
Generative AI has revolutionized software development with prompt-based code generation - protein design is next.
EvolutionaryScale today announced the release of its ESM3 model, the third-generation ESM model, which simultaneously reasons over the sequence, structure and functions of proteins, giving protein discovery engineers a programmable platform.
The startup, which emerged from the Meta FAIR (Fundamental AI Research) unit, recently landed funding led by Lux Capital, Nat Friedman and Daniel Gross, with investment from NVIDIA and Amazon.
At the forefront of programmable biology, EvolutionaryScale can assist researchers in engineering proteins that can help target cancer cells, find alternatives to harmful plastics, drive environmental mitigations and more.
EvolutionaryScale is pioneering the frontier of programmable biology with the scale-out model development of ESM3, which used NVIDIA H100 Tensor Core GPUs for the most compute ever put into a biological foundation model. The 98 billion parameter ESM3 model uses roughly 25x more flops and 60x more data than its predecessor, ESM2.
The company, which developed a database of more than 2 billion protein sequences to train its AI model, offers technology that can provide clues applicable to drug development, disease eradication and, literally, how humans have evolved at scale as a species - as its name suggests - for drug discovery researchers.
Accelerating In Silico Biological Research With ESM3 With leaps in training data, EvolutionaryScale aims to accelerate protein discovery with ESM3.
The model was trained on almost 2.8 billion protein sequences sampled from organisms and biomes, allowing scientists to prompt the model to identify and validate new proteins with increasing levels of accuracy.
ESM3 offers significant updates over previous versions. The model is natively generative, and it is an all to all model, meaning structure and function annotations can be provided as input rather than just as output.
Once it's made publicly available, scientists can fine-tune this base model to construct purpose-built models based on their own proprietary data. The boost in protein engineering capabilities due to ESM3's large-scale generative training across enormous amounts of data offers a time-traveling machine for in silico biological research.
Driving the Next Big Breakthroughs With NVIDIA BioNeMo ESM3 provides biologists and protein designers with a generative AI boost, helping improve their engineering and understanding of proteins. With simple prompts, it can generate new proteins with a provided scaffold, self-improve its protein design based on feedback and design proteins based on the functionality that the user indicates. These capabilities can be used in tandem in any combination to provide chain-of-thought protein design as if the user were messaging a researcher who had memorized the intricate three-dimensional meaning of every protein sequence known to humans and had learned the language fluently, enabling users to iterate back and forth.
In our internal testing we've been impressed by the ability of ESM3 to creatively respond to a variety of complex prompts, said Tom Sercu, co-founder and VP of engineering at EvolutionaryScale. It was able to solve an extremely hard protein design problem to create a novel Green Fluorescent Protein. We expect ESM3 will help scientists accelerate their work and open up new possibilities - we're looking forward to seeing how it will contribute to future research in the life sciences.
EvolutionaryScale will be opening an API for closed beta today and code and weights are available for a small open version of ESM3 for non-commercial use. This version is coming soon to NVIDIA BioNeMo, a generative AI platform for drug discovery. The full ESM3 family of models will soon be available to select customers as an NVIDIA NIM microservice, run-time optimized in collaboration with NVIDIA, and supported by an NVIDIA AI Enterprise software license for testing at ai.nvidia.com.
The computing power required to train these models is growing exponentially. ESM3 was trained using the Andromeda cluster, which uses NVIDIA H100 GPUs and NVIDIA Quantum-2 InfiniBand networking.
The ESM3 model will be available on select partner platforms, including Amazon Bedrock, Amazon Sagemaker, AWS HealthOMICs and NVIDIA BioNeMo.
See notice regarding software product information.
Most recent headlines
05/01/2027
Worlds first 802.15.4ab-UWB chip verified by Calterah and Rohde & Schwarz to be ...
04/08/2026
Dalet, a leading technology and service provider for media-rich organizations, t...
04/07/2026
April 7 2026, 19:00 (PDT) Detective Conan: Fallen Angel of the Highway Opens in...
01/06/2026
January 6 2026, 05:30 (PST) Dolby Sets the New Standard for Premium Entertainment at CES 2026
Throughout the week, Dolby brings to life the latest innovatio...
19/05/2026
Champaign, IL - March 16, 2026 Cobalt Digital, the leading designer and manufa...
19/05/2026
CHAMPAIGN, Ill. April 16, 2026 - Cobalt Digital today announced a partnership ...
19/05/2026
Las Vegas - April 18, 2026 Cobalt Digital, the leading designer and manufactur...
19/05/2026
LAS VEGAS April 18, 2026 - Advanced HDR by Technicolor and Cobalt Digital are ...
19/05/2026
LAS VEGAS - May 4, 2026 - Cobalt Digital, the leading designer and manufacturer of signal processing products, and a founding partner in the openGear initiativ...
19/05/2026
London - 11 May 2026 Cobalt Digital, the leading designer and manufacturer of award-winning signal processing products, and a founding partner in the openGear...
19/05/2026
eds3_5_jq(document).ready(function($) { $(#eds_sliderM519).chameleonSlider_2_1({ content_source:......
19/05/2026
Celebrating its ability to quickly adapt to changing requirements, Ross Production Services (RPS) has put its flexible infrastructure to good use, switching one...
19/05/2026
Share
Copy link
Facebook
X
Linkedin
Bluesky
Email...
19/05/2026
Share
Copy link
Facebook
X
Linkedin
Bluesky
Email...
19/05/2026
Grass Valley has entered into a three-year enterprise agreement with Phoenix Broadcast Solutions as the Singapore-based company expands its live production oper...
19/05/2026
Clear-Com supported Musikal Perahu Kertas, a large-scale musical theater production in Indonesia adapted from the acclaimed novel by Dee Lestari, through the d...
19/05/2026
Actus Digital, a LiveU company, and a leading provider of intelligent media monitoring and broadcast compliance platforms, announced today that METEO CONSULT ha...
19/05/2026
Globecast, a leading provider of managed services for the broadcast and media industry, today announced the completion of a major renovation of its Singapore fa...
19/05/2026
Following a major upgrade to its Connecticut remote production centre with the installation of three 60-fader Argo S consoles in 2023, RPS has switched one of t...
19/05/2026
PlayBox Technology today announced the launch of Celebro Play, a browser-based media orchestration platform designed specifically for broadcast facilities and p...
19/05/2026
Share
Copy link
Facebook
X
Linkedin
Bluesky
Email...
19/05/2026
Share
Copy link
Facebook
X
Linkedin
Bluesky
Email...
19/05/2026
Share
Copy link
Facebook
X
Linkedin
Bluesky
Email...
19/05/2026
Share
Copy link
Facebook
X
Linkedin
Bluesky
Email...
19/05/2026
LYNX Technik, provider of modular signal processing solutions for broadcast, post, and professional AV will showcase its latest signal processing solutions at B...
19/05/2026
Media Links, a leading developer and manufacturer of IP media transport solutions, has announced the integration of its Xscend platform with Skyline Communicat...
19/05/2026
Collaboration expands regional partner ecosystem as Media Links showcases IP media transport solutions on stand 4M4-4 and alongside Clearcast Asia on stand
Me...
19/05/2026
Company Highlights Labor-Saving Control and Custom Branding Opportunities Designed to Increase Integrator Profitability
LynTec, a leading manufacturer of ele...
19/05/2026
Mago Studio Moves AI Video Beyond Prompts with New Production-Focused Tools
Brie Clayton May 18, 2026
0 Comments
New Capabilities Bring Controllable, ...
19/05/2026
It May be Time to Stop and Take an AI Breather
Brie Clayton May 19, 2026
0 Comments
If the rock you stay on starts to roll, jump clean. Or you'll...
18/05/2026
Despite a bumpy start to the year, the provider of event-production support and ...
18/05/2026
Daktronics has partnered with the University of North Carolina to manufacture and install 11 LED displays totaling more than 10,000 square feet and more than 14...
18/05/2026
CBS LA has announced a multi-year partnership with the Los Angeles Rams, covering exclusive local broadcasts of Rams preseason games, weekly year-round programm...
18/05/2026
Skyline Communications has announced an integration between its DataMiner xOps p...
18/05/2026
eCLUTCH, the hybrid esports platform powered by iKOMG, has announced an expansion of its distribution across Europe, MENA, Africa, and Asia, along with new cont...
18/05/2026
Behind The Mic provides a roundup of recent news regarding on-air talent, includ...
18/05/2026
With 22 games this season, the production team looks forward to tweaking and enhancing the coverage
After 8,660 days off the air, the WNBA returned to NBC yest...
18/05/2026
(L-R) Midori Francis and Natalie Erika James attend the Saccharine premiere during the 2026 Sundance Film Festival at The Ray Theatre on January 22, 2026, in ...
18/05/2026
Last night, the Spotify Podcast Awards in Mexico returned to the country's capital. Now in its second year, the evening honors creators whose voices are hel...
18/05/2026
ZEN-Core synth goes mobile
Roland's powerful ZEN-Core software synthesizer has just been introduced to the iPad, offering a convenient entry point into ...
18/05/2026
Versatile new limiter plug-in announced
Based in Sheffield, UK, fedDSP offer a range of plug-ins that span the music production, live sound and high-end med...
18/05/2026
A new use for convolution?
Viiri Audio's debut plug-in aims to do something a little different with convolution processing, allowing users to adjust all...
18/05/2026
Delta Goodrem shines for SBS as more than 3.27 million Australians tune in for E...
18/05/2026
The Australian Defence Force uses L3Harris T4 and T7 robots for explosive ordnan...
18/05/2026
Continued investment across Europe and Germany is expanding local teams and improving access to stock, regional expertise, and specialist broadcast support.
CV...
18/05/2026
Agentic AI inference at one-tenth the cost per token with NVIDIA Vera Rubin NVL7...
18/05/2026
18 May 2026
Dubai and New York, May 18, 2026 - VEON Ltd. (NASDAQ: VEON), a glob...
18/05/2026
Monday 18 May 2026
Sky News offers ad-free podcasts and bonus episodes for just...
18/05/2026
Comscore March 2026 Consumer AI Chatbot Usage Rankings Show Claude Gaining Share OpenAI's ChatGPT maintains lead while Anthropic's Claude continues to c...
17/05/2026
Delta Goodrem's Eurovision Eclipse marks end of a stellar run
17 May, 2026
Media releases
Bulgaria wins Eurovision 2026
Relive every spellbinding mome...