Generative AI has revolutionized software development with prompt-based code generation - protein design is next.
EvolutionaryScale today announced the release of its ESM3 model, the third-generation ESM model, which simultaneously reasons over the sequence, structure and functions of proteins, giving protein discovery engineers a programmable platform.
The startup, which emerged from the Meta FAIR (Fundamental AI Research) unit, recently landed funding led by Lux Capital, Nat Friedman and Daniel Gross, with investment from NVIDIA and Amazon.
At the forefront of programmable biology, EvolutionaryScale can assist researchers in engineering proteins that can help target cancer cells, find alternatives to harmful plastics, drive environmental mitigations and more.
EvolutionaryScale is pioneering the frontier of programmable biology with the scale-out model development of ESM3, which used NVIDIA H100 Tensor Core GPUs for the most compute ever put into a biological foundation model. The 98 billion parameter ESM3 model uses roughly 25x more flops and 60x more data than its predecessor, ESM2.
The company, which developed a database of more than 2 billion protein sequences to train its AI model, offers technology that can provide clues applicable to drug development, disease eradication and, literally, how humans have evolved at scale as a species - as its name suggests - for drug discovery researchers.
Accelerating In Silico Biological Research With ESM3 With leaps in training data, EvolutionaryScale aims to accelerate protein discovery with ESM3.
The model was trained on almost 2.8 billion protein sequences sampled from organisms and biomes, allowing scientists to prompt the model to identify and validate new proteins with increasing levels of accuracy.
ESM3 offers significant updates over previous versions. The model is natively generative, and it is an all to all model, meaning structure and function annotations can be provided as input rather than just as output.
Once it's made publicly available, scientists can fine-tune this base model to construct purpose-built models based on their own proprietary data. The boost in protein engineering capabilities due to ESM3's large-scale generative training across enormous amounts of data offers a time-traveling machine for in silico biological research.
Driving the Next Big Breakthroughs With NVIDIA BioNeMo ESM3 provides biologists and protein designers with a generative AI boost, helping improve their engineering and understanding of proteins. With simple prompts, it can generate new proteins with a provided scaffold, self-improve its protein design based on feedback and design proteins based on the functionality that the user indicates. These capabilities can be used in tandem in any combination to provide chain-of-thought protein design as if the user were messaging a researcher who had memorized the intricate three-dimensional meaning of every protein sequence known to humans and had learned the language fluently, enabling users to iterate back and forth.
In our internal testing we've been impressed by the ability of ESM3 to creatively respond to a variety of complex prompts, said Tom Sercu, co-founder and VP of engineering at EvolutionaryScale. It was able to solve an extremely hard protein design problem to create a novel Green Fluorescent Protein. We expect ESM3 will help scientists accelerate their work and open up new possibilities - we're looking forward to seeing how it will contribute to future research in the life sciences.
EvolutionaryScale will be opening an API for closed beta today and code and weights are available for a small open version of ESM3 for non-commercial use. This version is coming soon to NVIDIA BioNeMo, a generative AI platform for drug discovery. The full ESM3 family of models will soon be available to select customers as an NVIDIA NIM microservice, run-time optimized in collaboration with NVIDIA, and supported by an NVIDIA AI Enterprise software license for testing at ai.nvidia.com.
The computing power required to train these models is growing exponentially. ESM3 was trained using the Andromeda cluster, which uses NVIDIA H100 GPUs and NVIDIA Quantum-2 InfiniBand networking.
The ESM3 model will be available on select partner platforms, including Amazon Bedrock, Amazon Sagemaker, AWS HealthOMICs and NVIDIA BioNeMo.
See notice regarding software product information.
North America Stories
26/03/2026
Extron and Audio-Technica have announced that their Design Solutions devices, Ce...
26/03/2026
SPORTEL Asia took place March 24-25 at the Orchard Hotel Singapore, drawing 370 participants representing more than 220 companies from 35 countries. Approximate...
26/03/2026
LTN will demonstrate satellite-to-IP migration solutions for broadcasters, cable networks, MVPDs, and station groups at NAB Show 2026 (Booth W2100).
The C-Ban...
26/03/2026
The Seattle Mariners have partnered with Daktronics to install an upgraded outfi...
26/03/2026
The Esports Foundation (EF) has awarded National Team Partner status to organizations and individuals across more than 100 countries and territories for the Esp...
26/03/2026
Telestream has announced expanded integration between its Vantage workflow platf...
26/03/2026
FOR-A Corporation has announced a partnership with Nippon TV and NVIDIA to distr...
26/03/2026
CBS Sports and the WNBA have expanded their partnership through a new long-term, multiplatform rights agreement. CBS Sports will feature up to 20 regular-season...
26/03/2026
Zac Brown Band will star in the Sunday Night Baseball show open on NBC and Peacock, NBC Sports announced. The open was filmed at American Family Field, home of ...
26/03/2026
Major League Baseball opens the 2026 season with nationally televised games across multiple media partners. Fans can visit MLB.com/Watch for a complete schedule...
26/03/2026
DIRECTV has announced an agreement to carry nine new MLB-operated team channels, covering the Cincinnati Reds, Detroit Tigers (Detroit SportsNet), Kansas City R...
26/03/2026
Nationals.TV, the Washington Nationals' local broadcast channel, is now avai...
26/03/2026
Starting Thursday, March 26, MLB.TV will be available on the ESPN App, giving fans access to more than 2,000 out-of-market regular season games. Fans can also r...
26/03/2026
By Matt Klein
Hello to everyone reading this - whether you're a current YEP, HPA member, or just YEP-curious. I'm Matt Klein, one of the co-chairs of t...
26/03/2026
Share
Copy link
Facebook
X
Linkedin
Bluesky
Email...
26/03/2026
Share
Copy link
Facebook
X
Linkedin
Bluesky
Email...
26/03/2026
Share
Copy link
Facebook
X
Linkedin
Bluesky
Email...
26/03/2026
28 participating companies, from start-ups to blue-chips, lead the UK Group as part of the GREAT Britain and Northern Ireland presence across all the Halls at N...
26/03/2026
Arkona Unveils BLADE//planner and Major Usability Enhancements at NAB 2026
Brie Clayton March 26, 2026
0 Comments
New graphical configuration tool and...
26/03/2026
Bitfocus showcases complete control at NAB Show 2026
Brie Clayton March 26, 2026
0 Comments
Continuing development drives advances in security, availa...
26/03/2026
Share
Copy link
Facebook
X
Linkedin
Bluesky
Email...
26/03/2026
Share
Copy link
Facebook
X
Linkedin
Bluesky
Email...
26/03/2026
Share
Copy link
Facebook
X
Linkedin
Bluesky
Email...
26/03/2026
Share
Copy link
Facebook
X
Linkedin
Bluesky
Email...
26/03/2026
Nevion introduces powerful new Panel Builder to enhance VideoIPath broadcast con...
26/03/2026
2026 Oscar Nominated Films Powered by Blackmagic Design
Brie Clayton March 25, 2026
0 Comments
DaVinci Resolve Studio used on 27 of this year's no...
26/03/2026
Leader to present full suite of advanced Test & Measurement solutions at NAB Sho...
26/03/2026
Boston Conservatory to Present New England and Collegiate Premiere of Groundbrea...
26/03/2026
Back to All News
Have a Wish Worth Dying For? Netflix's First Korean YA Hor...
26/03/2026
Back to All News
The Truthers, Starring Jose Coronado and St phanie Magnin, Pre...
26/03/2026
Editor's note: This post is part of Into the Omniverse, a series focused on ...
26/03/2026
That gaming backlog won't clear itself - GeForce NOW is here to help. Stream the latest titles straight from the cloud across a variety of devices.
This we...
25/03/2026
Live match directors Sarah Cheadle (Sky Sports), Rob Levi (TNT Sports), and Andrew Swift (BBC Sport) sit down with the Premier League's Rachel Nightingale t...
25/03/2026
The senior from Upstate New York is manning the mic while also interning for the athletic department's sports-information team
In the live-sports-video ind...
25/03/2026
Synamedia has announced ContentArmor Edge Watermarking, a server-side solution t...
25/03/2026
SES has announced meoSphere, a medium Earth orbit (MEO) satellite network targeted for operation by 2030. The first phase will pair SES-developed software-defin...
25/03/2026
TVU Networks is working with Reuters on a phased migration from satellite to a c...
25/03/2026
Nielsen has announced three senior appointments. Seth Ladetsky has been named Head of Global Sports. Trevor Fellows will lead Nielsen's advertiser and agenc...
25/03/2026
Anoki and Amagi have launched In-Scene Ads powered by Anoki ContextIQ across Amagi's portfolio of in-content ad formats for Free Ad-supported Streaming TV (...
25/03/2026
Arkona Technologies will announce a series of enhancements to its BLADE//runner platform at NAB 2026 (Booth C.1808). The updates focus on usability and workflow...
25/03/2026
Daktronics has installed two tower displays and a video wall in the Lexus Club at Petco Park in San Diego ahead of the 2026 season.
Continuing to improve the ...
25/03/2026
MultiDyne Video & Fiber Optic Systems is celebrating its 50th anniversary as NAB Show 2026 approaches. The company was founded in 1976 by Vincent Jachetta, an N...
25/03/2026
IPC, a provider of integrated communication solutions, will make its NAB 2026 de...
25/03/2026
Live production categories were led by NBC, FOX, and ESPN's NFL coverage...
25/03/2026
The Atlanta Braves and Spectrum have announced a multiyear distribution agreemen...
25/03/2026
(L-R) Charlie Tyrell and Daniel Roher attend The AI Doc: Or How I Became An Apocaloptimist Premiere during the 2026 Sundance Film Festival at The Ray Theatre ...
25/03/2026
L3Harris Technologies and RFTEQ Pty Ltd signed a memorandum of understanding to ...
25/03/2026
L3Harris delivers combat-ready Torpedo Tube Launch and Recovery system, which deploys and retrieves Iver4 900 autonomous underwater vehicles through submarine t...
25/03/2026
The company expands leadership team under Chief Revenue Officer Amilcar Perez
S...
Generative AI has revolutionized software development with prompt-based code generation - protein design is next.
