Generative AI has revolutionized software development with prompt-based code generation - protein design is next.
EvolutionaryScale today announced the release of its ESM3 model, the third-generation ESM model, which simultaneously reasons over the sequence, structure and functions of proteins, giving protein discovery engineers a programmable platform.
The startup, which emerged from the Meta FAIR (Fundamental AI Research) unit, recently landed funding led by Lux Capital, Nat Friedman and Daniel Gross, with investment from NVIDIA and Amazon.
At the forefront of programmable biology, EvolutionaryScale can assist researchers in engineering proteins that can help target cancer cells, find alternatives to harmful plastics, drive environmental mitigations and more.
EvolutionaryScale is pioneering the frontier of programmable biology with the scale-out model development of ESM3, which used NVIDIA H100 Tensor Core GPUs for the most compute ever put into a biological foundation model. The 98 billion parameter ESM3 model uses roughly 25x more flops and 60x more data than its predecessor, ESM2.
The company, which developed a database of more than 2 billion protein sequences to train its AI model, offers technology that can provide clues applicable to drug development, disease eradication and, literally, how humans have evolved at scale as a species - as its name suggests - for drug discovery researchers.
Accelerating In Silico Biological Research With ESM3 With leaps in training data, EvolutionaryScale aims to accelerate protein discovery with ESM3.
The model was trained on almost 2.8 billion protein sequences sampled from organisms and biomes, allowing scientists to prompt the model to identify and validate new proteins with increasing levels of accuracy.
ESM3 offers significant updates over previous versions. The model is natively generative, and it is an all to all model, meaning structure and function annotations can be provided as input rather than just as output.
Once it's made publicly available, scientists can fine-tune this base model to construct purpose-built models based on their own proprietary data. The boost in protein engineering capabilities due to ESM3's large-scale generative training across enormous amounts of data offers a time-traveling machine for in silico biological research.
Driving the Next Big Breakthroughs With NVIDIA BioNeMo ESM3 provides biologists and protein designers with a generative AI boost, helping improve their engineering and understanding of proteins. With simple prompts, it can generate new proteins with a provided scaffold, self-improve its protein design based on feedback and design proteins based on the functionality that the user indicates. These capabilities can be used in tandem in any combination to provide chain-of-thought protein design as if the user were messaging a researcher who had memorized the intricate three-dimensional meaning of every protein sequence known to humans and had learned the language fluently, enabling users to iterate back and forth.
In our internal testing we've been impressed by the ability of ESM3 to creatively respond to a variety of complex prompts, said Tom Sercu, co-founder and VP of engineering at EvolutionaryScale. It was able to solve an extremely hard protein design problem to create a novel Green Fluorescent Protein. We expect ESM3 will help scientists accelerate their work and open up new possibilities - we're looking forward to seeing how it will contribute to future research in the life sciences.
EvolutionaryScale will be opening an API for closed beta today and code and weights are available for a small open version of ESM3 for non-commercial use. This version is coming soon to NVIDIA BioNeMo, a generative AI platform for drug discovery. The full ESM3 family of models will soon be available to select customers as an NVIDIA NIM microservice, run-time optimized in collaboration with NVIDIA, and supported by an NVIDIA AI Enterprise software license for testing at ai.nvidia.com.
The computing power required to train these models is growing exponentially. ESM3 was trained using the Andromeda cluster, which uses NVIDIA H100 GPUs and NVIDIA Quantum-2 InfiniBand networking.
The ESM3 model will be available on select partner platforms, including Amazon Bedrock, Amazon Sagemaker, AWS HealthOMICs and NVIDIA BioNeMo.
See notice regarding software product information.
Most recent headlines
11/12/2025
Dalet, a leading provider of cloud-native, end-to-end media workflow solutions, ...
20/11/2025
LONDON The winners of the Rise Awards 2025, which recognize women and companies whose achievements have stood out in the media technology industry, have been an...
20/11/2025
SANTA MONICA & NEW YORK Lionsgate's Worldwide Television Distribution Group and Debmar-Mercury have launched MovieSphere Gold in more than 30 million homes....
20/11/2025
ALAMEDA, Calif. Clear-Com has introduced its four-channel HelixNet beltpack, a next-generation advancement of its widely used two-channel model, and anticipates...
20/11/2025
NEW PROVIDENCE, N.J. Streaming technology and services provider Kiswe has launched Kiswe Core, a next-generation cloud-based platform designed to simplify the s...
20/11/2025
MOUNTAIN VIEW, Calif. Dolby Laboratories has signed on as an official signature partner of the Bay Area Host Committee (BAHC) for the 2026 Super Bowl and the we...
20/11/2025
STUTTGART, Germany 3 Screen Solutions (3SS) has announced that the Canadian multiservice operator Telus has launched its Telus TV+ entertainment platform on Sam...
20/11/2025
Major League Baseball has announced deals with ESPN, NBCUniversal and Netflix covering 2026-2028 that make ESPN the exclusive rightsholder of MLB.TV, see regula...
20/11/2025
Berklee Presents Holiday Extravaganza: Duke Ellingtons The Nutcracker Suite and ...
19/11/2025
Sphere Sound Kicks Up Its Heels at Radio City Music HallUltra-immersive system from the singular Las Vegas venue is also ready for sportsBy Dan Daley, Audio Edi...
19/11/2025
The Future of Stadium and Arena Video Control Rooms: Tech Leaders Talk 4K, IP, a...
19/11/2025
One Year at Intuit Dome: Walking Through the Stunning Arena's Advanced Video...
19/11/2025
SVG Sit-Down: IMG's Francois Westcombe Goes Inside IMG's Annual Digital ...
19/11/2025
Inside Brighton & Hove Albion's fan-first media machine By George Bevir
Tuesday, November 18, 2025 - 10:10
Print This Story
Brighton & Hove Albion'...
19/11/2025
Rock Chalk Rebuild, Part 1: Kansas Athletics Brings New Production Power to Rebu...
19/11/2025
Rock Chalk Rebuild, Part 2: A Pro's Guide to Kansas Athletics' New Video...
19/11/2025
MLB Media Rights Shakeup: NBC Inks Three-Year Deal for Sunday Night Baseball, Pe...
19/11/2025
Rohan Parashuram Kanawade attends the premiere of Sabar Bonda (Cactus Pears) at the 2025 Sundance Film Festival at Egyptian Theatre on January 26, 2025, in Pa...
19/11/2025
Awards season is heating up, and the International Documentary Association just ...
19/11/2025
Aerojet Rocketdyne President Ken Bedingfield and Arkansas Gov. Sarah Huckabee Sanders were joined by state and local officials to celebrate the groundbreaking o...
19/11/2025
L3Harris and PentenAmio formalise their teaming agreement at MilCIS 2025, streng...
19/11/2025
Calrec gives Phoenix Broadcast Solutions its full support in strategic multi-year enterprise partnership New Singapore OB company invests in Calrec technology f...
19/11/2025
October brings a larger audience in front of TV screens. The cooler autumn weather and the continuation of new programming schedules brought increases in both t...
19/11/2025
IRVING, Texas Nexstar Media Group and Tegna filed applications on Nov. 18 with the Federal Communications Commission (FCC) seeking its consent to transfer broad...
19/11/2025
Vitec has acquired Datapath, a developer of real-time video processing for large-scale video walls, AVoIP content distribution and KVM control in mission-critic...
19/11/2025
NEVADA CITY, Calif. Telestream has introduced ARGUS Version 2.3, which introduces Live Look, a feature that lets operators inspect live and on-demand streams vi...
19/11/2025
STAMFORD, Conn. and NEW YORK Charter Communications, Inc. has announced a major deal with Amazon Web Services (AWS) that establishes AWS as one of Charters stra...
19/11/2025
TOKYO Atomos has announced a major firmware update that brings integrated camera control to the Ninja TX GO and Ninja TX its new CFexpress-based monitor-recor...
19/11/2025
Berklee's Signature Series Reimagines the Musical and Visual Artistry of Col...
19/11/2025
PlayBox Neo departed the NAB Show New York 2025 on a high note. The company's all-new PlayBox Neo Suite made a splash on the show floor, drawing strong inte...
19/11/2025
AAVBR (American Audio Visual Baton Rouge), a leading full-service event production company serving Louisiana and the Gulf Coast region, has enhanced its product...
19/11/2025
In its mission to deliver live event services combining advanced engineering with a creative approach to captivating live sports and entertainment experiences, ...
19/11/2025
NEW YORK Short-form vertical video has exploded across platforms like TikTok, Instagram and YouTube, but a new survey commissioned by Media.net, a provider of c...
19/11/2025
NEW YORK YES Network, the regional sports network home of the New York Yankees and Brooklyn Nets, and CAMB.AI have struck a partnership they said will leverage ...
19/11/2025
WASHINGTON The Federal Communications Commission has issued detailed guidance on filings that were disrupted by the government shutdown. While many of those fil...
19/11/2025
NEW YORK The popularity of NFL games is largely responsible for continued seasonal momentum in TV viewership into October (measured Sept. 29-Oct. 26), according...
19/11/2025
DirecTV has announced that its MyFree DirecTV streaming service has added seven new channels. Those include four sports services, NBA FAST, Red Bull TV, DAZN Ri...
19/11/2025
SURREY, U.K. Mark Roberts Motion Control (MRMC) has launched Flair Bridge, a compact device that transforms how operators control the company's motion-contr...
19/11/2025
WASHINGTON The Federal Communications Commission, which is continuing to rapidly ramp up its operations after the end of the federal government shutdown, has se...
19/11/2025
IRVING, Texas Nexstar Media Group and Tegna filed applications on Nov. 18 with the Federal Communications Commission (FCC) seeking its consent to transfer broad...
19/11/2025
Martin Freeman, Jessie Buckley, Wu-Tang Clan's Raekwon, Eddie the Eagle and ...
19/11/2025
Rohde & Schwarz collaborates with Broadcom to enable testing and validation of n...
19/11/2025
Back to All News
Innato, starring Imanol Arias and Elena Anaya, arrives on Netf...
19/11/2025
Back to All News
Guillermo del Toro Sits Down With Troll 2 Director Roar Uthaug...
19/11/2025
Some projects feel monumental from the moment the first phone call comes in. When BCE, the host broadcaster appointed to coordinate the national coverage, asked...
19/11/2025
November 19 2025, 08:00 (PST) BAY AREA HOST COMMITTEE AND DOLBY PARTNER TO DELIVER IMMERSIVE FAN EXPERIENCES
During the Week of Football's Biggest Game...
19/11/2025
Michael D. Higgins: Ireland's Ninth President features RT Archives footage and interviews across seven decades
Watch Wednesday 19 November at 9:35pm on RT...
19/11/2025
Scripps Research scientists receive $1.1 million to advance AI modeling for HIV vaccine development New AI system helps scientists rapidly pinpoint the most pro...
18/11/2025
Independent media across Central America are operating under intensifying financial pressure, yet there is a clear appetite for models that can sustain both ind...
Generative AI has revolutionized software development with prompt-based code generation - protein design is next.
