
Scripps Research scientists identify sensor underlying mechanical itch Finding could lead to better drug treatments for chronic itch conditions, like eczema
June 22, 2022
LA JOLLA, CA Scientists at Scripps Research have identified a protein in sensory nerves that works as a key detector of itch specifically the mechanical itch stimulus of crawling insects, wool fibers, or other irritating objects that touch the skin.
The discovery, published June 22, 2022, in Nature, is the first identification of a sensor for mechanical itch rather than chemically-triggered itch. It could lead to better treatments for itch conditions such as eczema and psoriasis.
These findings help us untangle the complexity of itch sensation, and suggest that PIEZO1 inhibitors could be very useful clinically, says study senior author Ardem Patapoutian, PhD, a professor in the Department of Neuroscience at Scripps Research, and a Howard Hughes Medical Institute investigator.
Itch is a distinct sensation with its own nerve circuitry and evolutionary purpose likely to alert organisms to potentially harmful chemicals, insects and parasites. Researchers over the past decade or so have identified itch-specific subsets of spinal neurons that extend nerve fibers into the skin and are sensitive to chemical triggers of itch such as the allergy mediator histamine. But so far, relatively little has been discovered about the circuitry of mechanical itch.
PIEZO1's role in mechanical itch was unexpected. Patapoutian won a share of last year's Nobel Prize for Medicine or Physiology for his lab's pioneering research on PIEZO1 and its sister-protein PIEZO2. These unique, propeller-shaped mechanosensor ion channels are embedded in the outer membranes of many cell types. They become activated when mechanically distorted, opening their ion channels and triggering various downstream events. Since 2010, Patapoutian and colleagues have shown that PIEZO2 is a key mechanosensor for light touch, the feeling of the positioning of the body and limbs, and the urge to urinate all via nerves in various tissues and organs. By contrast, the researchers have found that PIEZO1 has a variety of non-sensory roles throughout the body, for example in blood vessels and red blood cells.
While their initial studies suggested that PIEZO1 was not expressed in sensory neurons, other recent investigations have suggested that it is expressed at low levels in some subsets of these neurons. In the new study, Patapoutian and his team, including study first author Rose Hill, PhD, a postdoctoral research associate, followed up on this surprising lead.
In experiments in mice, they confirmed that PIEZO1 is expressed, and appears to be a functional, mechanical pressure-sensitive ion channel protein in two different types of sensory neuron that were already implicated in chemical itch. Mice with an overactive form of PIEZO1 were markedly more sensitive to itch sensations. By contrast, mice lacking PIEZO1 in their sensory neurons scratched themselves far less when stimulated on the skin with filaments that normally would trigger strong itch sensations. The researchers also showed that a PIEZO1-blocking compound alleviates scratching behaviors in mice with the equivalent of eczema.
We did see a dramatic effect on itch with this compound, and though it wasn't specific enough against PIEZO1 to develop into a drug, we hope eventually to develop a much more PIEZO1-specific compound for treating itch conditions, Hill says.
Curiously, the absence or enhancement of PIEZO1 activity in mice caused at least a small reduction or increase of scratching due to chemical itch triggers such as histamine implying that mechanical and chemical itch signals are indeed transmitted in some cases by the same sensory neurons.
The researchers are now investigating whether variants of the PIEZO1 gene in the human population are related to itch sensitivity. The Patapoutian lab published a paper in 2018 showing that a mildly overactive form of PIEZO1, which also has the effect of making red blood cells relatively resistant to malaria parasites, is present in about a third of people of African ancestry.
PIEZO1 transduces mechanical itch in mice was co-authored by Rose Hill, Meaghan Loud, Adrienne Dubin, Brooke Peet, and Ardem Patapoutian.
Funding was provided by the Howard Hughes Medical Institute, the National Institutes of Health (R35 NS105067), and the Helen Hay Whitney Foundation.
Neurological Disorders Patapoutian, Ardem
Most recent headlines
05/01/2027
Worlds first 802.15.4ab-UWB chip verified by Calterah and Rohde & Schwarz to be ...
06/09/2026
June 9 2026, 23:00 (PDT) Dolby and MagentaTV Bring Fans Closer to the FIFA Worl...
04/08/2026
Dalet, a leading technology and service provider for media-rich organizations, t...
04/07/2026
April 7 2026, 19:00 (PDT) Detective Conan: Fallen Angel of the Highway Opens in...
30/06/2026
Share
Copy link
Facebook
X
Linkedin
Bluesky
Email...
30/06/2026
Share
Copy link
Facebook
X
Linkedin
Bluesky
Email...
30/06/2026
Share
Copy link
Facebook
X
Linkedin
Bluesky
Email...
30/06/2026
Share
Copy link
Facebook
X
Linkedin
Bluesky
Email...
30/06/2026
Share
Copy link
Facebook
X
Linkedin
Bluesky
Email...
30/06/2026
Other World Computing Launches New Atlas Core Line with 256GB CFExpress 4.0 Type...
30/06/2026
DaVinci Resolve Studio Used for Taketoshi Sado's Perfume Cold Sleep -25 year...
30/06/2026
Scripps Research scientists demonstrate a faster, cheaper route to making critical drugs using common table sugar New method illustrates how to build a tough ch...
29/06/2026
By Andy Rayner, CTO, Appear
The 2026 FIFA World Cup is the largest football tou...
29/06/2026
A new multi-country study from ESL FACEIT Group, Hero Esports, and Niko Partners estimates that 400 million Gen Z consumers regularly engage with esports, under...
29/06/2026
ESPN will mark America's 250th anniversary with a series of content initiatives across its linear, digital, and streaming platforms, including a special edi...
29/06/2026
The Esports Foundation has named OBSBOT the Official Camera and Webcam Partner for the Esports World Cup 2026, bringing the company's AI-powered imaging tec...
29/06/2026
Insight Productions has launched Insight Storm, a 53-foot mobile broadcast unit designed specifically for esports production, live entertainment, and digital-fi...
29/06/2026
Gravity Media once again provided broadcast, streaming, and content-distribution...
29/06/2026
The All England Lawn Tennis Club and IBM have introduced new and enhanced digita...
29/06/2026
Four-layer instrument aimed at dark electronic music
Excite Audio's latest software instrument has been designed with dark drum and bass, atmospheric te...
29/06/2026
New AI Assistant, Multi-channel Audio, ARA2 improvements & more
Tracktion's DAW software has just received its latest major update, gaining a selection ...
29/06/2026
Details environmental policies & results
The Focusrite Group have just announced that following a long audit process, they have published their 2026 sustain...
29/06/2026
Share
Copy link
Facebook
X
Linkedin
Bluesky
Email...
29/06/2026
Share
Copy link
Facebook
X
Linkedin
Bluesky
Email...
29/06/2026
CVP, one of Europes leading suppliers of professional video and broadcast solutions, has announced the launch of CVP Warranty , a new extended warranty programm...
29/06/2026
Share
Copy link
Facebook
X
Linkedin
Bluesky
Email...
29/06/2026
Share
Copy link
Facebook
X
Linkedin
Bluesky
Email...
29/06/2026
Anthropic's Claude models in Microsoft Foundry - hosted on Microsoft Azure a...
29/06/2026
Arvato Systems Achieves AWS Cloud Operations Competency
The team behind the AWS Cloud Operations Competency (from left to right: Philipp Hellmich, Johanna Bod...
29/06/2026
RT today announced that Ger Gilroy will join the RT Podcasts team to present a daily sports podcast. Launching later this year, the new show will set the spor...
29/06/2026
RT Commercial announced OUTsurance as sponsor of the Oliver Callan show on RT Radio 1 from Wednesday 1 July.
Oliver Callan doubles the fun, delivering two ...
29/06/2026
Showcasing the importance of open source innovation in American AI, Palantir'...
28/06/2026
Half-size model joins Console 1 line-up
Shortly after the release of their new Flow Studio controller, Softube have announced the launch of another new surf...
28/06/2026
New EXO Series DSP control software announced
EVE Audio's EXO Series monitor range has just gained a new software element that provides remote access to...
28/06/2026
Freedman Labs Releases PrepMyMedia and ViewMyAttic for Post Production Professio...
27/06/2026
There's no doubt that you've seen the world through Amy Vincent's ey...
27/06/2026
Brings together saturation & lo-fi effects
Following on from the release of their Voxcraft vocal-processing plug-in, UJAM have announced the launch of Retro...
27/06/2026
A record 4.84 million Australians choose SBS as the Socceroos advance at FIFA Wo...
27/06/2026
Why CRAS Upgraded to Symphony I/O MK II When an audio school runs studios all day, every day, gear doesn't just need to sound good , it needs to survive rea...
27/06/2026
Share
Copy link
Facebook
X
Linkedin
Bluesky
Email...
27/06/2026
Share
Copy link
Facebook
X
Linkedin
Bluesky
Email...
27/06/2026
Krotos Video to Sound Plugin Now Available for Adobe Premiere Pro
Brie Clayton June 26, 2026
0 Comments
Editors can analyze footage, generate synchron...
27/06/2026
Mirai Media Elevates Digital and Broadcast Productions with Blackmagic Design
Brie Clayton June 26, 2026
0 Comments
Studio uses Ultimatte 12 HD and Po...
27/06/2026
DURHAM, N.C. - JUNE 26, 2026 - Lutra Cafe & Bakery has opened its first brick-and-mortar location at American Tobacco Campus after owner Chris McLaurin operated...
26/06/2026
In-venue and creative video staffers at the professional and collegiate level ha...
26/06/2026
Strike Fighter League (SFL), a professional air combat digital sport combining f...
26/06/2026
Wisycom has announced three new additions to its professional wireless ecosystem...
26/06/2026
Eurovision Services inaugurated an expanded Master Control Room (MCR) in Madrid on June 1, 2026, building on a broadcast hub the company has operated in the cit...
26/06/2026
Midco Sports and the University of North Dakota (UND) have announced a two-year ...
26/06/2026
Guntermann and Drunck (G&D) and VuWall, both part of the Panoptec Technologies Group, have appointed Vutec (Pty) Ltd as exclusive distributor for their KVM and ...