Sony Digital Rapids Pixel Power calrec Sony

Simple, but powerful' model reveals mechanisms behind neuron development

18/12/2017

Simple, but powerful' model reveals mechanisms behind neuron development JUPITER, Fla. Dec. 18, 2017 All things must come to an end. This is particularly true for neurons, especially the extensions called axons that transmit electrochemical signals to other nerve cells. Without controlled termination of individual neuron growth, the efficient and accurate construction of a nervous system is in serious jeopardy.

Scientists from the Florida campus of The Scripps Research Institute (TSRI) have now uncovered new insights into the regulatory network behind that termination. The study, led by TSRI Associate Professor Brock Grill, PhD, was recently published online ahead of print in the journal Development.

The scientists focused on axons, long cellular structures that project outward from the neuron body. When nerve cells fire, it's the axon that transmits the electrochemical signal to other neurons. Over the course of their development, axons extend, change their growth in response to cellular guidance cues and form synapses.

At the heart of this process is a specialized structure on the end of each axon called a growth cone. Successful development depends on the growth cone stopping at the correct destination and when the axon is the correct length, a process known as axon termination.

Using the nematode worm C. elegans as a model, Grill and his colleagues found for the first time that growth cone collapse prior to axon termination is protracted as the growth cone transitions from a dynamic to a static state.

We know very little about the process of how axons actually stop growing in a living animal, Grill says. What we found in our simple, but powerful model is that a signaling hub protein called RPM-1 is required to regulate the collapse of growth cones during axon termination.

It's the protracted nature of the process, Grill says, that is likely to make the transition and the termination permanent.

These findings provide new details on how growth cone collapse is regulated during axon termination in vivo. The study also shows that RPM-1 signaling destabilizes nerve cell microtubules large molecules that provide critical cell structure to facilitate growth cone collapse and axon termination.

When the scientists looked at the relationship between RPM-1 and other regulators of microtubule stability, they were surprised by the results.

They found that that while RPM-1 signaling destabilizes axon microtubules, the microtubule stabilizer Tau potentially inhibits RPM -1, something that was previously unknown.

People have very little knowledge about how TAU works under normal physiological conditions, says TSRI Research Associate Melissa Borgen, PhD, first author of the study. Our results suggest that Tau inhibition of RPM-1 is necessary for proper axon development, and offers the first evidence that RPM-1 can be regulated in vivo in neurons.

The research has implications for the development of neurological disorders as well. In mouse models, RPM-1 is an active force in axon degeneration and TAU has been linked to neurological disorders, including Alzheimer's disease and frontal temporal dementia.

You wouldn't necessarily have thought Tau and RPM-1 would function this way, Grill says. That's the power of genetics. Although we assessed the genetic relationship between Tau and RPM-1 in axon development, our results could have important implications for neurodegeneration.

In addition to Grill and Borgen, the other author of the study, RPM-1 Regulates Axon Termination by Affecting Growth Cone Collapse and Microtubule Stability, is Dandan Wang, PhD, of TSRI.

The study was supported by the National Institutes of Health (grant R01 NS072129) and the National Science Foundation (grant IOS-1121095).

About The Scripps Research Institute

The Scripps Research Institute (TSRI) is one of the worlds largest independent, not-for-profit organizations focusing on research in the biomedical sciences. TSRI is internationally recognized for its contributions to science and health, including its role in laying the foundation for new treatments for cancer, rheumatoid arthritis, hemophilia, and other diseases. An institution that evolved from the Scripps Metabolic Clinic founded by philanthropist Ellen Browning Scripps in 1924, the institute now employs more than 2,500 people on its campuses in La Jolla, CA, and Jupiter, FL, where its renowned scientists including two Nobel laureates and 20 members of the National Academies of Science, Engineering or Medicine work toward their next discoveries. The institutes graduate program, which awards PhD degrees in biology and chemistry, ranks among the top ten of its kind in the nation. In October 2016, TSRI announced a strategic affiliation with the California Institute for Biomedical Research (Calibr), representing a renewed commitment to the discovery and development of new medicines to address unmet medical needs. For more information, see www.scripps.edu.

# # #

For information:

Office of Communications

Tel: 858-784-2666

Fax: 858-784-8118

press@scripps.edu
LINK: http://www.scripps.edu/news/press/2017/20171215grill.html...
See more stories from scripps

Most recent headlines

22/06/2018

Africa Magic to announce AMVCAs nominees

-- -- Facebook Twitter Google Pinterest Nominees for the 2018 Africa Magic Viewers' Choice Awards (AMVCAs) will be announced via a televised broadc...

22/06/2018

NFVF calls filmmakers to attend the Nature Environment & Wildlife Filmmakers...

-- -- Facebook Twitter Google Pinterest The National Film and Video Foundation (NFVF) has announced the call for filmmakers to attend the Nature Enviro...

22/06/2018

Sonarworks intro new standard for accurate monitoring

Promises just +/-0.9dB difference across different devices Software > Processor Mixing Among its host of users, the Sonarworks Reference plug-in has become ...

22/06/2018

Ability to see through...

Image: Jason Dorfman/MIT CSAIL In the healthcare world, the ability to see through walls, could monitor diseases and help elderly people live longer in their o...

22/06/2018

Nanolaser copies chameleon ability to change...

Scientists have designed a nanolaser that can change colour in the same the way that chameleons are able to change the colour of their skin. Scientists at North...

22/06/2018

Exterity expands Middle...

Ahmad Bsat - Regional sales manager ME, Exterity Exterity, a provider of IP video and digital signage technologies, has announced several enhancements to its g...

22/06/2018

Peter Mathia joins the board of Lang

Peter Mathia as been added to the management board of German rental company Lang. Starting from July 1, Mathia will share this responsibility with chair Tobias ...

22/06/2018

Alcons Audio appoints Elit as distributor for Turkey

L-R: Emre Defne (Elit), Tom Back (Alcons) and nsal ak r (Elit) Alcons Audio has appointed Elit Light and Sound Technologies, based in Besiktas, Istanbul, as ...

22/06/2018

Superwog to forge new ground with a series for ABC COMEDY and YouTube

22 06 2018 - Media release Superwog to forge new ground with a series for ABC COMEDY and YouTube Superwog The ABC and Screen Australia are excited to announc...

22/06/2018

IBC2018 announces Cyber Security Forum to help media tackle cyber threats

IBC2018 announces Cyber Security Forum to help media tackle cyber threats posted: 22/06/2018 World's most influential media, entertainment and technol...

22/06/2018

More than 85 per cent of US millennials subscribe to at least one OTT service

Research suggests overall penetration of subscription OTT video services among the generation has topped out Author: Colby RamseyPublish date: Jun 22, 2018 ...

22/06/2018

Viacom to close down VIVA channel by end of 2018

Comedy Central will expand into a 24-hour service as a result Author: Colby RamseyPublish date: Jun 22, 2018 Viacom International Media Networks (VIMN) is t...

22/06/2018

Disney could get US antitrust approval for Fox deal "within weeks"

Report suggests approval could come as soon as two weeks Author: Jenny PriestleyPublish date: Jun 22, 2018 The Walt Disney Companys bid for control of 21st ...

22/06/2018

ARRI behind the scenes on WRATH OF SILENCE

ARRI behind the scenes on WRATH OF SILENCE Director Xin Yukun's critically acclaimed film, WRATH OF SILENCE, is a tough crime thriller set in a Chinese c...

22/06/2018

9 Most-Anticipated Upcoming Movies of 2018

22 June, 2018 - 07:46 2018 began with major roller coasters, yes, we saw the likes of Black Panther, Avengers: Infinity War, Deadpool 2, Ocean's 8, and ...

22/06/2018

Marvel fans are stoked after seeing the trailer to "Ant-Man and the Wasp

22 June, 2018 - 07:46 Marvel fans are stoked after seeing the trailer to Ant-Man and the Wasp, which flies into theaters on Friday, July 6. Many point out j...

22/06/2018

Arturia introduce Keylab MkII controllers

New controllers sport CV I/O and aluminium construction Hardware > MIDI Controller Video of Arturia announces KeyLab MkII Arturia's MIDI controller lin...

22/06/2018

Primetime Ratings: Fox Doubles Runner-Up Ratings

Fox was the big winner in the Wednesday ratings race, the Gordon Ramsay shows leading the network to a 1.0 in viewers 18-49, and a 5 share. That beat CBS at 0.5...

22/06/2018

Ozark' Back on Netflix Aug. 31

David Dwyer, Julia Garner Jessica Miglio/Netflix Season two of drama Ozark premieres on Netflix Aug. 31. Jason Bateman and Laura Linney play a married couple ...

22/06/2018

ABC Picks Up Roseanne' Spinoff Straight to Series

ABC has ordered a spinoff of Roseanne straight to series for this fall. The Conners (working title) will star John Goodman, Laurie Metcalf, Sara Gilbert, Lecy ...

22/06/2018

Media Alert: Koko the Gorilla, Spokesperson & Images Available

**Media Alert** Why Koko the Gorilla Mattered Featured twice on the cover of National Geographic magazine, Koko led to major revelations about animal empathy ...

22/06/2018

Claypaky Fixtures Help Paul Guthrie Give a Modern Edge to the Hall & Oates Legacy on Summer Tour Co-Headlining with Train

Claypaky Fixtures Help Paul Guthrie Give a Modern Edge to the Hall & Oates Legac...

22/06/2018

Firefly Glows With Bandit Lites

Firefly Glows With Bandit Lites posted: 21/06/2018 The Firefly Music Festival wrapped this weekend with Bandit Lites proud to once again provide the light...

22/06/2018

Marillion gets animated with the Claypaky Scenius Spot

Marillion gets animated with the Claypaky Scenius Spot posted: 21/06/2018 Marillion performing at the Brighton Dome and lit using the Claypaky Scenius Spot....

22/06/2018

Go Skateboarding Day 2018: Mastering the Edit

pros Jun 21, 2018 Around GoPro, skateboarding is a means of transportation, a daily source of entertainment (mongo ...) and the source of some of our favor...

22/06/2018

Delivering the right content at the wrong time can make it irrelevant

MediaTech 360 panel discusses personalisation and the use of data to improve user experiences Author: Colby RamseyPublish date: Jun 21, 2018 Day two of Medi...

22/06/2018

Detroit Lions Enhance Game-Day Presentation, Production Efficiency at Ford Field

Detroit Lions Enhance Game-Day Presentation, Production Efficiency at Ford Field $100 million project boosts LED display, upgrades control room, adds to broadca...

22/06/2018

InfoComm 2018: Live Sound's New Status Is Underscored

InfoComm 2018: Live Sound's New Status Is Underscored Show focuses on the use of A/V tech in creating experiences By Dan Daley, Audio Editor Thursday, Ju...

22/06/2018

InfoComm 2018: Projectors, PTZ Cameras Among Video Highlights at A/V Show

InfoComm 2018: Projectors, PTZ Cameras Among Video Highlights at A/V Show Several vendors showcased gear targeting the sports-venue market By Karen Hogan Ketch...

22/06/2018

Delfin award 2018: airport, waste tracking app and indoor playground among this year's winners

Delfin award 2018: airport, waste tracking app and indoor playground among this ...

22/06/2018

Ofcom findings on the acquisition by Reach plc of Northern & Shell's publishing assets

Ofcom findings on the acquisition by Reach plc of Northern & Shell's publish...

22/06/2018

SBS to broadcast all 2018 FIFA World Cup matches until end of Group Stage

SBS to broadcast all 2018 FIFA World Cup matches until end of Group Stage Wednesday 20 June News Release Michael Ebeid AM, CEO and Managing Director, SBS sa...

22/06/2018

M7 Group Delivers Live UHD Coverage of Iconic Soccer Tournament With Harmonic

SAN JOSE, Calif. - June 21, 2018 - Harmonic (NASDAQ: HLIT), the worldwide leader in video delivery technology and services, today announced that M7 Group, one o...

22/06/2018

AIMS Welcomes PESA as Associate Members

BOTHELL, Wash. - June 19, 2018 - The Alliance for IP Media Solutions (AIMS) today announced two new associate members: PESA and Sobey Digital Technology. The ...

22/06/2018

How to proactively engage with existing customers to Grow ARPU

21 June 2018 How to proactively engage with existing customers to Grow ARPU Share With customer acquisition and reducing churn being such a key focus for...

22/06/2018

MTN South Africa and Ericsson fuel the 5G racing line

Industry partners, MTN South Africa and Ericsson (NASDAQ:ERIC), have validated the technological prowess of fifth generation (5G) wireless technology in the fir...

22/06/2018

Twofour commissioned to produce brand new ITV4 entertainment show, Take The Tower, with Dolph Lundgren.

Published: Thu 21 Jun 2018 Twofour commissioned to produce brand new ITV4 enter...

22/06/2018

Strangers - Trailer

Published: Thu 21 Jun 2018 Video of Strangers.mp4 Watch and embed this video on your website. Simply play and click on the embed icon upper right to copy the...

21/06/2018

Kendrick, Halsey, Post Malone and Other Surprising Artists on Yoga Playlists Around the World

Yoga might be an ancient art, but the 5,000-year-old practice remains as essenti...

21/06/2018

Banijay Announces Key European Commission for All Against 1

Ahead of NATPE Budapest International 2018, Banijay Group confirms All Against 1, the interactive, studio-based entertainment format, which pits one contestant ...

21/06/2018

Korea Educational Broadcasting System Boosts Content Quality With QC From Interra Systems

BCA Events 2012. Events 2013. BCA Events 2013 Korea Educational Broadca...

21/06/2018

Utah Scientific Announces Sales Territory Modifications

Salt Lake City - June 21 , 2018 - Utah Scientific announced today the appointment of Robert Pennington as Northeast regional sales manager. Effective immediatel...

21/06/2018

Macau City's Dazzling House of Dancing Water' Expands Comms

Wuppertal June 21, 2018 Macau City's Dazzling House of Dancing Water' Expands Comms The House of Dancing Water, a breathtaking in-the-round water sho...

21/06/2018

Inside Man

Dalton Russell is a perfectionist bank robber who walks into a bank with his gang, efficient and fast. Detective Keith Frazier is trying to nail the robbers and...

21/06/2018

Safe House

A lethal prisoner and the CIA Agent escorting him from a compromised safe house must make their way to another safe house in South Africa without being taken ou...

21/06/2018

Seventh Son

An unlikely hero and his battle-hardened mentor embark on a daring adventure to vanquish a dark queen and her supernatural army. Publication date: July 15, 201...

21/06/2018

Rocky Balboa

At 58-years old, Rocky steps into the ring for one last bout. Publication date: July 17, 2018...

21/06/2018

Divergent

In a world where people are divided into factions based on virtues, Tris learns she is Divergent and will never fit in. When she discovers a plot to destroy all...

21/06/2018

NETFLIX BRINGS MR. SUNSHINE TO THE WORLD

June 21 2018, Seoul, Korea - Netflix, Inc., the worlds leading entertainment service, announced it has licensed the new Korean original drama Mr. Sunshine, a 24...

21/06/2018

Netflix reveals trailer for FLAVORS OF YOUTH from the producers of YOUR NAME

Watch and Share the Trailer for Flavors of Youth HERE Download key art: HERE **please download the photos and do not post the links** The world premiere scre...