New research model illuminates how organs communicate with each other Scripps Research, University of Southern California and collaborators uncover the proteins involved in key communication networks, which could help us better understand conditions like cancer and obesity.
August 17, 2022
LA JOLLA, CA Our many different organ systems are in constant communication with each other. During exercise, for example, muscles send out signals to fat and liver tissue to release their energy sources. While these communication networks play a critical role in our bodies every day, it has been historically difficult to uncover such pathways. Scientists at Scripps Research, University of Southern California and elsewhere have now successfully created a model to label and track the protein signals that enable organ-to-organ communication.
As the researchers described in Open Biology on August 10, 2022, their new mouse model marks the proteins that a cell secretes and tracks their movement throughout the body. This novel technology could shape our molecular understanding of healthy versus diseased tissue, as well as the role that inter-organ communication plays in disease onset and progression.
This new model can be likened to establishing a passport system in the body, as we are identifying where proteins are coming from and where they're going, says study co-first author Ilia Droujinine, PhD, Scripps fellow and principial investigator in the Department of Molecular Medicine at Scripps Research. We can finally bring these interconnected communications networks to light, and then develop treatments based on this new knowledge. Rui Yang and Amanda S. Meyer of the University of Southern California were also co-first authors and key contributors to this work.
Researchers have used other methods, such as viral approaches, to understand protein secretion and the ways that organs communicate with each other. While these techniques have provided invaluable insight into the proteins expressed in an organism, they aren't sensitive enough to label low-abundance proteins, or the origin and ultimate destination of protein interactions. But with this new model, scientists are now able to understand the exact path a particular protein takes.
In the study, the researchers used an enzyme called BirA*G3, which labels secreted proteins with a biotin tag. These biotin labels were then detected in live mice using a method called quantitative mass spectrometry proteomics, which is used to measure proteins in a sample. This revealed where the proteins originated from and where they traveled to in the body.
When BirA*G3 was broadly activated throughout the body, the researchers found that all secreted proteins were successfully labeled, even low-abundance proteins with hormone-like properties. Likewise, when BirA*G3 was activated solely in the liver, only secreted proteins related to that organ system were highlighted displaying the high specificity of the model as well.
Given the central role of key secreted proteins such as insulin, there is a great deal of interest in identifying novel secreted proteins, said Andrew McMahon, PhD, senior author of the study and chair of the Department of Stem Cell Biology and Regenerative Medicine at the University of Southern California. Genome studies are suggesting that many new proteins remain to be characterized. We're looking forward to a deep dive into this area now that we have validated the technology.
There are countless research applications for this technology, Droujinine notes. With this type of model, scientists can start to map unexplored disease pathways and ultimately develop targeted treatments, as many diseases originate in a single organ and then eventually spread to others. Cancer, with its metastatic properties, is one example. For another, studies have shown that many of the health complications that arise from obesity could be due to faulty organ communication, yet many of the molecular mechanisms remain unknown.
Any protein we discover that plays a role in disease has the potential be translated into a therapeutic, adds Droujinine.
In addition to Droujinine and McMahon, authors of the study, A genetic model for in vivo proximity labelling of the mammalian secretome, include Rui Yang, Amanda S. Meyer, Jinjin Guo, Jill A. McMahon of the University of Southern California (USC); Namrata D. Udeshi, Dominique K. Carey, Charles Xu and Steven A. Carr of Broad Institute of Harvard and MIT; Yanhui Hu, David Rocco and Norbert Perrimon of Harvard Medical School; Qiao Fang of University of Toronto; Jihui Sha and James Wohlschlege of UCLA; Shishang Qin of Peking University; and Alice Y. Ting of Chan Zuckerberg Biohub.
This work was supported by a NIH Transformative R01 grant 5R01DK121409 to A.P.M., A.Y.T., S.A.C. and N.P., and HHMI funding to N.P. I.A.D. acknowledges support from the Ellen Browning Scripps Foundation.
Molecular and Cellular Biology Droujinine, Ilia
North America Stories
06/04/2026
Michigan legends bring a new voice to the broadcast as TNT Sports and CBS Sports...
06/04/2026
From high school sports all the way up to the major leagues, building high-quali...
06/04/2026
Quickplay, an AI company for the media and entertainment industry, has been accepted into the Advanced tier of the TwelveLabs Ecosystem Partner Program. Quickpl...
06/04/2026
Grass Valley has announced the Future Playmakers Program, a global initiative to...
06/04/2026
El l der de operaciones impulsa la producci n en estudio mientras encuentra insp...
06/04/2026
The ops leader helps lead the charge in studio for the Spanish-language broadcas...
06/04/2026
Behind The Mic provides a roundup of recent news regarding on-air talent, includ...
06/04/2026
The National Hockey League (NHL), in partnership with Verizon and the New Jersey Devils, today announced the opening of the NHL Innovation Lab powered by Verizo...
06/04/2026
Rock League, a new professional curling league, has announced that ESPN+ will stream its inaugural 2026 season for fans in the United States. The first Rock Lea...
06/04/2026
Advanced Systems Group has announced the appointment of Andrea (Andy) Cummis as Vice President of Systems Design and Engineering. In this role, she will lead de...
06/04/2026
Backed by Bolt Ventures, the venture brings Bryson DeChambeau, Grant Horvat, and...
06/04/2026
With this environment we can start that collaboration even earlier because we ca...
06/04/2026
Share
Copy link
Facebook
X
Linkedin
Bluesky
Email...
06/04/2026
Share
Copy link
Facebook
X
Linkedin
Bluesky
Email...
06/04/2026
Dalet Showcases Dalia Agentic AI and End-to-End Media Workflows at NAB Show 2026
Brie Clayton April 6, 2026
0 Comments
Dalet, a leading technology and...
06/04/2026
OpenDrives Shows Off Sports Expertise in Sports Business Hub located in NAB Show...
06/04/2026
Proton to Demonstrate 3D Application at NAB 2026
Brie Clayton April 6, 2026
0 Comments
Yet further creative potential unleashed through innovation in ...
06/04/2026
Autoscript Highlights Voice-Driven Prompting and PTZ Solutions at NAB 2026
Brie Clayton April 6, 2026
0 Comments
Experience Autoscript Voice, PTZ prom...
06/04/2026
Mediaproxy Highlights Significant Enhancements to its LogServer suite at NAB Sho...
06/04/2026
Back to All News
Netflix Expands Kids Entertainment Lineup With Playground App ...
04/04/2026
The University of Arizona's Men's Basketball team has only loss twice th...
04/04/2026
1080p HDR arrives, a new generation of storytelling tools takes center stage, an...
04/04/2026
Michigan legends bring a new voice to the broadcast as TNT Sports and CBS Sports...
04/04/2026
Share
Copy link
Facebook
X
Linkedin
Bluesky
Email...
04/04/2026
Share
Copy link
Facebook
X
Linkedin
Bluesky
Email...
04/04/2026
Share
Copy link
Facebook
X
Linkedin
Bluesky
Email...
04/04/2026
Share
Copy link
Facebook
X
Linkedin
Bluesky
Email...
04/04/2026
DHD Introduces AI-Based Audio Noise Reduction to XD3 IP Core
Brie Clayton April 3, 2026
0 Comments
The accompanying image shows the rear panel of the ...
04/04/2026
Macnica Redefines ST 2110 Flexibility with Two Speeds on One Card
Brie Clayton April 3, 2026
0 Comments
New for NAB Show 2026, MEP100 SmartNIC now sup...
04/04/2026
Unified Media Workflows for Story-Centric Production
Brie Clayton April 3, 2026
0 Comments
Framelight X unifies field capture, editing and publishing ...
03/04/2026
Michigan's Fab Five will reunite for an alternate presentation of the Mich...
03/04/2026
Avid will exhibit at NAB Show 2026 (April 18-22, Booth N2226, Las Vegas Convention Center), demonstrating its Content Core platform and new AI-driven workflow c...
03/04/2026
Mark Roberts Motion Control (MRMC) has announced the appointment of Nick Barthee as Chief Operating Officer.
The announcement follows MRMC's transition fro...
03/04/2026
Interra Systems has announced that Elite Media Technologies has selected its BATON file-based QC solution for media workflows. Elite Media Technologies speciali...
03/04/2026
Ateme has announced that Moldtelecom has deployed Ateme technologies across its streaming workflow, covering encoding, delivery, operations, and analytics.
Mol...
03/04/2026
Grass Valley will demonstrate Framelight X, its content management platform, at NAB Show 2026. The platform connects capture, ingest, editing, and publishing in...
03/04/2026
Encompass Digital Media and Techex have announced a cloud-native Master Control ...
03/04/2026
Live Vertical Video automatically track the action on the court via AI technology and delivers a fully optimized, 9 16 live feed for viewers...
03/04/2026
As the Illini make their first trip to college basketball's biggest stage si...
03/04/2026
After last summer's Softball National Championship victory and last week'...
03/04/2026
The University of Arizona's Men's Basketball team has only loss twice th...
03/04/2026
Eight games across four tournaments will be played in three venues; accommodatio...
03/04/2026
The Ottawa Senators and Bell Media have announced a long-term rights extension for regional Ottawa Senators games on TSN and RDS. TSN Radio 1200 remains the exc...
03/04/2026
Massive production in Phoenix is run out of Game Creek Video Flagship mobile uni...
03/04/2026
New York April 2, 2026 TelevisaUnivision, the world's leading Spanish-la...
03/04/2026
Share
Copy link
Facebook
X
Linkedin
Bluesky
Email...
03/04/2026
Share
Copy link
Facebook
X
Linkedin
Bluesky
Email...
03/04/2026
Share
Copy link
Facebook
X
Linkedin
Bluesky
Email...
03/04/2026
Share
Copy link
Facebook
X
Linkedin
Bluesky
Email...
New research model illuminates how organs communicate with each other Scripps Research, University of Southern California and collaborators uncover the proteins involved in key communication networks, which could help us better understand conditions like cancer and obesity.
