Genome of near-extinct northern white rhino offers hope for reviving the species Breakthrough from Scripps Research, San Diego Zoo, Max Planck Institute and other collaborators paves way for stem cell-based reproduction.
May 13, 2025
LA JOLLA, CA The northern white rhinoceros is one of the rarest animals on Earth, with just two females left and no natural way for the species to reproduce. Now, an international team of scientists at Scripps Research, the San Diego Zoo Wildlife Alliance, Max Planck Institute for Molecular Genetics, and other collaborators have mapped the entire genome of a northern white rhino. This represents a crucial step toward bringing the critically endangered species back from the edge using advanced reproductive technologies.
The complete genome can be used as a reference to analyze the health of previously developed northern white rhinoceros stem cells. Eventually, those stem cells may be able to generate sperm and eggs to yield new rhinos. The genome was published on May 13, 2025, in PNAS.
Professor Emeritus Jeanne Loring posing with a northern white rhinoceros. Credit: Jeanne Loring What's so exciting about this milestone is that we're getting closer to being able to rescue animals that otherwise might go extinct during our lifetimes, says co-senior author Jeanne Loring, Professor Emeritus at Scripps Research and a research fellow at the San Diego Zoo Wildlife Alliance. This is great progress not only for white rhinos, but for the entire field of animal conservation.
The new effort combined cutting-edge DNA sequencing and genome mapping techniques to build a high-quality genome. Scientists used cells previously collected from a male northern white rhinoceros named Angalifu, who lived at the San Diego Zoo Safari Park until his death in 2014. At the time, his skin cells were cryopreserved in the San Diego Zoos Frozen Zoo .
We layered together multiple technologies to make the most accurate genomic map possible, says Loring. It's like the rhino version of the Human Genome Project.
This new genome also represents a vital tool toward saving the endangered species. In 2011, Loring's team created the first induced pluripotent stem cells from northern white rhinos. They have since, in collaboration with the San Diego Zoo, created other lines of stem cells from nine different individual northern white rhinos. These lab-grown cells have the ability to become any other cell type, including eggs and sperm that could potentially be used to create embryos.
Collaboration was integral to achieving this milestone, says Marisa Korody, a scientist in conservation genetics at the San Diego Zoo Wildlife Alliance. This high-quality reference genome is a key piece of the puzzle that helps us understand how the stem cells are functioning and guides our next steps in the genetic rescue process. None of it would be possible without the Frozen Zoo and the rhinos whose cells were preserved decades ago.
But one major hurdle has always been quality control. Without a reference genome, scientists didn't know whether any of those stem cells had picked up harmful mutations during lab growth a common problem in both human and animal stem cells. In the new research, Loring's team was able to use the new, complete genome to analyze the previously created stem cell lineages. They discovered that one of the most promising of the stem cell lines had a large chunk of DNA missing more than 30 million base pairs affecting over 200 genes, including those involved in reproduction and tumor suppression.
If we hadn't built this genome, we wouldn't have known that, adds Loring. We thought we had a good stem cell line, but it turns out it had a mutation that could have made it unsafe to use for reproduction. Now we can go back and screen all the others. This becomes the gold standard for deciding which cells to move forward with.
The new genome also settled lingering questions about how different northern and southern white rhinos really are. Some earlier data suggested significant DNA differences that might make it risky for southern white rhinos to be implanted with northern white rhino embryos. But updated comparisons show their genomes are strikingly similar, giving scientists confidence that southern white rhinos which are far more numerous can serve as surrogates without major complications.
For Loring, who's been working on this project since 2007, the new genome is a symbol of what's possible. Now that we have their genome, we can apply all the tools we've developed for humans CRISPR gene editing, reporter genes, everything to help rescue them.
The work also sets a powerful example for other endangered species, Loring says. Efforts to save hundreds of different endangered species from mammals and birds to plants and corals depend on careful biobanking like that being done by the Frozen Zoo.
The Frozen Zoo had the foresight to freeze actual cells from these animals, she says. That means we're not trying to recreate a species from scraps of ancient, damaged DNA. We have the real thing.
Ultimately, the goal is to grow healthy embryos and implant them into surrogate mothers, then raise the resulting calves in protected environments. It's not Jurassic Park, Loring is quick to point out, and it doesn't depend on gene editing or engineering.
We're not resurrecting a mystery species we're restoring one we still know intimately, she adds. The rhino is big, gentle and unforgettable. It's the perfect symbol for what science can do to fight extinction.
In addition to Loring, authors of the study, Genomic map of the functionally extinct northern white rhinoceros (Ceratotherium simum cottoni), were Gaojianyong Wang, Camilo Jose Hernandez-Toro, Alexander Meissner and Franz-Josef M ller of the Max Planck I
Most recent headlines
09/11/2025
Dalet today announced a transformative leap forward for media operations: Agentic Artificial Intelligence (AI) that unifies the Dalet ecosystem under one natura...
16/10/2025
Parks Associates has released new data showing that nearly half (45%) of U.S. internet homes watch free ad-supported streaming TV (FAST) services and 89% of U.S...
16/10/2025
TROY, Mich. -New data from J.D. Power's 2025 U.S. Residential Internet Service Provider Study shows that residential wireless internet providers are growing...
15/10/2025
Across the world, early-career reporters are interrogating systems that shape daily life, from mortuaries and classrooms to the corridors of legal education and...
15/10/2025
St. Louis Blues Pay Tribute to Ozzy Osbourne in New Pregame Open VideoThe NHL franchise worked with production firms 2WEI and 4th Floor CreativeBy Mark J Burns,...
15/10/2025
Cobalt Digital, G3DVu, Proxima Vision, and Telos Alliance Renew Premier Sponsors...
15/10/2025
By Paige Bethmann
Before my grandmother passed away in 2019, I went to visit her in the hospital where she'd been for a few weeks. When I arrived, the nurs...
15/10/2025
Two years ago, Spotify set out to grow the entire publishing industry by making ...
15/10/2025
People turn to DJ for a listening experience that feels personal, dynamic, and j...
15/10/2025
Las personas recurren a DJ para vivir una experiencia de escucha personal, din m...
15/10/2025
Rock legend Bruce Springsteen and luminary actor Jeremy Allen White came togethe...
15/10/2025
At Spotify, we're all about supporting rising talent and helping them connec...
15/10/2025
New SBS Documentary Series THE CANCER KILLERS Premieres 4 November on SBS & SBS ...
15/10/2025
SBS celebrates the Festivals of Lights with bold, illuminating stories across th...
15/10/2025
One of humanity's most profound questions continues: Is there any place in our galaxy suitable for life beyond Earth? NASA intends to find out, with the hel...
15/10/2025
eds3_5_jq(document).ready(function($) { $(#eds_sliderM519).chameleonSlider_2_1({ content_source:......
15/10/2025
Scality, a global leader in cyber-resilient storage software for the AI era, today announced the advancement of its comprehensive AI ecosystem certification pro...
15/10/2025
The Hollywood Professional Association (HPA) today unveiled key highlights of the 2026 HPA Tech Retreat, scheduled for Feb. 15 19 at the Westin Rancho Mirage Go...
15/10/2025
At NAB Show New York 2025 (Stand 244), Interra Systems will showcase the future of media QC, monitoring, and captioning, highlighting its award-winning, AI- and...
15/10/2025
Grass Valley today announced that RMC BFM, part of the CMA-CGM Group and France's third-largest private media group, has chosen Grass Valley's productio...
15/10/2025
Appear, the global leader in live production technology, will demonstrate how its powerful hardware and software innovations are shaping the future of hybrid, s...
15/10/2025
Rakim to Join Berklee's Hip-Hop Hall of Fame at Signature Series Concert The rap icon becomes the latest inductee, following luminaries such as Roxanne Sh...
15/10/2025
Berklee Brings Live Music to the Head of the Charles Student artists will perform on multiple riverfront stages during the 60th anniversary of the world's...
15/10/2025
CobbTV, the government access television channel for Cobb County, Ga. recently acquired an automated playout system from Pebble, a global provider of automation...
15/10/2025
OSLO, Norway Appear, the global leader in live production technology, will demonstrate how its powerful hardware and software innovations are shaping the future...
15/10/2025
NEW YORK The NBA is making major changes to the NBA App and NBA TV as it takes control of them from TNT Sports, which has long managed the league's digital ...
15/10/2025
SAN MATEO, Calif. In what promises to be a major expansion of interactive features and personalized content on the DirecTV platform, the operator and Glance hav...
15/10/2025
SAN JOSE, Calif. Roku has launched changes to its user interface (UI) that the streaming platform says will better showcase original programming on the platform...
15/10/2025
LOS ANGELES Software-defined data storage and data services provider OpenDrives has elevated Alex Dunfey to chief technology officer, responsible for driving th...
15/10/2025
Abu Dhabi, UAE October 15, 2025: Space42 (ADX: SPACE42), the UAE-based AI-powe...
15/10/2025
Sheldon Nichols and Will Trickett to find and prepare more classic cars for budget conscious would-be owners from Wiser Films
UKTV have recommissioned the clas...
15/10/2025
Wednesday 15 October 2025
Nick Cave
JPEG (275 KB)
Explore the creative univer...
15/10/2025
Wednesday 15 October 2025
From breaking up with your partner to quitting your job - new polling shows some messages are just too scary to send
Over a fifth (...
15/10/2025
Rohde & Schwarz unveils compact MXO 3 oscilloscopes with 4 and 8 channels: Advan...
15/10/2025
Back to All News
Revenge Series The Resurrected' Captivates Audiences Across Asia
Entertainment
15 October 2025
GlobalTaiwan
Link copied to clipboard
...
15/10/2025
Back to All News
Bringing the Best in VFX and Virtual Production Together as Eyeline
Jeffrey Shapiro
CEO, Eyeline
Business
15 October 2025
GlobalCanadaInd...
15/10/2025
Deployed by Astound Business Solutions, Harmonic's Primary Distribution Solution Ensures Outstanding Video Quality and Seamless Ad Insertion at the Edge
SA...
15/10/2025
Collaboration extends a trusted relationship as RMC BFM invests in scalable, fut...
15/10/2025
Series coming in 2026 stars Tom Vaughan-Lawlor, Justine Mitchell and Jason O'Mara released today
RT today released first look images of new comedy-drama ...
14/10/2025
SVG Europe Summit 2025: All Sessions Now Available to Watch on SVG PLAYNetworking event that preceded IBC2025 shone a light on elite live sports innovation acro...
14/10/2025
SVG Sit-Down: Author Rich Podolsky on Writing Madden & Summerall: How They Revo...
14/10/2025
SVG All-Stars: Michael Reiners, Coordinating Producer, FloRacingThe Illinois State grad steers a vast schedule of motorsports events at tracks across the countr...
14/10/2025
Content protection: Getting the right management for your DRM By Neal Romanek
Friday, October 10, 2025 - 10:11
Print This Story
Eluvio power the EPCR'...
14/10/2025
As League Takes Over Ops, NBA TV and NBA App Add 60 Games, Weekday Studio Show, ...
14/10/2025
Time and effort: World's largest student-led broadcast prepares to go On Air...
14/10/2025
(L-R) Guest, Kimberly Robinson Jones, Geeta Gandbhir, Pamela Dias, and Takema Ro...
14/10/2025
Lossless ist jetzt mit Spotify Premium verf gbar.
Verlustfreies Audio war eine...
14/10/2025
La qualit Lossless est disponible sur Spotify Premium.
Le format sans perte de...
14/10/2025
For the seventh edition of Spotify and FC Barcelona's artist jersey series, ...
Genome of near-extinct northern white rhino offers hope for reviving the species Breakthrough from Scripps Research, San Diego Zoo, Max Planck Institute and other collaborators paves way for stem cell-based reproduction.
