Scripps Florida Scientists Awarded Grant to Develop New Diagnostics for Cancer, Rheumatoid Arthritis, Colitis JUPITER, FL, May 1, 2014 Scientists from the Florida campus of The Scripps Research Institute (TSRI) have been awarded a $2.3 million grant from the National Institute of General Medical Sciences of the National Institutes of Health to develop new technology to diagnose cancer, rheumatoid arthritis and colitis.
Paul Thompson, a TSRI associate professor, will be the primary principal investigator for the four-year study.
We've already identified a number of biomarkers for rheumatoid arthritis that we're in the process of validating, Thompson said. The platform we are developing is faster and more versatile than existing technologies.
Such biomarkers could allow for better, more individually tailored treatments because they could be used to diagnose and monitor disease progression or remission as patients experience different treatment options.
At the heart of the new study is a unique group of enzymes known as protein arginine deiminases (PAD). An increase in PAD activity has been noted in a number of conditions, such as inflammatory diseases like rheumatoid arthritis as well as cancer and Alzheimer's disease.
PADs participate in reactions in the body that form the amino acid citrulline in proteins through a process known as citrullination, a modification that can have a significant impact on the structure and function of the modified proteins. While the exact role of citrullination remains unknown, inhibition of citrullination in animal models, using a compound developed by Thompson, has been shown to alleviate the severity of rheumatoid arthritis, ulcerative colitis, atherosclerosis, lupus, nerve damage and cancer.
In addition to developing biomarkers, the scientists will use the grant to better understand this modification and whether it provides a common link among these disparate diseases.
The number of the grant is 1R01GM110394-01.
About The Scripps Research Institute
The Scripps Research Institute (TSRI) is one of the worlds largest independent, not-for-profit organizations focusing on research in the biomedical sciences. TSRI is internationally recognized for its contributions to science and health, including its role in laying the foundation for new treatments for cancer, rheumatoid arthritis, hemophilia, and other diseases. An institution that evolved from the Scripps Metabolic Clinic founded by philanthropist Ellen Browning Scripps in 1924, the institute now employs about 3,000 people on its campuses in La Jolla, CA, and Jupiter, FL, where its renowned scientists including three Nobel laureates work toward their next discoveries. The institutes graduate program, which awards PhD degrees in biology and chemistry, ranks among the top ten of its kind in the nation. For more information, see www.scripps.edu.
# # #
For information:
Office of Communications
Tel: 858-784-2666
Fax: 858-784-8136
press@scripps.edu
Most recent headlines
05/01/2027
Worlds first 802.15.4ab-UWB chip verified by Calterah and Rohde & Schwarz to be ...
01/06/2026
January 6 2026, 05:30 (PST) Dolby Sets the New Standard for Premium Entertainment at CES 2026
Throughout the week, Dolby brings to life the latest innovatio...
01/05/2026
January 5 2026, 18:30 (PST) NBCUniversal's Peacock to Be First Streamer to ...
01/04/2026
January 4 2026, 18:00 (PST) DOLBY AND DOUYIN EMPOWER THE NEXT GENERATON OF CREATORS WITH DOLBY VISION
Douyin Users Can Now Create And Share Videos With Stun...
12/01/2026
Sports and Music Unite: A Look Back at the Operationally Ambitious FIFA Club Wor...
12/01/2026
Nielsen Panel Discussion Highlights World Cup Impact for FOX, Telemundo, MetLife...
12/01/2026
FIFA President Infantino Highlights How AI Will Impact 2026 FIFA World Cup and B...
12/01/2026
Baltimore Ravens' Jack Dana on Telling a Better Story With Media Management ...
12/01/2026
FOX Sports' Brad Cheney on Spectrum Debate's Impact on the Sports-Produc...
12/01/2026
Spotify's new co-CEOs, Alex Norstr m and Gustav S derstr m, start off the new year with a message of renewed leadership, creative responsibility, and what&#...
12/01/2026
At Spotify, we listen to a lot of music. And every year, our global editors and artist partnerships teams come together to spotlight the emerging voices we beli...
12/01/2026
Spotify's global editors and Songwriter & Publisher Partnerships team spend their days immersed in new music, tracking the writers behind the songs breaking...
12/01/2026
Nominations open for the fifth Australia for UNHCR - SBS Les Murray Award for Re...
12/01/2026
Australia and New Zealand VP Alan Clements shares L3Harris' leadership insig...
12/01/2026
Share Share by:
Copy link
Facebook
X
Whatsapp
Pinterest
Flipboard...
12/01/2026
Berklee International Folk Festival Celebrates 40 Years Featuring Grammy-winning alumna Arooj Aftab, the milestone concert and weeklong festival marks four de...
12/01/2026
Share Share by:
Copy link
Facebook
X
Whatsapp
Pinterest
Flipboard...
12/01/2026
Share Share by:
Copy link
Facebook
X
Whatsapp
Pinterest
Flipboard...
12/01/2026
X-Rite and Rhopoint Launch Rhopoint PANTORA Aesthetix to Streamline Creation of...
12/01/2026
12 Jan 2026
VEON's Kyivstar Launches 5G Pilot in Lviv Lviv, January 12, 2026 - VEON, a global digital operator (Nasdaq: VEON), today announces that Kyivsta...
12/01/2026
Monday 12 January 2026
The ultimate betrayal: Harry and Jamie Redknapp, Paul Me...
12/01/2026
Rohde & Schwarz opens larger office in Japan to increase its support for the Jap...
12/01/2026
Back to All News
WWE By the Numbers: Celebrating One Year on Netflix
From left to right: Rey Mysterio, Intercontinental Champion John Cena and Sheamus celebr...
12/01/2026
Welcome to the AVECO team: introducing new members of management
At AVECO, we are continuing to implement our #newAVECO strategy, which aims to build an even s...
12/01/2026
For the first time in the nine-year history of Dancing with the Stars, the first...
10/01/2026
By Bailey Pennick
One of the most exciting things about the Sundance Film Festi...
10/01/2026
This year, podcasts are making their Golden Globes debut with a new category honoring the medium's leading shows and creators. To mark the occasion, Spotify...
10/01/2026
Share Share by:
Copy link
Facebook
X
Whatsapp
Pinterest
Flipboard...
10/01/2026
Back to All News
Connection and Youth Defined: The Ramparts of Ice Brings a Hea...
09/01/2026
Rock-It Sports' Deron Brown & Laura Rowlands on Launching a New Brand, Suppl...
09/01/2026
Warner Bros. Discovery's Chris Brown on the Broadcaster's First French O...
09/01/2026
NFL Playoffs 2026: CBS Sports Travels to Jacksonville With Packed Arsenal of Pro...
09/01/2026
NFL Playoffs 2026: NBC Sports Is Set To Roll Out New Scorebar, Insert Graphics T...
09/01/2026
NFL Playoffs 2026: Prime Video Production Team Caps Historic Season With Iconic ...
09/01/2026
NFL Playoffs 2026: FOX Sports Kicks Off Postseason Slate With Two-Game Wild Card...
09/01/2026
NFL Playoffs 2026: ESPN's Run Brings Monday Night Football' Flagship Op...
09/01/2026
Share Share by:
Copy link
Facebook
X
Whatsapp
Pinterest
Flipboard...
09/01/2026
Share Share by:
Copy link
Facebook
X
Whatsapp
Pinterest
Flipboard...
09/01/2026
SMPTE , the home of media professionals, technologists, and engineers, today introduced the board officers and regional governors who will serve terms beginning...
09/01/2026
Globecast, the leading provider of broadcast, media and entertainment managed services, today announced the appointment of Chris Pulis as Group Chief Technology...
09/01/2026
The Hollywood Professional Association (HPA) today announced several updates to its board of directors. As part of HPA s annual governance cycle, new leadership...
09/01/2026
SDVI, the leading platform provider for cloud-native media supply chains, today announced that Simon Eldridge has been appointed chief operating officer. In thi...
09/01/2026
Cobalt Digital, the leading designer and manufacturer of award-winning ST 2110 and SDI signal processing products, and a founding partner in the openGear initi...
09/01/2026
iWedia, a global leader in connected TV software solutions, announces that its market-proven ATSC 3.0 software stack is powering the broadcast functionality of ...
09/01/2026
Amino, a global leader in enterprise video and digital signage technology, today announced a strategic partnership with Xibo, a leading global digital signage s...
09/01/2026
Share Share by:
Copy link
Facebook
X
Whatsapp
Pinterest
Flipboard...
09/01/2026
Share Share by:
Copy link
Facebook
X
Whatsapp
Pinterest
Flipboard...
09/01/2026
Share Share by:
Copy link
Facebook
X
Whatsapp
Pinterest
Flipboard...
09/01/2026
Share Share by:
Copy link
Facebook
X
Whatsapp
Pinterest
Flipboard...
Scripps Florida Scientists Awarded Grant to Develop New Diagnostics for Cancer, Rheumatoid Arthritis, Colitis JUPITER, FL, May 1, 2014 Scientists from the Florida campus of The Scripps Research Institute (TSRI) have been awarded a $2.3 million grant from the National Institute of General Medical Sciences of the National Institutes of Health to develop new technology to diagnose cancer, rheumatoid arthritis and colitis.
