Brain receptor that regulates body heat may also help accelerate weight loss A discovery from Scripps Research shows that blocking the kappa opioid receptor while on a restricted-calorie diet could help shed pounds faster.
November 27, 2019
LA JOLLA, CA The brain mechanism that enables us to maintain a constant body temperature may also be the key to rapid weight loss, a new study finds. In experiments involving mice that were given a calorie-restricted diet, scientists at Scripps Research discovered that blocking a brain receptor that normally regulates body heat resulted in significant weight reductions.
The findings will be further explored as a potential treatment approach for obesity, which the World Health Organization has called a global epidemic. Obesity affects virtually all age and socioeconomic groups increasing risk for heart disease, stroke, diabetes, cancer and many other serious health conditions.
The new study, led by Scripps Research Professor Bruno Conti, PhD, appears in Current Biology.
Up to 50 percent of what we eat every day is used as energy to maintain body temperature, Conti says. But when food is scarce, mammals adapt by lowering their temperature, limiting energy expenditure and the loss of body weight.
Some species, he notes, can go into complete hibernation. Of course, humans don't hibernate when they're on a calorie-restricted diet, but they do naturally experience a lower body temperature just like other mammals. And that makes it harder to lose weight when on a diet.
It's a basic survival mechanism, Conti says. The body is saying: Let's save energy today and maybe we will find food tomorrow.
In a continuation of their earlier research on lifespan and aging, Conti and his team investigated the cellular mechanisms that regulate the body's cooling response to calorie restriction. Biological data obtained in collaboration with the Scripps Research lab of Gary Siuzdak, PhD, suggested the possibility that opioid compounds that naturally occur within the body could be mediating these effects.
Next, the team tested whether blocking the activity of opioid receptors would affect body temperature during calorie restriction. It did. They also determined that this mechanism was uniquely regulated by one of the three known opioid receptor types: the kappa opioid receptor. The finding made sense, as the kappa receptor is the most abundant opioid receptor in the hypothalamus, the part of the brain already known to play a role in regulating both body temperature and feeding.
Conti's team then wondered if by blocking the kappa receptor, the body would continue to burn up calories to regulate heat even when food was restricted. We developed an experimental protocol that would allow us to determine what changes were happening as a result of body heat regulation, not diet, says Rigo Cintron-Colon, PhD, first author of the study.
In one set of experiments, the scientists observed two groups of lean mice that had already been on calorie-restricted diets for six weeks. One group was then treated with a drug to block the kappa receptor. The control group had adapted to the new diet and weight loss plateaued, while the experimental group showed greater energy expenditure and lost an additional 6 percent of body weight.
When we blocked the kappa receptor, the animals did not lower their temperature during calorie restriction and lost more body weight, Conti says.
Similar results were obtained with mice that had developed diet-induced obesity. Blocking the kappa opioid receptor during calorie restriction nearly doubled the body weight loss that the obese animals would normally undergo if the receptor was functional. However, when animals were allowed to eat freely, blocking the kappa opioid receptor had no effects on body temperature and did not alter the normal rate of body weight loss.
This is important, Conti says, as it tells us that kappa opioid blockers are effective in both lean mice and obese mice, but that the medicine is able to affect body weight only in animals that are dieting.
The findings suggest a possibility that by translating these findings into humans, a pharmaceutical product may be able to help those who are struggling to lose weight, despite their adherence to a calorie-restricted diet. As a next step, Conti would like to explore whether existing medicines that are known to block the kappa receptor could be repurposed and refined to safely treat obesity.
The tools to interact with this mechanism may already be available, and if they are, they may be able to translate quickly into a medicine, he says. Unfortunately for many people who are obese, losing weight isn't as simple as eating less.
Authors of the article, Activation of Kappa Opioid Receptor Regulates the Hypothermic Response to Calorie Restriction and Limits Body Weight Loss, include Rigo Cintron-Colon, Christopher W. Johnson, J. Rafael Montenegro-Burke, Carlos Guijas, Lila Faulhaber, Manuel Sanchez-Alavez, Carlos A. Aguirre, Kokila Shankar, Mona Singh, Andrea Galmozzi, Gary Siuzdak, Enrique Saez and Bruno Conti.
This work was supported by the National Institutes of Health (GM113894, RC2 DK114785, R01 GM114368-03, P30 MH062261-17, P01 DA026146-02) and the Cloud Credits Model Pilot, a component of the NIH Big Data to Knowledge program.
Diabetes, Obesity and Metabolic Disorders Conti, Bruno
Most recent headlines
11/12/2025
Dalet, a leading provider of cloud-native, end-to-end media workflow solutions, ...
03/12/2025
WASHINGTON The Federal Communications Commission has opened a docket for comments on the proposed $6.2 billion Nexstar acquisition for Tegna and set deadlines f...
03/12/2025
MILAN, Italy Brightcove has released seven new features designed to expand global reach, improve audience engagement, enhance live-streaming quality and streaml...
03/12/2025
NEW YORK Great American Media said it plans to launch Pure Flix Familia, a dedicated Spanish-language platform, in 2026....
03/12/2025
SOUTHPORT, Conn. Main Street Sports Group has announced that the FanDuel Sports Network app is now available directly on Vizio and on smart TVs with Vizio OS. T...
03/12/2025
SAN JOSE, Calif. Harmonic has announced that Telia, the second-largest telecom operator in Norway, is modernizing its broadband network with the company's c...
03/12/2025
GREEN BAY, Wis. Sinclair said Jay Zollar, vice president and general manager of WLUK-WCWF here, will retire Dec. 31 after 26 years running the stations. Station...
02/12/2025
Case Study: How Mid-Atlantic Sports Network Moved to All-IP Distribution in 60 D...
02/12/2025
2025 Sports Broadcasting Hall of Fame: Lee Corso, Coach, Commentator, FirebrandBy Ken Kerschbaumer
Tuesday, December 2, 2025 - 7:00 am
Print This Story | S...
02/12/2025
SVG All-Stars: Dan Nabors, Senior Director, Remote Engineering, TNT SportsThe veteran tech leader is helping guide Warner Bros. Discovery's at-home' re...
02/12/2025
National Lacrosse League Opens Season With New Cloud-Based Official Replay-Revie...
02/12/2025
Platinum White Paper: The Cinematic Look in Live Production - Bridging Aesthetic...
02/12/2025
SVG India Announces Advisory Board; JioStar's Prashant Khanna Named ChairmanBy Ken Kerschbaumer
Tuesday, December 2, 2025 - 11:15 am
Print This Story |...
02/12/2025
SVG Summit 2025 Preview: New AI Production Tools Workshop' Features ESPN, F...
02/12/2025
Written and directed by Hailey Gates, Atropia won the U.S. Grand Jury Prize: Dramatic at the 2025 Sundance Film Festival....
02/12/2025
The lightweight and highly portable CORVUS-RAVEN, recently demonstrated at the V...
02/12/2025
The lightweight, rugged Panther 2 tri-band VSAT delivers high-speed data communications for Internet, VPN connectivity and video transmission over commercial an...
02/12/2025
eds3_5_jq(document).ready(function($) { $(#eds_sliderM519).chameleonSlider_2_1({...
02/12/2025
NGID volunteers in the United States
NGID volunteers in Mexico
NGID volunteers in India
NGID volunteers in Spain
NGID volunteers in Australia
NGID voluntee...
02/12/2025
WASHINGTON The Federal Communications Commission's Media Bureau has issued a reminder that stations in DMAs 111 through 120 must implement its audio descrip...
02/12/2025
SAN DIEGO Sony Electronics today introduced the Alpha 7 V (ILCE-7M5), the fifth generation of its Alpha 7 full-frame mirrorless lineup, powered by the newly dev...
02/12/2025
WASHINGTON The Federal Communications Commission has opened a docket for comments on Nexstar Media Group's proposed $6.2 billion acquisition of Tegna and se...
02/12/2025
WASHINGTON The National Association of Broadcasters has added a trio of media executives, Veronica Rodriguez, Matt Schnaars and Jeff Warshaw, to its board of di...
02/12/2025
MILAN, Italy Brightcove has released seven new features designed to expand global reach, improve audience engagement, enhance live-streaming quality and streaml...
02/12/2025
BCNEXXT, the developers of the advanced playout platform Vipe, today announced a new Service Provider Partner agreement with NPC Media, the Australian managed p...
02/12/2025
DPA Microphones today announces the immediate availability of its new N-Series Digital Wireless Microphone System for customers throughout the U.S. In addition ...
02/12/2025
Hiltron Communications reports a well attended and successful Space Tech Expo exhibition, held at the Messe Bremen from Tuesday November 18 through Thursday Nov...
02/12/2025
The beginning of September saw Riverfire by Australian Retirement Trust, in association with Channel 9 and Triple M, kick off the 2025 Brisbane Festival in spec...
02/12/2025
SGM Lighting is pleased to announce an exciting new partnership with ACT Entertainment, under which ACT will serve as the exclusive distributor for SGM's ne...
02/12/2025
Harmonic (NASDAQ: HLIT) today announced that Telia, the second largest telecom operator in Norway, is modernizing its broadband network with the company's i...
02/12/2025
European cloud data protection specialist Keepit is expanding its sales network in the DACH region and has gained TIM AG, one of the leading value-added distrib...
02/12/2025
Featured products at ISE 2026
This year s ISE 2026 theme "Push Beyond" reflects Calrec s direction of travel. The company is dedicated to supporting the AV an...
02/12/2025
Czech Television, the national public broadcaster, has deployed one of the largest LiveU live production projects in the region for live sports and news coverag...
02/12/2025
Test & measurement innovator, Leader Electronics, has announced the release of v8.2 software for its ZEN and ZEN-W Series, bringing advanced cinematic camera se...
02/12/2025
Global provider of video streaming software and services, Accedo, and OTT platform provider, Magine Pro, have signed a binding agreement to carve out and merge ...
02/12/2025
With proven success in broadcast, OTT, and content supply chains, K.S Avinash set to scale Skandha's service-first approach across APAC
Skandha Media Servi...
02/12/2025
AJA Video Systems has joined the RAVENNA community, a network of partners devoted to advancing the RAVENNA standard for distributing real-time audio over intern...
02/12/2025
HUNT VALLEY, Md. Sinclair and its wholly-owned subsidiary One Media Technologies have released a new report focused on how ATSC 3.0, the IP-based NextGen TV sta...
02/12/2025
WASHINGTON The Federal Communications Commission's Media Bureau has issued a reminder that stations in DMAs 111 through 120 must implement its audio descrip...
02/12/2025
WASHINGTON Members of the Advanced Television Systems Committee have elected four industry veterans to three-year terms on the organization's board of direc...
02/12/2025
A new survey from S&P Global Market Intelligence Kagan highlights how important social media is for younger consumers, with Gen Z spending 5.1 hours a day on so...
02/12/2025
Faculty Notes: Fall/Winter 2025 Recent accomplishments, releases, and events by Berklee faculty.
December 1, 2025
By
Editorial Staff
The cast of Kind of M...
02/12/2025
Today, Mistral AI announced the Mistral 3 family of open-source multilingual, multimodal models, optimized across NVIDIA supercomputing and edge platforms.
M...
02/12/2025
Ring In The Holidays With Our Biggest Sale Ever On Ivory II Pianos!From now until December 31st, you can save 50% or more on every Ivory II piano and collection...
02/12/2025
Back to All News
Made in America: How Stranger Things' Electrified the US Economy
Entertainment
02 December 2025
GlobalUnited States
Link copied to cl...
02/12/2025
Back to All News
Culinary Class Wars' Season 2 Trailer Teases New Rules, R...
02/12/2025
--
The International Electrotechnical Commission (IEC), the International Organization for Standardization (ISO), and the International Telecommunication Unio...
02/12/2025
Harmonic's cOS Platform Will Redefine Subscribers' Quality of Experience, Lowering Churn SAN JOSE, Calif. - Dec. 2, 2025 - Harmonic (NASDAQ: HLIT) today...
02/12/2025
At AWS re:Invent, NVIDIA and Amazon Web Services expanded their strategic collab...
Brain receptor that regulates body heat may also help accelerate weight loss A discovery from Scripps Research shows that blocking the kappa opioid receptor while on a restricted-calorie diet could help shed pounds faster.
