Generative AI has revolutionized software development with prompt-based code generation - protein design is next.
EvolutionaryScale today announced the release of its ESM3 model, the third-generation ESM model, which simultaneously reasons over the sequence, structure and functions of proteins, giving protein discovery engineers a programmable platform.
The startup, which emerged from the Meta FAIR (Fundamental AI Research) unit, recently landed funding led by Lux Capital, Nat Friedman and Daniel Gross, with investment from NVIDIA and Amazon.
At the forefront of programmable biology, EvolutionaryScale can assist researchers in engineering proteins that can help target cancer cells, find alternatives to harmful plastics, drive environmental mitigations and more.
EvolutionaryScale is pioneering the frontier of programmable biology with the scale-out model development of ESM3, which used NVIDIA H100 Tensor Core GPUs for the most compute ever put into a biological foundation model. The 98 billion parameter ESM3 model uses roughly 25x more flops and 60x more data than its predecessor, ESM2.
The company, which developed a database of more than 2 billion protein sequences to train its AI model, offers technology that can provide clues applicable to drug development, disease eradication and, literally, how humans have evolved at scale as a species - as its name suggests - for drug discovery researchers.
Accelerating In Silico Biological Research With ESM3 With leaps in training data, EvolutionaryScale aims to accelerate protein discovery with ESM3.
The model was trained on almost 2.8 billion protein sequences sampled from organisms and biomes, allowing scientists to prompt the model to identify and validate new proteins with increasing levels of accuracy.
ESM3 offers significant updates over previous versions. The model is natively generative, and it is an all to all model, meaning structure and function annotations can be provided as input rather than just as output.
Once it's made publicly available, scientists can fine-tune this base model to construct purpose-built models based on their own proprietary data. The boost in protein engineering capabilities due to ESM3's large-scale generative training across enormous amounts of data offers a time-traveling machine for in silico biological research.
Driving the Next Big Breakthroughs With NVIDIA BioNeMo ESM3 provides biologists and protein designers with a generative AI boost, helping improve their engineering and understanding of proteins. With simple prompts, it can generate new proteins with a provided scaffold, self-improve its protein design based on feedback and design proteins based on the functionality that the user indicates. These capabilities can be used in tandem in any combination to provide chain-of-thought protein design as if the user were messaging a researcher who had memorized the intricate three-dimensional meaning of every protein sequence known to humans and had learned the language fluently, enabling users to iterate back and forth.
In our internal testing we've been impressed by the ability of ESM3 to creatively respond to a variety of complex prompts, said Tom Sercu, co-founder and VP of engineering at EvolutionaryScale. It was able to solve an extremely hard protein design problem to create a novel Green Fluorescent Protein. We expect ESM3 will help scientists accelerate their work and open up new possibilities - we're looking forward to seeing how it will contribute to future research in the life sciences.
EvolutionaryScale will be opening an API for closed beta today and code and weights are available for a small open version of ESM3 for non-commercial use. This version is coming soon to NVIDIA BioNeMo, a generative AI platform for drug discovery. The full ESM3 family of models will soon be available to select customers as an NVIDIA NIM microservice, run-time optimized in collaboration with NVIDIA, and supported by an NVIDIA AI Enterprise software license for testing at ai.nvidia.com.
The computing power required to train these models is growing exponentially. ESM3 was trained using the Andromeda cluster, which uses NVIDIA H100 GPUs and NVIDIA Quantum-2 InfiniBand networking.
The ESM3 model will be available on select partner platforms, including Amazon Bedrock, Amazon Sagemaker, AWS HealthOMICs and NVIDIA BioNeMo.
See notice regarding software product information.
North America Stories
04/06/2026
Sony Electronics is introducing the SRG-AS10, a 4K 60p-compatible PTZ auto-frami...
04/06/2026
This recent grad from Spring, TX, led creative-video output for the Aggies' men's basketball team last season and has been producing video and creating ...
04/06/2026
For the first time at a women's golf major, every player in the field will r...
04/06/2026
Three Panasonic PT-RQ45 40,000-lumen 3-Chip DLP projectors made their first live...
04/06/2026
Bitmovin and Akamai have announced a collaboration with NRJ Group, a French mult...
04/06/2026
Telestream will exhibit at InfoComm 2026 (Booth N7952), demonstrating media work...
04/06/2026
Sony has announced the development of RIALTO 65, a 65mm format image sensor block for the VENICE 2 digital cinema camera, targeting release in the first half of...
04/06/2026
KOKUSAI DENKI Electric America will exhibit at InfoComm 2026 (Booth N8025, June ...
04/06/2026
Bell Media's TSN and RDS are the exclusive Canadian broadcasters of FIFA Wor...
04/06/2026
The Challenge: Receiving Heavy Media Files From Road Games Quickly and ReliablyT...
04/06/2026
MASV, a managed file transfer platform used in broadcast and live sports product...
04/06/2026
NESN has announced the appointment of Fahad Haider as Vice President of Operations and Engineering. Haider returns to NESN, where he previously served as Vice P...
04/06/2026
David J. Halberstam, who spent almost 50 years in sports as a broadcaster and an executive, died June 2 after a years-long battle with brain cancer.
Over his l...
04/06/2026
Although collegiate production programs are tasked with delivering high-quality ...
04/06/2026
California studio, two production trucks, global distribution system are combine...
04/06/2026
New global program empowers and supports storytellers through scriptwriting course and access to industry experts
TikTok and Sundance Institute today announce...
04/06/2026
Share
Copy link
Facebook
X
Linkedin
Bluesky
Email...
04/06/2026
Bitmovin, a leading provider of video streaming infrastructure, and Akamai, the cybersecurity and cloud computing company that powers and protects business onli...
04/06/2026
American Underground (AU), the Startup Hub of the South and a community of mor...
04/06/2026
Share
Copy link
Facebook
X
Linkedin
Bluesky
Email...
04/06/2026
Share
Copy link
Facebook
X
Linkedin
Bluesky
Email...
04/06/2026
Share
Copy link
Facebook
X
Linkedin
Bluesky
Email...
04/06/2026
Share
Copy link
Facebook
X
Linkedin
Bluesky
Email...
04/06/2026
Share
Copy link
Facebook
X
Linkedin
Bluesky
Email...
04/06/2026
Share
Copy link
Facebook
X
Linkedin
Bluesky
Email...
04/06/2026
Share
Copy link
Facebook
X
Linkedin
Bluesky
Email...
04/06/2026
Share
Copy link
Facebook
X
Linkedin
Bluesky
Email...
04/06/2026
NVIDIA and Microsoft Reinvent Windows PCs for the Age of Personal AI
Brie Clayton June 3, 2026
0 Comments
RTX Spark - a 1-Petaflop Superchip, the Full...
04/06/2026
Inside the Peaky Blinders: The Immortal Man Grade
Brie Clayton June 3, 2026
0 Comments
Simone Grattarola discusses shaping the look in DaVinci Resolve...
04/06/2026
Cine Gear Expo Announces 2026 Awards of Excellence Recipients
Brie Clayton June 3, 2026
0 Comments
Ed Lachman ASC, Caleb Deschanel ASC, and M. David M...
04/06/2026
St. Vincents Live with Orchestra Tour to Feature Berklee Alum Ruby Plume Berklee alumni St. Vincent and Ruby Plume will appear on the same bill across seven d...
04/06/2026
Back to All News
All the Truth in My Lies Coming to Netflix on August 28
Entertainment
04 June 2026
GlobalSpain
Link copied to clipboard
Download the imag...
04/06/2026
Back to All News
Larry Tanz, VP of Content, EMEA, Delivers a Keynote Speech at ...
04/06/2026
Back to All News
Turn Your Living Room into a Stadium With the New FIFA World ...
04/06/2026
Keeping conversations real on LinkedIn Published on Jun 4, 2026 Categories: Product News
LinkedIn Corporate Communications
Share
LinkedIn
Facebook ...
04/06/2026
June's forecast with GeForce NOW: 100% chance of gaming.
GeForce NOW is lining up new adventures for the month, from big-name blockbusters to quirky indies...
03/06/2026
SES and Viva, Mexico's ultra low-cost airline, have launched multi-orbit satellite inflight connectivity on Viva's Airbus aircraft. A total of 60 A320s ...
03/06/2026
The College Football Playoff, ESPN, and TNT Sports have announced kick times and...
03/06/2026
RED Digital Cinema will exhibit at Cine Gear Expo 2026 (Booth 33, June 5-6, Universal Studios Lot), hosting three panels and hands-on product demonstrations.
P...
03/06/2026
Roku has announced the Soccer Zone, a dedicated hub for FIFA World Cup 2026 content available across the United States, Canada, Mexico, Brazil, Colombia, Argent...
03/06/2026
Liverpool FC and Wasabi Technologies have announced a multi-year extension of their partnership, with Wasabi continuing as the club's official cloud storage...
03/06/2026
Grass Valley has announced that Australian News Channel (ANC), operator of Sky News Australia, has deployed Grass Valley AMPP as part of the relocation of its n...
03/06/2026
The Riedel Group has announced the appointment of Gudrun Scharler as CEO of Riedel Networks. She succeeds Michael Martens, who has led Riedel Networks since 201...
03/06/2026
Clear-Com has announced the deployment of its intercom solutions at Itaka Arena ...
03/06/2026
Scott Coker has announced six senior executive appointments for his new global MMA promotion, which launched earlier this year with $60 million in financing. Ad...
03/06/2026
Telemundo, the exclusive Spanish-language home of the FIFA World Cup 2026, has announced its digital and social media programming for the tournament, running Ju...
03/06/2026
The Bundesliga has announced the launch of Captain, an AI assistant built into t...
03/06/2026
Anthony James Partners (AJP) is serving as technology consultant for a moderniza...
03/06/2026
Audio-Technica has announced the recipients of its annual sales rep firm awards for the 2025-26 fiscal year. The awards were presented by Jim Schanz, Executive ...
Generative AI has revolutionized software development with prompt-based code generation - protein design is next.
