Sony Pixel Power calrec Sony

February 21, 2019

22/02/2019

Electric car batteries inspire safer, cheaper way to manufacture compounds used in medicines

February 21, 2019

La Jolla, CA Recent advances in battery technology, from the engineering of their cases to the electrochemistry that takes place inside them, has enabled the rapid rise of Teslas, Leafs, Volts and other electric cars.

Now, scientists at Scripps Research, inspired by the refined electrochemistry of these batteries, have developed a battery-like system that allows them to make potential advancements for the manufacturing of medicines.

Their new method, reported February 22 in Science, avoids safety risks associated with a type of chemical reaction known as dissolving metal reduction, which is often used to produce compounds used in the manufacturing of medicines. Their method would offer tremendous advantages over current methods of chemical manufacturing, but until now, has largely been sidelined due to safety considerations.

The same types of batteries we use in our electric cars today were far too dangerous for commercial use a few decades ago, but now they are remarkably safe thanks to advances in chemistry and engineering, says Phil Baran, PhD, who holds the Darlene Shiley Chair in Chemistry at Scripps Research and is a senior author of the Science paper. By applying some of the same principles that made this new generation of batteries possible, we have developed a method to safely conduct powerfully reductive chemical reactions that have very rarely been used on a large scale because until now they were too dangerous or costly.

This could have a major impact on not only the manufacturing of pharmaceuticals, Baran adds, but also on the mindset of medicinal chemists who traditionally avoid such chemistry due to safety concerns. This problem was in fact brought to our attention by co-author Michael Collins, a medicinal chemist at Pfizer, for precisely this reason.

One of the most powerful reactions, and representative examples of this deeply reducing chemistry that chemists use to make new molecules is the Birch reduction, which was largely pioneered by Australian chemist Arthur Birch in the 1940s. This reductive reaction involves dissolving a reactive metal in liquid ammonia to manipulate ring-shaped molecules that can be used as the foundation for making many chemical products, including drug molecules.

The procedure calls for condensing ammonia or similar compounds, which are corrosive, toxic and volatile, and combining it with metals such as lithium that are prone to bursting into flames if exposed to air. The process must take place at extremely cold temperatures, requiring expensive equipment and specialists.

A rare example of the use of a dissolving metal reduction in pharmaceutical manufacturing is a compound that was previously in development at Pfizer, a remarkable achievement in chemical manufacturing that required a herculean effort. The system to produce the compound on a large scale required enough gaseous ammonia to fill three Boeing 747 airliners and must be conducted at -35 degrees Celsius. The lengths to which Pfizer went to utilize this chemistry are a testimony to the reaction's synthetic power.

To overcome these significant barriers to using such chemistry, Baran and his team looked to the advances made in battery manufacturing by joining forces with experts at the University of Utah, led by Shelley Minteer, PhD, and the University of Minnesota, led by Matthew Neurock, PhD.

The lithium-ion (Li-ion) batteries used in modern electronics such as mobile phones, laptop computers and electric cars rely on advances in an internal component called the solid electrolyte interphase (SEI). The SEI is a protective layer that forms on one of the electrodes inside a Li-ion when the battery is first charged and allows the battery to be recharged. Producing the safe and efficient batteries now used in consumer electronics relied on years of advances in optimizing the chemical conditions the composition of electrolytes, solvents and additives that produced the SEI.

The team noted that the reaction that forms the SEI in batteries is an electrochemical reaction akin to the Birch reaction and its relatives. They surmised that they could borrow from what battery makers had learned to pursue a safe and practical method of conducting an electroreduction reaction.

In many ways you're looking at similar situations powerful reactions that, when effectively harnessed, can provide tremendous utility, says Solomon Reisberg, a graduate student in the Baran lab and one of the co-authors on the Science paper. The team took advantage of the hard-won knowledge about the conditions that make reductive electrochemistry in batteries practical and used that knowledge to rethink how deeply reductive chemistry could be used on a large scale.

The Scripps Research team began by testing a range of additives used to prevent overcharging in Li-ion batteries and found that a combination of two, substances called dimethylurea and TPPA, made the Birch reaction possible at room temperature.

Testing various other materials used in batteries, Baran's team came up with a set of conditions that allowed them to not only conduct reductive electrosynthesis safely but also to increase the versatility of the reaction to create a wider variation of products that was not possible with previous electrochemical methods.

This method avoided the need for dissolving liquid metals in large quantities of ammonia and the associated cost and risks and instead used an electrolyte system similar to that used in batteries. In addition to the Birch reaction, the researchers were able to apply the technique to other types of powerful reactions often used in synthesis but rarely, if ever, used in industrial settings.

Chemists have been slow to adopt these electrosynthesis techniques,
LINK: https://www.scripps.edu/news-and-events/press-room/2019/20190221-baran...
See more stories from scripps

Most recent headlines

03/06/2024

Dalet and Veritone Reach Agreement to Distribute, Transact and Monetize Media Archives

Dalet, a leading technology and service provider for media-rich organizations, a...

28/04/2024

Mediahaus delivers the first SRT live-streaming sports production over 5G with URSA Broadcast G2

Mediahaus delivers the first SRT live-streaming sports production over 5G with U...

28/03/2024

ENCO to Add AI News Anchor to Qimera Virtual Production Set

NOVI, Mich. During the 2024 NAB Show, ENCO will be showcasing an AI-driven virtual anchor delivering live news from a realistic 3D virtual news set....

28/03/2024

Johan de Nysschen Named President and CEO of ARRI Americas

MUNICH ARRI has announced that Johan de Nysschen has been put in charge of the ARRI Americas team as president and CEO ARRI Americas Inc....

28/03/2024

Fubo Inks Carriage Deal with YES Network

NEW YORK The YES Network and FuboTV have reached a multi-year carriage agreement that will allow Fubo to launch YES in its Pro base channel plan in time for YES...

28/03/2024

Dalet to Demo AI-Enabled Production, Automation and Monetization at NAB 2024

PARIS Dalet has announced that during its 2024 NAB showcase (booth #W1713), attendees can experience firsthand Dalet's collaborative, AI-enabled workflows t...

28/03/2024

Blackmagic Design Used on 2024 Oscar Nominated Films

Blackmagic Design Used on 2024 Oscar Nominated Films Brie Clayton March 28, 2024 0 Comments Blackmagic Design congratulates the many film professional...

28/03/2024

Arkona to Introduce BLADE//master Control and Orchestration Service at NAB 2024

Arkona to Introduce BLADE//master Control and Orchestration Service at NAB 2024 Brie Clayton March 28, 2024 0 Comments New option for BLADE//runner ke...

28/03/2024

Join Maxon for NAB 2024

Join Maxon for NAB 2024 Brie Clayton March 28, 2024 0 Comments Maxon returns to NAB with presentations by artists from around the world and demos of t...

28/03/2024

Boston Conservatory to Present Center Stage Production of A Midsummer Night's Dream at The Huntington

Boston Conservatory to Present Center Stage Production of A Midsummer Night'...

28/03/2024

The 4K cameras giving audiences an astronaut's view of Earth

TVBEurope meets Charles Black, founder and CEO of Sen, which has sent a payload of 4K cameras to the ISS to livestream images of Earth to audiences around the w...

28/03/2024

2024 Big Night In Raises $145k to Support Triangle Arts Councils

Capitol Broadcasting and WRAL-TV once again proudly supported our local arts community with the broadcast of Big Night in for the Arts Thursday, March 7, 2024. ...

28/03/2024

JIC, MRC Announce Accord On Roles In Judging Measurement Companies

With more companies offering different approaches to measuring television viewing and campaign effectiveness, two of the groups that evaluate potential media bu...

28/03/2024

Hulu Added to Disney Plus App for Bundle Subscribers

The Walt Disney Co. said that it launched Hulu on Disney Plus, which makes Hulu programming available via the Disney Plus app....

28/03/2024

GroupM To Double Ad Spending On Women's Sports Programming

Giant media buyer GroupM said it plans to double its media spending on women's sports....

28/03/2024

Scripps Renews State Farm As Sponsor of Friday Night WNBA on Ion

Scripps Sports said that State Farm has signed a new multi-year agreement to continue as the title sponsor of Ion's Friday night WNBA telecasts....

28/03/2024

Elisabeth Moss, Kerry Washington Sign On for Imperfect Women' on Apple TV Plus

Elisabeth Moss and Kerry Washington will star in, and executive produce, Imperfe...

28/03/2024

Telemundo Station Group Addresses Climate Change With Month-Long Initiative

Telemundo Station Group launches the month-long climate change initiative Our Planet Thursday, March 28. The multiplatform campaign ends on Earth Day, April 22,...

28/03/2024

Circle City Broadcasting Renews Nielsen Ratings Deal

Nielsen said that Circle City Broadcasting, owner of WISH-TV in Indianapolis, has renewed its local TV measurement deal....

28/03/2024

Lionsgate Extends Deal With Seth Rogen's Point Grey Pictures

Lionsgate Television said it extended its deal with Point Grey Pictures, the production company led by Seth Rogen, Evan Goldberg and James Weaver....

28/03/2024

Ariana DeBose Back as Tonys Host

Ariana DeBose returns as host of the Tony Awards Sunday, June 16, on CBS and Paramount Plus. It is her third consecutive time hosting, and it will be the 77th T...

28/03/2024

The Steve Wilkos Show' Renewed for Season 18

The Steve Wilkos Show has been renewed for its 18th season in national syndication, Tracie Wilson, executive VP, NBCUniversal Syndication Studios & E! News, sai...

28/03/2024

Sinclair Selects Embrace as Its Media Orchestration Engine

PARIS Embrace, a developer of advanced automation and orchestration software solutions, has announced that Sinclair Broadcast Group has selected Embrace's P...

28/03/2024

Nielsen and Circle City Broadcasting Renew Local TV Measurement Deal

NEW YORK Nielsen has a multi-year renewal with Circle City Broadcasting, Indianas only locally owned and operated broadcast and digital news media network, for ...

28/03/2024

JVC to Demo Its First Ever 40x Zoom PTZ Camera Series at 2024 NAB Show

LAS VEGAS JVC Professional Video has announced that it will debut its new KY-PZ540 Series PTZ Cameras with 40x zoom at 2024 NAB Show (Booth C4720)....

28/03/2024

Brightcove Launches Cloud Playout 2.0

BOSTON Brightcove has announced the launch of Cloud Playout 2.0, a platform that the company said will offer customers new ways to create linear channels, monet...

28/03/2024

NBC Sports Chicago to Air First-Ever Animated Real-Time Local Sports Telecast

The Chicago Blackhawks and NBC Sports Chicago have announced a collaboration with the NHL to bring fans the first-ever local animated real-time sports telecast....

28/03/2024

The Best News Coverage is Real, Live, Balanced, Professional

The Best News Coverage is Real, Live, Balanced, Professional Andy Marken March 28, 2024 0 Comments Hero image source News of the World, Perfect Wo...

28/03/2024

Tonight on House of Zwide: Zanele informs Zola of her pregnancy

Tonight on House of Zwide: Zanele informs Zola of her pregnancyDon't miss Thursday, 28 March's riveting episode of South African soapie House of Zwide o...

28/03/2024

Tonight on Umkhokha: MaMzobe outsmarts Gabisile but Difa's suspicion rises

Tonight on Umkhokha: MaMzobe outsmarts Gabisile but Difa's suspicion risesDon't miss Thursday, 28 March's riveting episode of South African soapie U...

28/03/2024

Tonight on Uzalo: Mbatha wins Linda Sibiya over

Tonight on Uzalo: Mbatha wins Linda Sibiya overDon't miss Wednesday, 27 March's riveting episode of South African soapie Uzalo on SABC 1 on DStv channel...

28/03/2024

Greater Scope: Doctors Get Inside Look at Gut Health With AI-Powered Endoscopy

From humble beginnings as a university spinoff to an acquisition by the leading global medtech company in its field, Odin Vision has been on an accelerated jour...

28/03/2024

Generations: The Legacy - Wednesday's episode, 27 March 2024 [VIDEO]

Generations: The Legacy - Wednesday's episode, 27 March 2024 [VIDEO]Stay up to date with the latest episodes of your favourite South African soapie on The S...

28/03/2024

Prison Journalism: Witness the Cycle from the Streets

Prison Journalism: Witness the Cycle from the StreetsWesley Leong was incarcerated at the age of 15 in 1996 at Pollsmoor Prison. He is currently part of Restore...

28/03/2024

Prison Journalism: Inmate pre-release and release processes

Prison Journalism: Inmate pre-release and release processesDean Mashimbwe, a Zimbabwean migrant residing in Cape Town, was incarcerated at Pollsmoor Correctiona...

28/03/2024

Streaming today: When You Finish Saving The World' on Netflix - 28 March 2024

Streaming today: When You Finish Saving The World' on Netflix - 28 March 20...

28/03/2024

Prison Journalism: The Story of Paulus

Prison Journalism: The Story of PaulusDavid van Nek was incarcerated in Pollsmoor Prison from 2013 until 2015 and participated in the restorative justice progra...

28/03/2024

Prison Journalism: Inside and Outside

Prison Journalism: Inside and OutsideFawaaz Adendorff was incarcerated in Pollsmoor Correctional Centre and participated in a Restorative Justice programme whil...

28/03/2024

Tonight on Muvhango: Imani escapes Khumo's hellhole

Tonight on Muvhango: Imani escapes Khumo's hellholeDon't miss Thursday, 28 March's riveting episode of South African soapie Muvhango on SABC 2 on DS...

28/03/2024

Tonight on Generations: Kea can sense her brother is hiding something

Tonight on Generations: Kea can sense her brother is hiding somethingDon't miss Thursday, 28 March's riveting episode of South African soapie Generation...

28/03/2024

Tonight on Smoke and Mirrors: Magolide and Tiny compete against each other

Tonight on Smoke and Mirrors: Magolide and Tiny compete against each otherDon't miss Thursday, 28 March's riveting episode of South African soapie Smoke...

28/03/2024

Tonight on Champions: Washington's struggle takes an unexpected turn

Tonight on Champions: Washington's struggle takes an unexpected turnDon't miss Thursday, 28 March's riveting episode of South African soapie Champio...

28/03/2024

Tonight on Scandal: Tibi's meltdown softens a teacher

Tonight on Scandal: Tibi's meltdown softens a teacherDon't miss Thursday, 28 March's riveting episode of South African soapie Scandal! on e.tv on DS...

28/03/2024

Tonight on Gqeberha: Lulama tells Thulani that she's pregnant with his child

Tonight on Gqeberha: Lulama tells Thulani that she's pregnant with his childDon't miss Thursday, 28 March's riveting episode of South African soapie...

28/03/2024

Tonight on My Brother's Keeper: Ndumiso has the wrong end of the stick

Tonight on My Brother's Keeper: Ndumiso has the wrong end of the stickDon't miss Thursday, 28 March's riveting episode of South African soapie My Br...

28/03/2024

Tonight on Skeem Saam: Lehasa doubles down on his ill-treatment of Pretty

Tonight on Skeem Saam: Lehasa doubles down on his ill-treatment of PrettyDon't miss Thursday, 28 March's riveting episode of South African soapie Skeem ...

28/03/2024

Thales speeds up its development of AI for defence

Facebook Twitter LinkedIn Thales, Europe's leading high-tech company in the civil and defence fields, has announced the creation of cortAIx, which bri...

28/03/2024

Get Cozy With Palia' on GeForce NOW

Ease into spring with the warm, cozy vibes of Palia, coming to the cloud this GFN Thursday. It's part of six new titles joining the GeForce NOW library of ...

28/03/2024

Smoke and Mirrors: Wednesday's episode, 27 March 2024 [VIDEO]

Smoke and Mirrors: Wednesday's episode, 27 March 2024 [VIDEO]Stay up to date with the latest episodes of your favourite South African soapie on The South Af...

28/03/2024

Muvhango: Wednesday's episode, 27 March 2024 [VIDEO]

Muvhango: Wednesday's episode, 27 March 2024 [VIDEO]Stay up to date with the latest episodes of your favourite South African soapie on The South African web...