Scripps Florida Scientists Find Genetic Mutations Linked to Salivary Gland Tumors
28/07/2014
JUPITER, FL - July 28, 2014 Research conducted at the Florida campus of The Scripps Research Institute (TSRI) has discovered links between a set of genes known to promote tumor growth and mucoepidermoid carcinoma, an oral cancer that affects the salivary glands. The discovery could help physicians develop new treatments that target the cancer's underlying genetic causes.
The research, published this week online ahead of print by the Proceedings of the National Academy of Sciences, shows that a pair of proteins joined together by a genetic mutation known as CRTC1/MAML2 (C1/M2) work with MYC, a protein commonly associated with other cancers, to promote the oral cancer's growth and spread.
This research provides new insights into the molecular mechanisms of these malignances and points to a new direction for potential therapies, says TSRI biologist Michael Conkright, Ph.D., who led the study.
The C1/M2 protein is created when the genes encoding CRTC1 and MAML2 mutate into a single gene through a process known as chromosomal translocation. Such mutant chimera genes are linked to the formation of several forms of cancer. The team discovered that the C1/M2 protein further activates genetic pathways regulated by MYC, in addition to CREB, to begin a series of cellular changes leading to the development of mucoepidermoid carcinoma.
The identification of unique interactions between C1/M2 and MYC suggests that drugs capable of disrupting these interactions may have therapeutic potential in the treatment of mucoepidermoid carcinomas, said Antonio L. Amelio, Ph.D., first author of the study who is now assistant professor with the UNC School of Dentistry and member of the UNC Lineberger Comprehensive Cancer Center.
Researchers have known about the role of C1/M2 and its interactions with another protein, CREB, in the development of mucoepidermoid carcinoma, and physicians screen patients for the presence of the C1/M2 protein when testing for this cancer. These new findings deepen the understanding of C1/M2's role by revealing that it works with a family of cancer-associated genes known as the MYC family to drive the cellular changes necessary for a tumor to develop.
The discovery of these new protein interactions may also reveal insights into the mechanisms behind other cancers that arise due to other genetic mutations involving the CREB and MYC pathways.
In addition to Conkright and Amelio, other authors of the study, CRTC1/MAML2 gain-of-function interactions with MYC create a gene signature predictive of cancers with CREB MYC involvement, include Mohammad Fallahi of IT Informatics, Franz X. Schaub, Mariam B. Lawani, Adam S. Alperstein, Mark R. Southern, Brandon M. Young and John L. Cleveland of TSRI, and Min Zhang, Lizi Wu, Maria Zajac-Kaye and Frederic J. Kaye of Shands Cancer Center, University of Florida (Gainesville).
The research was supported in part by a Howard Temin Pathway to Independence Award in Cancer Research from the National Cancer Institute (NCI) (K99-CA157954), National Institutes of Health/NCI R01 Grant CA100603, a PGA National WCAD Cancer Research Fellowship and Ruth L. Kirschstein National Research Service Award from the National Cancer Institute (F32-CA134121), the Margaret Q. Landerberger Research Foundation, a Swiss National Foundation Postdoctoral Fellowship and monies from the State of Florida to TSRI's Scripps Florida.
About The Scripps Research Institute
The Scripps Research Institute (TSRI) is one of the worlds largest independent, not-for-profit organizations focusing on research in the biomedical sciences. TSRI is internationally recognized for its contributions to science and health, including its role in laying the foundation for new treatments for cancer, rheumatoid arthritis, hemophilia, and other diseases. An institution that evolved from the Scripps Metabolic Clinic founded by philanthropist Ellen Browning Scripps in 1924, the institute now employs about 3,000 people on its campuses in La Jolla, CA, and Jupiter, FL, where its renowned scientists including three Nobel laureates work toward their next discoveries. The institutes graduate program, which awards PhD degrees in biology and chemistry, ranks among the top ten of its kind in the nation. For more information, see www.scripps.edu.
# # #
For information:
Office of Communications
Tel: 858-784-2666
Fax: 858-784-8136
press@scripps.edu
LINK: | http://www.scripps.edu/news/press/2014/20140728conkright.html... |
See more stories from scripps |
Most recent headlines
04/08/2024
Dalet Appoints Santiago Solanas as CEO to Lead Next Era of Growth and Innovation
Dalet, a leading technology and service provider for media-rich organizations, is excited to announce Santiago Solanas as its new Chief Executive Officer (CEO)....
03/06/2024
Dalet and Veritone Reach Agreement to Distribute, Transact and Monetize Media Archives
Dalet, a leading technology and service provider for media-rich organizations, a...
08/05/2024
zweiB updates to latest version of R&SCLIPSTER
zweiB updates to latest version of R&S CLIPSTER Specialist in deliverables for cinema, events and trade shows Rohde & Schwarz, a global leader in broadcast...
07/05/2024
Your Guide to Having a Jam-Packed Sundance Institute Summer
There's something special about summer. We're not sure whether it's the warmer weather, the longer days, or something else a bit more magical, but s...
07/05/2024
NITV appoints Michael Rennie as Presenter and Senior Producer for NITV News
NITV appoints Michael Rennie as Presenter and Senior Producer for NITV News Media releases NITV has announced the appointment of Michael Rennie as Presenter...
07/05/2024
Network flexibility: A Vital Consideration for SATCOM Resiliency
The ability for line-of-site tactical voice and data networks to seamlessly traverse over Satellite Communications is an emerging requirement to assure warfight...
07/05/2024
L3Harris Avionics Repair Station Becomes the First in U.S. to Be Awarded European Military Airworthiness Certification
On April 5, 2024, the L3Harris Avionics Products Repair Station (NN2R037L) in Gr...
07/05/2024
Clear-Com Celebrates Theatre Triumphs in Light of 2024 Tony Award Nominations
eds3_5_jq(document).ready(function($) { $(#eds_sliderM519).chameleonSlider_2_1({ content_source:......
07/05/2024
macOS Ventura Compatible
Share this article width=32 height=32 loading=lazy data-lazy-src=https://apogeedigital.com/app/themes/juniper-theme/src/img/icons/facebook-purple.svg /> wid...
07/05/2024
Disney Streaming DTC Operations Produce Their First Profits
BURBANK, Calif. The Walt Disney Company has finally delivered some from profits from its hefty streaming investments, with the second quarter of its fiscal year...
07/05/2024
Bonnie Hammer, Jen Psaki Share Books and Workplace Lessons at 92nd Street Y
Bonnie Hammer, vice chair of NBCUniversal, and Jen Psaki, MSNBC host, read from their new books at the 92nd Street Y in Manhattan Wednesday, May 8. Hammer's...
07/05/2024
Paramount Plus Orders Tracy Morgan Comedy Set in World of The Neighborhood'
Paramount Plus has ordered the series Crutch, a comedy that is a spinoff of CBS comedy The Neighborhood. Tracy Morgan stars....
07/05/2024
Daytime Emmys Announce Lifetime Achievement Recipients
Edward J. and Melody Thomas Scott and Lidia Bastianich will receive Lifetime Achievement honors at the 51st annual Daytime Emmy Awards in June, the National Aca...
07/05/2024
Al Roker, Wendy McMahon, Stephen A. Smith Set for Giants of Broadcasting Honors
The 2024 Giants of Broadcasting & Electronic Arts luncheon and awards ceremony happens in New York November 12, and the honorees are Al Roker, weather and featu...
07/05/2024
Dabl Debuts New Weekday Schedule
Dabl Network has added The Wayans Bros., The Jamie Foxx Show, Living Single and Everybody Hates Chris to its weekday and weekend lineups. Those shows join the l...
07/05/2024
Disney Entertainment DTC Business Gets Out of the Red in Q2
After winning a proxy fight, The Walt Disney Co. said its entertainment business turned a profit and added subscribers in its fiscal second quarter....
07/05/2024
Victor Wembanyama, Top NBA Rookie, Featured On Pass The Rock'
NBA Entertainment is closing out the second season of its series Pass the Rock with a look at Victor Wembanyama of the San Antonio Spurs, the league's rooki...
07/05/2024
Syncbak Rebrands as Zeam Media After Streaming Platform Rollout
Syncbak, which provides stations with streaming capabilities, said it is rebranding as Zeam Media....
07/05/2024
Magnolia Pictures Licenses Content To Stream on Samsung TV Plus
Samsung has made a deal with Magnolia Pictures that will bring titles from Magnolia to the Samsung TV Plus free streaming platform....
07/05/2024
Amazon Rolling Out Interactive Commercial Formats for Prime Video (Upfronts)
Amazon, which has added commercials to Amazon Prime Video, is rolling out new interactive ad formats that will enable advertisers to engage streamers and sell s...
07/05/2024
Syncbak Now Zeam Media
Syncbak, a 15 year-old provider of streaming tech for local broadcast stations has rebranded itself, adopting the name of its streaming service launched in Febr...
07/05/2024
Maximising resources: Keys to POST Luxembourg's success in the evolving media landscape
POST Luxembourgs journey with TAG Video underscores how finding a vendor who und...
07/05/2024
Survey: Amazon's Push into Ad-Supported Streaming Is Working
PORTSMOUTH, N.H. New findings from Hub Entertainment Research provides extensive data showing that the majority of consumers will opt for lower cost ad-supporte...
07/05/2024
The Library of American Broadcasting Foundation Unveils the 2024 Award Recipients
NEW YORK The Library of American Broadcasting Foundation (LABF) has announced th...
07/05/2024
Lindsey Reiser Joins CBS News 24/7 as Anchor and Correspondent
CBS News has named Lindsey Reiser an anchor and correspondent for CBS News 24/7, the network's live, streaming news service. Reiser, who was most recently a...
07/05/2024
Tablet Shipments Show Signs of Recovery in Q1
NEEDHAM, Mass. After more than two years of decline, worldwide tablet shipments posted modest year-over-year growth of 0.5% in the first quarter of 2024 (1Q24),...
07/05/2024
ESPN Pulls in Highest April Prime Time Audiences on Record
ESPN is reporting that April was a record-setting month as the network delivered its best April prime time audience on record, dating back more than 30 years....
07/05/2024
Kirsten Donaldson Joins NAB as VP of Public Policy
WASHINGTON, D.C. The National Association of Broadcasters (NAB) has announced that Kirsten Donaldson has joined NAB as vice president of public policy. Donaldso...
07/05/2024
Don't miss Bark in the Park, Margaritaville Night & Bull Sharks Night this week at the DBAP
The Bulls are back home again this week from May 7-12! Don't miss out on any...
07/05/2024
SVG Sit-Down: AWS's Julie Souza on the Cloud and AI in Broadcast-Content Creation, Distribution
SVG Sit-Down: AWS's Julie Souza on the Cloud and AI in Broadcast-Content Cre...
07/05/2024
Deloitte Analysts Peter Giorgio and Michael Vovk: Sports Properties Need To Rethink Fan Engagement
Deloitte Analysts Peter Giorgio and Michael Vovk: Sports Properties Need To Reth...
07/05/2024
University of Texas' Jeff Hanel to Keynote 16th-Annual SVG College Summit
University of Texas' Jeff Hanel to Keynote 16th-Annual SVG College Summit Industry vet to discuss uniting live and creative in athletic department media arm...
07/05/2024
Premier League Trials RefCam During Crystal Palace v Manchester United Fixture
Premier League trials RefCam during Crystal Palace v Manchester United fixture By George Bevir Tuesday, May 7, 2024 - 09:34 Print This Story In a Premier ...
07/05/2024
CBS Sports Previews PGA Championship Plans; 125+ Cameras Include FlyCams, Bunker Cams, Live Drones, and Shallow-depth-of-field
CBS Sports Previews PGA Championship Plans; 125+ Cameras Include FlyCams, Bunker...
07/05/2024
Rohde & Schwarz brings cutting-edge solutions to TECNOSEC and DRONExpo 2024
Rohde & Schwarz brings cutting-edge solutions to TECNOSEC and DRONExpo 2024 Rohde & Schwarz will showcase its innovative portfolio at TECNOSEC and DRONExpo 20...
07/05/2024
Five New Games Join Netflix in May
Back to All News Five New Games Join Netflix in May Netflix Staff Entertainment 07 May 2024 Global Link copied to clipboard Five new games are launching ...
07/05/2024
Top 10 Week of Apr. 29: Baby Reindeer' Holds Strong; Heeramandi' Breaks Records; Katt Williams and Tom Brady Live Events Bring the Laughs
Back to All News Top 10 Week of Apr. 29: Baby Reindeer' Holds Strong; Hee...
07/05/2024
Blancco Wins 2024 SEAL Business Sustainability Award
Home News & Press Blancco Wins 2024 SEAL Business Sustainability Award Blancco Wins 2024 SEAL Business Sustainability Award May 07, 2024 Blancco's v...
07/05/2024
2024-05-07
CUPERTINO, CALIFORNIA Apple today unveiled the all-new Logic Pro for iPad 2 and Logic Pro for Mac 11, delivering breakthrough professional experiences for songw...
07/05/2024
Changes in Apple's privacy requirements
Apple's new Privacy Manifest requirement mandates that apps explicitly disclose the privacy-related data they collect, the purposes for this collection, and...
07/05/2024
Taylor Swift's Eras Tour arrives to shake up Europe
Taylor Swift's Eras Tour arrives to shake up EuropeHaving shaken four continents, Taylor Swift's Eras Tour finally brings the biggest pop culture icon o...
07/05/2024
Isiphetho: Destiny' beats Scandal!'
Isiphetho: Destiny' beats Scandal!'E.tv's latest telenovela Isiphetho: Destiny' beat the channel's longest running soapie, Scandal!' ...
07/05/2024
Now there's HELP for ex-prisoners to find work in South Africa
Now there's HELP for ex-prisoners to find work in South AfricaNew initiative for ex-prisoners to find work in South Africa proves it's never too late fo...
07/05/2024
Tonight on Scandal: Cohen is pulled into keeping a secret
Tonight on Scandal: Cohen is pulled into keeping a secretDon't miss Tuesday, 7 May's riveting episode of South African soapie Scandal! on e.tv on DStv c...
07/05/2024
Skeem Saam: Monday's episode, 6 May 2024 [video]
Skeem Saam: Monday's episode, 6 May 2024 [video]Missed an episode of Skeem Saam? No problem! Watch the latest episode of your favourite South African soapie...
06/05/2024
Gathering Is a Call to Action: A Letter From Ilyse McKimmie
By Ilyse McKimmie Now, more than ever That's a phrase so often used in the last few years that I've come to dread seeing it in notes like this one. A...
06/05/2024
From Petabytes To Exabytes: The Future Of Shared Storage
alt= class=wp-image-12099 data-lazy-src=/wp-content/uploads/2024/05/Blog-Exabyte-Storage-Demand-960x540-1.jpg/> Demand for storage solutions has reached unprece...
06/05/2024
Spotify Uplifts Bold, Emerging Artists in Honor of Asian and Pacific Islander Heritage Month
Around the world, Asian and Pacific Islander (API) artists continue to impact mu...
06/05/2024
Never Miss a New Release With Countdown Pages for Audiobooks
Spotify is making it easier for booklovers to count down the days, hours, minutes, and seconds until a new audiobook releases. With Countdown Pages for audioboo...