Sony Pixel Power calrec Sony

June 22, 2022

23/06/2022

Scripps Research scientists identify sensor underlying mechanical itch Finding could lead to better drug treatments for chronic itch conditions, like eczema

June 22, 2022

LA JOLLA, CA Scientists at Scripps Research have identified a protein in sensory nerves that works as a key detector of itch specifically the mechanical itch stimulus of crawling insects, wool fibers, or other irritating objects that touch the skin.

The discovery, published June 22, 2022, in Nature, is the first identification of a sensor for mechanical itch rather than chemically-triggered itch. It could lead to better treatments for itch conditions such as eczema and psoriasis.

These findings help us untangle the complexity of itch sensation, and suggest that PIEZO1 inhibitors could be very useful clinically, says study senior author Ardem Patapoutian, PhD, a professor in the Department of Neuroscience at Scripps Research, and a Howard Hughes Medical Institute investigator.

Itch is a distinct sensation with its own nerve circuitry and evolutionary purpose likely to alert organisms to potentially harmful chemicals, insects and parasites. Researchers over the past decade or so have identified itch-specific subsets of spinal neurons that extend nerve fibers into the skin and are sensitive to chemical triggers of itch such as the allergy mediator histamine. But so far, relatively little has been discovered about the circuitry of mechanical itch.

PIEZO1's role in mechanical itch was unexpected. Patapoutian won a share of last year's Nobel Prize for Medicine or Physiology for his lab's pioneering research on PIEZO1 and its sister-protein PIEZO2. These unique, propeller-shaped mechanosensor ion channels are embedded in the outer membranes of many cell types. They become activated when mechanically distorted, opening their ion channels and triggering various downstream events. Since 2010, Patapoutian and colleagues have shown that PIEZO2 is a key mechanosensor for light touch, the feeling of the positioning of the body and limbs, and the urge to urinate all via nerves in various tissues and organs. By contrast, the researchers have found that PIEZO1 has a variety of non-sensory roles throughout the body, for example in blood vessels and red blood cells.

While their initial studies suggested that PIEZO1 was not expressed in sensory neurons, other recent investigations have suggested that it is expressed at low levels in some subsets of these neurons. In the new study, Patapoutian and his team, including study first author Rose Hill, PhD, a postdoctoral research associate, followed up on this surprising lead.

In experiments in mice, they confirmed that PIEZO1 is expressed, and appears to be a functional, mechanical pressure-sensitive ion channel protein in two different types of sensory neuron that were already implicated in chemical itch. Mice with an overactive form of PIEZO1 were markedly more sensitive to itch sensations. By contrast, mice lacking PIEZO1 in their sensory neurons scratched themselves far less when stimulated on the skin with filaments that normally would trigger strong itch sensations. The researchers also showed that a PIEZO1-blocking compound alleviates scratching behaviors in mice with the equivalent of eczema.

We did see a dramatic effect on itch with this compound, and though it wasn't specific enough against PIEZO1 to develop into a drug, we hope eventually to develop a much more PIEZO1-specific compound for treating itch conditions, Hill says.

Curiously, the absence or enhancement of PIEZO1 activity in mice caused at least a small reduction or increase of scratching due to chemical itch triggers such as histamine implying that mechanical and chemical itch signals are indeed transmitted in some cases by the same sensory neurons.

The researchers are now investigating whether variants of the PIEZO1 gene in the human population are related to itch sensitivity. The Patapoutian lab published a paper in 2018 showing that a mildly overactive form of PIEZO1, which also has the effect of making red blood cells relatively resistant to malaria parasites, is present in about a third of people of African ancestry.

PIEZO1 transduces mechanical itch in mice was co-authored by Rose Hill, Meaghan Loud, Adrienne Dubin, Brooke Peet, and Ardem Patapoutian.

Funding was provided by the Howard Hughes Medical Institute, the National Institutes of Health (R35 NS105067), and the Helen Hay Whitney Foundation.

Neurological Disorders Patapoutian, Ardem
LINK: https://www.scripps.edu/news-and-events/press-room/2022/20220622-patap...
See more stories from scripps

Most recent headlines

05/01/2027

Worlds first 802.15.4ab-UWB chip verified by Calterah and Rohde & Schwarz to be demoed at CES 2026

Worlds first 802.15.4ab-UWB chip verified by Calterah and Rohde & Schwarz to be ...

01/06/2026

Dolby Sets the New Standard for Premium Entertainment at CES 2026

January 6 2026, 05:30 (PST) Dolby Sets the New Standard for Premium Entertainment at CES 2026 Throughout the week, Dolby brings to life the latest innovatio...

02/05/2026

Dalet Flex LTS Delivers Smarter Search, Faster Editing, and an AI-Ready Foundation for Modern Media

Dalet, a leading technology and service provider for media-rich organizations, t...

01/05/2026

NBCUniversal's Peacock to Be First Streamer to Integrate Dolby's Full Suite of Premium Picture and Sound Innovations

January 5 2026, 18:30 (PST) NBCUniversal's Peacock to Be First Streamer to ...

03/04/2026

TNT Sports and CBS Sports To Reunite Michigan's Iconic Fab Five' for Special NCAA Men's Final Four Altcast on truTV and HBO Max

Michigan's Fab Five will reunite for an alternate presentation of the Mich...

03/04/2026

NAB 2026: Avid To Showcase Content Core and AI Workflow Innovations

Avid will exhibit at NAB Show 2026 (April 18-22, Booth N2226, Las Vegas Convention Center), demonstrating its Content Core platform and new AI-driven workflow c...

03/04/2026

MRMC Appoints Nick Barthee as Chief Operating Officer

Mark Roberts Motion Control (MRMC) has announced the appointment of Nick Barthee as Chief Operating Officer. The announcement follows MRMC's transition fro...

03/04/2026

Elite Media Technologies Selects Interra Systems' BATON for File-Based QC

Interra Systems has announced that Elite Media Technologies has selected its BATON file-based QC solution for media workflows. Elite Media Technologies speciali...

03/04/2026

Moldtelecom Deploys Ateme Technologies Across Full Streaming Workflow

Ateme has announced that Moldtelecom has deployed Ateme technologies across its streaming workflow, covering encoding, delivery, operations, and analytics. Mol...

03/04/2026

NAB 2026: Grass Valley To Demonstrate Framelight X Content Management

Grass Valley will demonstrate Framelight X, its content management platform, at NAB Show 2026. The platform connects capture, ingest, editing, and publishing in...

03/04/2026

NAB 2026: Encompass Digital Media and Techex Launch Cloud-Based Master Control Service for Live Events

Encompass Digital Media and Techex have announced a cloud-native Master Control ...

03/04/2026

Peacock Debuts Its New Vertical-Video Experience for Live NBA Games on Monday

Live Vertical Video automatically track the action on the court via AI technology and delivers a fully optimized, 9 16 live feed for viewers...

03/04/2026

Illinois Creative Team Captures Men's Final Four Run With Trust, Timing, and a Few Water Guns

As the Illini make their first trip to college basketball's biggest stage si...

03/04/2026

Hook 'Em: University of Texas Athletics Produces Digital Content for a First-Person Experience

After last summer's Softball National Championship victory and last week'...

03/04/2026

Don't Be Lame: Arizona Men's Basketball Social Team Aims To Catch the Attention of Wildcat Fans

The University of Arizona's Men's Basketball team has only loss twice th...

03/04/2026

During Packed Weekend, Van Wagner Covers In-Venue Shows for Championships Across Indianapolis

Eight games across four tournaments will be played in three venues; accommodatio...

03/04/2026

Ottawa Senators and Bell Media Extend Regional Broadcast Rights Agreement

The Ottawa Senators and Bell Media have announced a long-term rights extension for regional Ottawa Senators games on TSN and RDS. TSN Radio 1200 remains the exc...

03/04/2026

ESPN's Women's Final Four Playbook: Bigger Compound, Bigger Trucks, Biggest Production Yet

Massive production in Phoenix running out of Flagship Mobile unit, Features 50+ ...

03/04/2026

Electro-Harmonix release EHX Classics Bundle

Iconic guitar pedals now available in plug-in form Guitar effects experts Electro-Harmonix have teamed up with MixWave to turn a collection of their most pr...

03/04/2026

FAC launch Bandit 2

New multi-band AUv3 plug-in announced Fred Anton Corvest (FAC) offer an extensive range of AUv3 plug-ins and iOS/iPadOS Apps, and their multiband effects pr...

03/04/2026

Pulsar-23: 1984 from SOMA Laboratory

Just 84 units to be released in the US Experimental synthesizer and sound-machine extraordinaires SOMA Laboratory have revealed an upcoming special-edition ...

03/04/2026

Iconic Instruments release Model 350 Tube Preamp

Emulates the input section of an Ampex 350 One of the latest arrivals to the Iconic Instruments range delivers a new tube preamp plug-in inspired by the cir...

03/04/2026

TelevisaUnivision and Nielsen Agree to New Media Intelligence Deal Covering Streaming, National and Local TV, and Radio

New York April 2, 2026 TelevisaUnivision, the world's leading Spanish-la...

03/04/2026

2026 NAB Show Exhibitor Insight: Techex

Share Copy link Facebook X Linkedin Bluesky Email...

03/04/2026

TelevisaUnivision Signs New Nielsen Media Intelligence Deal

Share Copy link Facebook X Linkedin Bluesky Email...

03/04/2026

The WNET Group, JIB Launch NHK World-Japan in New York

Share Copy link Facebook X Linkedin Bluesky Email...

03/04/2026

NAB Leadership Foundation Welcomes New Board Members

Share Copy link Facebook X Linkedin Bluesky Email...

03/04/2026

EverPass Media Expands Distribution Deal with Netflix

Share Copy link Facebook X Linkedin Bluesky Email...

03/04/2026

Versant Acquires AI-Data Platform StockStory

Share Copy link Facebook X Linkedin Bluesky Email...

03/04/2026

CVP Grows European Footprint with Strategic Expansion in...

CVP, one of Europe's leading suppliers of professional video and broadcast solutions, today announces the launch of its new German operation and the formati...

03/04/2026

MRMC Announces Appointment of Chief Operating Officer

Mark Roberts Motion Control (MRMC) today announces the appointment of Nick Barthee as Chief Operating Officer, strengthening its leadership as the company conti...

03/04/2026

Net Insight Introduces Programmable Trust Boundaries for...

Net Insight introduces programmable Trust Boundaries that make live media interconnection predictable as traffic moves between facilities, networks and cloud en...

03/04/2026

Winning in the new media economy: Avid showcases AI-powered, connected intelligence to unlock media value at NAB Show 2026

Winning in the new media economy: Avid showcases AI-powered, connected intellige...

03/04/2026

NUGEN Audio CEO Dr. Paul Tapper to Lead Presentation About Dialog Intelligibility and Loudness at NAB 2026

NUGEN Audio CEO Dr. Paul Tapper to Lead Presentation About Dialog Intelligibilit...

03/04/2026

NAB Show 2026: PlayBox Neo Highlights Workflow, Security, and IP Advances

NAB Show 2026: PlayBox Neo Highlights Workflow, Security, and IP Advances Brie Clayton April 2, 2026 0 Comments PlayBox Neo will showcase the latest i...

03/04/2026

For Taku Hirano, Everything Is Connected

For Taku Hirano, Everything Is Connected From touring and composition to teaching and instrument design, the in-demand percussionist sees it all as one body o...

03/04/2026

Berklee Honors Humberto Ramirez with Master of Latin Music Award

Berklee Honors Humberto Ramirez with Master of Latin Music Award The alumnus and acclaimed trumpeter is honored for his influence as a performer, composer, an...

03/04/2026

Competition Heats Up with Intrigue and Spices: Netflix Unveils Trailer for New Drama Made with Love'

Back to All News Competition Heats Up with Intrigue and Spices: Netflix Unveils...

02/04/2026

HBO and NFL Films Announce Hard Knocks: Training Camp with the Seattle Seahawks, Debuting August 11

HBO and NFL Films have announced Hard Knocks: Training Camp with the Seattle Sea...

02/04/2026

NAB 2026: Haivision Unveils Makito ONE Video Transport Platform

Haivision has announced the Makito ONE, a single-blade video encoding and decoding platform, at NAB Show 2026. The platform combines dual-channel video encoding...

02/04/2026

NAB 2026: Telestream Introduces UP.Lens Cloud-Based Multiviewer and Monitoring Service

Telestream has introduced UP.Lens, a cloud-based multiviewer and monitoring serv...

02/04/2026

NAB 2026: MRMC to Showcase Robotic Camera Technology and Mark 60th Anniversary

Mark Roberts Motion Control (MRMC) will exhibit at NAB Show 2026 (Booth C5220, April 19-22, Las Vegas Convention Center), marking the company's 60th anniver...

02/04/2026

NAB 2026: Net Insight Introduces Programmable Trust Boundaries for Live Media Interconnection

Net Insight has introduced programmable Trust Boundaries, a feature integrated i...

02/04/2026

NAB 2026: Bitmovin Adds SGAI Support to Playback Products

Bitmovin has announced support for SGAI (Server-Guided Ad Insertion) in its playback products, using HLS interstitials. SGAI combines elements of client-side an...

02/04/2026

Binghamton University Athletics Adds Riedel SimplyLive RiMotion R12 for Student-Run Productions

Riedel Communications' SimplyLive RiMotion R12 replay system is supporting B...

02/04/2026

NAB 2026: LTN and Ateme Announce Integration of Video Processing with IP Transport

LTN, a managed IP video transport company, and Ateme, a video compression and de...

02/04/2026

TDF Expands Channel Capacity on Terrestrial Broadcast Network with Harmonic

Harmonic has announced that TDF, a broadcast infrastructure operator in France, has deployed Harmonic's XOS Advanced Media Processor and ProStream X Video S...

02/04/2026

United Rugby Championship Reports First-Year Results with Eluvio Streaming Platform

Eluvio and the United Rugby Championship (URC) have announced first-year results...

02/04/2026

Kansas City Current and Scripps Sports Announce ION as Broadcast Home of 2026 Teal Rising Cup

The Kansas City Current and Scripps Sports have announced that ION will broadcas...