New research model illuminates how organs communicate with each other Scripps Research, University of Southern California and collaborators uncover the proteins involved in key communication networks, which could help us better understand conditions like cancer and obesity.
August 17, 2022
LA JOLLA, CA Our many different organ systems are in constant communication with each other. During exercise, for example, muscles send out signals to fat and liver tissue to release their energy sources. While these communication networks play a critical role in our bodies every day, it has been historically difficult to uncover such pathways. Scientists at Scripps Research, University of Southern California and elsewhere have now successfully created a model to label and track the protein signals that enable organ-to-organ communication.
As the researchers described in Open Biology on August 10, 2022, their new mouse model marks the proteins that a cell secretes and tracks their movement throughout the body. This novel technology could shape our molecular understanding of healthy versus diseased tissue, as well as the role that inter-organ communication plays in disease onset and progression.
This new model can be likened to establishing a passport system in the body, as we are identifying where proteins are coming from and where they're going, says study co-first author Ilia Droujinine, PhD, Scripps fellow and principial investigator in the Department of Molecular Medicine at Scripps Research. We can finally bring these interconnected communications networks to light, and then develop treatments based on this new knowledge. Rui Yang and Amanda S. Meyer of the University of Southern California were also co-first authors and key contributors to this work.
Researchers have used other methods, such as viral approaches, to understand protein secretion and the ways that organs communicate with each other. While these techniques have provided invaluable insight into the proteins expressed in an organism, they aren't sensitive enough to label low-abundance proteins, or the origin and ultimate destination of protein interactions. But with this new model, scientists are now able to understand the exact path a particular protein takes.
In the study, the researchers used an enzyme called BirA*G3, which labels secreted proteins with a biotin tag. These biotin labels were then detected in live mice using a method called quantitative mass spectrometry proteomics, which is used to measure proteins in a sample. This revealed where the proteins originated from and where they traveled to in the body.
When BirA*G3 was broadly activated throughout the body, the researchers found that all secreted proteins were successfully labeled, even low-abundance proteins with hormone-like properties. Likewise, when BirA*G3 was activated solely in the liver, only secreted proteins related to that organ system were highlighted displaying the high specificity of the model as well.
Given the central role of key secreted proteins such as insulin, there is a great deal of interest in identifying novel secreted proteins, said Andrew McMahon, PhD, senior author of the study and chair of the Department of Stem Cell Biology and Regenerative Medicine at the University of Southern California. Genome studies are suggesting that many new proteins remain to be characterized. We're looking forward to a deep dive into this area now that we have validated the technology.
There are countless research applications for this technology, Droujinine notes. With this type of model, scientists can start to map unexplored disease pathways and ultimately develop targeted treatments, as many diseases originate in a single organ and then eventually spread to others. Cancer, with its metastatic properties, is one example. For another, studies have shown that many of the health complications that arise from obesity could be due to faulty organ communication, yet many of the molecular mechanisms remain unknown.
Any protein we discover that plays a role in disease has the potential be translated into a therapeutic, adds Droujinine.
In addition to Droujinine and McMahon, authors of the study, A genetic model for in vivo proximity labelling of the mammalian secretome, include Rui Yang, Amanda S. Meyer, Jinjin Guo, Jill A. McMahon of the University of Southern California (USC); Namrata D. Udeshi, Dominique K. Carey, Charles Xu and Steven A. Carr of Broad Institute of Harvard and MIT; Yanhui Hu, David Rocco and Norbert Perrimon of Harvard Medical School; Qiao Fang of University of Toronto; Jihui Sha and James Wohlschlege of UCLA; Shishang Qin of Peking University; and Alice Y. Ting of Chan Zuckerberg Biohub.
This work was supported by a NIH Transformative R01 grant 5R01DK121409 to A.P.M., A.Y.T., S.A.C. and N.P., and HHMI funding to N.P. I.A.D. acknowledges support from the Ellen Browning Scripps Foundation.
Molecular and Cellular Biology Droujinine, Ilia
North America Stories
28/01/2026
Share Share by:
Copy link
Facebook
X
Linkedin
Bluesky
Email...
28/01/2026
Share Share by:
Copy link
Facebook
X
Linkedin
Bluesky
Email...
28/01/2026
Marshall Electronics launches the CV420-27X, its next-generation ultra-high-definition (UHD) IP camera, at ISE 2026 (Stand 4N900). Engineered for modern IP-base...
28/01/2026
Grass Valley has announced that Television Mobiles Ltd. (TVM), one of Europe's leading independent outside broadcast providers, has carried out a major refu...
28/01/2026
AI, graphics and virtual software power new production capabilities
FOR-A is bringing remarkable new technologies to FOMEX, the Future of Media Exhibition (ex...
28/01/2026
Continuing a longstanding collaboration, Riedel Communications and Nordic media technology company Media Tailor have once again joined forces to deliver a state...
28/01/2026
Pebble has appointed Paul Nagle-Smith as vice president for customer fulfilment, strengthening its senior leadership focus on customer delivery and operational ...
28/01/2026
Cloud playout solutions provider, Veset has announced that leading Mexican broadcaster, TV Azteca is using Veset Nimbus on AWS as a disaster recovery (DR) playo...
28/01/2026
Ensuring it can keep pace with a rapidly evolving live sports market, Balkan broadcast facility provider MVP Most Valuable Production has upgraded its flags...
28/01/2026
Akamai Technologies, Inc. (NASDAQ: AKAM), the cloud solutions provider that powers and protects life online, and Yospace, the leader in dynamic ad insertion tec...
28/01/2026
The renowned Reykjavik City Theatre (RCT) recently underwent a major intercom system upgrade using Clear-Com solutions. This milestone project utilizes Clear-C...
28/01/2026
Share Share by:
Copy link
Facebook
X
Linkedin
Bluesky
Email...
28/01/2026
Share Share by:
Copy link
Facebook
X
Linkedin
Bluesky
Email...
28/01/2026
Share Share by:
Copy link
Facebook
X
Linkedin
Bluesky
Email...
28/01/2026
Boston Conservatory Orchestra Premieres a New Piano Concerto by Peter and Leonar...
27/01/2026
L-R: Jonathan Cuchacovich, Sonia Kennebeck, Alan Fischer, Daeil Kim, Andrew Sta...
27/01/2026
Nielsen will continue to drive growth and provide local audience measurement
in...
27/01/2026
Share Share by:
Copy link
Facebook
X
Linkedin
Pinterest
Bluesky
Email...
27/01/2026
Share Share by:
Copy link
Facebook
X
Linkedin
Pinterest
Bluesky
Email...
27/01/2026
Share Share by:
Copy link
Facebook
X
Linkedin
Pinterest
Bluesky
Email...
27/01/2026
Amagi Media Labs Limited, the only cloud-native SaaS provider offering end-to-end solutions across live production, content preparation, distribution, and monet...
27/01/2026
Miri Technologies Inc. today unveiled its V410 live 4K video encoder/decoder for streaming, IP-based production workflows and AV-over-IP distribution. Designed ...
27/01/2026
The Paul E. Tsongas Center at UMass Lowell in Massachusetts has chosen Ikegami cameras for incorporation into its broadcast-quality television production facili...
27/01/2026
SipRadius, specialists in secure, low latency media transport, will show the pro AV community its end-to-end solution for high quality content distribution and ...
27/01/2026
Hiltron will highlight the fruits of its 45-plus years of experience in satellite communications system integration and product development at the annual GovSat...
27/01/2026
Klvr will demonstrate how its Charger Pro solution is delivering cost reduction and performance benefits for live entertainment and pro AV markets at ISE 2026 (...
27/01/2026
Amino, a global media technology leader in enterprise video and digital signage, today announced that its Integrated Systems Europe (ISE) 2026 booth (4N700) wil...
27/01/2026
ANI, India's leading news agency and a major content provider across the Asia Pacific region, today announced a significant expansion of its long standing p...
27/01/2026
Independent analysis confirms faster encoding, lower CPU usage, and improved perceptual quality compared to CBR and CRF
VisualOn, a leader in multimedia playba...
27/01/2026
Share Share by:
Copy link
Facebook
X
Linkedin
Pinterest
Bluesky
Email...
27/01/2026
Share Share by:
Copy link
Facebook
X
Linkedin
Pinterest
Bluesky
Email...
27/01/2026
Share Share by:
Copy link
Facebook
X
Linkedin
Pinterest
Bluesky
Email...
27/01/2026
Share Share by:
Copy link
Facebook
X
Linkedin
Pinterest
Bluesky
Email...
27/01/2026
Back to All News
When It Feels Real, Is It Still a Lie? The Art of Sarah' ...
27/01/2026
Back to All News
That Night premiering on Netflix March 13
Entertainment
27 January 2026
GlobalSpain
Link copied to clipboard
DOWNLOAD THE KEY ART
DOWNLO...
27/01/2026
Back to All News
Netflix Revealed the Future of Mexican Stories Coming in 2026
Entertainment
27 January 2026
GlobalMexico
Link copied to clipboard
Among t...
27/01/2026
Back to All News
Four New Japan Titles Announced for 2026: Viral Hit', On...
27/01/2026
Back to All News
What's Next on Netflix from Japan: Expanding the Possibili...
27/01/2026
AI, graphics and virtual software power new production capabilities...
26/01/2026
Share Share by:
Copy link
Facebook
X
Linkedin
Pinterest
Bluesky
Email...
26/01/2026
Share Share by:
Copy link
Facebook
X
Linkedin
Pinterest
Bluesky
Email...
26/01/2026
Share Share by:
Copy link
Facebook
X
Linkedin
Pinterest
Bluesky
Email...
26/01/2026
Share Share by:
Copy link
Facebook
X
Linkedin
Pinterest
Bluesky
Email...
26/01/2026
Advanced Systems Group (ASG) today announced an exclusive partnership with Nu Studio, the company behind the first modular, portable studio designed for immersi...
26/01/2026
OpenDrives, the leader in high-end video data management and workflow solutions, today announced an add-on investment to its previous funding rounds, led by IAG...
26/01/2026
SmallHD today announced a major update to its award-winning PageOS software, introducing Fleet Control, Portrait Mode, expanded Camera Control features, and Dow...
26/01/2026
Whether rigging a PTZ on a truss, sliding a Blackmagic camera across a mezzanine railing, or capturing the mayhem from inside a drum, Filipic delivers visuals t...
26/01/2026
Back to All News
Netflix Unveils Official Trailer for Salvador
Entertainment
26 January 2026
GlobalSpain
Link copied to clipboard
DISCOVER THE TRAILER
DO...
26/01/2026
Back to All News
Netflix Presents Our 2026 Series and Films and Announces New Projects
Entertainment
26 January 2026
GlobalSpain
Link copied to clipboard
...
New research model illuminates how organs communicate with each other Scripps Research, University of Southern California and collaborators uncover the proteins involved in key communication networks, which could help us better understand conditions like cancer and obesity.
