
At leading institutions across the globe, the NVIDIA DGX Spark desktop supercomputer is bringing data center class AI to lab benches, faculty offices and students' systems. There's even a DGX Spark hard at work in the South Pole, at the IceCube Neutrino Observatory run by the University of Wisconsin-Madison.
The compact supercomputer's petaflop class performance enables local deployment of large AI applications, from clinical report evaluators to robotics perception systems, all while keeping sensitive data on site and shortening iteration loops for researchers and learners.
Powered by the NVIDIA GB10 superchip and the NVIDIA DGX operating system, each DGX Spark unit supports AI models of up to 200 billion parameters and integrates seamlessly with the NVIDIA NeMo, Metropolis, Holoscan and Isaac platforms, giving students access to the same professional-grade tools used across the DGX ecosystem.
Read more below on how DGX Spark powers groundbreaking AI work at leading institutions worldwide.
IceCube Neutrino Observatory: Studying Particles in the South Pole At the University of Wisconsin-Madison's IceCube Neutrino Observatory in Antarctica, researchers are using DGX Spark to run AI models for its experiments studying the universe's most cataclysmic events, using subatomic particles called neutrinos.
Traditional astronomy methods, based on detecting light waves, enable observing about 80% of the known universe, according to Benedikt Riedel, computing director at the Wisconsin IceCube Particle Astrophysics Center. A new way to explore the universe - using gravitational waves and particles like neutrinos - unlocks examining the most extreme cosmic environments, including those involving supernovas and dark matter.
DGX Spark on a ceremonial South Pole marker. Image courtesy of Tim Bendfelt / NSF. There's no hardware store in the South Pole, which is technically a desert, with relative humidity under 5% and an elevation of 10,000 feet, meaning very limited power, Riedel said. DGX Spark allows us to deploy AI in a compartmentalized and easy fashion, at low cost and in such an extremely remote environment, to run AI analyses locally on our neutrino observation data.
NYU: Using Agentic AI for Radiology Reports At NYU's Global AI Frontier Lab, the ICARE (Interpretable and Clinically Grounded Agent Based Report Evaluation) project runs end-to-end on a DGX Spark in the lab. ICARE uses collaborating AI agents and multiple choice question generation to evaluate how closely AI generated radiology reports align with expert sources, enabling real time clinical evaluation and continuous monitoring without sending medical imaging data to the cloud.
Being able to run powerful LLMs locally on the DGX Spark has completely changed my workflow, said Lucius Bynum, data science assistant professor and a faculty fellow at the NYU Center for Data Science. I have been able to focus my efforts on quickly iterating and improving the research tool I'm developing.
NYU researchers also use DGX Spark to run LLMs locally as part of interactive causal modeling tools that generate and refine semantic causal models - structured, machine readable maps of cause and effect relationships between clinical variables, imaging findings and potential diagnoses. This setup lets teams rapidly design, test and iterate on advanced models without waiting for cluster resources, including for privacy- and security sensitive applications such as in healthcare, where data must stay on premises.
Harvard: Decoding Epilepsy With AI At Harvard's Kempner Institute for the Study of Natural and Artificial Intelligence, neuroscientists are using DGX Spark as a compact desktop supercomputer to probe how genetic mutations in the brain drive epilepsy. The system lets researchers run complex analyses in real time without needing to wait for access to large institutional clusters.
Kempner Institute Co-Director Bernardo Sabatini (left) and Kempner Senior AI Computing Engineer Bala Desinghu (right) use a DGX Spark supercomputer to study how disruptions to neurons in the brain can drive neurological disorders such as epilepsy. Image courtesy of Anna Olivella. The team, led by Kempner Institute Co-Director Bernardo Sabatini, is studying about 6,000 mutations in excitatory and inhibitory neurons, building protein-structure and neuronal-function prediction maps that guide which variants to test next in the lab.
DGX Spark acts as a bridge between benchtop and cluster scale computing at Harvard. Researchers first validate workflows and timing on a single DGX Spark, then scale successful pipelines to large GPU clusters for massive protein screens.
ASU: Enabling Campus Scale Innovation Arizona State University was among the first universities to receive multiple DGX Spark systems, which now support AI research across the campus, spanning initiatives for memory care, transportation safety and sustainable energy.
ASU doctoral students hold the NVIDIA DGX Spark for the first time. Both students are part of Professor YZ' Yang's Active Perception Group laboratory. Image courtesy of Alisha Mendez, ASU. One ASU team led by Yezhou YZ Yang, associate professor in the School of Computing and Augmented Intelligence, is using DGX Spark to power advanced perception and robotics research, including for applications such as AI enabled, search-and-rescue robotic dogs and assistance tools for visually impaired users.
Mississippi State: Empowering Computer Science and Engineering Students In the computer science and engineering department at Mississippi State University, DGX Spark serves as a hands on learning platform for the next generation of AI engineers.
The enthusiasm around DGX Spark at Mississippi State is captured through lab driven outreach, including an unboxing video created by a lab working to a
More from Nvidia
12/02/2026
At leading institutions across the globe, the NVIDIA DGX Spark desktop supercomputer is bringing data center class AI to lab benches, faculty offices and studen...
12/02/2026
A diagnostic insight in healthcare. A character's dialogue in an interactive...
12/02/2026
The GeForce NOW sixth-anniversary festivities roll on this February, continuing a monthlong celebration of NVIDIA's cloud gaming service.
This week brings ...
05/02/2026
Break out the cake and green sprinkles - GeForce NOW is turning six.
Since launch, members have streamed over 1 billion hours, and the party's just getting...
04/02/2026
Editor's note: This post is part of the Nemotron Labs blog series, which exp...
03/02/2026
At 3DEXPERIENCE World in Houston, NVIDIA founder and CEO Jensen Huang and Dassau...
29/01/2026
Mercedes-Benz is marking 140 years of automotive innovation with a new S-Class b...
29/01/2026
Editor's note: This post is part of Into the Omniverse, a series focused on ...
29/01/2026
Get ready to game - the native GeForce NOW app for Linux PCs is now available in beta, letting Linux desktops tap directly into GeForce RTX performance from the...
28/01/2026
Quantum technologies are rapidly emerging as foundational capabilities for economic competitiveness, national security and scientific leadership in the 21st cen...
22/01/2026
AI-powered driver assistance technologies are becoming standard equipment, funda...
22/01/2026
The wait is over, pilots. Flight control support - one of the most community-requested features for GeForce NOW - is live starting today, following its announce...
22/01/2026
AI has taken center stage in financial services, automating the research and exe...
22/01/2026
AI-powered content generation is now embedded in everyday tools like Adobe and Canva, with a slew of agencies and studios incorporating the technology into thei...
21/01/2026
From skilled trades to startups, AI's rapid expansion is the beginning of th...
21/01/2026
From skilled trades to startups, AI's rapid expansion is the beginning of th...
15/01/2026
NVIDIA kicked off the year at CES, where the crowd buzzed about the latest gaming announcements - including the native GeForce NOW app for Linux and Amazon Fire...
13/01/2026
NVIDIA and Lilly are putting together a blueprint for what is possible in the f...
09/01/2026
Every that was easy shopping moment is made possible by teams working to hit s...
08/01/2026
The next universal technology since the smartphone is on the horizon - and it ma...
08/01/2026
In the rolling hills of Berkeley, California, an AI agent is supporting high-stakes physics experiments at the Advanced Light Source (ALS) particle accelerator....
08/01/2026
NVIDIA is wrapping up a big week at the CES trade show with a set of GeForce NOW...
07/01/2026
AI has transformed retail and consumer packaged goods (CPG) operations, enhancin...
05/01/2026
At the CES trade show running this week in Las Vegas, NVIDIA announced that the ...
05/01/2026
Open-source AI is accelerating innovation across industries, and NVIDIA DGX Spar...
05/01/2026
NVIDIA DGX SuperPOD is paving the way for large-scale system deployments built on the NVIDIA Rubin platform - the next leap forward in AI computing.
At the CES...
05/01/2026
AI is powering breakthroughs across industries, helping enterprises operate with...
05/01/2026
NVIDIA founder and CEO Jensen Huang took the stage at the Fontainebleau Las Vega...
05/01/2026
At the CES trade show, NVIDIA today announced DLSS 4.5, which introduces Dynamic...
05/01/2026
2025 marked a breakout year for AI development on PC.
PC-class small language m...
05/01/2026
Announced at the CES trade show running this week in Las Vegas, NVIDIA is bringi...
01/01/2026
New year, new games, all with RTX 5080-powered cloud energy. GeForce NOW is kicking off 2026 by looking back at an unforgettable year of wins and wildly high fr...
25/12/2025
Holiday lights are twinkling, hot cocoa's on the stove and gamers are settling in for a well-earned break.
Whether staying in or heading on a winter getawa...
22/12/2025
The works of Plato state that when humans have an experience, some level of change occurs in their brain, which is powered by memory - specifically long-term me...
18/12/2025
NVIDIA will join the U.S. Department of Energy's (DOE) Genesis Mission as a ...
18/12/2025
Top-notch options for AI at the desktops of developers, engineers and designers ...
18/12/2025
Step out of the vault and into the future of gaming with Fallout: New Vegas streaming on GeForce NOW, just in time to celebrate the newest season of the hit Ama...
17/12/2025
The Hao AI Lab research team at the University of California San Diego - at the forefront of pioneering AI model innovation - recently received an NVIDIA DGX B...
17/12/2025
Editor's note: This post is part of Into the Omniverse, a series focused on ...
15/12/2025
NVIDIA today announced it has acquired SchedMD - the leading developer of Slurm, an open-source workload management system for high-performance computing (HPC) ...
15/12/2025
Modern workflows showcase the endless possibilities of generative and agentic AI on PCs.
Of many, some examples include tuning a chatbot to handle product-supp...
12/12/2025
In Las Vegas's T-Mobile Arena, fans of the Golden Knights are getting more than just hockey - they're getting a taste of the future. ADAM, a robot devel...
11/12/2025
Unveiling what it describes as the most capable model series yet for professional knowledge work, OpenAI launched GPT-5.2 today. The model was trained and deplo...
11/12/2025
Hunters, saddle up - adventure awaits in the cloud.
Journey into the world of M...
10/12/2025
The NVIDIA accelerated computing platform is leading supercomputing benchmarks once dominated by CPUs, enabling AI, science, business and computing efficiency w...
10/12/2025
The world's top-performing system for graph processing at scale was built on...
10/12/2025
As the scale and complexity of AI infrastructure grows, data center operators need continuous visibility into factors including performance, temperature and pow...
04/12/2025
Developers, researchers, hobbyists and students can take a byte out of holiday s...
04/12/2025
Editor's note: The Game Pass edition of Hogwarts Legacy' will also be supported on GeForce NOW when the Steam and Epic Games Store versions launch on t...
03/12/2025
The top 10 most intelligent open-source models all use a mixture-of-experts arch...