TSRI Scientists Prolong Young Adult State in Worms
01/12/2015
LA JOLLA, CA December 1, 2015 A new study led by scientists at The Scripps Research Institute (TSRI) shows that an antidepressant drug, called mianserin, can extend the young adult state in roundworms, a common model of aging.
While it is too soon to know whether the treatment has any effect in humans, the study reveals a new metric to track aging one that can reveal troubling age-associated changes relatively early in life.
We think it is exciting to see that extending lifespan by extending young adulthood can be done at all, said biologist Michael Petrascheck of TSRI.
In the study, published today in the journal eLife, the researchers administered mianserin to Caenorhabditis elegans, a type of roundworm with a typical lifespan of 21 days. The research built on the 2007 discovery that mianserin increases the lifespan of roundworms up to 40 percent.
We wanted to follow-up and study how this drug extends lifespan, said Petrascheck.
The researchers treated thousands of worms with either water or mianserin and looked at the activity of genes as the worms aged. The team observed surprising changes in gene expression. Groups of genes with similar functions were found to change expression in opposing directions. In metabolism, for example, some gene expression increased while other genes slowed down.
Interestingly, these shifts could be tracked reliably as the worms aged, giving researchers a new way to predict the lifespan of a worm, even if the worm was still an adolescent.
The researchers called this phenomenon transcriptional drift. By examining data from mice and from 32 humans, aged 26 to 106 years, they confirmed that the phenomenon also occurs in mammals.
We now have a reliable measuring tape in our tool box to study aging, said study first author Sunitha Rangaraju, a senior research associate at TSRI.
Instead of tracking aging by waiting to see when an organism dies, researchers could track transcriptional drift to see when age-related changes occur in an organism's lifespan. Having a new tool to study aging could help us make new discoveries, for example, to understand genetic predispositions where aging starts earlier, such as Hutchinson-Gilford progeria syndrome, said Rangaraju.
This new metric revealed that treatment with mianserin can suppress transcriptional drift, but only when administered early on. By intervening with mianserin on their first day of life, the researchers could prolong a worm's lifespan by 7 to 8 days. By tracking transcriptional drift, they found that they were specifically extending the duration of the worms' young adulthood. In fact, mianserin-treated ten-day-old worms had the transcriptional drift of three-day-old worms, thus prolonging the period of young adulthood by more than 3 fold.
Subsequent studies showed that the treatment could only pause aging, not reverse it. Treating the worms at day three showed only a small extension of lifespan, and treatment on day five showed no effect.
If you add the drug early, you preserve a youthful gene expression pattern, said Petrascheck. But if you add it too late, the damage is already done.
The findings suggest that mianserin blocks signals related to the regulation of serotonin, and this delays physiological changes associated with age including transcriptional drift and degenerative processes that lead to death.
A next step for the team will be to test the effect in mice and to investigate whether there are any side effects to the mianserin treatment.
We don't want people to get the impression they can take the drug we used in our study to extend their own teens or early twenties, added Petrascheck. We may have done this in worms, but there are millions of years of evolution between worms and humans.
In addition to Petrascheck and Rangaraju, authors of the study, Suppression of Transcriptional Drift Extends C. elegans Lifespan by Postponing the Onset of Mortality, were Gregory M. Solis, Ryan C. Thompson, Rafael L. Gomez-Amaro, Sandra E. Encalada and Daniel R. Salomon of TSRI; Leo Kurian of the University of Cologne; and Alexander B. Niculescu of the Indiana University School of Medicine, formerly of TSRI. See http://dx.doi.org/10.7554/eLife.08833
The study was supported by the National Institutes of Health (grant DP2 OD008398), The Ellison Medical foundation (grants AG-NS-0928-12 and AG-NS-0950-1), an MDA Development Grant, a National Science Foundation GRFP Fellowship and a Baxter Foundation Young Faculty Award. Some resources were provided by Shigen-Japan or the CGC, which is funded by National Institutes of Health Office of Research Infrastructure Programs (grant P40 OD010440).
About The Scripps Research Institute
The Scripps Research Institute (TSRI) is one of the worlds largest independent, not-for-profit organizations focusing on research in the biomedical sciences. TSRI is internationally recognized for its contributions to science and health, including its role in laying the foundation for new treatments for cancer, rheumatoid arthritis, hemophilia, and other diseases. An institution that evolved from the Scripps Metabolic Clinic founded by philanthropist Ellen Browning Scripps in 1924, the institute now employs about 2,700 people on its campuses in La Jolla, CA, and Jupiter, FL, where its renowned scientists including two Nobel laureates work toward their next discoveries. The institutes graduate program, which awards PhD degrees in biology and chemistry, ranks among the top ten of its kind in the nation. For more information, see www.scripps.edu.
# # #
For information:
Office of Communications
Tel: 858-784-2666
Fax: 858-784-8136
press@scripps.edu
LINK: | http://www.scripps.edu/news/press/2015/20151201petrascheck.html... |
See more stories from scripps |
Most recent headlines
04/08/2024
Dalet Appoints Santiago Solanas as CEO to Lead Next Era of Growth and Innovation
Dalet, a leading technology and service provider for media-rich organizations, is excited to announce Santiago Solanas as its new Chief Executive Officer (CEO)....
03/06/2024
Dalet and Veritone Reach Agreement to Distribute, Transact and Monetize Media Archives
Dalet, a leading technology and service provider for media-rich organizations, a...
28/04/2024
Mediahaus delivers the first SRT live-streaming sports production over 5G with URSA Broadcast G2
Mediahaus delivers the first SRT live-streaming sports production over 5G with U...
26/04/2024
Sundance Film Festival CDMX 2024 kicks off today at Cinpolis
Sundance Film Festival CDMX 2024 kicks-off today with screenings in 5 theaters in Mexico City and the opening-night film, FRIDA, directed by Carla Guti rrez...
26/04/2024
Interview: Lourdes Portillo, Director of Las madres de la Plaza de Mayo, La Ofrenda
[Editor's Note: This interview is part of a larger feature about the women d...
26/04/2024
Career insights instead of everyday school life
Once again this year, SGL Carbon opened its doors to interested children and young people. On the occasion of the German Girls and Boys Day, which took place on...
26/04/2024
L3Harris Technologies Reports Strong First Quarter 2024 Results, Increases 2024 Profitability Guidance
Orders1 of $5.5 billion; book-to-bill of 1.06x Revenue of $5.2 billion, up 17%,...
26/04/2024
What Makes A Network Resilient?
Five Considerations For Communications Modernization In The 21st Century In the digital-enabled battlespace, the Joint Force needs to shoot, move and communica...
26/04/2024
CBS Sports Launches New Free Streaming Channel
CBS Sports has launched Champions League as a new, 24-hour streaming channel that will serve as the year-round destination for nonstop highlights of the UEFA ...
26/04/2024
Roku Streaming Homes Hit 81.6M
Despite tough competition in the streaming space, Roku reported solid results in Q1 2024, beating revenue expectations, with total net revenue up 19% YoY to $88...
26/04/2024
Sarah Farrell Named General Manager Of Pinewood Toronto Studios
LONDON AND TORONTO Pinewood Toronto Studios has appointed Sarah Farrell as general manager of the Studios in downtown Toronto....
26/04/2024
Quantum to Offer Advanced Filesharing Technology and Performance in StorNext and Myriad Solutions
Quantum to Offer Advanced Filesharing Technology and Performance in StorNext and...
26/04/2024
FilmLight Colour Awards welcomes 2024 entries and introduces new Emerging Talent' award
FilmLight Colour Awards welcomes 2024 entries and introduces new Emerging Talen...
26/04/2024
Picture Shop Announces Chris Evans as Head of Unscripted
Picture Shop Announces Chris Evans as Head of Unscripted Brie Clayton April 26, 2024 0 Comments Picture Shop announced Chris Evans will lead Unscripte...
26/04/2024
Participate in a Survey - The Impact of AI on Media and the Creative Industry
Participate in a Survey - The Impact of AI on Media and the Creative Industry Pascal Wagner April 26, 2024 0 Comments By participating in this survey,...
26/04/2024
Hi Barbie! Mattel Launching First FAST Channels on Samsung TV Plus
Toy maker Mattel said it is working with Samsung to launch its first free ad-supported streaming television (FAST) channels later this year....
26/04/2024
Marty Moe Named President Of Trusted Media Brands
Trusted Media Brands (TMB) said it named Marty Moe as president....
26/04/2024
Ron Howard Directs Jim Henson Documentary for Disney Plus
Ron Howard is the director on Jim Henson Idea Man, a documentary that premieres on Disney Plus May 31. Henson of course created Kermit the Frog, Miss Piggy, Big...
26/04/2024
Kraken Skate Away From RSN Root Sports for Deals With Tegna, Amazon
The ice continues to melt under the regional sports network business as the Seattle Kraken of the National Hockey League have made a long-term deal to broadcast...
26/04/2024
Warner Bros. Discovery Launches Olli First-Party Data Platform
Heading into the upfronts, Warner Bros. Discovery said it launched Olli, a first-party data platform advertiser can use for converged, targeted advertising camp...
26/04/2024
The Equalizer' Gets Season 5 on CBS
CBS has renewed the drama The Equalizer, which will see season five on in 2024-2025. Queen Latifah stars....
26/04/2024
The CW Inks New Deal for Miss USA, Miss Teen USA
The CW has entered into an exclusive multiyear broadcast partnership for the Miss USA Pageant and the Miss Teen USA Pageant. The 73rd Miss USA Pageant will air ...
26/04/2024
Fuse Urging Young Viewers To Vote With Blunt Campaign
Fuse Media isn't mincing words in a campaign urging its young viewers to register and participate in the 2024 elections....
26/04/2024
Neil Gaiman's Sandman' Universe Expands With Dead Boy Detectives'
Dead Boy Detectives, a series from Neil Gaiman about a detective agency staffed by ghosts, debuts on Netflix April 25. George Rexstrew and Jayden Revri are in t...
26/04/2024
The Story Collective opens largest film and TV studio in the heart of London
The Story Collective has gradually repurposed the former Mortlake Brewery to include production offices, workshops and sound stages By Matthew Corrigan Publi...
26/04/2024
Richard Perkett joins Amagi as chief product officer
Perkett joins the company following a 25 year career in product management, product marketing, engineering and user experience (UX) across multiple industries ...
26/04/2024
Teradek Announces Smaller More Robust Built-in Antennas f...
Teradek, the industry leader in wireless video transmitters and receivers, announced today the launch of new Bolt 6 LT 750 and Bolt 6 Monitor Module 750 RX with...
26/04/2024
Amagi Names Richard Perkett Chief Product Officer
NEW YORK Amagi has appointed Richard Perkett chief product officer (CPO)....
26/04/2024
NAB Board Election Results Announced
WASHINGTON, D.C. The National Association of Broadcasters (NAB) has announced the results of the 2024 NAB Radio and Television Board of Directors elections. The...
26/04/2024
Mattel to Launch First FAST Channels on Samsung TV Plus
EL SEGUNDO, Calif. & NEW YORK Mattel has announced a deal to launch its first three 24/7 free ad supported streaming (FAST) channels on Samsung TV Plus, Samsung...
26/04/2024
NextGen TV Launches In Portland, Maine
PORTLAND, Maine Viewers here can now receive the NextGen TV signals of five local stations with the launch of ATSC 3.0 service from host station WPFO, which is ...
26/04/2024
Rogers Inks Agreement to Deploy Comcast's Products and Technologies
TORONTO Rogers Communications has signed a 10-year agreement with Comcast to bring the latest Xfinity products and technology to Canadians....
26/04/2024
Calrec scoops third Argo win with NAB Show Product of the...
Calrec is very pleased to announce the benefits of its highly flexible approach to customer service has been recognized with a third award for the Argo range. T...
26/04/2024
New Adobe Photoshop with Advanced Generative Fill and Generate Image Brings New Superpowers to All
New Adobe Photoshop with Advanced Generative Fill and Generate Image Brings New ...
26/04/2024
Trends And Takeaways From NAB Show 2024
Trends And Takeaways From NAB Show 2024 Melanie Ciotti April 25, 2024 0 Comments NAB's Eric Trabb (right) awards SNS with two NAB Show Product of ...
26/04/2024
Sony's Ci Media Cloud Keeps NHRA Moving
Sony's Ci Media Cloud Keeps NHRA Moving Brie Clayton April 25, 2024 0 Comments Cloud-Based Media Asset Management and Collaboration Platform Accel...
26/04/2024
2024 Emerging Leaders Internship Program Open for Applications, Deadline May 31st
Capitol Broadcasting & Leadership Triangle Collaborate for Third Year Capitol B...
26/04/2024
MIX 101.5 Launches New YouTube Shows
The staff at CBC Radio have been hard at work creating several new features for listeners and viewers. Several debuts are taking place this spring. I have nev...
26/04/2024
Cricket Finds Its Digital Home in Bangladesh: VEON's Banglalink to Stream ICC Cricket on Toffee
26 Apr 2024 Cricket Finds Its Digital Home in Bangladesh: VEON's Banglalink...
26/04/2024
NBA Playoffs 2024: ESPN Rolls Out Huge Production Operation for Busy First Round
NBA Playoffs 2024: ESPN Rolls Out Huge Production Operation for Busy First Round Tech deployments include miked on-field personnel, shot-distance tracking, AR g...
26/04/2024
NHL Stanley Cup Playoffs: ESPN Ops Team Navigates Both Sides of the Border With Canadian Teams' Strong Showing
NHL Stanley Cup Playoffs: ESPN Ops Team Navigates Both Sides of the Border With ...
26/04/2024
NFL Draft 2024: Behind the Scenes in Downtown Detroit (Photo Gallery)
Behind the Scenes at the 2024 NFL Draft in Detroit (Photo Gallery) After just the first round, the 2024 NFL Draft has already made quite an impression in Detroi...
26/04/2024
NFL Draft 2024: Van Wagner Powers Onsite Entertainment Experience for Record Crowds in Detroit
NFL Draft 2024: Van Wagner Powers Onsite Entertainment Experience for Record Cro...
26/04/2024
Rohde & Schwarz presents spectrum dominance in all domains at AOC Europe
Rohde & Schwarz presents spectrum dominance in all domains at AOC Europe Rohde & Schwarz demonstrates the next generation of SIGINT/EW systems and sensor fusi...
26/04/2024
MCine Mauritius is to use Qube Wire for all future DCP deliveries across their exhibition chain on the Island
MCine Mauritius is to use Qube Wire for all future DCP deliveries across their e...
26/04/2024
Skeem Saam' May Spoiler: Has Lehasa killed Khwezi?
Skeem Saam' May Spoiler: Has Lehasa killed Khwezi?The Skeem Saam' May teasers mention Lehasa being apologetic about killing someone. Is it his baby mam...
26/04/2024
Skeem Saam: Thursday's episode, 25 April 2024 [video]
Skeem Saam: Thursday's episode, 25 April 2024 [video]Missed an episode of Skeem Saam? No problem! Watch the latest episode of your favourite South African s...
26/04/2024
Prison Journalism: Some issues to consider
Prison Journalism: Some issues to considerWesley Leong was incarcerated at the age of 15 in 1996 at Pollsmoor Prison. He is currently part of Restore's rese...
26/04/2024
Tonight on Scandal: A line is crossed and a mother starts to lose focus
Tonight on Scandal: A line is crossed and a mother starts to lose focusDon't miss Friday, 26 April's riveting episode of South African soapie Scandal! o...