Scripps Research chemists develop new sustainable reaction for creating unique molecular building blocks The building blocks can be used to create polymers with previously unexplored structures and fine-tunable properties, with applications across energy storage and more.
August 08, 2024
LA JOLLA, CA Polymers can be thought of like trains: Just as a train is composed of multiple cars, polymers are made up of multiple monomers, and the couplings between the train cars are similar to the chemical bonds that link monomers together. While polymers have myriad applications from drug delivery to construction materials their structures and functions are restricted by the chemically similar monomer building blocks they're composed of.
Now, Scripps Research chemists and additional collaborators have developed a new reaction to create unique monomers in a controlled way. This reaction, which uses nickel as a catalyst, ultimately enables scientists to create polymers with unique and modifiable properties for drug delivery, energy storage, microelectronics and more. The study was published in Nature Synthesis on August 8, 2024.
This study shows how earth-abundant metal catalysts can unlock the path toward previously unknown materials with unparalleled structural and functional diversity, says senior author Keary Engle, PhD, a professor in the Department of Chemistry and dean of Graduate and Postdoctoral Studies at Scripps Research.
The Engle lab at Scripps Research focuses on developing new chemical reactions to build a wide and diverse array of small molecules, typically with applications in drug discovery. In this study, the Scripps Research team collaborated with polymer researchers at the Georgia Institute of Technology and the University of Pittsburgh to test whether their methods could be scaled up to create unique polymers.
The properties of polymers are very much dependent on what type of chemistry is on the backbone, so if you can modify the chemistry of the building blocks, then you can easily apply it to the macromolecular structure that youre building, says Anne Ravn, PhD, a postdoctoral researcher in the Engle lab at Scripps Research and co-first author on the paper. With this project we wanted to test whether our strategy for developing small molecules could be applied to a bigger picture to provide new building blocks for polymer synthesis.
The paper's other first authors are Van Tran, PhD, who worked on the project as a graduate student in the Engle lab; Camille Rubel, a current graduate student in the Engle lab; Mizhi Xu, PhD, a former graduate student in the Gutekunst lab at the Georgia Institute of Technology; and Yue Fu, PhD, a former graduate student in the Liu lab at the University of Pittsburgh.
To create the new monomers, the Scripps Research team developed a chemical reaction that alters the structure of a starting molecule by using nickel as a catalyst. The nickel-catalyzed reaction added two new functional groups to the molecule small side chains that confer different chemical and physical properties on the ensuing polymer, for example, how flexible, elastic or soluble it is.
Then, the team's collaborators at Georgia Institute of Technology used another chemical reaction to link the monomers together via polymerization, resulting in polymers with a unique structure.
Most commercial polymers have two carbons in between each functional group that are not decorated with any side chains, but in this case, the functional groups are much closer in space, which creates a material with different properties, says Ravn.
In the future, the team plans to explore the impact of substituting different functional groups onto the monomers.
Our strategy allows us to decorate' the molecule with much more flexibility than other methods, which gives us more freedom to explore different types of functionalities in the building blocks, says Ravn. Were now working to expand the method to explore how introducing other types of functional groups changes the properties of the material.
Because nickel is more abundant than many other metal catalysts used in this type of chemical reaction, the researchers say that their method holds promise as an environmentally sustainable method for polymer production. They're also exploring ways to make the products even more sustainable.
From an environmental perspective, we want to find a method to degrade these long polymers so that we can get back to the original building blocks, which would allow us to reuse them, says Ravn. This is a tool that we hope to fine-tune in the future to ultimately create new technologies that are useful for society.
Ni-catalysed dicarbofunctionalization for the synthesis of sequence-encoded cyclooctene monomers was co-authored by Ethan Wagner, Steven R. Wisniewski, Peng Liu, and Will Gutekunst of Scripps Research.
Support for the research was provided by the Department of Energy (DESC0023205), the National Science Foundation (CHE-2102550), the Independent Research Fund Denmark (grant ID: 10.46540/3102-00009B), and the Schimmel Family Endowed Scholarship Fund.
Molecular Medicine Engle, Keary
North America Stories
23/10/2025
A deadline is looming for a new carriage deal between Verizon's Fios TV and Nexstar, with both Verizon and the pay TV-backed American Television Alliance bl...
23/10/2025
NEW YORK During a high-profile session at NAB Show New York, new survey data was shared that revealed significant public concern over artificial intelligence (A...
23/10/2025
BELLEVUE, Wash. and NEW YORK Fox Weather has tapped T-Mobile has as its preferred communications provider and announced that all Fox Weather reporters are being...
23/10/2025
PBS and Amazon Web Services have announced the network is using generative AI to provide enhanced search results to viewers on the PBS App and PBS LearningMedia...
22/10/2025
Prime Video Inks Deal To Present NFL Black Friday Game Worldwide By SVG Staff
Wednesday, October 22, 2025 - 10:06 am
Print This Story | Subscribe
Story ...
22/10/2025
NBA Tip-Off: ESPN Goes 1080p HDR End-to-End, Flipping HDR Switch on REMI and REM...
22/10/2025
FloSports Empowers Division II, III Athletic Departments With Turnkey Production...
22/10/2025
Wall Street Video Summit Debuts, Bringing Together 200 Financial Enterprise Vide...
22/10/2025
Dueling Pianos: International Chopin Piano Competition Is as Competitive as a Ba...
22/10/2025
The Orion spacecraft for NASA's Artemis II mission is stacked on the Space Launch System (SLS) rocket in High Bay 3 of the Vehicle Assembly Building at Kenn...
22/10/2025
L3Harris' Hybrid SATCOM is resilient by design, offering path diversity that eliminates vulnerabilities by routing data across the best available networks i...
22/10/2025
WASHINGTON, D.C. Organizers of NAB Show New York said they are expecting more than 12,000 registered attendees from about 100 countries along with 260 exhibitor...
22/10/2025
WASHINGTON, D.C The organizers of The 2025 NAB Show New York have announced that they are expecting more than 12,000 registered attendees from about 100 countr...
22/10/2025
Masque Sound, a leading theatrical sound reinforcement, installation and design company, supplied an extensive gear package of professional-grade equipment for ...
22/10/2025
Lightware, a global leader in signal management and AV connectivity solutions, is seeing strong market momentum for the UCX-3x3-TPX-RX20, a compact transmitter-...
22/10/2025
MELVILLE, N.Y. Chyron has released PAINT 10.2, the latest update for its telestration platform, adding support for SMPTE ST 2110 IP workflows, expanding brandin...
22/10/2025
WASHINGTON Run3TV today said NBCUniversal is joining as an investor in the ATSC 3.0 Framework Authority, which develops the Run3TV NextGen TV application platfo...
22/10/2025
ATLANTA swXtch.io will feature two new networking solutions extending the company's reach across more cloud and on-prem workflows at NAB Show New York, set ...
22/10/2025
The Warner Bros. Discoverys HBO Max streaming services has increased prices for all its streaming tiers effectively immediately for new customers. Existing cust...
22/10/2025
LOS ANGELES OpenDrives has signed a new distribution partnership deal with Versatile Distribution Services (VDS) to strengthen its channel and streamline how it...
22/10/2025
WASHINGTON, D.C The organizers of The 2025 NAB Show New York have announced that they are expecting more than 12,000 registered attendees from about 100 countr...
22/10/2025
Samora Pinderhughes Brings Immersive Sound to Berklee's Signature Series The artist and composer, who's worked with Herbie Hancock, Robert Glasper, Co...
22/10/2025
BMI Day at Berklee Celebrates Composer Fil Eisler and Awards Scholarship to Stud...
22/10/2025
October 22nd, 2025 TRIBECA ANNOUNCES STAR-STUDDED LINEUP OF MEMBERSHIP EVENTS F...
22/10/2025
European Broadcaster Upgrades To Grass Valley's NativeIP LDX 135 Cameras And...
21/10/2025
NAB New York 2025: Although AES Show Is on Its Own, Audio Will Be a Major Part o...
21/10/2025
NAB New York 2025: Business of Broadcast and Media,' Future of Content'...
21/10/2025
SVG All-Stars: Ethan Folz, Senior Director, Digital Operations and Quality of Ex...
21/10/2025
NBA on NBC/Peacock: Livestream Offers Graphic Overlays, Predictive Gaming, Ancil...
21/10/2025
NBA on NBC/Peacock: At the Front Bench With Producer Frank DiGraci and Director ...
21/10/2025
NBA on NBC/Peacock: NBC Sports, NEP Build Ultra-Flexible Production Plan That Se...
21/10/2025
Indigenous storytelling has been at the heart of the work of the Sundance Instit...
21/10/2025
Top L-R: Mysterious Skin, American Dream Second Row L-R: Little Miss Sunshine, D...
21/10/2025
Critical Design Review completion is a key milestone on the path toward Wideband Global Satellite Communications certification for the network in 2026, opening ...
21/10/2025
New Australian undersea training range to implement and improve warfighting tactics, proficiency and safety; enable joint/allied training that contributes to pr...
21/10/2025
September, the beginning of autumn, brought an expected revival to the TV market, largely due to the new fall TV schedules. The time spent in front of the TV sc...
21/10/2025
Broadcast Booms with 20% Uptick vs. August, Achieving Largest Monthly
Increase ...
21/10/2025
During September, streaming's share of TV viewing in Mexico settled at 24.5%, a marginal shift of -0.5 share points from the previous month.
Disclaimer: YU...
21/10/2025
RENNES, France BBright and GlobalM have conducted a technical trial validating Ultra HD interoperability across the entire contribution chain in the cloud, achi...
21/10/2025
Kokusai Denki Electric America will mark the U.S. debut of a new 4K camera at the 2025 NAB New York, Oct. 22-23. Now available, the Z-HD6500-S1 UHD/HD productio...
21/10/2025
Triveni Digital, a trusted leader in ATSC 1.0 and 3.0 service delivery, data broadcasting, and quality assurance solutions, will showcase its entire NEXTGEN TV ...
21/10/2025
Radio Azzurra FM, longest-running radio station in the province of Novara, northwest Italy, has invested in an DHD SX2 audio routing and mixing console for inte...
21/10/2025
Globecast, the leading provider of broadcast, media and entertainment managed services, has announced the appointment of G Morgan as Executive Vice President of...
21/10/2025
Visual Data announces the appointment of Maz Al-Jumaili as Senior Vice President, Worldwide Localization, to advance client engagement, strategic partnerships, ...
21/10/2025
As Amazon's Prime Video prepares to launch its coverage of NBA basketball under a major new deal, Grup Mediapro has announced that it is working with the st...
21/10/2025
ATLANTA Good news for consumers using an Atlanta DTH receiver to watch ATSC 3.0: with a new software update, they will be able to blanket their homes with Wi-Fi...
21/10/2025
While recent news has been heavily focused on Hispanic migration into the U.S., The 2025 Hispanic Market Report from Claritas highlights the fact that this gr...
21/10/2025
MAIDENHEAD, UK RWS has hired Michael Wayne as its head of media and entertainment in Los Angeles where he will lead the company's media localization busines...
21/10/2025
Imagine Communications and Rohde & Schwarz today announced a definitive agreement under which Imagine will acquire Pixel Power Limited, a wholly owned subsidiar...
Scripps Research chemists develop new sustainable reaction for creating unique molecular building blocks The building blocks can be used to create polymers with previously unexplored structures and fine-tunable properties, with applications across energy storage and more. 
