Nanotech strategy shows promise for treating autoimmune disease In a Scripps Research study, a nanoparticle treatment cured' mice that had a genetic arthritis condition.
December 01, 2022
LA JOLLA, CA Scientists at Scripps Research have reported success in initial tests of a new, nanotech-based strategy against autoimmune diseases.
The scientists, who reported their results on November 23, 2022, in the journal ACS Nano, engineered cell-like nanoparticles that target only the immune cells driving an autoimmune reaction, leaving the rest of the immune system intact and healthy. The nanoparticles greatly delayed, and in some animals even prevented, severe disease in a mouse model of arthritis.
The potential advantage of this approach is that it would enable safe, long-term treatment for autoimmune diseases where the immune system attacks its own tissues or organs using a method that won't cause broad immune suppression, as current treatments do, says study senior author James Paulson, PhD, Cecil H. and Ida M. Green Chair of Chemistry in the Department of Molecular Medicine at Scripps Research.
Autoimmune diseases such as rheumatoid arthritis are caused when the immune system mistakenly attacks a person's own tissues or organs. These illnesses affect an estimated 10 million people in the U.S. alone. Treatments are available and can be effective for many patients, but they tend to suppress the immune system indiscriminately, creating an enhanced susceptibility to infections and cancers among other side effects.
Paulson and his team have taken an approach that targets the immune system more narrowly. Many autoimmune diseases are triggered or driven by immune attacks on just one protein in the patient's body, known as a self-antigen. The idea underlying the nanoparticle strategy is to eliminate or deactivate only the immune cells that attack that self-antigen an approach that could be at least as effective as broad immune suppression, without the side effects. Autoimmune diseases that are dominated by immune responses to a single self-antigen include some forms of arthritis, the skin blister disease known as pemphigus and the thyroid ailment Graves' disease.
The researchers, including first author Katarzyna Brzezicka, PhD, a postdoctoral research associate in the Paulson lab, research assistant Britni Arlian, and other lab members, designed nanoparticles that could deactivate two types of immune cells: B cells and T cells. On its surface, each nanoparticle bore copies of a target self-antigen, plus a sugar-related molecule that can bind to a special off switch receptor on B cells called CD22. B cells, which make antibodies and are specific to different antigens, will effectively shut themselves off if they encounter both the particular antigen they target and the binding partner of CD22 at the same time.
Each nanoparticle also was laced with a powerful compound called rapamycin to stimulate the production of immune cells called regulatory T cells. Treg cells, as they're also known, are responsible for suppressing other T cells needed to generate an autoimmune attack. The overall aim of the study was to effectively knock out only the B and T cells that recognize the self-antigen, leaving the rest of the B- and T-cell populations intact.
The researchers first demonstrated that their nanoparticle-based strategy could tolerize the mouse immune system to a chicken protein, ovalbumin, that would otherwise trigger a strong response. Next, they tested the strategy in a widely used mouse model of arthritis, in which the mouse immune system is genetically predisposed to attack a self-antigen called GPI. The scientists showed that treatment of the mice with GPI-tolerizing nanoparticles at the age of three weeks greatly delayed the development of arthritis signs that would normally appear a week or two later. In fact, about a third of the mice remained arthritis-free for the maximum follow-up period of 300 days. Tests confirmed that the treatment dramatically reduced the mice's production of anti-GPI antibodies, and at the same time boosted their Treg populations.
Paulson says his team plans to follow up these highly promising results with further optimization of the nanoparticle strategy.
We were able to cure' a third of these animals in this early demonstration, and I think theres the potential to combine our nanoparticles with other immune modulator treatments to make it even more effective, Paulson says. So that will our next step as well as demonstrating our technology against other autoimmune diseases caused by unwanted immune responses to a self-antigen.
Suppression of Autoimmune Rheumatoid Arthritis with Hybrid Nanoparticles That Induce B and T Cell Tolerance to Self-Antigen was co-authored by Katarzyna Brzezicka, Britni Arlian, Shengyang Wang, Merissa Olmer, Martin Lotz, and James Paulson, all of Scripps Research.
This work was funded in part by the National Institutes of Health (R01AI050143, R01AI132790).
Autoimmune Diseases Immunology & Microbiology Paulson, James
Most recent headlines
11/12/2025
Dalet, a leading provider of cloud-native, end-to-end media workflow solutions, ...
19/11/2025
Sphere Sound Kicks Up Its Heels at Radio City Music HallUltra-immersive system from the singular Las Vegas venue is also ready for sportsBy Dan Daley, Audio Edi...
19/11/2025
The Future of Stadium and Arena Video Control Rooms: Tech Leaders Talk 4K, IP, a...
19/11/2025
One Year at Intuit Dome: Walking Through the Stunning Arena's Advanced Video...
19/11/2025
SVG Sit-Down: IMG's Francois Westcombe Goes Inside IMG's Annual Digital ...
19/11/2025
Inside Brighton & Hove Albion's fan-first media machine By George Bevir
Tuesday, November 18, 2025 - 10:10
Print This Story
Brighton & Hove Albion'...
19/11/2025
Rock Chalk Rebuild, Part 1: Kansas Athletics Brings New Production Power to Rebu...
19/11/2025
Rock Chalk Rebuild, Part 2: A Pro's Guide to Kansas Athletics' New Video...
19/11/2025
MLB Media Rights Shakeup: NBC Inks Three-Year Deal for Sunday Night Baseball, Pe...
19/11/2025
Rohan Parashuram Kanawade attends the premiere of Sabar Bonda (Cactus Pears) at the 2025 Sundance Film Festival at Egyptian Theatre on January 26, 2025, in Pa...
19/11/2025
Awards season is heating up, and the International Documentary Association just ...
19/11/2025
Aerojet Rocketdyne President Ken Bedingfield and Arkansas Gov. Sarah Huckabee Sanders were joined by state and local officials to celebrate the groundbreaking o...
19/11/2025
L3Harris and PentenAmio formalise their teaming agreement at MilCIS 2025, streng...
19/11/2025
Calrec gives Phoenix Broadcast Solutions its full support in strategic multi-year enterprise partnership New Singapore OB company invests in Calrec technology f...
19/11/2025
October brings a larger audience in front of TV screens. The cooler autumn weather and the continuation of new programming schedules brought increases in both t...
19/11/2025
IRVING, Texas Nexstar Media Group and Tegna filed applications on Nov. 18 with the Federal Communications Commission (FCC) seeking its consent to transfer broad...
19/11/2025
Vitec has acquired Datapath, a developer of real-time video processing for large-scale video walls, AVoIP content distribution and KVM control in mission-critic...
19/11/2025
NEVADA CITY, Calif. Telestream has introduced ARGUS Version 2.3, which introduces Live Look, a feature that lets operators inspect live and on-demand streams vi...
19/11/2025
STAMFORD, Conn. and NEW YORK Charter Communications, Inc. has announced a major deal with Amazon Web Services (AWS) that establishes AWS as one of Charters stra...
19/11/2025
TOKYO Atomos has announced a major firmware update that brings integrated camera control to the Ninja TX GO and Ninja TX its new CFexpress-based monitor-recor...
19/11/2025
Berklee's Signature Series Reimagines the Musical and Visual Artistry of Col...
19/11/2025
PlayBox Neo departed the NAB Show New York 2025 on a high note. The company's all-new PlayBox Neo Suite made a splash on the show floor, drawing strong inte...
19/11/2025
AAVBR (American Audio Visual Baton Rouge), a leading full-service event production company serving Louisiana and the Gulf Coast region, has enhanced its product...
19/11/2025
In its mission to deliver live event services combining advanced engineering with a creative approach to captivating live sports and entertainment experiences, ...
19/11/2025
NEW YORK Short-form vertical video has exploded across platforms like TikTok, Instagram and YouTube, but a new survey commissioned by Media.net, a provider of c...
19/11/2025
NEW YORK YES Network, the regional sports network home of the New York Yankees and Brooklyn Nets, and CAMB.AI have struck a partnership they said will leverage ...
19/11/2025
WASHINGTON The Federal Communications Commission has issued detailed guidance on filings that were disrupted by the government shutdown. While many of those fil...
19/11/2025
NEW YORK The popularity of NFL games is largely responsible for continued seasonal momentum in TV viewership into October (measured Sept. 29-Oct. 26), according...
19/11/2025
DirecTV has announced that its MyFree DirecTV streaming service has added seven new channels. Those include four sports services, NBA FAST, Red Bull TV, DAZN Ri...
19/11/2025
SURREY, U.K. Mark Roberts Motion Control (MRMC) has launched Flair Bridge, a compact device that transforms how operators control the company's motion-contr...
19/11/2025
WASHINGTON The Federal Communications Commission, which is continuing to rapidly ramp up its operations after the end of the federal government shutdown, has se...
19/11/2025
IRVING, Texas Nexstar Media Group and Tegna filed applications on Nov. 18 with the Federal Communications Commission (FCC) seeking its consent to transfer broad...
19/11/2025
Martin Freeman, Jessie Buckley, Wu-Tang Clan's Raekwon, Eddie the Eagle and ...
19/11/2025
Rohde & Schwarz collaborates with Broadcom to enable testing and validation of n...
19/11/2025
Back to All News
Innato, starring Imanol Arias and Elena Anaya, arrives on Netf...
19/11/2025
Back to All News
Guillermo del Toro Sits Down With Troll 2 Director Roar Uthaug...
19/11/2025
Some projects feel monumental from the moment the first phone call comes in. When BCE, the host broadcaster appointed to coordinate the national coverage, asked...
19/11/2025
November 19 2025, 08:00 (PST) BAY AREA HOST COMMITTEE AND DOLBY PARTNER TO DELIVER IMMERSIVE FAN EXPERIENCES
During the Week of Football's Biggest Game...
19/11/2025
Michael D. Higgins: Ireland's Ninth President features RT Archives footage and interviews across seven decades
Watch Wednesday 19 November at 9:35pm on RT...
19/11/2025
Scripps Research scientists receive $1.1 million to advance AI modeling for HIV vaccine development New AI system helps scientists rapidly pinpoint the most pro...
18/11/2025
Independent media across Central America are operating under intensifying financial pressure, yet there is a clear appetite for models that can sustain both ind...
18/11/2025
NBA Debuts New Comms Infrastructure and Systems for RefereesTwo-phase rollout is intended to improve game flow, enhance officiating accuracyBy Dan Daley, Audio ...
18/11/2025
Platinum White Paper: How Aggreko Delivers Certainty For Broadcasters On The Wor...
18/11/2025
Kiswe Extends DTC Products With Kiswe Core Cloud-Based Tool for Distributing Con...
18/11/2025
Spanish Basketball Federation partners with ScorePlay to power digital transform...
18/11/2025
HBS selects BBright encoders and decoders to connect ST 2110 live production wor...
18/11/2025
Ashes to Ashes: Inside TNT Sports' hybrid and maverick' production plan...
18/11/2025
SVG All-Stars: Mimi Fotopoulos, Director, Talent and Production Operations, Tenn...
18/11/2025
SVG LIVE! Conference Explores the Tech Side of Sports and Entertainment ConvergenceLive sports and music productions increasingly share gear and infrastructureB...
Nanotech strategy shows promise for treating autoimmune disease In a Scripps Research study, a nanoparticle treatment cured' mice that had a genetic arthritis condition.
