FDA accepts IND application for novel immunotherapeutic for prostate cancer in development by Calibr at Scripps Research
August 20, 2019
La Jolla, CA Calibr, the drug development division of Scripps Research, announced today that the U.S. Food and Drug Administration (FDA) has cleared its investigational new drug application (IND) for CCW702, a novel immunotherapeutic for the treatment of patients with metastatic castration-resistant prostate cancer. CCW702 has the potential to be effective in patients who have failed prior treatments and have exhausted their treatment options, because it works differently than traditional chemotherapeutics and androgen deprivation therapies, says Travis Young, PhD, vice president of Biologics at Calibr, who led the pre-clinical development of the molecule. We are truly excited about the opportunity to evaluate the safety and anti-tumor activity of this molecule in patients.
CCW702 is a first-of-its-kind molecule designed to redirect a patient's own immune system to eliminate malignant cancer cells. The molecule uses a unique design that combines the specificity of a validated imaging agent for prostate cancer with the potency of immunotherapy. In preclinical work, this design proved highly effective at completely eliminating tumors in animal models of prostate cancer.
The launch of this clinical study Calibr's fourth overall and second being run independently by the institute is another major milestone for the new model being pioneered at Scripps Research, where innovative discoveries are translated into new medicines within the nonprofit enterprise. CCW702 began as a research project in the laboratory of Peter Schultz, PhD, at Scripps Research and progressed to the IND stage by Calibr through support from the Wellcome Trust. The molecule is manufactured using unnatural amino acid technology pioneered in Schultz's laboratory in collaboration with Ambrx Inc.
This program exemplifies the relationship between Scripps Research and Calibr in the ability to bring high-risk, high-reward programs forward into clinical trials to create impact for patients and value for the institute that stimulates and supports further research, says Schultz, president and CEO of Scripps Research. This model has the potential to be transformative in the way new medicines are developed.
Clinical development of CCW702 will be led by Calibr's new Chief Medical Officer Pamela D. Garzone, PhD. Her leadership will be critical as Calibr advances additional programs into the clinic over the next 18 months, with another IND filing expected by the end of the year.
About Scripps Research
A leading nonprofit biomedical research institute, Scripps Research is ranked #1 the world by Nature for scientific innovation. US News and World Report consistently ranks our graduate school in the top ten in the United States. Our unique structure merges foundational studies in biology, chemistry and computer science with translational research to produce the next generation of drugs and advances in digital and precision medicine. On campuses in California and Florida, scientists in the institute's five academic research departments work hand-in-hand with researchers of the Scripps Research Translational Institute and Calibr, its drug discovery division. We train the next generation of scientific leaders, expand the frontiers of human knowledge and accelerate the development of new medicines to improve lives around the planet.
About Wellcome
Wellcome exists to improve health for everyone by helping great ideas to thrive. We're a global charitable foundation, both politically and financially independent. We support scientists and researchers, take on big problems, fuel imaginations and spark debate.
Cancer Science News
Most recent headlines
04/08/2024
Dalet, a leading technology and service provider for media-rich organizations, is excited to announce Santiago Solanas as its new Chief Executive Officer (CEO)....
03/06/2024
Dalet, a leading technology and service provider for media-rich organizations, a...
28/04/2024
Mediahaus delivers the first SRT live-streaming sports production over 5G with U...
23/04/2024
Psychology can play an important role in helping us understand what audiences respond to (Dr Jon Roozenbeek, Cambridge Social Decision-Making Lab)
For newsroom...
23/04/2024
IN ADDITION TO FICTION AND DOCUMENTARY FEATURES, THE SELECTION INCLUDES:
PRO...
23/04/2024
Today, we announced our first quarter 2024 earnings. In a solid start to the year, Spotify reported
Monthly Active Users grew 19% Y/Y to 615 million.
Subscri...
23/04/2024
Idag publicerar Spotify sina finansiella resultat f r f rsta kvartalet 2024. ret har inletts stabilt:
M natliga aktiva anv ndare kade med 19 % j mf rt med f...
23/04/2024
In the last decade, as K-Pop cemented its status as a global phenomenon, Spotify has helped fans around the world keep their fingers on the pulse at every step ...
23/04/2024
Social entrepreneur Hedayat Osyan wins Les Murray Award for Refugee Recognition
23 April, 2024
Media releases
The prestigious award is now in its third yea...
23/04/2024
LONDON IBC is now accepting nominations for its IBC2024 Innovation Awards, which honor achievements in technological innovation and social impact media & entert...
23/04/2024
WASHINGTON, D.C. In response to the introduction of the Broadcast VOICES Act that seeks to encourage more diversity in the ownership of TV and radio stations, t...
23/04/2024
MIAMI, Fla. As part of a push to expand its FAST channel and streaming operations, Hemisphere Media Group has launched its free ad supported television (FAST) c...
23/04/2024
LOS ANGELES DirecTV is adding seven new channels to its rapidly expanding streaming lineup through new licensing agreements with Cineverse Corp. and Scripps Net...
23/04/2024
Entitled Our Creative Future, the manifesto calls for radical new action' t...
23/04/2024
The company has secured investment from private equity firm PAI Partners, which also holds a stake in outside broadcasting company EMG
By Jenny Priestley
Pub...
23/04/2024
Cameron also said he recognised Marlow as a potential UK and European base for his new company, LIGHTSTORM 3D
By Matthew Corrigan
Published: April 23, 2024 ...
23/04/2024
The five categories cover Content Creation, Content Distribution, Content Everywhere, Social Impact and Environment & Sustainability
By Matthew Corrigan
Publ...
23/04/2024
He played a central role in securing key broadcast rights, including the FIFA World Cup 2018 and 2022
By Matthew Corrigan
Published: April 23, 2024
He pla...
23/04/2024
IBC is preparing to honour the highest achievements in technological innovation and social impact with the launch of its prestigious IBC2024 Innovation Awards, ...
23/04/2024
BREA, Calif. Bolin Technology is integrating Network Device Interface (NDI) across its product line, bringing support for the latest NDI technologies to its PTZ...
23/04/2024
WYOMISSING, Pa. PENN Entertainment has announced that longtime Disney and ESPN executive Aaron LaBerge has been named chief technology officer effective July 1,...
23/04/2024
In response to an FCC ruling in March proposing a $1.2 million fine against Nexstar and a ruling that Mission Broadcasting sell WPIX, Nexstar has filled a respo...
23/04/2024
Sony has announced new details about how the National Hot Rod Association (NHRA) is using Sony's Ci Media Cloud platform to streamline its workflows and spe...
23/04/2024
Esports' rapid rise to popularity can be attributed to many factors, from technological advancements that have enhanced the quality of modern gaming experie...
23/04/2024
OpenDrives, Inc., the global provider of software-defined media workflow solutions and data management capabilities, has been selected as a winner in the 2024 N...
23/04/2024
BCNEXXT is pleased to announce that Vpe has won the 2024 NAB Show Product of the Year Award in the Asset Management, Automation and Playout category. The offici...
23/04/2024
Gravity Media, a world leading global provider of complex live creative production and media services, today outlined the broadcast technology and television pr...
23/04/2024
Scality, a global leader in cyber-resilient storage for the AI era, today announced the appointment of Peter Brennan as Chief Executive Officer (CEO) of Scality...
23/04/2024
Blackmagic Design today announced ATEM 1 M/E Constellation 4K and ATEM 2 M/E Constellation 4K switchers, two new Ultra HD models of the ATEM Constellation famil...
23/04/2024
Blackmagic Design today announced Blackmagic Videohub 120x120 12G, the newest model in the Videohub 12G router family. The massive Blackmagic Videohub 120x120 1...
23/04/2024
Blackmagic Design today announced new lower prices for Blackmagic Video Assist 3G and 12G models. Customers can save US$200 on all models. These lower prices ma...
23/04/2024
Adder Technology continues to shine brightly, with its groundbreaking product, the ADDERLink INFINITY 3000 (ALIF3000), once again taking center stage. Hot on t...
23/04/2024
Pliant Technologies' CRP-C12 Compact Radio Pack is an Audio Production, Processing and Networking category winner in the 2024 NAB Show Product of the Year A...
23/04/2024
SipRadius, the specialists in live media transport and transcoding, will showcase their world-leading implementation of AV1 and JPEG-XS over transport streams a...
23/04/2024
Composer Rafael Krux has added a Prism Sound Dream ADA-128 modular conversion system to his production studio where he creates music for commercials, trailers, ...
23/04/2024
PMC proudly provides the ultimate large-scale Dolby Atmos audio system for the legendary musician Steven Wilson at the High End, Munich. He will share his exten...
23/04/2024
Particles emitting from a 3D rotating shape's edge
Graham Quince April 22, 2024
0 Comments
In Fixin' FX, people send me their problematic proj...
23/04/2024
Hollyland Technology Announces a New Line of Video Transmitters: Introducing the...
23/04/2024
Charlotte Deleste, anchor at WISC Madison, Wisconsin, is leaving the station. Her final day on the air is April 24. Deleste has spent 18 years there....
23/04/2024
Top WNBA draft choice Caitlin Clark will appear on local broadcast for 17 games next season in a deal between Tegna and the Indiana Fever....
23/04/2024
Abu Dhabi, 23 April, 2024 : Partnership delivers greater cybersecurity to Thura...
23/04/2024
Soccer's Appeal to Younger Audiences: Inside the Gamification of European Fo...
23/04/2024
With NBA and NHL Playoffs in Full Swing, Never a Dull Moment for TNT Sports Prod...
23/04/2024
NAB 2024: AT&T Business's Scott Beckett Details Transmission Firepower With ...
23/04/2024
NAB 2024: Manufacturers focus on cinematic look for live productions By George Bevir
Tuesday, April 23, 2024 - 10:40
Print This Story
With live sports pro...
23/04/2024
Save the Date: SVG Sports Content Management Forum Returns to NYC on July 24 By SVG Staff
Tuesday, April 23, 2024 - 4:05 pm
Print This Story | Subscribe
...
23/04/2024
Published On: April 23rd, 2024
data-orig-src=https://www.sgo.es/wp-content/upl...
23/04/2024
Rohde & Schwarz introduces new R&S SMB100B microwave signal generator for analog...
23/04/2024
Back to All News
Who's In for Something Really Fun ? The Curtain Rises on ...
FDA accepts IND application for novel immunotherapeutic for prostate cancer in development by Calibr at Scripps Research 
