation challenges) which often lack participant diversity.
We're now focusing on expanding the reach of our research app platform, by making it available to both iOS and Android users, says Steven Steinhubl, MD, director of digital medicine at Scripps Research Translational Institute. We also want to provide individualized information back to participants and ultimately find ways to improve pregnancy health for all women.
In addition to Radin and Steinhubl, authors of the study The Healthy Pregnancy Research Program: Transforming Pregnancy Research Through a ResearchKit App include Andrew I. Su and Eric Topol of Scripps Research; Hansa Bhargava and Benjamin Greenberg of WebMD; and Brian M. Bot and Megan Doerr of Sage Bionetworks.
This work was supported in part by the National Institutes of Health/National Center for Advancing Translational Sciences grant UL1TR001114 and a grant from the Qualcomm Foundation.
About Scripps Research
Scripps Research is ranked the most influential scientific institution in the world for its impact on innovation. A nonprofit research organization, Scripps expands basic knowledge in the biosciences and uses these fundamental advancements to develop profound innovations that improve well-being. Scripps researchers lead breakthrough studies that address the world's most pressing health concerns, accelerating the creation and delivery of medical breakthroughs to better human health across the globe. Our educational and training programs mold talented and committed students and postdocs into the next generation of leading scientists.
Radin, Jennifer Translational Institute
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Transforming pregnancy research with a smartphone app 
