
Scripps Research scientists identify sensor underlying mechanical itch Finding could lead to better drug treatments for chronic itch conditions, like eczema
June 22, 2022
LA JOLLA, CA Scientists at Scripps Research have identified a protein in sensory nerves that works as a key detector of itch specifically the mechanical itch stimulus of crawling insects, wool fibers, or other irritating objects that touch the skin.
The discovery, published June 22, 2022, in Nature, is the first identification of a sensor for mechanical itch rather than chemically-triggered itch. It could lead to better treatments for itch conditions such as eczema and psoriasis.
These findings help us untangle the complexity of itch sensation, and suggest that PIEZO1 inhibitors could be very useful clinically, says study senior author Ardem Patapoutian, PhD, a professor in the Department of Neuroscience at Scripps Research, and a Howard Hughes Medical Institute investigator.
Itch is a distinct sensation with its own nerve circuitry and evolutionary purpose likely to alert organisms to potentially harmful chemicals, insects and parasites. Researchers over the past decade or so have identified itch-specific subsets of spinal neurons that extend nerve fibers into the skin and are sensitive to chemical triggers of itch such as the allergy mediator histamine. But so far, relatively little has been discovered about the circuitry of mechanical itch.
PIEZO1's role in mechanical itch was unexpected. Patapoutian won a share of last year's Nobel Prize for Medicine or Physiology for his lab's pioneering research on PIEZO1 and its sister-protein PIEZO2. These unique, propeller-shaped mechanosensor ion channels are embedded in the outer membranes of many cell types. They become activated when mechanically distorted, opening their ion channels and triggering various downstream events. Since 2010, Patapoutian and colleagues have shown that PIEZO2 is a key mechanosensor for light touch, the feeling of the positioning of the body and limbs, and the urge to urinate all via nerves in various tissues and organs. By contrast, the researchers have found that PIEZO1 has a variety of non-sensory roles throughout the body, for example in blood vessels and red blood cells.
While their initial studies suggested that PIEZO1 was not expressed in sensory neurons, other recent investigations have suggested that it is expressed at low levels in some subsets of these neurons. In the new study, Patapoutian and his team, including study first author Rose Hill, PhD, a postdoctoral research associate, followed up on this surprising lead.
In experiments in mice, they confirmed that PIEZO1 is expressed, and appears to be a functional, mechanical pressure-sensitive ion channel protein in two different types of sensory neuron that were already implicated in chemical itch. Mice with an overactive form of PIEZO1 were markedly more sensitive to itch sensations. By contrast, mice lacking PIEZO1 in their sensory neurons scratched themselves far less when stimulated on the skin with filaments that normally would trigger strong itch sensations. The researchers also showed that a PIEZO1-blocking compound alleviates scratching behaviors in mice with the equivalent of eczema.
We did see a dramatic effect on itch with this compound, and though it wasn't specific enough against PIEZO1 to develop into a drug, we hope eventually to develop a much more PIEZO1-specific compound for treating itch conditions, Hill says.
Curiously, the absence or enhancement of PIEZO1 activity in mice caused at least a small reduction or increase of scratching due to chemical itch triggers such as histamine implying that mechanical and chemical itch signals are indeed transmitted in some cases by the same sensory neurons.
The researchers are now investigating whether variants of the PIEZO1 gene in the human population are related to itch sensitivity. The Patapoutian lab published a paper in 2018 showing that a mildly overactive form of PIEZO1, which also has the effect of making red blood cells relatively resistant to malaria parasites, is present in about a third of people of African ancestry.
PIEZO1 transduces mechanical itch in mice was co-authored by Rose Hill, Meaghan Loud, Adrienne Dubin, Brooke Peet, and Ardem Patapoutian.
Funding was provided by the Howard Hughes Medical Institute, the National Institutes of Health (R35 NS105067), and the Helen Hay Whitney Foundation.
Neurological Disorders Patapoutian, Ardem
Most recent headlines
05/01/2027
Worlds first 802.15.4ab-UWB chip verified by Calterah and Rohde & Schwarz to be ...
07/10/2026
Dalet, a leading technology and service provider for media-rich organizations, today announced the latest Long-Term Supported (LTS) release of Dalet Flex. Build...
09/09/2026
Sony Electronics has announced the SEL814G, the company's first fisheye zoom G Lens for full-frame Alpha E-mount cameras. The lens will be available in Octo...
09/09/2026
Telestream has announced an expansion of its Practical AI capabilities across th...
09/09/2026
Haivision and Chyron have announced a technology partnership integrating Haivisi...
09/09/2026
Omaha Productions has released ManningCast: Heist, a short film featuring Peyton and Eli Manning attempting to break into NFL Commissioner Roger Goodell's o...
09/09/2026
Imagine Communications will demonstrate the next evolution of XVR at IBC2026 (Stand 1.B73, RAI Amsterdam, September 11-14).
XVR is Imagine's channel-in-a-b...
09/09/2026
swXtch.io has announced abbe, an AI-based orchestration layer for live media workflows, making its world premiere at IBC2026 (Meeting Room 5.MR13, Hall 5, Septe...
09/09/2026
NFL Films has announced the second season of Inside the NFL on X as an X Original, premiering Wednesday, September 9. The series marks Inside the NFL's 50th...
09/09/2026
LiveU has announced an expanded partnership with The Associated Press, deploying the largest fleet of LU900Q intelligent production units in the industry as par...
09/09/2026
Diversified has announced plans to consolidate its four existing New Jersey locations into a new facility in Newark, expected to be fully operational by the end...
09/09/2026
Wisycom will exhibit new RF products at IBC2026 (Stand 8.D60, September 11-14), including the MATF Wideband Antenna Matrix, PFL Portable RF over Fiber Box, and ...
09/09/2026
Guntermann & Drunck (G&D) and VuWall, both Panoptec companies, will introduce vsNEO at IBC2026 (Stand 8.B63, September 11, RAI Amsterdam). Pre-orders open in ea...
09/09/2026
Mo-Sys has completed a business restructuring and relocated to a new facility in Canada Water, London. As part of the reorganization, Selin Kemal has been promo...
09/09/2026
Aicox has integrated TAG Video Systems' Core monitoring platform into Telef nica's TSAmediaHUB audiovisual contribution and distribution infrastructure....
09/09/2026
Blackmagic Design has released DaVinci Resolve 21.1, a free update available now through the Blackmagic Design website. The release adds new AI tools, workflow ...
09/09/2026
ESPN and Apple Music have announced a collaboration on music curation for Monday...
09/09/2026
Sacramento Production Services has completed a wireless audio overhaul at Sutter Health Park, home of the Athletics during their three-year residency in Sacrame...
09/09/2026
NDI and NVIDIA have announced a collaboration to develop AI-powered workflows enabling broadcasters to create and distribute multilingual content from a single ...
09/09/2026
Christopher Chip Adams, Troy Aikman, Jim Dove, Jim Eady, Bucky Gunts, Robert A. Iger, Charlie Jablonski, Robert Kraft, Tom Rinaldi, and Dick Stockton to be ho...
09/09/2026
ND2 returns as the primary unit, While FNIA gets SSQC and new flexible Rover...
09/09/2026
New parts aimed at hip-hop and pop productions
The latest update to Celemony's innovative virtual session musician expands the collection of built-in in...
09/09/2026
Save up to 40% until 21 September 2026
Sonarworks are currently running their Autumn Sale, with discounts of up to 40% currently available across their rang...
09/09/2026
Upcoming title officially launches in September 2026
Bjooks' celebrations for this year's 909 Day will be welcome news amongst drum machine lovers, ...
09/09/2026
NITV to bring First Nations netball to audiences nationwide
9 September, 2026
Media releases
Every match of the 2026 First Nations Tournament will be live ...
09/09/2026
The National Film and Video Foundation (NFVF) invites eligible Tier 1 and 2 South African production companies to submit proposals to serve as the Facilitating ...
09/09/2026
Italy launch follows UK and Germany as Nielsen expands product across EMEA
Milan, Italy, September 9, 2026 - Nielsen, a global leader in audience measurement, ...
09/09/2026
Planned solutions tackle accuracy, cost and latency barriers to deploying AI at ...
09/09/2026
Share
Copy link
Facebook
X
Linkedin
Bluesky
Email...
09/09/2026
Studio Technologies, a leading manufacturer of high-quality audio, video, and fiber-optic solutions, introduces its new Model 791 Control Console at IBC 2026 (N...
09/09/2026
Maxon, maker of powerful, approachable software solutions for creators working in 2D and 3D design, motion graphics, visual effects and visualization, is headin...
09/09/2026
NUGEN Audio unveils DialogCheck v1.2, the latest evolution of its intelligent dialog intelligibility and compliance tool, at IBC 2026 (Pod P27). With a sharpene...
09/09/2026
Trusted Partner Network Launches Fix It or Risk It to Help the Entertainment Industry Tackle Everyday Security Risks
Industry-Wide Campaign Launches at IBC2...
09/09/2026
Share
Copy link
Facebook
X
Linkedin
Bluesky
Email...
09/09/2026
Share
Copy link
Facebook
X
Linkedin
Bluesky
Email...
09/09/2026
AI has moved firmly beyond experimentation in UK advertising, with more than eight in ten marketers (83%) now actively using or piloting AI in production, accor...
09/09/2026
IBC2026 - Stand 7.D22
At IBC2026, Pixitmedia by DataCore will showcase its latest capabilities designed to simplify distributed production, accelerate workflow...
09/09/2026
Stockholm, Sweden September 9th, 2026 At IBC2026, on booth 1.B47, Net Insight will showcase Open Live Media, its architecture for delivering resilient live ...
09/09/2026
Net Insight today announced that DMC Production Norway is continuing the use of its Open Live Media technology for premium European football, deploying Nimbra 5...
09/09/2026
Amagi, the media industry cloud platform for unified broadcast, streaming, and monetization, will showcase four new AI-native capabilities at IBC2026, Hall 5, S...
09/09/2026
Limecraft today announces version 2026.6 of its AI-powered production platform, extending capabilities for connected media operations. An AI-assisted approach t...
09/09/2026
Telestream, a global leader in media workflow technologies, today announced the next evolution of its Practical AI strategy, evolving its comprehensive portfoli...
09/09/2026
Dalet, a leading technology and service provider for media-rich organizations, today announced the appointment of Brian Doheny as Chief Executive Officer (CEO)....
09/09/2026
LiveU is now a Clarus Integrated Reseller, bringing Starlink's fast, reliable broadband directly into LiveU's cellular bonding EcoSystem through a singl...
09/09/2026
Share
Copy link
Facebook
X
Linkedin
Bluesky
Email...
09/09/2026
Share
Copy link
Facebook
X
Linkedin
Bluesky
Email...
09/09/2026
Share
Copy link
Facebook
X
Linkedin
Bluesky
Email...
09/09/2026
Share
Copy link
Facebook
X
Linkedin
Bluesky
Email...
09/09/2026
Wisycom is showcasing the latest additions to its ecosystem of professional RF technologies at IBC 2026 (Stand 8.D60). This includes its new MATF Wideband Anten...
09/09/2026
AMSTERDAM, IBC2026 VisualOn, Inc. and Cires21 today released an updated joint whitepaper at IBC 2026 demonstrating measurable, high-impact improvements in visu...