
New research model illuminates how organs communicate with each other Scripps Research, University of Southern California and collaborators uncover the proteins involved in key communication networks, which could help us better understand conditions like cancer and obesity.
August 17, 2022
LA JOLLA, CA Our many different organ systems are in constant communication with each other. During exercise, for example, muscles send out signals to fat and liver tissue to release their energy sources. While these communication networks play a critical role in our bodies every day, it has been historically difficult to uncover such pathways. Scientists at Scripps Research, University of Southern California and elsewhere have now successfully created a model to label and track the protein signals that enable organ-to-organ communication.
As the researchers described in Open Biology on August 10, 2022, their new mouse model marks the proteins that a cell secretes and tracks their movement throughout the body. This novel technology could shape our molecular understanding of healthy versus diseased tissue, as well as the role that inter-organ communication plays in disease onset and progression.
This new model can be likened to establishing a passport system in the body, as we are identifying where proteins are coming from and where they're going, says study co-first author Ilia Droujinine, PhD, Scripps fellow and principial investigator in the Department of Molecular Medicine at Scripps Research. We can finally bring these interconnected communications networks to light, and then develop treatments based on this new knowledge. Rui Yang and Amanda S. Meyer of the University of Southern California were also co-first authors and key contributors to this work.
Researchers have used other methods, such as viral approaches, to understand protein secretion and the ways that organs communicate with each other. While these techniques have provided invaluable insight into the proteins expressed in an organism, they aren't sensitive enough to label low-abundance proteins, or the origin and ultimate destination of protein interactions. But with this new model, scientists are now able to understand the exact path a particular protein takes.
In the study, the researchers used an enzyme called BirA*G3, which labels secreted proteins with a biotin tag. These biotin labels were then detected in live mice using a method called quantitative mass spectrometry proteomics, which is used to measure proteins in a sample. This revealed where the proteins originated from and where they traveled to in the body.
When BirA*G3 was broadly activated throughout the body, the researchers found that all secreted proteins were successfully labeled, even low-abundance proteins with hormone-like properties. Likewise, when BirA*G3 was activated solely in the liver, only secreted proteins related to that organ system were highlighted displaying the high specificity of the model as well.
Given the central role of key secreted proteins such as insulin, there is a great deal of interest in identifying novel secreted proteins, said Andrew McMahon, PhD, senior author of the study and chair of the Department of Stem Cell Biology and Regenerative Medicine at the University of Southern California. Genome studies are suggesting that many new proteins remain to be characterized. We're looking forward to a deep dive into this area now that we have validated the technology.
There are countless research applications for this technology, Droujinine notes. With this type of model, scientists can start to map unexplored disease pathways and ultimately develop targeted treatments, as many diseases originate in a single organ and then eventually spread to others. Cancer, with its metastatic properties, is one example. For another, studies have shown that many of the health complications that arise from obesity could be due to faulty organ communication, yet many of the molecular mechanisms remain unknown.
Any protein we discover that plays a role in disease has the potential be translated into a therapeutic, adds Droujinine.
In addition to Droujinine and McMahon, authors of the study, A genetic model for in vivo proximity labelling of the mammalian secretome, include Rui Yang, Amanda S. Meyer, Jinjin Guo, Jill A. McMahon of the University of Southern California (USC); Namrata D. Udeshi, Dominique K. Carey, Charles Xu and Steven A. Carr of Broad Institute of Harvard and MIT; Yanhui Hu, David Rocco and Norbert Perrimon of Harvard Medical School; Qiao Fang of University of Toronto; Jihui Sha and James Wohlschlege of UCLA; Shishang Qin of Peking University; and Alice Y. Ting of Chan Zuckerberg Biohub.
This work was supported by a NIH Transformative R01 grant 5R01DK121409 to A.P.M., A.Y.T., S.A.C. and N.P., and HHMI funding to N.P. I.A.D. acknowledges support from the Ellen Browning Scripps Foundation.
Molecular and Cellular Biology Droujinine, Ilia
North America Stories
25/03/2026
Share
Copy link
Facebook
X
Linkedin
Bluesky
Email...
25/03/2026
Share
Copy link
Facebook
X
Linkedin
Bluesky
Email...
25/03/2026
Share
Copy link
Facebook
X
Linkedin
Bluesky
Email...
25/03/2026
SipRadius, specialists in secure, low-latency media transport, will drive innovation and interoperability still further with the launch of the SipMX Alliance at...
25/03/2026
QuickLink, a leading provider of award-winning video production and remote contribution solutions, will showcase its award-winning StudioPro ecosystem at The 2...
25/03/2026
Alfalite, the only European manufacturer of LED screens, will once again be present at NAB Show, the leading global event for the broadcast, media and entertain...
25/03/2026
PC, a leading provider of integrated communication solutions, will make its NAB 2026 Show debut in Booth C 3341. The company will highlight the newly branded On...
25/03/2026
Open video transport network simplifies satellite transition with new partnerships and global reach as spectrum auction nears
LTN will demonstrate how its purp...
25/03/2026
Test & measurement innovator, Leader Electronics, will present the full range of Leader, PHABRIX and LeaderPhabrix T&M solutions at the NAB Show, which takes pl...
25/03/2026
MNC Software, a global leader in network management and operational support systems tailored to the broadcast and media industry, today announced the appointmen...
25/03/2026
Share
Copy link
Facebook
X
Linkedin
Bluesky
Email...
25/03/2026
Share
Copy link
Facebook
X
Linkedin
Bluesky
Email...
25/03/2026
Starfish highlights flexible TS Splicer releases and new Monitoring Dashboard at...
25/03/2026
XLNTSOUND Elevates Video Production with Blackmagic Design
Brie Clayton March 24, 2026
0 Comments
Audio company upgrades workflow with Blackmagic Cine...
25/03/2026
First Time Exhibitor IPC Introduces One Link Keypanels for One Connect Intercom ...
25/03/2026
At the half-time whistle of the UEFA EURO 2020 round of 16 football match betwee...
24/03/2026
Utah Scientific to Showcase a Variety of Hybrid SDI/IP Innovations at the 2026 N...
24/03/2026
Mediaproxy will showcase an updated version of its LogPlayer interface at NAB Sh...
24/03/2026
C gep de Jonqui re, a public college in Qu bec, has upgraded its TV studio complex with five Calrec Brio consoles and a Dante IP network. The installation was c...
24/03/2026
The American Association of Professional Baseball (AAPB) has announced new and r...
24/03/2026
National Telecom Public Company Limited (NT) used Ateme's KYRION platform fo...
24/03/2026
Grass Valley has expanded its relationship with ImSoPROD, the TV production entity of FDJ United, with the deployment of LDX C98 compact cameras across its nati...
24/03/2026
The E.W. Scripps Company is launching Scripps Sports Network (SSN), a free, ad-s...
24/03/2026
NEP Group has launched NEP Platform, a new software orchestration system that un...
24/03/2026
Daktronics has partnered with the Arizona Diamondbacks to design, manufacture and install a new LED video display and three ribbon boards at Chase Field in Phoe...
24/03/2026
Grass Valley has completed an upgrade of University of Pittsburgh Athletics'...
24/03/2026
Daktronics is upgrading eight LED displays at Wrigley Field in Chicago, totaling more than 8,300 square feet, using the Daktronics Renew product line. The upgra...
24/03/2026
Advanced Systems Group has appointed Kevin Poole as Senior Project and Support Manager within the ASG Workflow and Tools practice. The position is newly created...
24/03/2026
In an increasingly streaming-centric world, protecting high-value live sports co...
24/03/2026
Mediaproxy will showcase an updated version of its LogPlayer interface at NAB Show, April 19-22 in Las Vegas, booth W1423. The update includes AI tools, native ...
24/03/2026
The production studio has worked with content juggernauts such as MrBeast, The R...
24/03/2026
The event will also feature a State of the Industry address from sports-media veteran and strategic advisor Patrick Crakes....
24/03/2026
Victory , a free sports streaming service owned by A Parent Media Co. (APMC), has launched its NWSL Sunday Night Soccer franchise. The platform says the launch ...
24/03/2026
Sports content in free streaming is still relatively scant, but it's growing, right along with its monetization capabilities
Streaming-tech company Wurl re...
24/03/2026
Directed by Greg DeHart, the doc will feature Sports Broadcasting Hall of Famers...
24/03/2026
For the first time ever, Tubi - Fox's free streaming service - is working w...
24/03/2026
L3Harris ramps up production of its VAMPIRE C-UxS system....
24/03/2026
For more than 70 years, L3Harris has delivered essential fuzes and safe-and-arm solutions that bring the might to multi-domain battlefields across the globe, ...
24/03/2026
Grass Valley has strengthened its long-standing relationship with ImSoPROD, the TV production entity of the FDJ United, with the deployment of Grass Valley LDX ...
24/03/2026
At the 2026 NAB Show in Las Vegas, Utah Scientific will spotlight its expanding portfolio of hybrid SDI/IP routing, conversion, control, and signal management s...
24/03/2026
Fresh off its global reveal at ISE 2026 in Barcelona, the new V410 live 4K encoder/decoder from Miri Technologies Inc. will make its North American debut at the...
24/03/2026
Cinegy GmbH, premier provider of software-defined television technology, will show how its solutions answer the real challenges facing content creators and broa...
24/03/2026
Canberra-based radio and online broadcast network ArtSound FM (https://artsound.fm/) has invested in DHD audio mixing consoles for two new studios at its headqu...
24/03/2026
IBC today announced the nine projects selected for its 2026 Accelerator Media Innovation Programme, bringing together organisations from across broadcast, strea...
24/03/2026
Mediaproxy, the global standard for software-based IP compliance monitoring and multiviewing solutions, will showcase the next generation of its industry-leadin...
24/03/2026
Underscoring its global reputation as one of Canada's most renowned colleges for television production, the C gep de Jonqui re public college in Qu bec has ...
24/03/2026
Leading video software provider Synamedia today announced the launch of the industry's first edge watermarking solution that enables faster disruption of pi...
24/03/2026
Experience Commerce, a leading full-service digital marketing agency and part of the Cheil SWA Group, has secured the annual social media mandate for Fiat Payme...
24/03/2026
Share
Copy link
Facebook
X
Linkedin
Bluesky
Email...
24/03/2026
Share
Copy link
Facebook
X
Linkedin
Bluesky
Email...