
Professor Stuart Lipton awarded $5 million to study the chemical biology of air pollution on the human brain The grant from the NIA/NIH will support research into how air pollution could lead to the development of Alzheimer's disease.
October 01, 2024
LA JOLLA, CA Stuart Lipton, MD, PhD, professor and Step Family Foundation Endowed Chair, and Tomohiro Nakamura, PhD, Institute Investigator in the Neurodegeneration New Medicines Center and Department of Molecular Medicine at Scripps Research, have been awarded about $5 million from the National Institute on Aging (NIA) to study the impacts of air pollution on the human brain specifically, how air pollution could contribute to Alzheimer's disease and related dementias.
The NIA grant will support research over a five-year period as he and his team investigate how pollution sources including vehicle exhaust, wildfires contribute to a chemical reaction discovered by Lipton referred to as SNO and how this impacts the development of Alzheimer's disease. NIA, part of the National Institutes of Health (NIH), is focused on expanding our scientific understanding of the nature of aging, improving the health and well-being of older adults, and supporting and conducting research on aging and the challenges and needs of older adults.
The NIA's award shows not only how dedicated the organization is to improving human health, but its confidence that Scripps Research has the potential to make an enduring impact on these serious diseases, Lipton says.
SNO is a reaction that results from exposure to air pollution, which causes nitrogen (N) and oxygen (O) atoms to combine with a sulfur (S) atom on a wide variety of proteins and disrupt their function, resulting in brain damage. This reaction, termed S-nitrosylation, has been observed to cause a SNO storm of reactions in Alzheimer's brain neurons by Lipton and his team. A recent paper from the Lipton group in the journal Science described many of the biochemical pathways affect by the aberrant SNO storm in the brain.
In collaboration with Scripps Research professor John Yates III, PhD, Lipton's research uses mass spectrometry to discover the proteins that undergo SNO reactions and potentially contribute to the development of Alzheimer's and other dementias. Identifying these SNO proteins is a critical step in developing new therapeutic targets for diseases, while potentially also helping inform strategies on controlling air pollution.
Climate change, caused by human actions affecting the composition of air in the atmosphere, has already had a critical impact on global health. It's vital that we continue to expand this body of research to inform strategies and new therapeutics that address human disease influenced by environmental factors, Lipton says.
Along these lines, the California Institute of Regenerative Medicine (CIRM) recently made a companion award for Lipton to study the chemical biology of air pollution in autism and intellectual disabilities.
At Scripps Research, Lipton's lab focuses on investigating molecular signaling pathways in order to prevent neuronal and synaptic injury that occurs as the human body ages, as well as in neurodegenerative diseases like Alzheimer's, Parkinson's and other forms of dementia. His research into the drivers of Alzheimer's disease has already led to real-world results. Lipton is well-known for developing the FDA-approved drug memantine marketed commercially as Namenda , Namenda XR , and Namzaric represents one of only two medicines approved to treat moderate-to-severe forms of Alzheimer's. The drug is also used off-label for other forms of dementia, such as vascular dementia caused by multiple strokes and Lewy body dementia.
Neuroscience Molecular and Cellular Biology Lipton, Stuart
Most recent headlines
05/01/2027
Worlds first 802.15.4ab-UWB chip verified by Calterah and Rohde & Schwarz to be ...
09/10/2026
September 10 2026, 06:00 (PDT) Dolby Expands Dolby OptiView Platform with New Capabilities at IBC 2026
New Sports Intelligence helps providers better unders...
07/10/2026
Dalet, a leading technology and service provider for media-rich organizations, today announced the latest Long-Term Supported (LTS) release of Dalet Flex. Build...
23/09/2026
Four control rooms support B1G+ streams, videoboard shows, creative content, and...
23/09/2026
By Andrew Cohen, SVG Coorespondant
The Mountain West debuted its new Replay Operations Center at the start of this football season, bringing real-time collabor...
23/09/2026
The Taylorville, IL, native is pushing creative boundaries at Ball State, gaining reps across directing, technical directing, tape, and more than 100 ESPN+ broa...
23/09/2026
Alexander Heller, Nevada Jose, Will Brill, and Giselle Bonilla pose with cast members at The Musical premiere during the 2026 Sundance Film Festival at Eccles...
23/09/2026
Includes natural and processed patches
The Crow Hill Company's latest sample library captures a children's choir comprising a troupe of boys perform...
23/09/2026
Plug-in offers six bands of saturation
Kreuzberg Audio's product range includes a selection of plug-ins and virtual instruments aimed primarily at hard-...
23/09/2026
Latest DAW update now live
SoundBridge have announced that the latest update for the remote-collaboration-focused DAW is now available. The release of Sound...
23/09/2026
Koori Knockout returns home exclusively to NITV and SBS On Demand in 2026
11 September, 2026
Media releases
Fans can catch all the live action exclusively ...
23/09/2026
Rohde & Schwarz acquires NEOSAT and PHYTRONIC and strengthens its competencies i...
23/09/2026
1. ABOUT THE PROGRAMME
The National Film and Video Foundation (NFVF) invites applications from experienced producers who own or manage a South African product...
23/09/2026
The National Film and Video Foundation (NFVF) is pleased to announce the opening...
23/09/2026
Download Now!
To receive a short case study showcasing NHK Technologies, Inc. (NT) s audio setup, please enter the following details:
--
First Name* Fir...
23/09/2026
Nielsen CMI data reveals a changing fast-food landscape, with value, convenience...
23/09/2026
Share
Copy link
Facebook
X
Linkedin
Bluesky
Email...
23/09/2026
Share
Copy link
Facebook
X
Linkedin
Bluesky
Email...
23/09/2026
COW Jobs: Blender on Windows - Generalist - Remote
Brie Clayton September 23, 2026
0 Comments
Application Users - Blender on Windows - Generalist
Se...
23/09/2026
Version 1.8 recognised for new workflow tools, boosted control panel flexibility and ease of integration into IP networks...
23/09/2026
Hiltron Communications reports a successful 2026 International Broadcasting Convention, held at the RAI Amsterdam. Exhibiting on stand A37 in Hall 1, Hiltron ex...
23/09/2026
Reinforcing its long-term commitment to the Middle East and North Africa (MENA) broadcast market, LiveU is presenting the Q Era at CABSAT 2026, on Stand H1-D35 ...
23/09/2026
Agence France-Presse (AFP), a global news agency, and Dalet, a leading technology and service provider for media-rich organizations, today announced a partnersh...
23/09/2026
Berklee Connect Unlocks the Power of a Global Network Katie Vitolins BM '04 knows firsthand what Berklee's alumni community can make possible. Now she...
23/09/2026
Share
Copy link
Facebook
X
Linkedin
Bluesky
Email...
23/09/2026
Share
Copy link
Facebook
X
Linkedin
Bluesky
Email...
23/09/2026
Share
Copy link
Facebook
X
Linkedin
Bluesky
Email...
23/09/2026
Share
Copy link
Facebook
X
Linkedin
Bluesky
Email...
23/09/2026
Share
Copy link
Facebook
X
Linkedin
Bluesky
Email...
23/09/2026
Westminster Schools, a K through 12 school in Atlanta, Georgia with approximately 2,000 students, has transformed its student broadcast and digital storytelling...
23/09/2026
The 2026 edition of CABSAT and SATExpo may have a new home and dates in the diary, but it still retains a strong presence from UK companies in the GREAT Britain...
23/09/2026
Glensound will return to CABSAT with new developments in professional monitoring and Dante interfacing, alongside its established commentary, esports and parlia...
23/09/2026
A great watch - Radio Times
TV's most likeable proper bloke - Daily Telegraph
23rd September 2026, London: Guy Martin returns to free streaming service...
23/09/2026
Wednesday 23 September 2026
Sky Sports to show England Men's tour of South ...
23/09/2026
Comscore Partners with datafuelX to Bring Seamless Currency Adoption Into a Comp...
23/09/2026
Luxembourg, 23 September 2026 - SES today announced the appointment of Mr. Michel Scholer, Secretary General of the Luxembourg Government and Chief of Staff to ...
23/09/2026
RT One and RT Player, Friday 25 September
Ceol le Ch ile, a new series that follows Irish artists as they collaborate with musicians from diverse background...
23/09/2026
Available now on RT Listen
New information has come to light in the case of mi...
23/09/2026
When Sakeena Fiza describes her work as a validation engineer at NVIDIA, she does so in terms more befitting a detective story than a world-class engineering la...
22/09/2026
From Malaysia to Mexico and from DR Congo to Ukraine, this year's 12 finalists for the 2026 Thomson Foundation Young Journalist of the Year award tell extra...
22/09/2026
The annual preseason content-gathering event brought 36 NHL players to Las Vegas, where ESPN used 2.5 kilowatts of laser power and a motion-control camera syste...
22/09/2026
Neumann has introduced the KK 104 A (cardioid) and KK 105 A (supercardioid) wireless capsule heads, succeeding the KK 204 and KK 205. The new capsules are compa...
22/09/2026
The NFL and TMRW Sports have announced a new annual Pro Flag Showcase to be held during Super Bowl LXI week in Los Angeles. The event will feature top flag foot...
22/09/2026
Washington State University has unveiled a new end zone video display and audio ...
22/09/2026
Disney's SVP of Live Operations and Engineering details the technology behin...
22/09/2026
Cosm has announced two senior promotions. Mazen Alawar has been promoted to SVP,...
22/09/2026
Mississippi State University's University Television Center has purchased four KOKUSAI DENKI SK-UHD7000-S2 cameras since 2024, with plans to add two more, a...
22/09/2026
Net Insight has announced that Christine Kjellvard will assume the role of interim Chief Financial Officer on November 1, 2026. Kjellvard has previously held in...
22/09/2026
Net Insight has announced Zyntai TimeNode Access, a compact PTP Grandmaster designed for distributed edge sites. The product carries secure, precise time across...
22/09/2026
Sam Hazeldine, Austin Amelio, Padraic McKinley, Julia Jones, and Ethan Hawke attend the premiere of The Weight at The Ray Theatre on January 26, 2026, in Park...