Professor Stuart Lipton awarded $5 million to study the chemical biology of air pollution on the human brain The grant from the NIA/NIH will support research into how air pollution could lead to the development of Alzheimer's disease.
October 01, 2024
LA JOLLA, CA Stuart Lipton, MD, PhD, professor and Step Family Foundation Endowed Chair, and Tomohiro Nakamura, PhD, Institute Investigator in the Neurodegeneration New Medicines Center and Department of Molecular Medicine at Scripps Research, have been awarded about $5 million from the National Institute on Aging (NIA) to study the impacts of air pollution on the human brain specifically, how air pollution could contribute to Alzheimer's disease and related dementias.
The NIA grant will support research over a five-year period as he and his team investigate how pollution sources including vehicle exhaust, wildfires contribute to a chemical reaction discovered by Lipton referred to as SNO and how this impacts the development of Alzheimer's disease. NIA, part of the National Institutes of Health (NIH), is focused on expanding our scientific understanding of the nature of aging, improving the health and well-being of older adults, and supporting and conducting research on aging and the challenges and needs of older adults.
The NIA's award shows not only how dedicated the organization is to improving human health, but its confidence that Scripps Research has the potential to make an enduring impact on these serious diseases, Lipton says.
SNO is a reaction that results from exposure to air pollution, which causes nitrogen (N) and oxygen (O) atoms to combine with a sulfur (S) atom on a wide variety of proteins and disrupt their function, resulting in brain damage. This reaction, termed S-nitrosylation, has been observed to cause a SNO storm of reactions in Alzheimer's brain neurons by Lipton and his team. A recent paper from the Lipton group in the journal Science described many of the biochemical pathways affect by the aberrant SNO storm in the brain.
In collaboration with Scripps Research professor John Yates III, PhD, Lipton's research uses mass spectrometry to discover the proteins that undergo SNO reactions and potentially contribute to the development of Alzheimer's and other dementias. Identifying these SNO proteins is a critical step in developing new therapeutic targets for diseases, while potentially also helping inform strategies on controlling air pollution.
Climate change, caused by human actions affecting the composition of air in the atmosphere, has already had a critical impact on global health. It's vital that we continue to expand this body of research to inform strategies and new therapeutics that address human disease influenced by environmental factors, Lipton says.
Along these lines, the California Institute of Regenerative Medicine (CIRM) recently made a companion award for Lipton to study the chemical biology of air pollution in autism and intellectual disabilities.
At Scripps Research, Lipton's lab focuses on investigating molecular signaling pathways in order to prevent neuronal and synaptic injury that occurs as the human body ages, as well as in neurodegenerative diseases like Alzheimer's, Parkinson's and other forms of dementia. His research into the drivers of Alzheimer's disease has already led to real-world results. Lipton is well-known for developing the FDA-approved drug memantine marketed commercially as Namenda , Namenda XR , and Namzaric represents one of only two medicines approved to treat moderate-to-severe forms of Alzheimer's. The drug is also used off-label for other forms of dementia, such as vascular dementia caused by multiple strokes and Lewy body dementia.
Neuroscience Molecular and Cellular Biology Lipton, Stuart
Most recent headlines
05/01/2027
Worlds first 802.15.4ab-UWB chip verified by Calterah and Rohde & Schwarz to be ...
07/10/2026
Dalet, a leading technology and service provider for media-rich organizations, today announced the latest Long-Term Supported (LTS) release of Dalet Flex. Build...
06/09/2026
June 9 2026, 23:00 (PDT) Dolby and MagentaTV Bring Fans Closer to the FIFA Worl...
04/08/2026
Dalet, a leading technology and service provider for media-rich organizations, t...
16/07/2026
Share
Copy link
Facebook
X
Linkedin
Bluesky
Email...
16/07/2026
Share
Copy link
Facebook
X
Linkedin
Bluesky
Email...
16/07/2026
Share
Copy link
Facebook
X
Linkedin
Bluesky
Email...
16/07/2026
Share
Copy link
Facebook
X
Linkedin
Bluesky
Email...
16/07/2026
Share
Copy link
Facebook
X
Linkedin
Bluesky
Email...
16/07/2026
Zixi, a leader in live video delivery and workflow orchestration, and Comcast Technology Solutions (CTS) today announced a strategic new integration to deliver ...
16/07/2026
Blackmagic Design Cameras Capture Immersive Flight for New Cirrus App
Brie Clayton July 15, 2026
0 Comments
Leader in Personal Aviation taps URSA Cin...
16/07/2026
XenData Announces LTO Archive Appliances with both File and S3 Object Storage In...
15/07/2026
The 2026 FIFA World Cup is a big deal for DAZN, which has distribution rights in three markets: Italy, Spain, and Japan. Each requires a different editorial app...
15/07/2026
As sports-media organizations manage rapidly growing content libraries and incre...
15/07/2026
HBS director of digital Johannes Franken talks SVG Europe through the operation built to serve FIFA World Cup 2026 rights holders remotely from Stratford, east ...
15/07/2026
IBC has unveiled the conference program for IBC2026, with this year's event ...
15/07/2026
Software-defined wideband RF platform supports 96-kHz monitoring, streamlined fr...
15/07/2026
New AI-powered module enables broadcasters and content owners to extract dialogu...
15/07/2026
Weeklong gathering at EBU headquarters will test new IPMX capabilities and expand certified product ecosystem...
15/07/2026
Force Tech has announced the appointment of Bryan Adams, CTS, as Vice President of Integration. Adams will oversee AV and broadcast integration project delivery...
15/07/2026
USA Sports has announced an exclusive English-language agreement with the Bundes...
15/07/2026
ITV Sport's FIFA World Cup 2026 coverage has been produced from one of the m...
15/07/2026
Program will provide professional camera kits, training, and technical support to participating local newsrooms...
15/07/2026
San Francisco church becomes first U.S. deployment of the 2 M/E production switcher...
15/07/2026
Former ESPN and NFL Network executive to advise startup league on media, distribution, technology, and fan engagement...
15/07/2026
The Houston-based RSN is the live-game home of the Astros and Rockets...
15/07/2026
Launched alongside new FreqSoft installer
Designed to bridge the gap between hardware and software, Freqport's FreqInOut FO1 unit provides a simple way ...
15/07/2026
Save up to 55% on software until 23 July 2026
Expressive E have just launched their Summer Offer sale, with discounts of up to 55% now applied across their ...
15/07/2026
Real-time stem-separation tool updated
zplane have recently released a new and improved version of their real-time stem-separation plug-in which they say ma...
15/07/2026
A new benchmark in bass enhancement
Described as a new benchmark in bass enhancement , Baby Audio's latest release has been designed to augment the lo...
15/07/2026
DMC Production's AR 1 and AR 2 units reverse the conventional OB workflow, keeping all production-critical processing at the venue while operators work remo...
15/07/2026
Share
Copy link
Facebook
X
Linkedin
Bluesky
Email...
15/07/2026
Share
Copy link
Facebook
X
Linkedin
Bluesky
Email...
15/07/2026
GigaCloud, a leading Ukrainian cloud service provider, and Cubbit, the first geo-distributed cloud storage enabler, today announced a new Business Alliance Part...
15/07/2026
SMPTE, the global society for media professionals, technologists, and engineers, has announced the launch of the SMPTE 110th Anniversary Campaign, a fundraising...
15/07/2026
Studio Technologies, a leading manufacturer of high-quality audio, video, and fiber-optic solutions, unveils the new StudioComm Model 762 Stereo Level Control, ...
15/07/2026
COW Jobs: Producer, Virtual Events - Hybrid, Full Time, Salaried
Brie Clayton July 15, 2026
0 Comments
Producer, Virtual Events (Hybrid | Full-time | ...
15/07/2026
Brazilian media organization builds nationwide CDN with Broadpeak's high-performance software for low-latency streaming and new content distribution service...
15/07/2026
DHD announces a new utility designed to increase the efficiency of its audio mixing systems during initial installation and subsequent configuration.
Anyone w...
15/07/2026
BCNEXXT Brings Next-Generation Vipe to IBC2026, Breaking the 1:1 Channel-to-Server Ratio New innovations liberate broadcasters from legacy playout infrastructur...
15/07/2026
Share
Copy link
Facebook
X
Linkedin
Bluesky
Email...
15/07/2026
Share
Copy link
Facebook
X
Linkedin
Bluesky
Email...
15/07/2026
General-purpose robots and autonomous machines are moving from research labs to ...
15/07/2026
Wednesday 15 July 2026
Screeners and press pack now available: Gomorrah: The Or...
15/07/2026
Trinity's Treasures features Ruth Negga, Eleanor McEvoy, and David Norris, a...
15/07/2026
Join geographer Dr Susan Hegarty, Engineer Tim Joyce and Architect Orla Murphy a...
15/07/2026
Home to leading manufacturers, robotics pioneers, infrastructure builders and iconic gaming companies, of course, Japan is one of the world's centers of AI ...
14/07/2026
South end zone videoboard, cloud-based control system will be ready for 2026 football season...
14/07/2026
Redesigned website, enhanced mobile app unify content, ticketing, and personalized fan engagement...
Professor Stuart Lipton awarded $5 million to study the chemical biology of air pollution on the human brain The grant from the NIA/NIH will support research into how air pollution could lead to the development of Alzheimer's disease.
