Researchers pinpoint brain cells that delay first bite of food A set of neurons identified by Scripps Research scientists influence the start of eating and drinking.
July 10, 2024
LA JOLLA, CA Do you grab a fork and take a first bite of cake, or say no and walk away? Our motivation to eat is driven by a complex web of cells in the brain that use signals from within the body, as well as sensory information about the food in front of us, to determine our behaviors. Now, Scripps Research scientists have identified a group of neurons in a small and understudied region of the brain the parasubthalamic nucleus (PSTN) that controls when an animal decides to take a first bite of food.
In the study, published in Molecular Psychiatry on July 4, 2024, the team of scientists set out to selectively manipulate a group of PSTN cells that dial up their activity during periods of binge-eating. Other scientists have observed that many PSTN cells become active following a large meal, but the team wondered how these cells might influence appetite.
In our study, we used a technique that let us turn on cells in the mouse brain that were activated by a specific experience in this case, binge-eating, says Jeff Dunning, PhD, a staff scientist at Scripps Research and first author of the new paper. Once we have captured this ensemble of PSTN cells, we can turn them on like a light switch and watch what happens to the animals' eating and drinking.
The research team found that the ensemble of cells sensitive to binge-eating were capable of drastically changing the behavior of mice. Hungry mice normally start chowing down on food quickly once it becomes available to them. But when researchers turned on this ensemble of PSTN cells, mice were much slower to begin eating and, surprisingly, much faster to drink water.
Our results tell us that this specific group of PSTN cells guide the early stages of hunger-driven decision making, before eating actually occurs, says Dunning. The effect on water drinking is somewhat counterintuitive, but it might be related to prandial thirst the phenomenon whereby thirst gets stimulated as soon as we start eating.
By manipulating even smaller sets of cells within the PSTN, the team pieced apart exactly which groups of cells were responsible for the delayed eating and accelerated drinking. They also discovered that yet another group of PSTN cells drives a different effect, urging the mice to eat more sweet foods.
Altogether, these results reveal that PSTN neurons exert a complex combination of functions, says senior author Candice Contet, PhD, associate professor in the Department of Molecular Medicine at Scripps Research. Several studies had previously shown that PSTN activity can limit the amount of food eaten, but the fact that certain PSTN neurons control the onset of feeding or drinking, or even promote the consumption of food treats,' is entirely novel.
Contet, Dunning and colleagues think that their findings may have relevance for eating disorders where people have either too much or not enough control over the initiation of feeding the decision to succumb to that first bite or wait longer. Beyond food and water, similar mechanisms may be at play in the loss of control over the consumption of rewarding substances such as drugs of abuse, which the team is currently investigating.
In addition to Contet and Dunning, authors of the study, The parasubthalamic nucleus refeeding ensemble delays feeding initiation and hastens water drinking, include Catherine Lopez, Colton Krull, Max Kreifeldt, Maggie Angelo and Leeann Shu of Scripps Research; and Charu Ramakrishnan and Karl Deisseroth of Stanford University.
This work was supported by funding from the National Institutes of Health (AA026685, AA027636, AA006420, AA027372, and AA007456).
Translational Medicine Contet, Candice
Most recent headlines
05/01/2027
Worlds first 802.15.4ab-UWB chip verified by Calterah and Rohde & Schwarz to be ...
04/08/2026
Dalet, a leading technology and service provider for media-rich organizations, t...
04/07/2026
April 7 2026, 19:00 (PDT) Detective Conan: Fallen Angel of the Highway Opens in...
09/06/2026
The National Film and Video Foundation (NFVF) is a statutory body mandated to spearhead the equitable growth and development of the South African film and video...
09/06/2026
The BBC has found its Hercule Poirot.
After Deadline revealed last month that t...
09/06/2026
Media buyers and sellers can now compare YouTube reach from computer, mobile, an...
09/06/2026
Share
Copy link
Facebook
X
Linkedin
Bluesky
Email...
09/06/2026
Share
Copy link
Facebook
X
Linkedin
Bluesky
Email...
09/06/2026
A project aimed at modernizing scheduling operations across Mediaset's channel portfolio
Mediagenix, a global leader in smart content solutions to profitab...
09/06/2026
tvONE, an ACT Entertainment brand, debuts its most powerful video processor ever built: the 4RU CALICO PRO (C7-PRO-4200), at InfoComm 2026 (Booth N6813). Engine...
09/06/2026
Composer and Conductor Eric Whitacre to Receive Honorary Doctorate at Berklee Va...
09/06/2026
Share
Copy link
Facebook
X
Linkedin
Bluesky
Email...
09/06/2026
Share
Copy link
Facebook
X
Linkedin
Bluesky
Email...
09/06/2026
Share
Copy link
Facebook
X
Linkedin
Bluesky
Email...
09/06/2026
Technology collaboration to validate AMPP and Lawo HOME orchestration integration, showcasing Dynamic Media Facility principles in practice.
Grass Valley and ...
09/06/2026
Bitmovin, a leading provider of video streaming solutions, today announced that Axel Springer SE, international media and technology company, has deployed Playe...
09/06/2026
LiveU, the global leader in live IP-video solutions, today announced a landmark deployment with the Oceania Football Confederation (OFC) that has brought Video ...
09/06/2026
Share
Copy link
Facebook
X
Linkedin
Bluesky
Email...
09/06/2026
Share
Copy link
Facebook
X
Linkedin
Bluesky
Email...
09/06/2026
Share
Copy link
Facebook
X
Linkedin
Bluesky
Email...
09/06/2026
Share
Copy link
Facebook
X
Linkedin
Bluesky
Email...
09/06/2026
Share
Copy link
Facebook
X
Linkedin
Bluesky
Email...
09/06/2026
Two Alumni Win Tony Awards Mike Morris and Cedric Leiba Jr. won awards for Best Orchestrations and Best Play, respectively.
June 8, 2026
By
Tori Donahue
...
09/06/2026
Tuesday 9 June 2026
Katie Price: Nothing to Hide, a candid and unfiltered accou...
09/06/2026
Back to All News
Netflix Unveils First Images And Poster For Wrath, A New Brazi...
09/06/2026
Enni Continues to Rely on Arvato Systems - And Will Be Using AEP.EnerS4 Billing Solution
Arvato Systems to implement transformation project for SAP S/4HANA Ut...
09/06/2026
These special programmes will highlight RT 's connection with the Irish diaspora
This year, RT is marking 100 years of public broadcasting in Ireland with...
08/06/2026
The two execs discuss the goals and the challenges of building a huge multi-cult...
08/06/2026
This industry legend has been a road warrior since the early '90s and is, today, a lynchpin on College GameDay
The sports-production industry continues to ...
08/06/2026
DAZN has agreed a multi-year rights partnership with Extreme Fighting Championship (EFC), expanding its global combat sports portfolio.
DAZN will broadcast EFC...
08/06/2026
As fans move across broadcast, streaming, social, mobile and creator-led platforms, and they expect every angle, in real time, TVU Networks has released a new e...
08/06/2026
Infront has further strengthened the 2026 Diamond League's international bro...
08/06/2026
Grass Valley has announced the appointment of Sam Craig as Vice President, Global Pre-Sales. Based in the United States, Craig will lead Grass Valley's glob...
08/06/2026
SMPTE has announced its summer 2026 education lineup covering IP networking and SMPTE ST 2110, including two standalone courses, a 13-week boot camp, and a hand...
08/06/2026
Sportradar Group AG has announced a multi-year global agreement with Kalshi, a p...
08/06/2026
FIFA and Gamefam have announced the launch of a FIFA World Cup 2026 event on Roblox, running June 5 through July 31, 2026. The event centers on FIFA Super Socce...
08/06/2026
A collaboration of NHL Productions, Monumental Sports, and Michael Levitt Produc...
08/06/2026
CBS Sports production staffer Bryce Adair has died at the age of 31 after sustaining injuries during a car accident on Wednesday while in Ohio working the the P...
08/06/2026
Behind The Mic provides a roundup of recent news regarding on-air talent, including new deals, departures, and assignments compiled from press releases and repo...
08/06/2026
WMT Digital today announced the launch of WMT Fan Intelligence, designed to unif...
08/06/2026
The Heat are the seventh NBA team to air their games over-the-air next season...
08/06/2026
Paramount and UFC have announced an expansion of their media rights partnership making Paramount the exclusive home of UFC Numbered Event main cards in Canada ...
08/06/2026
The Qatar Football Association (QFA), in cooperation with Sponix and broadcaster...
08/06/2026
Project B has announced the appointment of Host Broadcast Services (HBS) as Offi...
08/06/2026
The Buckeyes now produce and stream upwards of 200 sports events annually with a...
08/06/2026
At Spotify, our commitment to the LGBTQIA community is year-round. Through GLOW, our global music program, we celebrate and amplify the contributions of queer ...
08/06/2026
Get Hands-on With Keyboard & Synth Brands
GearExpo UK wouldn't be complete without some synth action, and we've got some of the industry's most ...
08/06/2026
50 popular in-ear monitoring system profiles added
The latest update for IK Multimedia's headphone-correction system has just arrived, and introduces ca...
08/06/2026
Manny Marroquin signature cans upgraded with SLAM Technology
The flagship model in Audeze's Manny Marroquin Signature Series has just been treated to an...
Researchers pinpoint brain cells that delay first bite of food A set of neurons identified by Scripps Research scientists influence the start of eating and drinking.
