
FDA accepts IND application for novel immunotherapeutic for prostate cancer in development by Calibr at Scripps Research
August 20, 2019
La Jolla, CA Calibr, the drug development division of Scripps Research, announced today that the U.S. Food and Drug Administration (FDA) has cleared its investigational new drug application (IND) for CCW702, a novel immunotherapeutic for the treatment of patients with metastatic castration-resistant prostate cancer. CCW702 has the potential to be effective in patients who have failed prior treatments and have exhausted their treatment options, because it works differently than traditional chemotherapeutics and androgen deprivation therapies, says Travis Young, PhD, vice president of Biologics at Calibr, who led the pre-clinical development of the molecule. We are truly excited about the opportunity to evaluate the safety and anti-tumor activity of this molecule in patients.
CCW702 is a first-of-its-kind molecule designed to redirect a patient's own immune system to eliminate malignant cancer cells. The molecule uses a unique design that combines the specificity of a validated imaging agent for prostate cancer with the potency of immunotherapy. In preclinical work, this design proved highly effective at completely eliminating tumors in animal models of prostate cancer.
The launch of this clinical study Calibr's fourth overall and second being run independently by the institute is another major milestone for the new model being pioneered at Scripps Research, where innovative discoveries are translated into new medicines within the nonprofit enterprise. CCW702 began as a research project in the laboratory of Peter Schultz, PhD, at Scripps Research and progressed to the IND stage by Calibr through support from the Wellcome Trust. The molecule is manufactured using unnatural amino acid technology pioneered in Schultz's laboratory in collaboration with Ambrx Inc.
This program exemplifies the relationship between Scripps Research and Calibr in the ability to bring high-risk, high-reward programs forward into clinical trials to create impact for patients and value for the institute that stimulates and supports further research, says Schultz, president and CEO of Scripps Research. This model has the potential to be transformative in the way new medicines are developed.
Clinical development of CCW702 will be led by Calibr's new Chief Medical Officer Pamela D. Garzone, PhD. Her leadership will be critical as Calibr advances additional programs into the clinic over the next 18 months, with another IND filing expected by the end of the year.
About Scripps Research
A leading nonprofit biomedical research institute, Scripps Research is ranked #1 the world by Nature for scientific innovation. US News and World Report consistently ranks our graduate school in the top ten in the United States. Our unique structure merges foundational studies in biology, chemistry and computer science with translational research to produce the next generation of drugs and advances in digital and precision medicine. On campuses in California and Florida, scientists in the institute's five academic research departments work hand-in-hand with researchers of the Scripps Research Translational Institute and Calibr, its drug discovery division. We train the next generation of scientific leaders, expand the frontiers of human knowledge and accelerate the development of new medicines to improve lives around the planet.
About Wellcome
Wellcome exists to improve health for everyone by helping great ideas to thrive. We're a global charitable foundation, both politically and financially independent. We support scientists and researchers, take on big problems, fuel imaginations and spark debate.
Cancer Science News
Most recent headlines
05/01/2027
Worlds first 802.15.4ab-UWB chip verified by Calterah and Rohde & Schwarz to be ...
01/06/2026
January 6 2026, 05:30 (PST) Dolby Sets the New Standard for Premium Entertainment at CES 2026
Throughout the week, Dolby brings to life the latest innovatio...
02/05/2026
Dalet, a leading technology and service provider for media-rich organizations, t...
01/05/2026
January 5 2026, 18:30 (PST) NBCUniversal's Peacock to Be First Streamer to ...
01/04/2026
January 4 2026, 18:00 (PST) DOLBY AND DOUYIN EMPOWER THE NEXT GENERATON OF CREATORS WITH DOLBY VISION
Douyin Users Can Now Create And Share Videos With Stun...
12/03/2026
Rohde & Schwarz Cybersecurity expands SITLine network encryptor portfolio - more...
12/03/2026
Rohde & Schwarz to showcase future-proof EMC testing solutions at EMV 2026 Rohde & Schwarz will participate in EMV 2026, Europe's premier trade fair and c...
12/03/2026
Johannesburg, 11 March 2026 - The 19th Annual South African Film and Television ...
12/03/2026
MELBOURNE, Fla., March 11, 2026 - L3Harris Technologies (NYSE: LHX) and Shield AI have successfully demonstrated a first-of-its-kind integration combining L3Har...
12/03/2026
The incorporation of Artificial Intelligence and Machine Learning into modern, converged all-domain systems is enabling true Joint Electromagnetic Spectrum Oper...
12/03/2026
MELBOURNE, Fla., March 12, 2026 - L3Harris Technologies (NYSE: LHX) today announ...
12/03/2026
Modern media operations demand a platform that unites automation, orchestration, and human oversight without compromise. In this post, we explore the six key te...
12/03/2026
A deep dive into the platform
Architecture The Blue Lucy platform follows a distributed microservices architecture, meaning the overall operational capability...
12/03/2026
Orchestration platform enables broadcasters to deploy multiple AI models safely with full auditability, rights protection, and regulatory oversight.
LONDON, En...
12/03/2026
Cost pressures, switching intent and demand for savings and credit products are ...
12/03/2026
For the first time, Nielsen breaks out demographic information about FAST and AV...
12/03/2026
Share
Copy link
Facebook
X
Linkedin
Bluesky
Email...
12/03/2026
Appear's high-performance, ultra-low latency encoding platform augments LTN's fully managed global IP network and orchestration platform
LTN, a leader ...
12/03/2026
2026 NAB Show Exhibitor Preview
April 18-22
Las Vegas
Booth C3519
Summary:
At the 2026 NAB Show in Las Vegas, Boland Communications will be showing the bro...
12/03/2026
Riedel Communications today announced the continued expansion of its Managed Technology Division in the Americas and the appointment of Jan Schaffner as Vice Pr...
12/03/2026
Grass Valley and integration partner Tab M Solutions have completed Phase 1 of a new broadcast production control room for the University of Illinois Division o...
12/03/2026
NAKIVO, a global provider of backup and ransomware recovery solutions, announces the general availability of NAKIVO Backup & Replication v11.2. This release exp...
12/03/2026
Share
Copy link
Facebook
X
Linkedin
Bluesky
Email...
12/03/2026
Share
Copy link
Facebook
X
Linkedin
Bluesky
Email...
12/03/2026
Share
Copy link
Facebook
X
Linkedin
Bluesky
Email...
12/03/2026
Share
Copy link
Facebook
X
Linkedin
Bluesky
Email...
12/03/2026
Share
Copy link
Facebook
X
Linkedin
Bluesky
Email...
12/03/2026
Share
Copy link
Facebook
X
Linkedin
Bluesky
Email...
12/03/2026
COW Jobs: Editor de V deo - Direct Response, Performance Ads - Brazil, Remote
Brie Clayton March 11, 2026
0 Comments
Editor(a) de V deo (Direct Respon...
12/03/2026
Avatar: Fire and Ash Graded with DaVinci Resolve Studio
Brie Clayton March 11, 2026
0 Comments
Colorist delivers premium cinematic color across 2D, 3D...
12/03/2026
Boston Conservatory to Timoth e Chalamet: We Care About Ballet and Opera Boston Conservatory at Berklee students and faculty respond to the actors recent comm...
12/03/2026
Wuppertal March 12, 2026
Riedel Expands Managed Technology Division in the Ame...
12/03/2026
Back to All News
Netflix Develops an Unprecedented Series About the Passionate ...
12/03/2026
Back to All News
Netflix Opens Eyeline Studios in Hyderabad, Anchoring Long-Ter...
12/03/2026
Back to All News
A Documentary About Ronaldinho Ga cho Leads Netflix's Slat...
12/03/2026
Advanced Media Server Delivers Double the Channel Density at Half the Cost per C...
12/03/2026
Editor's note: This post is part of Into the Omniverse, a series focused on ...
12/03/2026
The Late Late Show Show St Patrick's Day special
Dancing with the Stars f...
12/03/2026
GeForce NOW is bringing the game to the Game Developers Conference (GDC), running this week in San Francisco. While developers build the future of gaming, GeFor...
11/03/2026
Share
Copy link
Facebook
X
Linkedin
Bluesky
Email...
11/03/2026
Matrox Video will showcase its vision for the future of live production at NAB 2026 in Las Vegas, April 19-22, highlighting how broadcasters and media organizat...
11/03/2026
Geneva-based technology company, GlobalM SA, is presenting its GMX Distributed Video Gateway, a software-defined IP media transport platform designed to replace...
11/03/2026
Backlight (booth #N2829), the company behind Iconik and Wildmoka, which power video workflows for large media and entertainment organizations, has released the ...
11/03/2026
QuickLink, a leading provider of award-winning video production and remote guest contribution solutions, presents its latest StudioEdge models at The NAB Show ...
11/03/2026
Telestream, a global leader in media workflow technologies, today announced the expansion of Telestream Cloud Services with the introduction of UP, a new cloud-...
11/03/2026
Operative, the preferred advertising management provider for the world's leading media brands, today announced the launch of AOS for digital media, an AI-po...
11/03/2026
Calrec will be located in Central Hall, on Booth C6907
Choice without compromise
The broadcast industry is going through a rapid evolution that s signalling a...
11/03/2026
The new service is hosted and operated entirely in the Netherlands, combining data sovereignty, resilience, scalability, and predictable costs without relying...
11/03/2026
Ease Live, an Evertz company and leader in interactive graphical overlays, today announced the successful deployment of its platform on Red Bull TV for Premier ...
11/03/2026
Mediagenix, a global leader in smart content solutions to profitably connect the right content to the right audience, is advancing its Semantic Intelligence cap...