Sony Pixel Power calrec Sony

June 22, 2022

23/06/2022

Scripps Research scientists identify sensor underlying mechanical itch Finding could lead to better drug treatments for chronic itch conditions, like eczema

June 22, 2022

LA JOLLA, CA Scientists at Scripps Research have identified a protein in sensory nerves that works as a key detector of itch specifically the mechanical itch stimulus of crawling insects, wool fibers, or other irritating objects that touch the skin.

The discovery, published June 22, 2022, in Nature, is the first identification of a sensor for mechanical itch rather than chemically-triggered itch. It could lead to better treatments for itch conditions such as eczema and psoriasis.

These findings help us untangle the complexity of itch sensation, and suggest that PIEZO1 inhibitors could be very useful clinically, says study senior author Ardem Patapoutian, PhD, a professor in the Department of Neuroscience at Scripps Research, and a Howard Hughes Medical Institute investigator.

Itch is a distinct sensation with its own nerve circuitry and evolutionary purpose likely to alert organisms to potentially harmful chemicals, insects and parasites. Researchers over the past decade or so have identified itch-specific subsets of spinal neurons that extend nerve fibers into the skin and are sensitive to chemical triggers of itch such as the allergy mediator histamine. But so far, relatively little has been discovered about the circuitry of mechanical itch.

PIEZO1's role in mechanical itch was unexpected. Patapoutian won a share of last year's Nobel Prize for Medicine or Physiology for his lab's pioneering research on PIEZO1 and its sister-protein PIEZO2. These unique, propeller-shaped mechanosensor ion channels are embedded in the outer membranes of many cell types. They become activated when mechanically distorted, opening their ion channels and triggering various downstream events. Since 2010, Patapoutian and colleagues have shown that PIEZO2 is a key mechanosensor for light touch, the feeling of the positioning of the body and limbs, and the urge to urinate all via nerves in various tissues and organs. By contrast, the researchers have found that PIEZO1 has a variety of non-sensory roles throughout the body, for example in blood vessels and red blood cells.

While their initial studies suggested that PIEZO1 was not expressed in sensory neurons, other recent investigations have suggested that it is expressed at low levels in some subsets of these neurons. In the new study, Patapoutian and his team, including study first author Rose Hill, PhD, a postdoctoral research associate, followed up on this surprising lead.

In experiments in mice, they confirmed that PIEZO1 is expressed, and appears to be a functional, mechanical pressure-sensitive ion channel protein in two different types of sensory neuron that were already implicated in chemical itch. Mice with an overactive form of PIEZO1 were markedly more sensitive to itch sensations. By contrast, mice lacking PIEZO1 in their sensory neurons scratched themselves far less when stimulated on the skin with filaments that normally would trigger strong itch sensations. The researchers also showed that a PIEZO1-blocking compound alleviates scratching behaviors in mice with the equivalent of eczema.

We did see a dramatic effect on itch with this compound, and though it wasn't specific enough against PIEZO1 to develop into a drug, we hope eventually to develop a much more PIEZO1-specific compound for treating itch conditions, Hill says.

Curiously, the absence or enhancement of PIEZO1 activity in mice caused at least a small reduction or increase of scratching due to chemical itch triggers such as histamine implying that mechanical and chemical itch signals are indeed transmitted in some cases by the same sensory neurons.

The researchers are now investigating whether variants of the PIEZO1 gene in the human population are related to itch sensitivity. The Patapoutian lab published a paper in 2018 showing that a mildly overactive form of PIEZO1, which also has the effect of making red blood cells relatively resistant to malaria parasites, is present in about a third of people of African ancestry.

PIEZO1 transduces mechanical itch in mice was co-authored by Rose Hill, Meaghan Loud, Adrienne Dubin, Brooke Peet, and Ardem Patapoutian.

Funding was provided by the Howard Hughes Medical Institute, the National Institutes of Health (R35 NS105067), and the Helen Hay Whitney Foundation.

Neurological Disorders Patapoutian, Ardem
LINK: https://www.scripps.edu/news-and-events/press-room/2022/20220622-patap...
See more stories from scripps

Most recent headlines

04/11/2022

Game better with DTS Headphone:X

The best gamers know DTS Headphone:X technology ups their play. Now major magazines have caught on, too. DTS Headphone:X technology creates immersive soundsc...

01/07/2022

L3Harris Infrared Space Technology to Enhance Battlefield Imagery and Missile Defense Detection

MELBOURNE, Fla. - A L3Harris Technologies (NYSE:LHX) infrared instrument set to ...

01/07/2022

Nominations Open for Best of Show Awards at IBC 2022

IBC is back for its first in-person gathering in three years, and so too is Future's annual IBC Best of Show awards program which celebrates the innovation ...

01/07/2022

Gray Television Names Brad Moses New GM of WTVG

ATLANTA Gray Television Inc. appointed Brad Moses the general manager of WTVG-TV (ABC) in Toledo, Ohio, effective July 25....

01/07/2022

National Geographic Names Karen Greenfield Senior VP Diversity & Inclusion

National Geographic has tapped Karen Greenfield to fill the newly created position of senior VP of content, diversity and inclusion....

01/07/2022

LPTVBA Taps Peter Saad as Association's Executive Director

STAMFORD CONN. The LPTV Broadcasters Association has appointed Peter Saad as the organization's new executive director. He is a seasoned attorney who has be...

01/07/2022

PlayBox Neo HD Playout with eMAM Go Live at TV5HD Thailand

PlayBox Neo HD Playout with eMAM Go Live at TV5HD Thailand Brie Clayton July 1, 2022 0 Comments Accompanying diagram shows the MAM and playout workflow...

01/07/2022

Quidich Innovates Game-Changing Camera Solutions for Live Sports Broadcasts with AJA FS-HDR

Quidich Innovates Game-Changing Camera Solutions for Live Sports Broadcasts with...

01/07/2022

Phil Harrelson to Lead DI and New Dailies Services at Nice Shoes

Phil Harrelson to Lead DI and New Dailies Services at Nice Shoes Brie Clayton July 1, 2022 0 Comments Nice Shoes has hired post-production veteran Phil...

01/07/2022

Center for Music Therapy to Partner with Underserved Communities in Berklees Backyard

Center for Music Therapy to Partner with Underserved Communities in Berklees Bac...

01/07/2022

Berklee's Two Track Series Celebrates Pride' to Kick off Summer

Berklee's Two Track Series Celebrates Pride' to Kick off Summer The popular YouTube series features students performing original music and exploring ...

01/07/2022

Esin Aydingoz Named Assistant Chair of Berklees Film Scoring Department

Esin Aydingoz Named Assistant Chair of Berklees Film Scoring Department An acclaimed TV, film, and video game composer from Istanbul, Turkey, Aydingoz starts ...

01/07/2022

Diana Horowitz Named to VP Sales Post at Imagine Communications

DENVER Imagine Communications has appointed Diana Horowitz the company's vice president, strategic sales, advertising technology. In the newly created posit...

01/07/2022

New NEXTGEN TV Logo Certification Test Suite Released

Eurofins Digital Testing (EDT), in partnership with the Consumer Technology Association and National Association of Broadcasters, has announced the release of t...

01/07/2022

SES Launches Broadcast Satellite via SpaceX

CAPE CANAVERAL, Fla. SES announced the successful launch of its SES-22 satellite onboard a SpaceX Falcon 9 rocket from SpaceX's Space Launch Complex 40 at C...

01/07/2022

L.A. Public Health Officials Tell TV, Film Crews to Mask While Indoors

LOS ANGELES TV and film production personnel in Los Angeles have been told by public health authorities to wear masks while indoors due to rising Covid cases....

01/07/2022

The new challenges in OTT

iWedias J r me Vial takes a look at the OTT landscape By Contributor Published: July 1, 2022 iWedia's J r me Vial takes a look at the OTT landscape t...

01/07/2022

Amazon to share Champions League rights with BT Sport

Amazon has won the rights to Tuesday night games, with BT Sport airing Champions League matches on Wednesday By Jenny Priestley Published: June 30, 2022 Upd...

01/07/2022

EBU's DG Noel Curran to serve further six years in office

Organisation also appoints two new members to its executive board By Jenny Priestley Published: July 1, 2022 Organisation also appoints two new members to ...

01/07/2022

Thum + Mahr acquired by Broadcast Solutions

Co-founders Peter Thum and Hanno Mahr will become advisors to the company, which will remain in Monheim an Rhein By Jenny Priestley Published: July 1, 2022 ...

01/07/2022

Best of Show at IBC 2022 nominations open

Awards celebrate the innovation and craft of the industry's R&D teams by recognising some of the standout products and solutions on display in Amsterdam By...

01/07/2022

SBE Wraps Up Another Successful Membership Recruitment Drive

The Society of Broadcast Engineers has announced the wrapup of another successful membership recruitment drive, adding 68 new members to the professional societ...

01/07/2022

TelevisaUnivision to Launch ViX+ SVOD Tier on July 21

MIAMI In news that will dramatically expand Spanish-language SVOD streaming content in the Americas, TelevisaUnivision has announced that its ViX+ service will ...

01/07/2022

Maxon Releases Update For One Toolset

BAD HOMBURG, Germany Maxon has released an update of its Maxon One Toolset, including new features, enhanced performance and various fixes....

01/07/2022

KASA-TV Launches Spanish-Language App for Local News, Weather

ALBUQUERQUE, N.M. Five months after debuting the only locally-produced Spanish-language newscasts in the Albuquerque-Santa Fe market, Telemundo Nuevo M xico / K...

01/07/2022

Report: Nexstar Close to Deal for CW Network

IRVING, Texas Nexstar Media Group is close to acquiring a majority stake in the CW broadcast network, according to a report in the Wall Street Journal (opens in...

01/07/2022

Comcasts Xfinity Stream App Launches On Apple TV 4K and Apple TV HD

PHILADELPHIA Comcast has launched the Xfinity Stream app on Apple TV 4K and Apple TV HD, giving Xfinity TV customers another way to access their pay TV subscrip...

01/07/2022

Disney+s America the Beautiful' uses Top Gun' Style Camera Techniques

As Top Gun Maverick dazzles audiences worldwide this summer, with its advanced camera work displaying dizzying hypersonic flying visuals, a new Disney+ series...

01/07/2022

CBC News Plans Fall Launch of Free Streaming News Channel

OTTAWA, Canada As part of a new strategic plan to better serve audiences across Canada on both television and digital platforms, CBC News has announced plans to...

01/07/2022

Horowitz Named to VP Sales Post at Imagine Communications

DENVER Imagine Communications has appointed Diana Horowitz the company's vice president, strategic sales, advertising technology. In the newly created posit...

01/07/2022

iFIT Energizes Interactive Health and Fitness with Ikegami HDK-99 Cameras

iFIT Energizes Interactive Health and Fitness with Ikegami HDK-99 Cameras Brie Clayton June 30, 2022 0 Comments 6.4 million member subscriber base expe...

01/07/2022

Ikegami Europe Announces Unicam UHK-X750 4K-UHD HDR Studio Camera

Ikegami Europe Announces Unicam UHK-X750 4K-UHD HDR Studio Camera Brie Clayton June 30, 2022 0 Comments Accompanying image shows a perspective view of ...

01/07/2022

Crystal Vision and Singular Become Technology Partners

Crystal Vision and Singular Become Technology Partners Brie Clayton June 30, 2022 0 Comments Crystal Vision has become an official member of the Singul...

01/07/2022

HMS Networks AB acquires Global M2M Pty Ltd

HMS Industrial Networks AB, a wholly owned subsidiary of HMS Networks AB (publ), has today acquired all shares in Global M2M Pty Ltd, located in Melbourne, Aust...

01/07/2022

Fujifilm announces price increase for select Fujifilm-manufactured LTO Ultrium data tape products

Fujifilm announces price increase for select Fujifilm-manufactured LTO Ultrium d...

01/07/2022

UNSTOPPABLE ENTERTAINMENT WITH OVER 135 CHANNELS FOR ONLY RM99.99*

01 July 2022 UNSTOPPABLE ENTERTAINMENT WITH OVER 135 CHANNELS FOR ONLY RM99.99* KUALA LUMPUR, 1 July 2022 Stream endless entertainment with over 135 channe...

01/07/2022

Bloke and his American Bantu' hits State Theatre with stellar cast

Bloke and his American Bantu' hits State Theatre with stellar cast Bloke and his American Bantu' is directed by local actor and writer Sello Maake kaNcu...

01/07/2022

All-inclusive AEW celebrates Pride month in style

All-inclusive AEW celebrates Pride month in styleAs a company All Elite Wrestling (AEW) has embraced the notion of making space for people from all walks of lif...

01/07/2022

Jumped for joy': #HouseofZwide celebrates Funani stealing Ona's DNA

Jumped for joy': #HouseofZwide celebrates Funani stealing Ona's DNA House of Zwide' viewers are applauding Funani's investigative skills and loo...

01/07/2022

WATCH: Muvhango - Tonight's teaser E389 S22

WATCH: Muvhango - Tonight's teaser E389 S22Don't miss out on the latest drama in Muvhango! by SA TV and Soapies 01-07-2022 16:02 in Muvhango Frida...

01/07/2022

WATCH: Scandal - Tonight's teaser E66 S14

WATCH: Scandal - Tonight's teaser E66 S14Get to know what's happening on tonight's episode! by SA TV and Soapies 01-07-2022 16:04 in Scandal F...

01/07/2022

WATCH: Uzalo- Tonight's teaser E85 S8

WATCH: Uzalo- Tonight's teaser E85 S8Don't get left behind, catch up on Uzalo now! by SA TV and Soapies 01-07-2022 16:06 in Soapies Friday's E...

01/07/2022

WATCH: The River - Tonight's teaser E105 S5

WATCH: The River - Tonight's teaser E105 S5Watch tonight's episode of The River and catch the latest episode every weekday at 20:00 on 1 Magic, don'...

01/07/2022

WATCH: Gomora - Tonight's teaser E50 S3

WATCH: Gomora - Tonight's teaser E50 S3Don't miss out on what's happening on tonight's episode of Gomora, and watch the latest episode every wee...

01/07/2022

WATCH: Generations - The Legacy, tonight's teaser E160 S8

WATCH: Generations - The Legacy, tonight's teaser E160 S8Keen to know what's happening on the latest episode of Generations: The Legacy? by SA TV and ...

01/07/2022

WATCH: Skeem Saam - Tonight's teaser E259 S10

WATCH: Skeem Saam - Tonight's teaser E259 S10Find out what's going on tonight on Skeem Saam! by SA TV and Soapies 01-07-2022 16:14 in SkeemSaam Fr...

01/07/2022

How EBU Members rallied to help keep Ukrainian broadcaster UA:PBC on air

How EBU Members rallied to help keep Ukrainian broadcaster UA:PBC on air...

01/07/2022

Soapie teasers: What's happening in 7de Laan in July 2022?

Soapie teasers: What's happening in 7de Laan in July 2022?Another great month ahead. by SA TV and Soapies 01-07-2022 08:03 in Soapies 7de Laan Soapie ...

01/07/2022

Soapie teasers: What's happening in The River this July 2022?

Soapie teasers: What's happening in The River this July 2022?This month is dramatic in The River. by SA TV and Soapies 01-07-2022 08:15 in Soapies The...