Sony Pixel Power calrec Sony

August 20, 2019

21/08/2019

FDA accepts IND application for novel immunotherapeutic for prostate cancer in development by Calibr at Scripps Research

August 20, 2019

La Jolla, CA Calibr, the drug development division of Scripps Research, announced today that the U.S. Food and Drug Administration (FDA) has cleared its investigational new drug application (IND) for CCW702, a novel immunotherapeutic for the treatment of patients with metastatic castration-resistant prostate cancer. CCW702 has the potential to be effective in patients who have failed prior treatments and have exhausted their treatment options, because it works differently than traditional chemotherapeutics and androgen deprivation therapies, says Travis Young, PhD, vice president of Biologics at Calibr, who led the pre-clinical development of the molecule. We are truly excited about the opportunity to evaluate the safety and anti-tumor activity of this molecule in patients.

CCW702 is a first-of-its-kind molecule designed to redirect a patient's own immune system to eliminate malignant cancer cells. The molecule uses a unique design that combines the specificity of a validated imaging agent for prostate cancer with the potency of immunotherapy. In preclinical work, this design proved highly effective at completely eliminating tumors in animal models of prostate cancer.

The launch of this clinical study Calibr's fourth overall and second being run independently by the institute is another major milestone for the new model being pioneered at Scripps Research, where innovative discoveries are translated into new medicines within the nonprofit enterprise. CCW702 began as a research project in the laboratory of Peter Schultz, PhD, at Scripps Research and progressed to the IND stage by Calibr through support from the Wellcome Trust. The molecule is manufactured using unnatural amino acid technology pioneered in Schultz's laboratory in collaboration with Ambrx Inc.

This program exemplifies the relationship between Scripps Research and Calibr in the ability to bring high-risk, high-reward programs forward into clinical trials to create impact for patients and value for the institute that stimulates and supports further research, says Schultz, president and CEO of Scripps Research. This model has the potential to be transformative in the way new medicines are developed.

Clinical development of CCW702 will be led by Calibr's new Chief Medical Officer Pamela D. Garzone, PhD. Her leadership will be critical as Calibr advances additional programs into the clinic over the next 18 months, with another IND filing expected by the end of the year.

About Scripps Research

A leading nonprofit biomedical research institute, Scripps Research is ranked #1 the world by Nature for scientific innovation. US News and World Report consistently ranks our graduate school in the top ten in the United States. Our unique structure merges foundational studies in biology, chemistry and computer science with translational research to produce the next generation of drugs and advances in digital and precision medicine. On campuses in California and Florida, scientists in the institute's five academic research departments work hand-in-hand with researchers of the Scripps Research Translational Institute and Calibr, its drug discovery division. We train the next generation of scientific leaders, expand the frontiers of human knowledge and accelerate the development of new medicines to improve lives around the planet.

About Wellcome

Wellcome exists to improve health for everyone by helping great ideas to thrive. We're a global charitable foundation, both politically and financially independent. We support scientists and researchers, take on big problems, fuel imaginations and spark debate.

Cancer Science News
LINK: https://www.scripps.edu/news-and-events/press-room/2019/20190820-calib...
See more stories from scripps

Most recent headlines

05/01/2027

Worlds first 802.15.4ab-UWB chip verified by Calterah and Rohde & Schwarz to be demoed at CES 2026

Worlds first 802.15.4ab-UWB chip verified by Calterah and Rohde & Schwarz to be ...

01/06/2026

Dolby Sets the New Standard for Premium Entertainment at CES 2026

January 6 2026, 05:30 (PST) Dolby Sets the New Standard for Premium Entertainment at CES 2026 Throughout the week, Dolby brings to life the latest innovatio...

02/05/2026

Dalet Flex LTS Delivers Smarter Search, Faster Editing, and an AI-Ready Foundation for Modern Media

Dalet, a leading technology and service provider for media-rich organizations, t...

01/05/2026

NBCUniversal's Peacock to Be First Streamer to Integrate Dolby's Full Suite of Premium Picture and Sound Innovations

January 5 2026, 18:30 (PST) NBCUniversal's Peacock to Be First Streamer to ...

01/04/2026

DOLBY AND DOUYIN EMPOWER THE NEXT GENERATON OF CREATORS WITH DOLBY VISION

January 4 2026, 18:00 (PST) DOLBY AND DOUYIN EMPOWER THE NEXT GENERATON OF CREATORS WITH DOLBY VISION Douyin Users Can Now Create And Share Videos With Stun...

26/03/2026

Phantom C-Series High-Speed Cameras Set a New Standard for Automotive Crash and Safety Imaging

Wayne, N.J., March 26, 2026 Phantom High-Speed announces the latest product li...

25/03/2026

In The Hot Seat: The Art of Directing a Premier League Match

Live match directors Sarah Cheadle (Sky Sports), Rob Levi (TNT Sports), and Andrew Swift (BBC Sport) sit down with the Premier League's Rachel Nightingale t...

25/03/2026

SVG Students To Watch: Kyle Maier, St. Bonaventure University

The senior from Upstate New York is manning the mic while also interning for the athletic department's sports-information team In the live-sports-video ind...

25/03/2026

NAB 2026: Synamedia Launches Edge Watermarking Solution, Marks 10 Years of ContentArmor

Synamedia has announced ContentArmor Edge Watermarking, a server-side solution t...

25/03/2026

SES Taps K2 Space to Build meoSphere MEO Satellite Network

SES has announced meoSphere, a medium Earth orbit (MEO) satellite network targeted for operation by 2030. The first phase will pair SES-developed software-defin...

25/03/2026

Reuters and TVU Networks Begin Satellite-to-IP Migration for Live News Distribution

TVU Networks is working with Reuters on a phased migration from satellite to a c...

25/03/2026

Nielsen Names Three Senior Hires in Sports, Advertising, and Publishing Roles

Nielsen has announced three senior appointments. Seth Ladetsky has been named Head of Global Sports. Trevor Fellows will lead Nielsen's advertiser and agenc...

25/03/2026

Anoki and Amagi Bring Scene-Level Intelligence to In-Content CTV Ads

Anoki and Amagi have launched In-Scene Ads powered by Anoki ContextIQ across Amagi's portfolio of in-content ad formats for Free Ad-supported Streaming TV (...

25/03/2026

NAB 2026: Arkona to Unveil BLADE//planner and Platform Updates

Arkona Technologies will announce a series of enhancements to its BLADE//runner platform at NAB 2026 (Booth C.1808). The updates focus on usability and workflow...

25/03/2026

San Diego Padres Partners With Daktronics to Enhance Petco Park

Daktronics has installed two tower displays and a video wall in the Lexus Club at Petco Park in San Diego ahead of the 2026 season. Continuing to improve the ...

25/03/2026

NAB 2026: MultiDyne Marks 50th Anniversary

MultiDyne Video & Fiber Optic Systems is celebrating its 50th anniversary as NAB Show 2026 approaches. The company was founded in 1976 by Vincent Jachetta, an N...

25/03/2026

NAB 2026: IPC to Debut with One Connect Intercom Platform and New One Link Keypanels

IPC, a provider of integrated communication solutions, will make its NAB 2026 de...

25/03/2026

ESPN Tops 2026 Sports Emmy Nominations With 63 Nods

Live production categories were led by NBC, FOX, and ESPN's NFL coverage...

25/03/2026

Atlanta Braves and Spectrum Reach Multiyear Distribution Agreement for BravesVision

The Atlanta Braves and Spectrum have announced a multiyear distribution agreemen...

25/03/2026

The AI Doc Asks the Question No One Wants to Answer

(L-R) Charlie Tyrell and Daniel Roher attend The AI Doc: Or How I Became An Apocaloptimist Premiere during the 2026 Sundance Film Festival at The Ray Theatre ...

25/03/2026

Kelsey Lu and Savanah Leaf Lean Into the Emotional Core of Running To Pain' in Episode Three of Directed By'

Directed By, Spotify's documentary-style series that pulls back the curtain ...

25/03/2026

BTS and Spotify Bring ARIRANG' to Top Fans in New York City

BTS is so back., This week, the global pop superstars took the stage at New York City's Pier 17 for their first U.S. performance in four years. Part of Spo...

25/03/2026

Step Into Sound at Our New Spotify Listening Lounge in London

How you listen can shape what you hear. That's the idea behind the new Spotify Listening Lounge, an acoustic space at our London headquarters purpose-built ...

25/03/2026

Iconic Instruments launch Transport Vintage Tape

Tape effects taken to the extreme The latest release from New York-based developer Iconic Instruments is said to accurately recreate the saturation and comp...

25/03/2026

Sonuscore introduce Fantasy Vocal Phrases

Launched alongside new Vocal Phrases bundle Sonuscore's latest release has been designed specifically for composers working on fantasy TV, film and game...

25/03/2026

Steinberg unveil Nuendo 15

Latest update now live The latest version of Steinberg's post-production-focused DAW has just arrived, and comes packed with new dialogue editing, sound...

25/03/2026

Rohde & Schwarz joins FormFactor's MeasureOne partner program

Rohde & Schwarz joins FormFactor's MeasureOne partner program FormFactor and Rohde & Schwarz advance their partnership for on-wafer RF component character...

25/03/2026

L3Harris, RFTEQ Sign Agreement to Advance Sovereign Electronic Warfare Capability in Australia

L3Harris Technologies and RFTEQ Pty Ltd signed a memorandum of understanding to ...

25/03/2026

L3Harris to Provide Autonomous Underwater Capability for US Navy Submarines

L3Harris delivers combat-ready Torpedo Tube Launch and Recovery system, which deploys and retrieves Iver4 900 autonomous underwater vehicles through submarine t...

25/03/2026

Nielsen Names New Senior Leaders Supporting Sports, Advertising and Publishing Clients

The company expands leadership team under Chief Revenue Officer Amilcar Perez S...

25/03/2026

Stable TV Viewership in Poland in February as Warner Bros. Discovery Retains Top Spot

Winter Olympic Games Opening Ceremony features in top 10 programmes of the month...

25/03/2026

Mediaproxy to Show Upgrades to LogServer at 2026 NAB Show

Share Copy link Facebook X Linkedin Bluesky Email...

25/03/2026

Hitomi transforms production synchronisation with the lau...

Providing wide view timing visibility across the entire production chain...

25/03/2026

Bitfocus showcases complete control at NAB Show 2026

Continuing development drives advances in security, availability, access and connectivity...

25/03/2026

Caudalie Paris HQ elevates brand experience with INFiLED...

Caudalie, the renowned French cosmetics brand, has unveiled a state-of-the-art 200-seat auditorium at its new headquarters in the historic Marais district of ce...

25/03/2026

Telestream Unlocks Adobe-Centric Media Pipeline and Strea...

Telestream, a global leader in media workflow technologies, today announced expanded integration with Adobe Premiere, Adobe Media Encoder (AME), and Frame.io, d...

25/03/2026

Marshall Electronics Showcases New Feature Rich CV320 and...

Marshall Electronics is expanding its lineup of high-performance POV cameras designed for broadcast, live production and professional AV applications with the d...

25/03/2026

OOONA Achieves TPN Gold Star Shield - the Highest Level o...

OOONA, a global provider of professional management and production tools for the media localization industry, announced today that it has been awarded the TPN G...

25/03/2026

Gray Media to Simulcast 2026 Atlanta Braves Home Opener

Share Copy link Facebook X Linkedin Bluesky Email...

25/03/2026

2026 NAB Show Exhibitor Insight: Appear

Share Copy link Facebook X Linkedin Bluesky Email...

25/03/2026

Deepfakes Vulnerable to AI Fingerprint Hacks, Study Finds

Share Copy link Facebook X Linkedin Bluesky Email...

25/03/2026

SipMX launches at NAB Show 2026 to democratize media orch...

SipRadius, specialists in secure, low-latency media transport, will drive innovation and interoperability still further with the launch of the SipMX Alliance at...

25/03/2026

QuickLink to Showcase StudioPro Video Production Ecosyste...

QuickLink, a leading provider of award-winning video production and remote contribution solutions, will showcase its award-winning StudioPro ecosystem at The 2...

25/03/2026

Alfalite returns to NAB Show alongside FOR-A showcasing L...

Alfalite, the only European manufacturer of LED screens, will once again be present at NAB Show, the leading global event for the broadcast, media and entertain...

25/03/2026

First Time Exhibitor IPC Introduces One Link Keypanels fo...

PC, a leading provider of integrated communication solutions, will make its NAB 2026 Show debut in Booth C 3341. The company will highlight the newly branded On...

25/03/2026

LTN showcases satellite-to-IP migration solutions for cha...

Open video transport network simplifies satellite transition with new partnerships and global reach as spectrum auction nears LTN will demonstrate how its purp...

25/03/2026

Leader to present full suite of advanced Test and Measure...

Test & measurement innovator, Leader Electronics, will present the full range of Leader, PHABRIX and LeaderPhabrix T&M solutions at the NAB Show, which takes pl...

25/03/2026

MNC Software Appoints Heartland Video Systems as North Am...

MNC Software, a global leader in network management and operational support systems tailored to the broadcast and media industry, today announced the appointmen...

25/03/2026

Samsung Launches Shoppable TV Experience with Amazon

Share Copy link Facebook X Linkedin Bluesky Email...

25/03/2026

Gray Media to Simulcast 2026 Atlanta Braves to Home Opener

Share Copy link Facebook X Linkedin Bluesky Email...