Sony Pixel Power calrec Sony

April 16, 2021

17/04/2021

Making memories: Neural plasticity depends on a noncoding RNA's unexpected journey A new study sheds light on a complex process in the brain that enables us to learn and form memories.

April 16, 2021

JUPITER, FL Making memories involves more than seeing friends or taking photos. The brain constantly adapts to new information and stores memories by building neuron connections, or synapses. How neurons do this reaching out arm-like dendrites to communicate with other neurons requires a ballet of genes, signaling molecules, cellular scaffolding and protein-building machinery.

A new study from scientists at Scripps Research and the Max Planck Florida Institute for Neuroscience finds a central role for one signaling molecule: a long, noncoding RNA that the scientists named ADEPTR.

Using a variety of technologies, including confocal and two-photon microscopy, they track ADEPTR's moves watching as it forms, travels and amasses at the synapse and activates other proteins upon a neuron's stimulation.

Its journey to the far reaches of a brain cell is made possible by a cellular carrier that that tiptoes along a dendrite's microtubule scaffolding. Called a kinesin motor, it deposits ADEPTR near the synapse junction, where it activates other proteins.

The team also found that if ADEPTR is silenced, new synapses don't form during stimulation.

The study, Activity regulated synaptic targeting of lncRNA ADEPTR mediates structural plasticity by localizing Sptn1 and AnkB in dendrites, is published in the journal Science Advances.

Illuminating the dark matter

Long noncoding RNAs have often been described as genomic dark matter, because their role in cells has yet to be fully characterized, especially in neurons, says the study's lead author, Scripps Research neuroscientist Sathyanarayanan Puthanveettil, PhD. Puthanveettil's team is finding that the RNAs play a signaling role in neural plasticity or how neurons adapt and change with experience.

Here we report activity-dependent dendritic targeting of a newly transcribed long noncoding RNA for modulating synapse function, and describe its underlying mechanisms, Puthanveettil says. These studies bring novel insights into the functions of long noncoding RNAs at the synapse.

The first author is Eddie Grinman, a graduate student in Puthanveettil's lab.

A long noncoding RNA is a type of RNA that exceeds 200 nucleotides, and does not get translated into protein. There are thousands of these long noncoding RNA in our cells, but in most cases, their function isn't yet known. What is known is that usually, they tend to stay within the cell nucleus. Some regulate the transcription of genes.

It was surprising to see a long noncoding RNA move from nucleus to the synapse so rapidly and robustly, Grinman says.

A magnificent complexity

The hippocampus is the part of the brain where learning, memory and emotions reside. Working in hippocampal neurons from mice, the team stimulated the neurons with pharmacological activators of learning-related signaling. They found through molecular and high-resolution imaging techniques that the ADEPTR long noncoding RNA was rapidly expressed and transported to the outer arms of the cell. There, the ADEPTR molecules interact with proteins that play a role in structural organization of synapses, proteins called spectrin 1 and ankyrin B.

They found that ADEPTR became downregulated if exposed to an inhibitory neurotransmitter, GABA.

These findings add another layer of complexity in synapse modulation and plasticity, Puthanveettil says. Synaptically localized long noncoding RNA are important regulators of adaptive neuronal function.

Going forward, the team intends to continue characterizing how stimulation affects neuronal plasticity. Also, the authors hope to learn more about the role of ADEPTR in vivo.

It would be interesting to learn what role ADEPTR plays in forming new memories in living organisms, says Grinman.

The work is revealing one of the most fundamental processes of learning and memory: adaptation to changing information and circumstances.

Neural plasticity is what allows us to learn, respond to stimuli, and lay down long-term memories, Puthanveettil says. There is still much to learn about the magnificent complexity of this fundamental biological process.

In addition to Puthanveettil and Grinman, the authors of the study include Yosef Avchalumov, Isabel Espadas, and Supriya Swarnkar of Scripps Research, Florida; and Yoshihisa Nakahata and Ryohei Yasuda of the Max Planck Florida Institute for Neuroscience.

Funding for the work was provided by the National Institutes of Health, 5R01MH094607-05, 1R21DA039417-01A1 and 1R01MH119541-01A1.

Neuroscience Puthanveettil, Sathyanarayanan
LINK: https://www.scripps.edu/news-and-events/press-room/2021/20210416-putha...
See more stories from scripps

Most recent headlines

12/05/2021

When seeing becomes understanding: The centrality of metadata in the management of media assets

The ability to generate thoughts and build relationships within the stream of co...

11/05/2021

MRC: Nielsen Understated TV Numbers for February 2021

NEW YORK-Nielsen's TV viewership numbers were understated for February 2021, this according to an analysis of its procedures by the Media Rating Council'...

11/05/2021

NAB to FCC: Long Past Time' to Decide on Final White Space Rules

WASHINGTON-The National Association of Broadcasters is urging the FCC to stop dithering and make a final decision on its proposal to use a terrain-based model t...

11/05/2021

AIMS TechFest 2021 Opens Registration

BOTHWELL, Wash.-The Alliance for IP Media Solutions (AIMS) has opened registration for the AIMS TechFest 2021 Presents: IP Showcase, a free, live virtual event ...

11/05/2021

Minow Assesses the State of TV 60 Years After Vast Wasteland' Remarks

WASHINGTON-On May 9, 1961, then newly appointed FCC Chairman Newton Minow called television a vast wasteland, criticizing the medium for its violence, inanity...

11/05/2021

IBC Opens Submissions for IBC 2021 Innovation Awards

LONDON-As IBC 2021 eyes a return to an in-person conference, the annual IBC Innovation Awards are ramping up, with the official call for entries now open. Submi...

11/05/2021

Verbit Acquires Vitac Captioning Provider

NEW YORK-Verbit, an AI-powered transcription platform, has announced its acquisition of Vitac, a provider of captioning products and solutions....

11/05/2021

Grass Valley Supplies LiveTouch Replay System to Studio Berlin

MONTREAL-Grass Valley's LiveTouch replay and highlights system has been added to Studio Berlin's live production workflow as part of a recent upgrade. S...

11/05/2021

Megan Clappe Is Named an SBE Fellow

Congratulations to Megan Clappe, who has just been raised to the cherished membership rank of Fellow by the Society of Broadcast Engineers....

11/05/2021

Cooke S7/i Lenses the Pick for Netflix's Below Zero'

LEICESTER, U.K.-Netflix's recent Spanish-language action thriller Below Zero was shot using Cooke S7/i full frame lenses, the choice of cinematographer Is...

11/05/2021

NAB's Smith Looks Toward Brighter Broadcast Future With Help of New Policies

WASHINGTON-The world is beginning to see the light at the end of the tunnel of the Covid-19 pandemic, and on the other side is a brighter, better future for b...

11/05/2021

Bruno Henriquet Appointed to Lead Warner Bros. International TV Production France

Bruno Henriquet Appointed to Lead Warner Bros. International TV Production Franc...

11/05/2021

Magyar Telekom results for the first quarter of 2021

Magyar Telekom results for the first quarter of 2021 Budapest, May 11, 2021 17:30 Magyar Telekom today reported its consolidated financial results for the ...

11/05/2021

SVG SportsTech On Demand: Supponor's Steve Plunkett on Adding Analytics Value to Live Virtual Advertising

SVG SportsTech On Demand: Supponor's Steve Plunkett on Adding Analytics Valu...

11/05/2021

SVG SportsTech On Demand: RT Software's Luke Harrison Breaks Down the Modular Approach to Graphics Production

SVG SportsTech On Demand: RT Software's Luke Harrison Breaks Down the Modula...

11/05/2021

SVG SportsTech On Demand: Fastly's Zac Shenker on Content Security and Supporting Streaming of the Super Bowl

SVG SportsTech On Demand: Fastly's Zac Shenker on Content Security and Suppo...

11/05/2021

SVG SportsTech On Demand: TVU Networks' Jared Timmins on Responding to Remote Needs in Sports

SVG SportsTech On Demand: TVU Networks' Jared Timmins on Responding to Remot...

11/05/2021

SailGP Returns for a Second Season With the Ultimate Remote Production' Setup

SailGP returns for a second season with the ultimate remote production' set...

11/05/2021

NBA Virtual-Reality Broadcasts on Oculus Fueled By Fully Cloud-based Decentralized Workflow

NBA Virtual-Reality Broadcasts on Oculus Fueled By Fully Cloud-based Decentraliz...

11/05/2021

Sundance Institute Names 20 Fellows Across Feature Film Directors and Screenwriters Labs, Native Lab

PARK CITY, UTAH - The Sundance Institute today named the artists and projects se...

11/05/2021

SNS Releases New ShareBrowser Media Asset Management Software

St. Louis, MO-May 11, 2021-Studio Network Solutions (SNS), the world leader in workflow storage servers for professional media teams, today announced that the l...

11/05/2021

Spotify: For the Record' Explores the Art-and Science-of Lullabies

What is it about a lullaby that gently nudges a fussy newborn or rambunctious toddler into a slumber? On the latest episode of our podcast, Spotify: For the Rec...

11/05/2021

Kayo Chingonyi Decodes Black' from Dave's Brit Award-Winning Album PSYCHODRAMA'

For the past several years, Spotify Original podcast DISSECT has delved deep int...

11/05/2021

Sony Expands Functionality of Camera Remote SDK and Increases Range of Compatible Models

Alpha 1 and RX0 II added to list of compatible Sony's cameras Latest versio...

11/05/2021

Award-winning actress Noomi Rapace and renowned actor Nicholas Pinnock join the cast of Django

A CANAL+ cr ation originale and Sky original TV series starring Matthias Schoena...

11/05/2021

Riverdance: The Animated Adventure, a Sky Original is coming exclusively to Sky Cinema and NOW on 28 May 2021

If you were swept away by the phenomenon that is celebrated by millions globally...

11/05/2021

Joe Marler stars in Sky Sports documentary exploring the matter of Mental Health

Big Boys Don't Cry follows the England Rugby forward as he discusses his own struggles and learns new methods of managing mental wellbeing. Sky Sports has ...

11/05/2021

RT and Virgin Media in deal over Six Nations Rugby

Six Nations Rugby today confirmed that it has commenced joint long form contract discussions with broadcasters Virgin Media Television and RT having agreed a j...

11/05/2021

RT continues proud support of School Digital Champion Programme

#digitalchamps RT is proud to continue its support of the School Digital Champion Programme which culminates in the annual showcase (virtual) event this Wedne...

11/05/2021

Create in Record Time with New NVIDIA Studio Laptops from Dell, HP, Lenovo, Gigabyte, MSI and Razer

New NVIDIA Studio laptops from Dell, HP, Lenovo, Gigabyte, MSI and Razer were an...

11/05/2021

Keeping Games up to Date in the Cloud

GeForce NOW ensures your favorite games are automatically up to date, avoiding game updates and patches. Simply login, click PLAY, and enjoy an optimal cloud ga...

11/05/2021

CircleCI Reaches $1.7 Billion Valuation with $100 Million in New Financing

Greenspring Associates leads Series F financial round as demand for the leading CI/CD provider explodes, topping 2.5 million jobs processed per day San Francis...

11/05/2021

Lauren Lyle to star as Karen Pirie in ITV cold case murder drama Karen Pirie

Lauren Lyle to star as Karen Pirie in ITV cold case murder drama, Karen Pirie Lauren Lyle to star as Karen Pirie in ITV cold case murder drama, based on acclai...

11/05/2021

Grass Valley s LiveTouch Helps Studio Berlin Ramp Up Replay Capability

MONTREAL, May 11, 2021 - Grass Valley announces that its LiveTouch replay and highlights system will become a key element of Studio Berlins upgraded live produc...

11/05/2021

THIRD QUARTER AND NINE-MONTH 2020-21 REVENUES

Press release - 11 May 2021 17:47 THIRD QUARTER AND NINE-MONTH 2020-21 REVENUES Facebook LinkedIn Twitter Download as PDF Full Year revenue objective u...

11/05/2021

DPA MICROPHONES INTRODUCES TWO NEW HEADSET MICROPHONES

Solutions Combine DPAs Renowned 5mm Capsules With Award-winning 6066 Design. DPA Microphones announces the 4466 CORE Omnidirectional and 4488 CORE Directional ...

11/05/2021

MY

MY Date Released:07 May 2021 Share Tweet 7 2021 1 GFK RAM 94% 2060 28 2 ...

11/05/2021

2021-05-11

Apple helps keep the App Store a safe and trusted place for users to discover apps by detecting and taking action against fraudulent developers and users....

11/05/2021

Ross Video Receives Official Designation as a Canadian Compassionate Company (CCC)

Ottawa, Canada, May 11th, 2021 Ross Video is an Ottawa-based technology compan...

11/05/2021

Ross Launches Ultrix Carbonite - The Mid-Size Hyper-Converged Production Platform

Ottawa, Canada, May 11th 2021 - In February of this year Ross announced the laun...

11/05/2021

Excitement surrounds Durham Bulls home opener

The Bulls face the Jacksonville Jumbo Shrimp at 6:35. The Durham Bulls will play a game at their home field on Tuesday, and it's not your average opening n...

11/05/2021

Boomers Back: Chris Berman Signs Extension With ESPN

Chris Berman, who joined ESPN a month after it launched in 1979, has signed a new multi-year deal with the sports TV giant....

11/05/2021

TV By the Numbers: NBA Basketball Scores for Watch-Time

This is a quick snapshot of TV by the numbers for the week of May 3-9, revealing the most-watched shows and networks using glass-level data from Vizios Inscape,...

11/05/2021

Team Whistle Names Matt Koenig VP, Programming and Monetization

Team Whistle named Matt Koenig VP of programming and monetization for WhistleTV....

11/05/2021

NBCU's Linda Yaccarino Calls Trust Key to Growth

Trust matters, said Linda Yaccarino, NBCUniversal's global chairman for advertising and partnerships, in an opinion piece posted Tuesday on the NBCU Togethe...

11/05/2021

Evergent Platform To Support AWS For Media & Entertainment Initiative

Evergent said its revenue and user management platform will support the Amazon Web Services for Media & Entertainment initiative....

11/05/2021

How Nielsen Undercount Revelations Will Affect The Upfront

Networks and distributors represented by the VAB want more information about how much undercounting of viewers happened at Nielsen during the COVID-19 pandemic ...