Calibr announces preliminary clinical data from first-in-human clinical trial of switchable CAR-T Cells (CLBR001 SWI019) in lymphoma patients at 63rd Annual ASH Meeting
Two of the first three patients in the lowest dose cohort experienced a complete response to therapy with the longest response being 11 months (ongoing) at the time of data cut-off
The novel switchable CAR-T therapy showed a favorable profile with no toxicities associated with the cell product (CLBR001) alone, validating the universal platform approach to cell therapy
December 08, 2021
LA JOLLA, CA Calibr, a division of Scripps Research focused on the bench to bedside development of transformative medicines, will present preliminary data on the development of a novel switchable CAR-T cell platform for patients with relapsed/refractory lymphoma and leukemia. Preclinical IND-enabling studies supporting the first-in-human clinical study will be presented on December 11 at 5:30 p.m. and the clinical data will be presented on December 12 at 6:00 p.m. at the 63rd Annual ASH meeting.
CLBR001 SWI019 is the first clinical demonstration of Calibr's novel switchable CAR-T cell platform technology, in which the activity of a universal CAR-T cell product (CLBR001) is controlled through dosage of an antibody-based molecule targeting CD19 referred to as a switch (SWI019). The approach represents a paradigm shift from conventional CAR-T cell therapy in that the activity of the CAR-T cells can be switched on or off through dosing of the switch to the patient. This type of switchable control over the cells is expected to improve safety T cell durability of the therapy. Importantly, the CLBR001 switchable CAR-T is universal; by changing the switch, the CAR-T cells can be programmed to attack different antigen targets and thereby treat multiple cancers.
As of the data cutoff, 5 patients (2 with mantle cell lymphoma (MCL), 2 with follicular lymphoma (FL), and 1 with marginal zone lymphoma (MZL)) had been treated across two cohorts. Two of the first three patients who received the lowest doses of CLBR001 and SWI019 in cohort 1 of the dose escalation trial experienced a complete response to treatment as assessed by Lugano criteria. Durability of the response appears promising, with the longest response ongoing at 11 months. Treatment in cohort 2 is ongoing.
In the preliminary safety and tolerability data for CLBR001 SWI019, no adverse events related to the cell product CLBR001 alone were reported, validating the design of the universal cell product to be functionally off in the absence of SWI019. Following administration of the switch molecule SWI019, two subjects experienced transient cytokine release syndrome (CRS) of severity grades 1 and 3. The subject who experienced Grade 1 CRS also experienced Grade 1 immune effector cell-associated neurotoxicity syndrome (ICANS). These cases of CRS/ICANS resolved quickly with typical CRS treatment followed by holding or reducing SWI019 dose, supporting the ability to adjust the CAR-T response in real time.
We are very excited by initial signs of activity even at the lowest doses of CLBR001 and SWI019, says Travis Young, PhD, Calibr's vice president of biologics and lead on the CAR-T development at Calibr. We believe this underscores the potential of this therapy to not only benefit patients with blood cancers, but patients with solid tumors as well.
Liana Nikolaenko, MD, from City of Hope is the lead author on the poster presentation. Switchable CAR-T cell platform, as designed by Calibr, is a remarkable technology enabling a delivery of the targeted therapy for patients with relapsed or refractory B-cell malignancies with a unique approach to mitigate potential toxicities that could be associated with CAR-T cell treatment, which can be severe and life-threatening, says Nikolaenko. The preliminary results of this novel approach are encouraging.
Calibr has partnered the switchable CAR-T cell platform with AbbVie and together they are collaborating on developing the switchable CAR-T cell platform for solid tumor indications. AbbVie holds certain rights to commercialization.
Presentation times
Poster: 2822 First in Human Study of an On/Off Switchable CAR-T Cell Platform Targeting CD19 for B Cell Malignancies (CLBR001 SWI019)
Session Date/Time: Sunday, December 12, 2021, 6:00 p.m.--8:00 p.m.
Presenter: Liana Nikolaenko, MD, City of Hope
Poster: 1695 IND-Enabling Studies of a Switchable Chimeric Antigen Receptor-T Cell (CLBR001 SWI019) to Support First in Human Clinical Study
Session Date/Time: Saturday, December 11, 2021, 5:30 p.m.--7:30 p.m.
Presenter: Eduardo Laborda, PhD, Calibr at Scripps Research
About CLBR001 SWI019:
Calibr at Scripps Research is currently enrolling patients with B cell malignancies including lymphomas and chronic lymphocytic leukemia to an open label Phase I clinical study to test the safety and tolerability of CLBR001 SWI019 (NCT04450069). Up to 30 patients may be enrolled in the multi-center dose escalation trial to determine the optimal dose of CLBR001 and SWI019. Additional information on the study can be found at https://clinicaltrials.gov/ct2/show/NCT04450069.
About Calibr at Scripps Research:
Calibr was founded on the principle that the creation of new medicines can be accelerated by pairing world-class biomedical research with state-of-the-art drug discovery and development capabilities. Leveraging the unique scientific framework of Scripps Research, Calibr has created a portfolio of drug candidates based on Scripps technologies, and is shaping a new paradigm for advancing nonprofit biomedical research to impact patients while re-investing in further innovative research.
Cancer Calibr Calibr
Most recent headlines
04/08/2024
Dalet, a leading technology and service provider for media-rich organizations, is excited to announce Santiago Solanas as its new Chief Executive Officer (CEO)....
03/06/2024
Dalet, a leading technology and service provider for media-rich organizations, a...
29/04/2024
29 04 2024 - Media release Screen Australia announces James J. Robinson's debut feature First Light
First Light
Principal Photography is underway on Firs...
29/04/2024
Capitol Broadcasting recently became the inaugural company honored with inductio...
28/04/2024
Mediahaus delivers the first SRT live-streaming sports production over 5G with U...
27/04/2024
On April 26, L3Harris Chair and CEO Christopher E. Kubasik joined CNBC's Mor...
27/04/2024
PORTLAND, Oregon Audinate Group Limited, the developer of the Dante AV-over-IP solution, announced significant new additions to Dante Connect, its cloud-based D...
27/04/2024
TORONTO Bell Media has launched 10 English and French-language FAST channels featuring entertainment, factual, news, and sports programming. The new free stream...
27/04/2024
An extensive new analysis of the news segments in the broadcast evening news programs of ABC, CBS, NBC and PBS has found that broadcasters devoted most of their...
27/04/2024
GERMANTOWN, Md. EchoStar's Hughes Network Systems has opened a new manufacturing facility and private 5G incubation center in Germantown, Maryland....
27/04/2024
Harry Pappas, one of three brothers who founded Pappas Telecasting Companies in 1971, died April 24. He was 78 years old....
27/04/2024
ATLANTA and LONDON Mexican telecommunications and broadcast company Televisa has selected Synamedia for an overhaul of its broadcast distribution....
27/04/2024
Participate in the Survey - The Impact of AI on Media and the Creative Industry
Pascal Wagner April 26, 2024
0 Comments
By participating in this surve...
27/04/2024
SDVI Rally Access Workstation Earns Two Top Awards at 2024 NAB Show
Brie Clayton April 26, 2024
0 Comments
SDVI, the leading platform provider for clo...
27/04/2024
Berklee's Music and Health Institute Launches Community Health Musician Cert...
27/04/2024
Charter Communications reported higher first-quarter profits despite continued cord-cutting and competition for broadband customers....
27/04/2024
Two environmentally-focused groups are partnering to engage the unscripted TV world in finding better ways to address climate change. Reality of Change is an ec...
27/04/2024
Sarah Garcia has been promoted to weekend anchor at KTLM McAllen, Texas, known as Telemundo 40. Starting April 27, she will anchor Noticias Telemundo 40 weekend...
27/04/2024
CBS Sports said it launched a new 24-hour free, ad supported streaming television (FAST) channel devoted to the UEFA Champions League....
27/04/2024
Comcast chairman and CEO Brian Roberts received $35.4 million in compensation in 2023, up 11% from the previous year, according to a proxy statement filed by th...
27/04/2024
Art Happens Here With John Lithgow, which sees the actor study dance, ceramics, silk-screen printing and vocal jazz with students in Los Angeles, debuts on PBS ...
27/04/2024
Remember Leave It to Beaver? Bewitched? Dragnet? When cable ratings were rising?...
27/04/2024
Next up for the weekend binge at Catchy Comedy is Gomer Pyle, U.S.M.C. Every weekend, Catchy Comedy features The Catchy Binge, a marathon of a classic sitcom....
26/04/2024
Sundance Film Festival CDMX 2024 kicks-off today with screenings in 5 theaters in Mexico City and the opening-night film, FRIDA, directed by Carla Guti rrez...
26/04/2024
[Editor's Note: This interview is part of a larger feature about the women d...
26/04/2024
Once again this year, SGL Carbon opened its doors to interested children and young people. On the occasion of the German Girls and Boys Day, which took place on...
26/04/2024
Orders1 of $5.5 billion; book-to-bill of 1.06x
Revenue of $5.2 billion, up 17%,...
26/04/2024
Five Considerations For Communications Modernization In The 21st Century
In the digital-enabled battlespace, the Joint Force needs to shoot, move and communica...
26/04/2024
CBS Sports has launched Champions League as a new, 24-hour streaming channel that will serve as the year-round destination for nonstop highlights of the UEFA ...
26/04/2024
Despite tough competition in the streaming space, Roku reported solid results in Q1 2024, beating revenue expectations, with total net revenue up 19% YoY to $88...
26/04/2024
LONDON AND TORONTO Pinewood Toronto Studios has appointed Sarah Farrell as general manager of the Studios in downtown Toronto....
26/04/2024
Quantum to Offer Advanced Filesharing Technology and Performance in StorNext and...
26/04/2024
FilmLight Colour Awards welcomes 2024 entries and introduces new Emerging Talen...
26/04/2024
Picture Shop Announces Chris Evans as Head of Unscripted
Brie Clayton April 26, 2024
0 Comments
Picture Shop announced Chris Evans will lead Unscripte...
26/04/2024
Participate in a Survey - The Impact of AI on Media and the Creative Industry
Pascal Wagner April 26, 2024
0 Comments
By participating in this survey,...
26/04/2024
Toy maker Mattel said it is working with Samsung to launch its first free ad-supported streaming television (FAST) channels later this year....
26/04/2024
Trusted Media Brands (TMB) said it named Marty Moe as president....
26/04/2024
Ron Howard is the director on Jim Henson Idea Man, a documentary that premieres on Disney Plus May 31. Henson of course created Kermit the Frog, Miss Piggy, Big...
26/04/2024
The ice continues to melt under the regional sports network business as the Seattle Kraken of the National Hockey League have made a long-term deal to broadcast...
26/04/2024
Heading into the upfronts, Warner Bros. Discovery said it launched Olli, a first-party data platform advertiser can use for converged, targeted advertising camp...
26/04/2024
CBS has renewed the drama The Equalizer, which will see season five on in 2024-2025. Queen Latifah stars....
26/04/2024
The CW has entered into an exclusive multiyear broadcast partnership for the Miss USA Pageant and the Miss Teen USA Pageant. The 73rd Miss USA Pageant will air ...
26/04/2024
Fuse Media isn't mincing words in a campaign urging its young viewers to register and participate in the 2024 elections....
26/04/2024
Dead Boy Detectives, a series from Neil Gaiman about a detective agency staffed by ghosts, debuts on Netflix April 25. George Rexstrew and Jayden Revri are in t...
26/04/2024
The Story Collective has gradually repurposed the former Mortlake Brewery to include production offices, workshops and sound stages
By Matthew Corrigan
Publi...
26/04/2024
Perkett joins the company following a 25 year career in product management, product marketing, engineering and user experience (UX) across multiple industries
...
26/04/2024
Teradek, the industry leader in wireless video transmitters and receivers, announced today the launch of new Bolt 6 LT 750 and Bolt 6 Monitor Module 750 RX with...
26/04/2024
NEW YORK Amagi has appointed Richard Perkett chief product officer (CPO)....
26/04/2024
WASHINGTON, D.C. The National Association of Broadcasters (NAB) has announced the results of the 2024 NAB Radio and Television Board of Directors elections. The...
Calibr announces preliminary clinical data from first-in-human clinical trial of switchable CAR-T Cells (CLBR001 SWI019) in lymphoma patients at 63rd Annual ASH Meeting 
