Sony Digital Rapids Pixel Power calrec Sony

May 14, 2019

15/05/2019

FDA approves phase 1/2 clinical trial with ABX196 in patients with liver cancer ABX196 to be tested in combination with checkpoint inhibitor nivolumab to treat hepatocellular carcinoma

May 14, 2019

LA JOLLA, CA The U.S. Food and Drug Administration has approved an investigational new drug (IND) application for a phase 1/2 clinical trial of ABX196, a liver cancer therapy developed in the laboratory of Scripps Research Professor Luc Teyton, MD, PhD, and licensed to French pharmaceutical company Abivax.

The FDA approval allows Abivax testing of ABX196 in patients with hepatocellular carcinoma (HCC), the most common form of liver cancer. ABX196 showed potent efficacy against HCC in preclinical testing.

The translation of basic research discoveries to the clinic is the greatest achievement we can hope for as clinician scientists. says Teyton, who is also a member of Abivax's Scientific Advisory Board. The use of ABX196 in the context of immunotherapy has been shown to be beneficial in multiple animal models of cancer, but the results with hepatocellular carcinoma are spectacular. We are looking forward to impacting the disease in patients, especially given the limitations of current therapies.

The open IND allows Abivax to test ABX196 in combination with nivolumab (Opdivo, Bristol-Myers Squibb), a checkpoint inhibitor, in a first phase 1/2 clinical trial to treat patients with HCC. The initial dose-escalation phase of the study will be conducted at the Scripps MD Anderson Cancer Center in San Diego, California, USA; additional leading cancer centers in the U.S. will be involved in the subsequent expansion phase of the study. The first patient is expected to be enrolled this summer.

We are thrilled to have been given the green light by FDA for our U.S. study. says Hartmut J. Ehrlich, MD, chief executive officer of Abivax. This open IND allows Abivax, in collaboration with leading key opinion leaders at internationally renowned U.S. cancer centers of excellence, to explore the clinical potential of our iNKT agonist ABX196 to broaden and potentiate the activity of the checkpoint inhibitor nivolumab. Based on its unique mechanism of action and exciting preclinical data in several cancer models, we believe ABX196 is a promising immunotherapeutic product candidate for patients with liver cancer that may also have potential in other cancers.

ABX196 is a synthetic glycolipid agonist of invariant natural killer T cells (iNKT) in a liposomal formulation. A phase 1 clinical trial conducted by Abivax in healthy volunteers has been completed and demonstrated safety and tolerability as well as a potent activation of iNKT cells. ABX196, both alone and in combination with a checkpoint inhibitor, showed a statistically highly significant therapeutic effect in reducing tumor growth as measured by MRI and increasing survival in mice with HCC. Abivax holds exclusive rights to ABX196 from Scripps Research, the University of Chicago, and Brigham Young University.

Despite the recent introduction of checkpoint inhibitors, hepatocellular carcinoma continues to be a substantial therapeutic challenge, as only about 20 percent of the treated patients show a response to these new drugs says Darren Sigal, MD, program director of GI Oncology at Scripps Clinic and Scripps MD Anderson Cancer Center in San Diego, and principal investigator of the study. While checkpoint inhibitors block a do not attack me' signal on cancer cells, ABX196 activates iNKT cells, a subpopulation of lymphocytes that is critical for mounting an effective immune response. The synergy between these two molecules carries substantial promise for improved outcomes for patients with this deadly cancer.

Checkpoint inhibitors like nivolumab are a leading class of therapeutic monoclonal antibodies that block certain endogenous proteins (PD-1/PDL-1) made by immune cells, such as T cells, as well as some cancer cells. These proteins effectively hijack the immune system, causing it to keep immune responses in check and preventing T cells from killing cancer cells. When these proteins are blocked, the brakes on the immune system are released and T cells are able to kill cancer cells much more efficiently. In some cancers, treatment with checkpoint inhibitors has been highly efficacious. However, due to the tumor micro-environment in other cancers, such as HCC, checkpoint inhibitors can have difficulties exerting their effects. ABX196 is intended as a drug that will potentiate the efficacy of checkpoint inhibitors by activating iNKT cells to kill tumor cells.

HCC is the most common form (75 to 90 percent) of primary liver cancer in adults. It typically occurs in the setting of chronic liver inflammation and/or cirrhosis and is closely linked to chronic viral infection such as hepatitis B or C, exposure to toxins such as alcohol, and to certain diseases such as non-alcoholic steatohepatitis (NASH).

The incidence of and deaths related to HCC are increasing in the United States and globally due to hepatitis B and C virus infections, as well as NASH. Prevalence data from 2018 show a total of 79,000 cases of HCC in the U.S. and G5 Europe (Germany, France, Italy, Spain and the UK), with 67,000 new cases, and a total of 260,000 cases in China with 338,000 new cases. Globally, there were 841,000 new cases of liver cancer (ranking it sixth of all reported cancers) and 782,000 fatalities (ranking it fourth) in 2018.

Currently, the American Cancer Society reports five-year survival rates in the U.S. of 31 percent for localized HCC, 11 percent for regional, and 2 percent for distant or metastatic, indicating a clear unmet medical need for improved therapies for HCC.

Cancer Immunology & Microbiology Teyton, Luc
LINK: https://www.scripps.edu/news-and-events/press-room/2019/20190514-teyto...
See more stories from scripps

Most recent headlines

31/05/2020

Q-SYS and Crestron plug-ins for Powersoft' amplifiers

Q-SYS and Crestron plug-ins for Powersoft' amplifiers posted: 31/05/2020 Feature-rich updates permit extended control over amp functionality, facilita...

31/05/2020

2020 Grammy Awards Marks First Major Telecast With Large-Scale Deployment of Claypaky Xtylos Fixtures

2020 Grammy Awards Marks First Major Telecast With Large-Scale Deployment of Cla...

31/05/2020

Cultuur Centrum Brugge Makes Major Investment In Yamaha Mixing Consoles

Cultuur Centrum Brugge Makes Major Investment In Yamaha Mixing Consoles posted: 31/05/2020 The 150 year old Koningklijke Stadschouwburg (Royal City Theate...

31/05/2020

Inspired in self-isolation

Inspired in self-isolation posted: 31/05/2020 With Covid-19 lockdowns worldwide and health authorities urging people to self-isolate and practice social d...

31/05/2020

Real-time Image-Cytometry for Next Generation Single-cell Theranostics Applications

Engineers from Vision Research Inc. (the makers of Phantom Cameras) & Spicatek I...

30/05/2020

METLIFE ANNOUNCES CHANGE TO VIRTUAL-ONLY 2020 ANNUAL SHAREHOLDERS MEETING

METLIFE ANNOUNCES CHANGE TO VIRTUAL-ONLY 2020 ANNUAL SHAREHOLDERS MEETING NEW YORK, May 29, 2020 MetLife, Inc. (NYSE: MET) today announced that in order to s...

30/05/2020

NAB Statement on Police Action Against Louisville TV Station Crew During Protest

NAB Statement on Police Action Against Louisville TV Station Crew During Protest WASHINGTON, D.C. - In response to Louisville police firing pepper balls at a l...

30/05/2020

Sound and Vision Entertainment and Freeman Provide Secure Remote Production Needs for Spring Draft

Sound and Vision Entertainment and Freeman Provide Secure Remote Production Need...

30/05/2020

Sooner Routhier, Cory FitzGerald and Travis Shirley on June 3rd Elation Hour

Sooner Routhier, Cory FitzGerald and Travis Shirley on June 3rd Elation Hour posted: 30/05/2020 Top lighting designers Sooner Routhier, Cory FitzGerald and ...

30/05/2020

LTN Global launches LTN Wave: an IP-based alternative to satellite distribution

LTN Global launches LTN Wave: an IP-based alternative to satellite distribution posted: 30/05/2020 LTN Global, the industry leader in transformative media t...

30/05/2020

Hitachi HDTV Cameras Help Bring Top-Tier Athletics Productions to National Audiences for University of North Alabama

-- Spanning a 130-acre campus in historic Florence, Alabama, the University of...

30/05/2020

Short Film 886 Delivers For Vimeo's Stories in Place

-- This film is part of Vimeo's Stories In Place series that chronicles small businesses as they navigate a world in flux. Shuttered due to the pandemic, ...

30/05/2020

Magewell Expands Recording and Live Streaming Capabilities in Ultra Stream Encoders

-- Magewell has released a new upgrade for its award-winning Ultra Stream fami...

30/05/2020

Mediacorp Singapores Upcoming Classmates Shot and Posted by Echo Entertainment Using URSA Mini Pro and DaVinci Resolve

-- Blackmagic Design today announced that Singapore based Echo Entertainment u...

30/05/2020

Fans in Poland will return on stadiums

Fans in Poland will return on stadiums posted: 29/05/2020 Football fans in Poland will be able to watch matches at the stadiums starting from 19th of June...

30/05/2020

The Parliament of Tasmania Captures Important Governmental Proceedings With Telemetrics Robotic Camera Systems

The mission of the Parliament of Tasmania, where official proceedings are held a...

30/05/2020

ICG Pays Tribute to Allen Daviau, ASC with Riding in the Car with Allen

ICG offers a remembrance of cinematic icon Allen Daviau, ASC in its May web exclusive here. Enjoy the May digital edition of ICG Magazine here!...

30/05/2020

The Show Must Go On!

IABM and SMPTE are collaborating to put on a show for and with members! Be a part of The Show Must Go On! by submitting photos of your unglamorous workspace, ...

30/05/2020

New Release of the Adobe Creative Cloud Video Apps

Adobe recently announced a new release for Creative Cloud video and audio applications, including Premiere Pro, After Effects, Audition, Character Animator and ...

30/05/2020

Crafty Apes Transitions to Remote Work with Support from RFX and Teradici

Crafty Apes, a visual effects and production studio with a list of impressive credits that includes Jumanji: The Next Level, Watchmen, Hustlers, and Dolemite is...

30/05/2020

Real-Time Remote Editing from ClearView Flex

Sohonet explores how best to recreate the over-the-shoulder, real-time editing experience with your teams and clients from home with ClearView Flex. Editors ca...

30/05/2020

Scale Logic Hosts 2020 Media & Entertainment Virtual Conference

Scale Logic hosted its first M&E Virtual Conference on April 29, 2020, introducing attendees to the foremost in new solutions for evolving media workflows, incl...

30/05/2020

Adobe Updates Promote Performance and Stability

Adobe is providing updates more frequently, allowing teams to iterate faster, and has introduced the public Beta program that expands Adobe's test base and ...

30/05/2020

Expansion of Leadership Team Supports Accelerating Demand for Dynamic Media Orchestration Platform Services

Levels Beyond, Inc., builders of the industry-leading media orchestration platfo...

30/05/2020

Trinity Broadcasting Network Upgrades Clustered Storage with creative.space

When the Trinity Broadcasting Networks (TBN), the world's largest Christian television broadcast group with 32 international networks reaching every major c...

30/05/2020

Vidovation Launches Webinar Series

Vidovation's foremost experts in broadcast, sports, news, and video production discuss transmitters and encoders portfolio enhancements in a new webinar ser...

30/05/2020

The Role of HPA In COVID Response and Recovery

1) As the COVID crisis hit the industry in March, how HPA was able to respond? As the COVID crisis transitioned all of us to work from home and eliminated the...

30/05/2020

Storytelling and the Era of the Empath: Poppy Crum

By: Adrian Pennington I am passionate about creating technology that enables us to translate the creator's true intent, technologist and neuroscientist P...

30/05/2020

How active streaming protection can ensure service security

As operators extend or migrate their service to an IP environment new challenges arise. Unlike traditional linear TV, the network and endpoint devices are not c...

30/05/2020

Quibi Adds AirPlay Capability in Latest Update

LOS ANGELES-Quibi has added a new feature that provides additional viewing capabilities to what was at first supposed to be a mobile-only streaming service. Acc...

30/05/2020

Intelsat Warns FCC of Video Quality Concerns Post C-Band Transition

WASHINGTON-Intelsat has told the FCC that due to current procedures for the C-band transition, it will likely be unable to prevent interference issues post-tran...

30/05/2020

NAB Announces 2020 Service to America Award Finalists

WASHINGTON-The finalists for the 2020 Service to America Awards have been announced by the NAB Leadership Foundation, which recognize outstanding community serv...

30/05/2020

ARRI Hires Ivo Ivanoski as Lighting Division GM

MUNICH-ARRI has announced the hiring of Ivo Ivanoski to the role of general manager for the company's lighting business unit. Ivanoski is expected to take o...

30/05/2020

Haystack TV Launches Interactive News Ticker on Roku

SAN FRANCISCO & LOS GATOS, Calif.-OTT news source Haystack TV has upped its game as a provider of viewer-specific personalized news with the launch of Newsline,...

30/05/2020

Net Insight announces changes to Executive Management team

Net Insight selected for new nationwide IP media network in the Middle East Stockholm, Sweden - Net Insight's partner Middle East Telecommunications Company...

29/05/2020

Sky Sports will show 64 live Premier League games, and make 25 available free to air

64 live games on Sky Sports from the provisional re-start date of 17th June 25 ...

29/05/2020

Sky News to debate how the world will change after COVID-19

Sky News has announced a new series of debate programmes titled After The Pandemic: Our New World, the first 'The World At Large' will air on Monday 1 ...

29/05/2020

Industrial network market shares 2020 according to HMS Networks

Increased market share for Industrial Ethernet fieldbus decline continues and wireless stays stable Industrial network connectivity for devices and machines i...

29/05/2020

AppDynamics Delivers New Research

San Francisco - May 27, 2020 - AppDynamics, a Cisco company and the world's largest and fastest growing APM vendor, today released a special edition of its ...

29/05/2020

Cisco Live 2020-Here's everything you need to know

SAN JOSE, Calif., May 29, 2020 For the first time in its 30 years, Cisco Live 2020 is an all-digital event. The conference will bring attendees everything from ...

29/05/2020

Inspiration from Home: AICP Launches Online Panels on Creativity and Collaboration

Inspiration from Home: AICP Launches Online Panels on Creativity and Collaborati...

29/05/2020

NETFLIX ANNOUNCING THE CAST OF ICELANDIC SERIES KATLA - BY ACCLAIMED DIRECTOR BALTASAR KORMAKUR

Photo Credit: Netflix / Lilja Jonsdottir Amsterdam -- May 29, 2020 -- The filmi...

29/05/2020

THE AMERICAN CINEMATHEQUE AND NETFLIX JOIN FORCES TO PRESERVE HOLLYWOOD'S HISTORIC EGYPTIAN THEATRE

The collaboration will allow the American Cinematheque to expand the scope and d...

29/05/2020

The second edition of the Shah Marai Award, launched by AFP, is won by Naim Nadir

Photographer Naim Nadir, from Kabul, has won the second edition of the Shah Mara...

29/05/2020

ITV Racing to broadcast 21 races on first weekend as British racing resumes

Pictured: Ed Chamberlin ITV Racing to broadcast 21 races on first weekend as British racing resumes ITV Racing is planning to resume broadcasting with three d...

29/05/2020

Berklee Alumni and Faculty Honored by the Jazz Journalists Association

The Jazz Journalists Association (JJA) recognized 11 Berklee alumni and faculty members with JJA Jazz Awards in a number of categories this year. Berklee'...

29/05/2020

SVG Sit-Down: EditShare's Conrad Clemson Provides Update on Company's Evolution in His First Year as CEO

SVG Sit-Down: EditShare's Conrad Clemson Provides Update on Company's Ev...

29/05/2020

Legends Behind the Lens: Mark McCormack

Legends Behind the Lens: Mark McCormack One of the industrys all-time businessmen painted a prosperous future for sports on television By Brandon Costa, Direct...

29/05/2020

The Return of Live Sports Production Continues With MotoAmerica Championship

The Return of Live Sports Production Continues With MotoAmerica Championship LDM Worldwide rolls out production focused on safety, quality By Jason Dachman, C...