Low-sugar' vaccine can provide broad immunity against coronavirus variants Scripps Research chemistry professor Chi-Huey Wong presents results from his team's studies at the ACS Spring 2025 Digital Meeting.
March 25, 2025
- Press release written and provided by the American Chemical Society-
LA JOLLA, CA Sugar coatings aren't only for candies; they also help viruses, like the ones that cause COVID-19, hide from their hosts' immune system. Now, researchers have developed a universal vaccine that targets coronaviruses and the sugars that they use as cover. As demonstrated in animal studies, the vaccine removed sugar molecules from an area of a coronavirus spike protein that rarely mutates and created effective and plentiful antibodies to inactivate the virus.
Chi-Huey Wong, a chemistry professor at Scripps Research, will present results from his team's studies today at the ACS Spring 2025 Digital Meeting, a meeting of the American Chemical Society.
Wong says that the premise of this research is simple: It's an effective vaccine that targets more than one coronavirus at a time, which will allow individuals to receive a single shot for protection against multiple infectious agents. An ongoing Phase I clinical trial led by Rock Biotherapeutics has completed enrollment and dosing, and will be discussed by Wong during his ACS Spring 2025 Digital Meeting presentation.
For a lot of vaccines, like smallpox and tetanus, we only have to be immunized once, Wong says. But we have to take a flu shot every year. He adds that the high rate of mutation seen in the SARS-CoV- 2 virus specifically, the receptor binding domain on the virus' spike protein has led to an unprecedented number of COVID-19 vaccine updates.
The low-mutation region that Wong's team chose to target for the new vaccine is within the stalk region of the virus' spike protein. However, this stalk is coated with chains of sugar molecules called glycans from the host's cells. And the sugar coating keeps antibodies from recognizing, and therefore inactivating, the virus.
So, the researchers devised a low-sugar vaccine that removes the protective glycans through enzymatic digestion and creates antibodies that specifically target the low-mutation stalk region of the virus' spike protein, should the actual virus enter the body.
In animal studies with hamsters and mice, the universal vaccine created more diverse antibodies with higher titers (concentrations in the blood, where immune system cells travel throughout the body) compared to individual vaccines against variants of SARS-CoV, as well as MERS-CoV, the virus that causes Middle East respiratory syndrome. This improved and broadened the vaccine's protection. Wong says tPhhe team's new vaccine could also provide protection against coronaviruses that cause influenza and the common cold.
In addition to vaccines for viral infections, Wong's team is using the technique to develop vaccines for the treatment of various cancers. They recently published two studies on glycan targets on cancer cells and enzymes linked to the synthesis of glycans on cancer cells in the Journal of the American Chemical Society.
This research was funded by Academia Sinica.
Visit the ACS Spring 2025 program to learn more about this presentation, Development of low-sugar universal vaccines and glycoengineered antibodies with improved Fc-mediated killing and other science presentations.
COVID-19 Chemistry Immunology & Microbiology Wong, Chi-Huey
Most recent headlines
05/01/2027
Worlds first 802.15.4ab-UWB chip verified by Calterah and Rohde & Schwarz to be ...
07/10/2026
Dalet, a leading technology and service provider for media-rich organizations, today announced the latest Long-Term Supported (LTS) release of Dalet Flex. Build...
08/09/2026
Comcast Technology Solutions (CTS) has announced a multi-year agreement with A E...
08/09/2026
Spectra Logic today announced the availability of Media Insight, a new capabilit...
08/09/2026
Rogers Communications and Quebecor have announced a 12-year sublicensing agreement for French-language national NHL games beginning with the 2026-27 season. TVA...
08/09/2026
Skyline Communications and Bridge Technologies will demonstrate two integrations...
08/09/2026
Boland Communications will make the European debut of its 4K55HDR7SNB 55-inch super-narrow-bezel monitor at IBC2026 (Stand 12.C57, RAI Amsterdam, September 11-1...
08/09/2026
Ateme and Comcast Technology Solutions (CTS) have announced a collaboration comb...
08/09/2026
Haivision has joined the IBC Accelerator Media Innovation Programme as part of t...
08/09/2026
Blackmagic Design has announced price reductions on its PYXIS 6K and Cinema Camera 6K models, effective immediately through Blackmagic Design resellers worldwid...
08/09/2026
AI-Media will demonstrate its LEXI Suite at IBC2026 (Booth 5.C34, September 11-1...
08/09/2026
Bitmovin and Ad Insertion Platform (AIP) have announced the first live deploymen...
08/09/2026
Grass Valley will demonstrate story-centric media workflows at IBC2026 (Booth 9.A01, RAI Amsterdam, September 11-14), connecting newsroom production, content ma...
08/09/2026
M2A Media and Ateme have announced a partnership integrating Ateme's video processing solutions into M2A Media's MediaToAnywhere platform for live sport...
08/09/2026
Ikegami will exhibit at IBC2026 (Stand 12.A31, RAI Amsterdam, September 11-14), including a Day 1 introduction of new cameras in the UNICAM XE series. Additiona...
08/09/2026
Broadcast industry analysts will be gathering plenty of insights at the 2026 IBC Show this weekend in Amsterdam, but Caretta Research has offered up some though...
08/09/2026
SENSHI and DAZN have announced a global broadcast partnership that will bring SENSHI's live events free to viewers in more than 200 markets. The partnership...
08/09/2026
New architecture built with Evertz will bring 4K HDR to Monday Night Football, N...
08/09/2026
Built for rap producers, by rap producers
Sauceware Audio, the independent plug-in company founded by Grammy-nominated producer Jacob (Travis Scott, 21 Sava...
08/09/2026
Classic Sound Techniques design revived
Warm Audio's latest release delivers a meticulous recreation of the preamp circuitry employed by the Sound Techn...
08/09/2026
Latest soft synth inspired by the Memorymoog
XILS Lab have just launched a software instrument that draws its inspiration from Moog's iconic Memorymoog,...
08/09/2026
The Airport Chaplain takes off as SBS's biggest launch of 2026
8 September, 2026
Media releases
1.67 million viewers on National Total TV to date
Best...
08/09/2026
Share
Copy link
Facebook
X
Linkedin
Bluesky
Email...
08/09/2026
Mo-Sys, the world-leading developer of virtual production, camera robotics and image tracking technology, has completed a business restructuring, which has incl...
08/09/2026
New York, September 8, 2026 The TSAmediaHUB audiovisual contribution and distribution infrastructure developed by Telef nica's Audiovisual Services area re...
08/09/2026
Expanded Riyadh operation brings Asharq and Thmanyah services together on a resilient on-premises Pebble platform.
Pebble, the leading automation, content mana...
08/09/2026
Techex, a pioneering leader in live video workflows, will showcase its broadest software feature set to date at IBC 2026 (Stand 2.B45), extending its lead in so...
08/09/2026
Visitors to Grass Valley's booth at IBC2026 will be introduced to new Framelight X capabilities that connect content acquisition, management, editing and pu...
08/09/2026
BCNEXXT will showcase the latest evolution of Vipe at IBC2026 (Stand 2.B09), introducing a series of innovations designed to deliver higher-quality audience exp...
08/09/2026
Bitmovin, a provider of video streaming solutions, has partnered with Ad Insertion Platform (AIP), a leading innovator in advanced ad insertion technologies, to...
08/09/2026
Brainstorm, a leading manufacturer of real-time graphics and augmented and virtual production, is announcing a major package of enhancements to its Suite 7 soft...
08/09/2026
Big Blue Marble is supporting TDF, French infrastructure and network operator, broadcasting Digital Terrestrial Television (DTT) and radio services, as a techno...
08/09/2026
Agents work inside a single production environment, from incoming wire copy to a live studio show...
08/09/2026
Building on their strategic partnership, Ceeblue and Layercake make the unthinkable possible: scalable sub-second streaming over standard DRM, SSAI, and CDN wor...
08/09/2026
Brainstorm, a leading manufacturer of real-time graphics, augmented and virtual production, is completing the environment for fast-paced broadcast production wi...
08/09/2026
A SaaS portfolio built to work together, helping operators grow audiences, monetise smarter and run leaner, on their own terms
At IBC 2026 (stand 1.B49) Synam...
08/09/2026
Accedo, global provider of video streaming software and services, has been selected by PlayOn Sports, a national leader in high school sports technology, to exp...
08/09/2026
LiveU, the leader in live IP-video solutions, is enabling The Associated Press to take global newsgathering to the next stage with intelligent connectivity and ...
08/09/2026
Mediagenix, a global leader in smart content solutions to profitably connect the right content to the right audience, today announced the latest evolution of it...
08/09/2026
Compact, power-efficient X Platform performance brings broadcast-grade reliability and ultra-low latency to space-constrained remote production (REMI) workflows...
08/09/2026
Zixi, the leader in live video delivery and workflow orchestration, and Kiloview, a leading provider of professional IP video encoding and decoding solutions, t...
08/09/2026
Collaboration gives content owners scalable CDN capacity and broadcasters enhanced flexibility, including for C-band transition planning
Quortex today announce...
08/09/2026
Share
Copy link
Facebook
X
Linkedin
Bluesky
Email...
08/09/2026
Telos Alliance and Pluxbox Announce Dynamic Media Facility Integration Partnersh...
08/09/2026
J nger Audio Showcases Industry-First S-ADM Cloud Workflow at IBC 2026
Search
Dolby, MainConcept, Techex and J nger Audio will showcase the industry's ...
08/09/2026
Tuesday 8 September 2026
Sky Go gets a major upgrade for Sky Glass and Sky Stream customers
Today, Sky launches a new version of the Sky Go app for Sky Glass ...
08/09/2026
Documentary thriller simulating a Russian attack on UK soil will culminate in a live final episode reuniting the playersTuesday 8 September 2026
Trailer releas...
08/09/2026
Tuesday 8 September 2026
Jamie Demetriou and Amelia Dimoldenberg to host next t...
08/09/2026
Wuppertal September 8, 2026
Riedel Introduces New OnAir Headset PlatformRiedel Communications today announced the launch of its new OnAir headset platform, a...
Low-sugar' vaccine can provide broad immunity against coronavirus variants Scripps Research chemistry professor Chi-Huey Wong presents results from his team's studies at the ACS Spring 2025 Digital Meeting.
