Nanoparticle vaccine for COVID-19 spurs robust immune response in preclinical tests The novel vaccine technology, developed at Scripps Research, uses virus-like protein nanoparticles to elicit high levels of protective antibodies.
September 21, 2020
LA JOLLA, CA In a new study that demonstrates the promise of a novel vaccine approach for COVID-19, Scripps Research scientist Jiang Zhu, PhD, showed that his protein nanoparticle technology successfully triggered a strong immune response in mice. Zhu, who co-founded the spinoff company Ufovax to commercialize the technology and manufacturing platform, says he hopes to advance the vaccine into clinical trials early next year.
The nanoparticle vaccine technology leverages a unique design that's unlike the majority of other COVID-19 vaccine candidates now in clinical testing. Each nanoparticle in the vaccine mimics the natural ball-like shape of a virus, which the immune system is trained to immediately recognize, explains Zhu, associate professor in the Department of Integrative Structural and Computational Biology.
These microscopic spheres are then studded with spike proteins resembling those of the SARS-CoV-2 virus.
Spike proteins are the tools this virus uses to efficiently attach to and infect healthy cells, so we need the immune system to recognize them as the enemy, Zhu says. Our vaccine design enables immune cells to encounter these proteins in a more natural conformation embedded on a spherical particle so they'll know what to do when they face the virus in real life.
By contrast, most experimental COVID-19 vaccines rely on full-length spike proteins that have been modified to remain stable in the body as they interact with the immune system; they are not connected to a virus-like particle. Thus, they may not generate strong enough of an antibody response to prevent COVID-19, Zhu says.
In his pursuit of a safer and more effective path to COVID-19 immunity, Zhu designed spike proteins and attached them to the spherical protein nanoparticles through an elegant self-assembly process he says will ensure the forming a ball-shape particle of a fixed size and enable efficient vaccine production on an industrial scale.
Notably, as part of their work to optimize the spike protein, he and his team identified a problematic element of the spike called the HR2 stalk, which is a flexible hinge connecting the spike to the virus surface, and decided to delete that segment from spike proteins used in the vaccine.
The scientists then tested the nanoparticle vaccine against the altered spike protein known as S2P that's used in most other vaccines, as well as against their own engineered spike protein. To determine efficacy of each approach, they measured antibody responses in mice.
Zhu's nanoparticle vaccine elicited neutralizing antibodies at levels of up to ten times greater than the S2P spike proteins alone and induced critically needed T-cell immunity. The research appears in bioRxiv, an open-access repository of studies not yet published in a peer-reviewed scientific journal.
Our study provides a promising next-generation COVID-19 vaccine candidate that is ready for evaluation in human trials, Zhu says.
Zhu has previously used his nanoparticle technology to develop investigational vaccines for other infectious diseases including SARS, MERS, HIV, RSV, Ebola, malaria and tuberculosis.
The study, Self-assembling nanoparticles presenting receptor binding domain and stabilized spike as next-generation COVID-19 vaccines, was authored by Linling He, Xiaohe Lin, Ying Wang, Ciril Abraham, Cindy Sou, Timothy Ngo, Yi Zhang, Ian Wilson and Jiang Zhu.
The work was funded by the National Institutes of Health [AI129698 and AI140844] and Ufovax. Ufovax holds exclusive intellectual property rights to the technology and several vaccine products, including for COVID-19.
COVID-19 Zhu, Jiang
Most recent headlines
05/01/2027
Worlds first 802.15.4ab-UWB chip verified by Calterah and Rohde & Schwarz to be ...
09/10/2026
Share
Copy link
Facebook
X
Linkedin
Bluesky
Email...
09/10/2026
Share
Copy link
Facebook
X
Linkedin
Bluesky
Email...
09/10/2026
Share
Copy link
Facebook
X
Linkedin
Bluesky
Email...
09/10/2026
September 10 2026, 06:00 (PDT) Dolby Expands Dolby OptiView Platform with New Capabilities at IBC 2026
New Sports Intelligence helps providers better unders...
08/10/2026
Modern venues have come a long way since the tinny, echoing audio of the mid 20t...
08/10/2026
ESPN's first Super Bowl production will stream in English and Spanish on Disney+, while the ESPN App carries the full slate of game, ManningCast, studio, an...
08/10/2026
From high-school videoboards to War Eagle Productions, the Opelika native is learning how to lead shows and capture big moments
The future of live sports produ...
08/10/2026
The Television Academy and Prime Video have announced a six-year agreement making Prime Video the exclusive global home of the Emmy Awards beginning with the 20...
08/10/2026
Techex will exhibit at NAB Show New York 2026 (Booth 623, Javits Center, October...
08/10/2026
X Games has announced the appointment of Steve Rogers as Chief Operating Officer. Rogers previously served as COO of World Supercross and spent nearly a decade ...
08/10/2026
Fonn Group has appointed Trevor Spielmann as Sales Director for Germany, Austria, and Switzerland. Spielmann joins from EVS, where he held sales and business de...
08/10/2026
The flagship program will originate from major PG events with a four-camera production, live distribution across PGTV, social platforms
Perfect Game is bringin...
08/10/2026
Innovation rarely happens in a vacuum. More often, it happens at the point of collision: when worlds that have run on separate tracks begin to converge. That is...
08/10/2026
For decades, the production and broadcast services business has run on a familia...
08/10/2026
Uplynk, Zixi, BroadView Software, and Grass Valley have published The IP Converg...
08/10/2026
The NFL has announced the return of the Big Data Bowl, the league's analytics competition, now in its ninth year and again powered by AWS. Registration is o...
08/10/2026
Eutelsat has renewed its partnership with T l diffusion d'Alg rie (TDA), Algeria's national broadcasting network operator, for continued distribution of...
08/10/2026
Disney will livestream Super Bowl LXI on February 14, 2027, alongside the game's broadcast on ESPN and ABC. All Disney subscribers in the United States wi...
08/10/2026
RHStv and Red House Streaming have announced an expansion of their partnership w...
08/10/2026
Gray Media has announced a distribution agreement with TEGNA and DAZN to simulca...
08/10/2026
SVG readers can save 10% on registration and receive a complimentary Solutions H...
08/10/2026
PROTON Camera Innovations GmbH has been named a recipient of a 2026 Technology a...
08/10/2026
Industry leaders discuss real-world cloud workflows for live game production, pl...
08/10/2026
The next-gen audio technology joins Dolby Vision as part of Apple TV's immersive F1 experience...
08/10/2026
David France, Jesse Short Bull, Mato Wayuhi, N. Bird Runningwater, Jodi Archambau, Jhane Myers, Paul McGuire, Amber Morning Star Byars, Holly Macarro, Nick Tils...
08/10/2026
Dynamic panning plug-ins get an upgrade
Sound Particles have just announced major updates for two of their popular dynamic panning plug-ins. Energy Panner 2...
08/10/2026
New expandable instrument boasts full DMNO engine
UDO Audio have just announced the upcoming release of a new, expandable synth that packs the power of the ...
08/10/2026
Two new subwoofers added to monitoring line-up
ADAM Audio's monitoring range has just been expanded with two new DSP-equipped subwoofers, the Sub8 PRO a...
08/10/2026
eds3_5_jq(document).ready(function($) { $(#eds_sliderM519).chameleonSlider_2_1({ content_source:......
08/10/2026
Calrec gives broadcasters freedom of choice at NAB Show New York We're looking forward to meeting up with you all at NAB New York on 21st-22nd October.
Cal...
08/10/2026
Share
Copy link
Facebook
X
Linkedin
Bluesky
Email...
08/10/2026
Share
Copy link
Facebook
X
Linkedin
Bluesky
Email...
08/10/2026
Share
Copy link
Facebook
X
Linkedin
Bluesky
Email...
08/10/2026
Share
Copy link
Facebook
X
Linkedin
Bluesky
Email...
08/10/2026
Share
Copy link
Facebook
X
Linkedin
Bluesky
Email...
08/10/2026
Share
Copy link
Facebook
X
Linkedin
Bluesky
Email...
08/10/2026
Globecast, a leading provider of broadcast, media and entertainment managed services, will showcase its next generation of media orchestration services at NAB S...
08/10/2026
Clear-Com played a critical role in the production communications infrastructure for Rock in Rio 2026, one of the world's largest and most recognized music...
08/10/2026
Sohonet Launches ClearView Rush: A Leap Forward in Studio Review, Built for Crea...
08/10/2026
Share
Copy link
Facebook
X
Linkedin
Bluesky
Email...
08/10/2026
Share
Copy link
Facebook
X
Linkedin
Bluesky
Email...
08/10/2026
Share
Copy link
Facebook
X
Linkedin
Bluesky
Email...
08/10/2026
Share
Copy link
Facebook
X
Linkedin
Bluesky
Email...
08/10/2026
Ikegami announces a major expansion to its range of broadcast-quality live production cameras. Scheduled for introduction on Ikegami booth 708 at NAB New York, ...
08/10/2026
Calrec will be located at Booth 444.
Freedom to choose
The media landscape is evolving quickly, and the broadcasters best placed for what comes next will be...
08/10/2026
LiveU has announced that CRD Audiovisuel relied on LiveUs LU900Q intelligent production unit, with built-in native LiveU IQ (LIQ ) connectivity, to deliver live...
08/10/2026
Share
Copy link
Facebook
X
Linkedin
Bluesky
Email...
08/10/2026
Share
Copy link
Facebook
X
Linkedin
Bluesky
Email...
Nanoparticle vaccine for COVID-19 spurs robust immune response in preclinical tests The novel vaccine technology, developed at Scripps Research, uses virus-like protein nanoparticles to elicit high levels of protective antibodies.
