Sony Pixel Power calrec Sony

December 01, 2022

02/12/2022

Nanotech strategy shows promise for treating autoimmune disease In a Scripps Research study, a nanoparticle treatment cured' mice that had a genetic arthritis condition.

December 01, 2022

LA JOLLA, CA Scientists at Scripps Research have reported success in initial tests of a new, nanotech-based strategy against autoimmune diseases.

The scientists, who reported their results on November 23, 2022, in the journal ACS Nano, engineered cell-like nanoparticles that target only the immune cells driving an autoimmune reaction, leaving the rest of the immune system intact and healthy. The nanoparticles greatly delayed, and in some animals even prevented, severe disease in a mouse model of arthritis.

The potential advantage of this approach is that it would enable safe, long-term treatment for autoimmune diseases where the immune system attacks its own tissues or organs using a method that won't cause broad immune suppression, as current treatments do, says study senior author James Paulson, PhD, Cecil H. and Ida M. Green Chair of Chemistry in the Department of Molecular Medicine at Scripps Research.

Autoimmune diseases such as rheumatoid arthritis are caused when the immune system mistakenly attacks a person's own tissues or organs. These illnesses affect an estimated 10 million people in the U.S. alone. Treatments are available and can be effective for many patients, but they tend to suppress the immune system indiscriminately, creating an enhanced susceptibility to infections and cancers among other side effects.

Paulson and his team have taken an approach that targets the immune system more narrowly. Many autoimmune diseases are triggered or driven by immune attacks on just one protein in the patient's body, known as a self-antigen. The idea underlying the nanoparticle strategy is to eliminate or deactivate only the immune cells that attack that self-antigen an approach that could be at least as effective as broad immune suppression, without the side effects. Autoimmune diseases that are dominated by immune responses to a single self-antigen include some forms of arthritis, the skin blister disease known as pemphigus and the thyroid ailment Graves' disease.

The researchers, including first author Katarzyna Brzezicka, PhD, a postdoctoral research associate in the Paulson lab, research assistant Britni Arlian, and other lab members, designed nanoparticles that could deactivate two types of immune cells: B cells and T cells. On its surface, each nanoparticle bore copies of a target self-antigen, plus a sugar-related molecule that can bind to a special off switch receptor on B cells called CD22. B cells, which make antibodies and are specific to different antigens, will effectively shut themselves off if they encounter both the particular antigen they target and the binding partner of CD22 at the same time.

Each nanoparticle also was laced with a powerful compound called rapamycin to stimulate the production of immune cells called regulatory T cells. Treg cells, as they're also known, are responsible for suppressing other T cells needed to generate an autoimmune attack. The overall aim of the study was to effectively knock out only the B and T cells that recognize the self-antigen, leaving the rest of the B- and T-cell populations intact.

The researchers first demonstrated that their nanoparticle-based strategy could tolerize the mouse immune system to a chicken protein, ovalbumin, that would otherwise trigger a strong response. Next, they tested the strategy in a widely used mouse model of arthritis, in which the mouse immune system is genetically predisposed to attack a self-antigen called GPI. The scientists showed that treatment of the mice with GPI-tolerizing nanoparticles at the age of three weeks greatly delayed the development of arthritis signs that would normally appear a week or two later. In fact, about a third of the mice remained arthritis-free for the maximum follow-up period of 300 days. Tests confirmed that the treatment dramatically reduced the mice's production of anti-GPI antibodies, and at the same time boosted their Treg populations.

Paulson says his team plans to follow up these highly promising results with further optimization of the nanoparticle strategy.

We were able to cure' a third of these animals in this early demonstration, and I think theres the potential to combine our nanoparticles with other immune modulator treatments to make it even more effective, Paulson says. So that will our next step as well as demonstrating our technology against other autoimmune diseases caused by unwanted immune responses to a self-antigen.

Suppression of Autoimmune Rheumatoid Arthritis with Hybrid Nanoparticles That Induce B and T Cell Tolerance to Self-Antigen was co-authored by Katarzyna Brzezicka, Britni Arlian, Shengyang Wang, Merissa Olmer, Martin Lotz, and James Paulson, all of Scripps Research.

This work was funded in part by the National Institutes of Health (R01AI050143, R01AI132790).

Autoimmune Diseases Immunology & Microbiology Paulson, James
LINK: https://www.scripps.edu/news-and-events/press-room/2022/20221201-pauls...
See more stories from scripps

Most recent headlines

06/10/2025

France Tlvisions Wins Prestigious 2025 EBU Technology & Innovation Award in Groundbreaking Collaboration with Dalet

France T l visions, France's leading broadcaster, has received the 2025 EBU ...

04/09/2025

Monumental Sports & Entertainment and Dalet Win Prestigious 2025 NAB Show Project of the Year Award

Monumental Sports & Entertainment (MSE), in collaboration with Dalet, has been a...

07/08/2025

Tata Motors & Dolby Bring Dolby Atmos to Harrier.ev, Redefining In-Car Entertainment Experience

July 8 2025, 22:30 (PDT) Tata Motors & Dolby Bring Dolby Atmos to Harrier.ev, R...

18/07/2025

Realm of Satan Disturbs the Comfortable at 2024 Sundance Film Festival

Blanche Barton, Peter Gilmore, Scott Cummings, Sundance Institute Director of Programming Kim Yutani, and Peggy Nadramia throwing horns. (Stephen Lovekin/Shutte...

18/07/2025

Give Me the Backstory: Get to Know Heidi Ewing and Rachel Grady, the Directors of FOLKTALES

By Jessica Herndon One of the most exciting things about the Sundance Film Fest...

18/07/2025

NESN Unveils Enhanced NESN 360 App for iOS, Android Devices

BOSTON Sports network NESN today relaunched the NESN 360 app with a redesigned user experience and upgrades....

18/07/2025

Berklee Singers Wow the Competition on Netflixs Building the Band

Berklee Singers Wow the Competition on Netflixs Building the Band Netflixs new music competition show features two Berklee artists looking to make their pop b...

18/07/2025

Trump Expected to Sign Bill Defunding CPB After House Approves $1B Cuts

As the House of Representatives voted early Friday morning to eliminate federal funding for public broadcasting, advocates warned that the elimination of $1 bil...

18/07/2025

Imagine Communications Sharpens Focus on Sports, Live Events Market

DENVER Imagine Communications has announced that it is deepening its commitment to the North American sports and live events market with investments in its prod...

18/07/2025

Netflix Beats Revenue, Profit Expectations

LOS GATOS, Calif. Netflix once again reported strong financial growth, with revenue increasing 16% year-over-year to $11.079 billion in Q2 2025 as net income s...

18/07/2025

Live from the 153rd Open Championship: SMT Enhances Video Board Experience; Enables Practice Scheduling for Players

Live from the 153rd Open Championship: SMT Enhances Video Board Experience; Enab...

18/07/2025

ShotTracker's Davyeon Ross on Revolutionizing Basketball On the Court and Beyond Through Tracking Tech

ShotTracker's Davyeon Ross on Revolutionizing Basketball On the Court and ...

18/07/2025

Home Pitch: How the Danish League Brought Its Live Match Production In-House

Home Pitch: How the Danish League Brought Its Live Match Production In-House Matchday Production produced 800+ matches across Denmark in its first year By Geor...

18/07/2025

Live From the 153rd Open Championship: EMG Debuts Spidercam for Golf, Expands Support for NBC Sports

Live From the 153rd Open Championship: EMG Debuts Spidercam for Golf, Expands Su...

18/07/2025

Usyk vs Dubois II: Bringing the Fight to Life with State of the Art Cameras and Graphics from DAZN and Gravity Media

Usyk vs Dubois II: Bringing the fight to life with state of the art cameras and ...

18/07/2025

Usyk vs Dubois II: DAZN's Head of Boxing Chris Glanville Talks Helicopters, a Ringwalk Spectacular and Directing the Action

Usyk vs Dubois II: DAZN's head of boxing Chris Glanville talks helicopters, ...

18/07/2025

Live From the 153rd Open Championship: NBC Expands Unilateral Effort; Shared Studio Gives Live From,' NBC Sports a Great View

Live From the 153rd Open Championship: NBC Expands Unilateral Effort; Shared Stu...

18/07/2025

Warner Bros. Discovery's Anne Graham on Training New Professionals to Ensure the Future of the Business

Warner Bros. Discovery's Anne Graham on Training New Professionals to Ensure...

18/07/2025

Live From the 153rd Open Championship: How R&A Spidercam Became a Reality for Golf Coverage

Live From the 153rd Open Championship: How R&A Spidercam Became a Reality for Go...

18/07/2025

ESPN Bulks Up Onsite Studios, Cameras, Player Mics for WNBA All-Star Weekend

ESPN Bulks Up Onsite Studios, Cameras, Player Mics for WNBA All-Star Weekend Besides the game, four studio shows will be produced onsite By Jason Dachman, Edit...

18/07/2025

The Sky Arts Awards Are Back, Live From The Roundhouse This September

Friday 18 July 2025 Credit: Marc Sethi The Sky Arts Awards will return on 16 September, once again taking place at the iconic Roundhouse in London. Produced b...

18/07/2025

2025-07-18

This month, players can dive into special crossover events featuring SpongeBob SquarePants in Snake.io+ and Crossy Road Castle, available exclusively on Apple A...

18/07/2025

Hurling Fans Flock Together for a Night of Craic agus Ceol on RT's Up For The Match this Saturday night

Up for the Match brings the fun, the passion-and a bit of Riverdance- tomorrow n...

17/07/2025

Realm of SatanDisturbs the Comfortable at 2024 Sundance Film Festival

Blanche Barton, Peter Gilmore, Scott Cummings, Sundance Institute Director of Programming Kim Yutani, and Peggy Nadramia throwing horns. (Stephen Lovekin/Shutte...

17/07/2025

Audiobooks+ Brings More Choice and Flexibility to Spotify Premium Subscribers

Spotify's goal with audiobooks is to help grow the publishing industry and create the best possible experience for booklovers, which is why we're launch...

17/07/2025

L3Harris to Expand Solid Rocket Motor Production in Arkansas

An advanced large solid rocket motor hot fire test conducted at L3Harris' Camden, Arkansas, site....

17/07/2025

L3Harris Has the Future of PNT Ready Now

L3Harris payloads and components have been on board every U.S. GPS satellite-more than 70 missions since the 1970s. Our technology is at the core of GPS availab...

17/07/2025

L3Harris Introduces Launched Effects Vehicles to Increase US Multi-Domain Superiority

L3Harris' pack of launched effects is comprised of multi-role vehicles that ...

17/07/2025

Nielsen taps Ryan Moore as Chief Business Officer of Gracenote

NEW YORK - July 17, 2025 - Gracenote, the content data business unit of Nielsen, has announced the appointment of Ryan Moore to the new role of Chief Business O...

17/07/2025

David Cohen Joins Miri Technologies as VP, Sales and Business Development

READING, Pa. Network technology startup Miri Technologies has added David Cohen as vice president, business development. He'll be tasked with expanding the ...

17/07/2025

Berklee Wins CASE Award for Standout Digital Campaign

Berklee Wins CASE Award for Standout Digital Campaign The Alumni Affairs team's Variations Signature Series earned recognition for offering an authentic p...

17/07/2025

Senate Votes to Strip Federal Funds for Public Broadcasting

Early Thursday morning, the U.S. Senate voted to cut federal funding for PBS and NPR in a bill that also included cuts for foreign aid. In a 51-48 vote, the act...

17/07/2025

British Innovation Leads the Way at IBC2025

GREAT Britain and Northern Ireland Pavilions across IBC2025 (12 15 September, RAI Amsterdam) feature a remarkable 34 companies, each providing unique, innovativ...

17/07/2025

SMPTE Forms Study Group on Content Provenance and Authenticity In Media

WHITE PLAINS, N.Y. The Society of Motion Picture and Television Engineers today introduced its Content Provenance and Authenticity (CPA) in Media Study Group (S...

17/07/2025

NBCU Reports Highest Sales Volume in History' for 2025-26 Upfronts

NEW YORK Despite widespread concerns about a soft advertising market, NBCUniversal said it closed its 2025-26 upfront negotiation cycle with a record ad sales v...

17/07/2025

Study: TV Ads Are Top Influencer of Older Adults Buying Retirement Homes

NEW YORK Television advertising remains an effective means to market and influence younger baby boomer and Generation X consumers approaching retirement age, ac...

17/07/2025

Service Electric Cable TV Deploys OpenVault PMN

ALLENTOWN, Pa. & JERSEY CITY, N.J. Service Electric Cable TV and OpenVault have announced that the operator is deploying the OpenVault Proactive Network Manage...

17/07/2025

FCC Chair Outlines Busy Summer Agenda That Includes Major EAS Vote

WASHINGTON Following up on his first major policy speech just two ago, Federal Communications Commission Chair Brendan Carr is promising to buck the usual summ...

17/07/2025

SES Receives All Required Regulatory Approvals to Complete Intelsat Acquisition

Luxembourg, 14 July 2025 - SES received the final regulatory approvals for the SES-Intelsat transaction, including the US Federal Communications Commission. O...

17/07/2025

Berklee Alumni Nominated for 2025 Emmy Awards

Berklee Alumni Nominated for 2025 Emmy Awards Twenty-seven Berklee alumni received nominations across categories in sound mixing, sound editing, and compositi...

17/07/2025

What We Watched the First Half of 2025

Back to All News What We Watched the First Half of 2025 Entertainment 17 July 2025 Global Link copied to clipboard Today, we're sharing our latest Eng...

17/07/2025

Vote for Ivory 3 American Concert D in the MIDI Innovation Awards!

Cast your vote in 2 categories for Ivory 3 American Concert DIvory 3 American Concert D is in the 2025 MIDI Innovation Awards and we are honored to be nominated...

17/07/2025

SVG Sit-Down: OpenDrives' Sean Lee, Michael Wilsker, and Jason Matousek on Evolving Data Management

SVG Sit-Down: OpenDrives' Sean Lee, Michael Wilsker, and Jason Matousek on E...

17/07/2025

Oracle's Geoff Tognetti on Staying Ahead of the AI Curve Through Further Adoption

Oracle's Geoff Tognetti on Staying Ahead of the AI Curve Through Further Ado...

17/07/2025

NBA's Summer League Is a Hot Bed of AI, Immersive Innovation Testing

NBA's Summer League Is a Hot Bed of AI, Immersive Innovation Testing Audio mixing, intelligent camera framing are among AI-driven efforts By Ken Kerschbaum...

17/07/2025

SVG's TranSPORT Conference Returns to NYC on Oct. 21; Register Today!

SVG's TranSPORT Conference Returns to NYC on Oct. 21; Register Today! By SVG Staff Thursday, July 17, 2025 - 8:29 am Print This Story | Subscribe St...

17/07/2025

Gravity Media Chosen as Group Name for Merged OB Business

Gravity Media chosen as group name for merged OB business By George Bevir Wednesday, July 16, 2025 - 11:30 Print This Story Gravity Media executive chairm...

17/07/2025

SES Closes Deal to Acquire Intelsat, Creating New Giant in Satellite Connectivity

SES Closes Deal to Acquire Intelsat, Creating New Giant in Satellite Connectivit...

17/07/2025

How MLB Pulled Off That Unforgettable Hank Aaron Tribute at the All-Star Game

How MLB Pulled Off That Unforgettable Hank Aaron Tribute at the All-Star Game Vintage content, state-of-the-art projection/processing combine in marvelous mile...

17/07/2025

Riedel Communications Powers Handa Opera on Sydney Harbour with Integrated Network and Comms Solutions

Wuppertal July 17, 2025 Riedel Communications Powers Handa Opera on Sydney Har...