TSRI scientists discover workings of first promising Marburg virus treatment New study reveals key differences between Marburg and Ebola viruses
January 10, 2018
LA JOLLA, CA Jan. 10, 2018 With a mortality rate of up to 88 percent, Marburg virus can rip through a community in days. In 2005, an outbreak of Marburg virus struck a pediatric ward in the country of Angola. With no treatment available, doctors struggled to help as the virus killed 329 of 374 infected patients.
Now, scientists at The Scripps Research Institute (TSRI) have discovered the workings of the first promising treatment for Marburg virus, a pathogen with the same pandemic potential as Ebola virus. The research builds on previous studies showing that an antibody called MR191 can neutralize Marburg though no one knew exactly how it targeted the virus.
For the new study, TSRI scientists created a map of the virus' structure and revealed through high-resolution imaging how MR191 targets and neutralizes the virus. This antibody or a strategy to elicit this antibody in patients could finally give doctors a way to successfully treat the disease.
This is the first antibody therapeutic found that could treat Marburg, says Erica Ollmann Saphire, PhD, a TSRI professor and senior author of the study, published today in the journal Cell Host & Microbe.
With this new structure, we can start to see how this treatment works, adds Liam King, a TSRI graduate student and first author of the study. We have also learned new things about the virus itself that could lead to new treatments and vaccines.
The scientists used a high-resolution imaging technique called x-ray crystallography and found that MR191 neutralizes the virus by mimicking the host receptor and plugging into a spot on the viral surface called the receptor binding site. With this site occupied, the virus can no longer attach itself to human cells and spread infection.
The imaging also shows part of the architecture of a wing that sticks out of the side of the viral structure. The wing was particularly important for researchers to map since it appears to be one of only two known sites where protective human antibodies can bind.
As researchers draw up the battle plans against Marburg virus, they are noticing important ways Marburg differs from its close relative, Ebola virus. The new study reveals that, unlike the wing on Ebola virus, Marburg's wing folds around the outside of the glycoprotein spike.
That finding and others in this structure tell us that Marburg is constructed differently from its cousin, the Ebola virus, says Ollmann Saphire. That means the therapeutic strategy for one may need to be different from the other.
Another key difference: While both viruses use a structure called a glycan cap to shield the vulnerable receptor binding site from the human immune system, the new study reveals that MR191 can get around the glycan cap on Marburg virus an ability scientists have not observed for any antibodies against Ebola virus.
Ollmann Saphire says the next step is to study how known mutations in Marburg evade such antibodies and to use that information to devise second-line treatments. Soon, the team hopes to see the antibody therapeutic go into clinical trials. As part of this effort, study collaborators at Vanderbilt University have licensed MR191 to a commercial partner.
In addition to Ollmann Saphire and King, authors of the study, The Marburg virus-neutralizing human monoclonal antibody MR191 targets a conserved site to block virus receptor binding, include Marnie L. Fusco, Robert N. Kirchdoerfer and Kathryn M. Hastie of The Scripps Research Institute; Andrew I. Flyak of the Vanderbilt University Medical Center and the California Institute of Technology; Philipp A. Ilinykh and Kai Huang of the University of Texas Medical Branch; Bronwyn Gunn and Galit Alter of the Ragon Institute of Massachusetts General Hospital, Massachusetts Institute of Technology and Harvard University; Amandeep K. Sangha and Jens Meiler of Vanderbilt University; and James E. Crowe Jr. of the Vanderbilt University Medical Center.
The study was supported by the National Institutes of Health (grants R01AI089498, U19AI109762, U19AI109762, HDTRA1-13-1-0034, 1U19AI109711 and R21AI121799).
Infectious Diseases Integrative Structural & Computational Biology Ollmann Saphire, Erica
Most recent headlines
04/08/2024
Dalet, a leading technology and service provider for media-rich organizations, is excited to announce Santiago Solanas as its new Chief Executive Officer (CEO)....
03/06/2024
Dalet, a leading technology and service provider for media-rich organizations, a...
08/05/2024
zweiB updates to latest version of R&S CLIPSTER Specialist in deliverables for cinema, events and trade shows
Rohde & Schwarz, a global leader in broadcast...
07/05/2024
There's something special about summer. We're not sure whether it's the warmer weather, the longer days, or something else a bit more magical, but s...
07/05/2024
NITV appoints Michael Rennie as Presenter and Senior Producer for NITV News
Media releases
NITV has announced the appointment of Michael Rennie as Presenter...
07/05/2024
The ability for line-of-site tactical voice and data networks to seamlessly traverse over Satellite Communications is an emerging requirement to assure warfight...
07/05/2024
On April 5, 2024, the L3Harris Avionics Products Repair Station (NN2R037L) in Gr...
07/05/2024
eds3_5_jq(document).ready(function($) { $(#eds_sliderM519).chameleonSlider_2_1({ content_source:......
07/05/2024
Share this article
width=32 height=32 loading=lazy data-lazy-src=https://apogeedigital.com/app/themes/juniper-theme/src/img/icons/facebook-purple.svg />
wid...
07/05/2024
BURBANK, Calif. The Walt Disney Company has finally delivered some from profits from its hefty streaming investments, with the second quarter of its fiscal year...
07/05/2024
Bonnie Hammer, vice chair of NBCUniversal, and Jen Psaki, MSNBC host, read from their new books at the 92nd Street Y in Manhattan Wednesday, May 8. Hammer's...
07/05/2024
Paramount Plus has ordered the series Crutch, a comedy that is a spinoff of CBS comedy The Neighborhood. Tracy Morgan stars....
07/05/2024
Edward J. and Melody Thomas Scott and Lidia Bastianich will receive Lifetime Achievement honors at the 51st annual Daytime Emmy Awards in June, the National Aca...
07/05/2024
The 2024 Giants of Broadcasting & Electronic Arts luncheon and awards ceremony happens in New York November 12, and the honorees are Al Roker, weather and featu...
07/05/2024
Dabl Network has added The Wayans Bros., The Jamie Foxx Show, Living Single and Everybody Hates Chris to its weekday and weekend lineups. Those shows join the l...
07/05/2024
After winning a proxy fight, The Walt Disney Co. said its entertainment business turned a profit and added subscribers in its fiscal second quarter....
07/05/2024
NBA Entertainment is closing out the second season of its series Pass the Rock with a look at Victor Wembanyama of the San Antonio Spurs, the league's rooki...
07/05/2024
Syncbak, which provides stations with streaming capabilities, said it is rebranding as Zeam Media....
07/05/2024
Samsung has made a deal with Magnolia Pictures that will bring titles from Magnolia to the Samsung TV Plus free streaming platform....
07/05/2024
Amazon, which has added commercials to Amazon Prime Video, is rolling out new interactive ad formats that will enable advertisers to engage streamers and sell s...
07/05/2024
Syncbak, a 15 year-old provider of streaming tech for local broadcast stations has rebranded itself, adopting the name of its streaming service launched in Febr...
07/05/2024
POST Luxembourgs journey with TAG Video underscores how finding a vendor who und...
07/05/2024
PORTSMOUTH, N.H. New findings from Hub Entertainment Research provides extensive data showing that the majority of consumers will opt for lower cost ad-supporte...
07/05/2024
NEW YORK The Library of American Broadcasting Foundation (LABF) has announced th...
07/05/2024
CBS News has named Lindsey Reiser an anchor and correspondent for CBS News 24/7, the network's live, streaming news service. Reiser, who was most recently a...
07/05/2024
NEEDHAM, Mass. After more than two years of decline, worldwide tablet shipments posted modest year-over-year growth of 0.5% in the first quarter of 2024 (1Q24),...
07/05/2024
ESPN is reporting that April was a record-setting month as the network delivered its best April prime time audience on record, dating back more than 30 years....
07/05/2024
WASHINGTON, D.C. The National Association of Broadcasters (NAB) has announced that Kirsten Donaldson has joined NAB as vice president of public policy. Donaldso...
07/05/2024
The Bulls are back home again this week from May 7-12! Don't miss out on any...
07/05/2024
SVG Sit-Down: AWS's Julie Souza on the Cloud and AI in Broadcast-Content Cre...
07/05/2024
Deloitte Analysts Peter Giorgio and Michael Vovk: Sports Properties Need To Reth...
07/05/2024
University of Texas' Jeff Hanel to Keynote 16th-Annual SVG College Summit Industry vet to discuss uniting live and creative in athletic department media arm...
07/05/2024
Premier League trials RefCam during Crystal Palace v Manchester United fixture By George Bevir
Tuesday, May 7, 2024 - 09:34
Print This Story
In a Premier ...
07/05/2024
CBS Sports Previews PGA Championship Plans; 125+ Cameras Include FlyCams, Bunker...
07/05/2024
Rohde & Schwarz brings cutting-edge solutions to TECNOSEC and DRONExpo 2024 Rohde & Schwarz will showcase its innovative portfolio at TECNOSEC and DRONExpo 20...
07/05/2024
Back to All News
Five New Games Join Netflix in May
Netflix Staff
Entertainment
07 May 2024
Global
Link copied to clipboard
Five new games are launching ...
07/05/2024
Back to All News
Top 10 Week of Apr. 29: Baby Reindeer' Holds Strong; Hee...
07/05/2024
Home News & Press Blancco Wins 2024 SEAL Business Sustainability Award
Blancco Wins 2024 SEAL Business Sustainability Award May 07, 2024
Blancco's v...
07/05/2024
CUPERTINO, CALIFORNIA Apple today unveiled the all-new Logic Pro for iPad 2 and Logic Pro for Mac 11, delivering breakthrough professional experiences for songw...
07/05/2024
Apple's new Privacy Manifest requirement mandates that apps explicitly disclose the privacy-related data they collect, the purposes for this collection, and...
07/05/2024
Taylor Swift's Eras Tour arrives to shake up EuropeHaving shaken four continents, Taylor Swift's Eras Tour finally brings the biggest pop culture icon o...
07/05/2024
Isiphetho: Destiny' beats Scandal!'E.tv's latest telenovela Isiphetho: Destiny' beat the channel's longest running soapie, Scandal!' ...
07/05/2024
Now there's HELP for ex-prisoners to find work in South AfricaNew initiative for ex-prisoners to find work in South Africa proves it's never too late fo...
07/05/2024
Tonight on Scandal: Cohen is pulled into keeping a secretDon't miss Tuesday, 7 May's riveting episode of South African soapie Scandal! on e.tv on DStv c...
07/05/2024
Skeem Saam: Monday's episode, 6 May 2024 [video]Missed an episode of Skeem Saam? No problem! Watch the latest episode of your favourite South African soapie...
06/05/2024
By Ilyse McKimmie
Now, more than ever
That's a phrase so often used in the last few years that I've come to dread seeing it in notes like this one. A...
06/05/2024
alt= class=wp-image-12099 data-lazy-src=/wp-content/uploads/2024/05/Blog-Exabyte-Storage-Demand-960x540-1.jpg/> Demand for storage solutions has reached unprece...
06/05/2024
Around the world, Asian and Pacific Islander (API) artists continue to impact mu...
06/05/2024
Spotify is making it easier for booklovers to count down the days, hours, minutes, and seconds until a new audiobook releases. With Countdown Pages for audioboo...
TSRI scientists discover workings of first promising Marburg virus treatment New study reveals key differences between Marburg and Ebola viruses
