Professor Stuart Lipton awarded $5 million to study the chemical biology of air pollution on the human brain The grant from the NIA/NIH will support research into how air pollution could lead to the development of Alzheimer's disease.
October 01, 2024
LA JOLLA, CA Stuart Lipton, MD, PhD, professor and Step Family Foundation Endowed Chair, and Tomohiro Nakamura, PhD, Institute Investigator in the Neurodegeneration New Medicines Center and Department of Molecular Medicine at Scripps Research, have been awarded about $5 million from the National Institute on Aging (NIA) to study the impacts of air pollution on the human brain specifically, how air pollution could contribute to Alzheimer's disease and related dementias.
The NIA grant will support research over a five-year period as he and his team investigate how pollution sources including vehicle exhaust, wildfires contribute to a chemical reaction discovered by Lipton referred to as SNO and how this impacts the development of Alzheimer's disease. NIA, part of the National Institutes of Health (NIH), is focused on expanding our scientific understanding of the nature of aging, improving the health and well-being of older adults, and supporting and conducting research on aging and the challenges and needs of older adults.
The NIA's award shows not only how dedicated the organization is to improving human health, but its confidence that Scripps Research has the potential to make an enduring impact on these serious diseases, Lipton says.
SNO is a reaction that results from exposure to air pollution, which causes nitrogen (N) and oxygen (O) atoms to combine with a sulfur (S) atom on a wide variety of proteins and disrupt their function, resulting in brain damage. This reaction, termed S-nitrosylation, has been observed to cause a SNO storm of reactions in Alzheimer's brain neurons by Lipton and his team. A recent paper from the Lipton group in the journal Science described many of the biochemical pathways affect by the aberrant SNO storm in the brain.
In collaboration with Scripps Research professor John Yates III, PhD, Lipton's research uses mass spectrometry to discover the proteins that undergo SNO reactions and potentially contribute to the development of Alzheimer's and other dementias. Identifying these SNO proteins is a critical step in developing new therapeutic targets for diseases, while potentially also helping inform strategies on controlling air pollution.
Climate change, caused by human actions affecting the composition of air in the atmosphere, has already had a critical impact on global health. It's vital that we continue to expand this body of research to inform strategies and new therapeutics that address human disease influenced by environmental factors, Lipton says.
Along these lines, the California Institute of Regenerative Medicine (CIRM) recently made a companion award for Lipton to study the chemical biology of air pollution in autism and intellectual disabilities.
At Scripps Research, Lipton's lab focuses on investigating molecular signaling pathways in order to prevent neuronal and synaptic injury that occurs as the human body ages, as well as in neurodegenerative diseases like Alzheimer's, Parkinson's and other forms of dementia. His research into the drivers of Alzheimer's disease has already led to real-world results. Lipton is well-known for developing the FDA-approved drug memantine marketed commercially as Namenda , Namenda XR , and Namzaric represents one of only two medicines approved to treat moderate-to-severe forms of Alzheimer's. The drug is also used off-label for other forms of dementia, such as vascular dementia caused by multiple strokes and Lewy body dementia.
Neuroscience Molecular and Cellular Biology Lipton, Stuart
Most recent headlines
05/01/2027
Worlds first 802.15.4ab-UWB chip verified by Calterah and Rohde & Schwarz to be ...
04/08/2026
Dalet, a leading technology and service provider for media-rich organizations, t...
04/07/2026
April 7 2026, 19:00 (PDT) Detective Conan: Fallen Angel of the Highway Opens in...
09/06/2026
The BBC has found its Hercule Poirot.
After Deadline revealed last month that t...
09/06/2026
Media buyers and sellers can now compare YouTube reach from computer, mobile, an...
09/06/2026
Share
Copy link
Facebook
X
Linkedin
Bluesky
Email...
09/06/2026
Share
Copy link
Facebook
X
Linkedin
Bluesky
Email...
09/06/2026
A project aimed at modernizing scheduling operations across Mediaset's channel portfolio
Mediagenix, a global leader in smart content solutions to profitab...
09/06/2026
tvONE, an ACT Entertainment brand, debuts its most powerful video processor ever built: the 4RU CALICO PRO (C7-PRO-4200), at InfoComm 2026 (Booth N6813). Engine...
09/06/2026
Composer and Conductor Eric Whitacre to Receive Honorary Doctorate at Berklee Va...
09/06/2026
Share
Copy link
Facebook
X
Linkedin
Bluesky
Email...
09/06/2026
Share
Copy link
Facebook
X
Linkedin
Bluesky
Email...
09/06/2026
Share
Copy link
Facebook
X
Linkedin
Bluesky
Email...
09/06/2026
Technology collaboration to validate AMPP and Lawo HOME orchestration integration, showcasing Dynamic Media Facility principles in practice.
Grass Valley and ...
09/06/2026
Bitmovin, a leading provider of video streaming solutions, today announced that Axel Springer SE, international media and technology company, has deployed Playe...
09/06/2026
LiveU, the global leader in live IP-video solutions, today announced a landmark deployment with the Oceania Football Confederation (OFC) that has brought Video ...
09/06/2026
Share
Copy link
Facebook
X
Linkedin
Bluesky
Email...
09/06/2026
Share
Copy link
Facebook
X
Linkedin
Bluesky
Email...
09/06/2026
Share
Copy link
Facebook
X
Linkedin
Bluesky
Email...
09/06/2026
Share
Copy link
Facebook
X
Linkedin
Bluesky
Email...
09/06/2026
Share
Copy link
Facebook
X
Linkedin
Bluesky
Email...
09/06/2026
Two Alumni Win Tony Awards Mike Morris and Cedric Leiba Jr. won awards for Best Orchestrations and Best Play, respectively.
June 8, 2026
By
Tori Donahue
...
09/06/2026
Enni Continues to Rely on Arvato Systems - And Will Be Using AEP.EnerS4 Billing Solution
Arvato Systems to implement transformation project for SAP S/4HANA Ut...
09/06/2026
These special programmes will highlight RT 's connection with the Irish diaspora
This year, RT is marking 100 years of public broadcasting in Ireland with...
08/06/2026
The two execs discuss the goals and the challenges of building a huge multi-cult...
08/06/2026
This industry legend has been a road warrior since the early '90s and is, today, a lynchpin on College GameDay
The sports-production industry continues to ...
08/06/2026
DAZN has agreed a multi-year rights partnership with Extreme Fighting Championship (EFC), expanding its global combat sports portfolio.
DAZN will broadcast EFC...
08/06/2026
As fans move across broadcast, streaming, social, mobile and creator-led platforms, and they expect every angle, in real time, TVU Networks has released a new e...
08/06/2026
Infront has further strengthened the 2026 Diamond League's international bro...
08/06/2026
Grass Valley has announced the appointment of Sam Craig as Vice President, Global Pre-Sales. Based in the United States, Craig will lead Grass Valley's glob...
08/06/2026
SMPTE has announced its summer 2026 education lineup covering IP networking and SMPTE ST 2110, including two standalone courses, a 13-week boot camp, and a hand...
08/06/2026
Sportradar Group AG has announced a multi-year global agreement with Kalshi, a p...
08/06/2026
FIFA and Gamefam have announced the launch of a FIFA World Cup 2026 event on Roblox, running June 5 through July 31, 2026. The event centers on FIFA Super Socce...
08/06/2026
A collaboration of NHL Productions, Monumental Sports, and Michael Levitt Produc...
08/06/2026
CBS Sports production staffer Bryce Adair has died at the age of 31 after sustaining injuries during a car accident on Wednesday while in Ohio working the the P...
08/06/2026
Behind The Mic provides a roundup of recent news regarding on-air talent, including new deals, departures, and assignments compiled from press releases and repo...
08/06/2026
WMT Digital today announced the launch of WMT Fan Intelligence, designed to unif...
08/06/2026
The Heat are the seventh NBA team to air their games over-the-air next season...
08/06/2026
Paramount and UFC have announced an expansion of their media rights partnership making Paramount the exclusive home of UFC Numbered Event main cards in Canada ...
08/06/2026
The Qatar Football Association (QFA), in cooperation with Sponix and broadcaster...
08/06/2026
Project B has announced the appointment of Host Broadcast Services (HBS) as Offi...
08/06/2026
The Buckeyes now produce and stream upwards of 200 sports events annually with a...
08/06/2026
At Spotify, our commitment to the LGBTQIA community is year-round. Through GLOW, our global music program, we celebrate and amplify the contributions of queer ...
08/06/2026
Get Hands-on With Keyboard & Synth Brands
GearExpo UK wouldn't be complete without some synth action, and we've got some of the industry's most ...
08/06/2026
50 popular in-ear monitoring system profiles added
The latest update for IK Multimedia's headphone-correction system has just arrived, and introduces ca...
08/06/2026
Manny Marroquin signature cans upgraded with SLAM Technology
The flagship model in Audeze's Manny Marroquin Signature Series has just been treated to an...
08/06/2026
Air domain supremacy redefined - New counter UAS, space solutions and directiona...
08/06/2026
he BBC and BritBox have announced that Edward Bluemel (We Might Regret This, My ...
08/06/2026
Share
Copy link
Facebook
X
Linkedin
Bluesky
Email...
Professor Stuart Lipton awarded $5 million to study the chemical biology of air pollution on the human brain The grant from the NIA/NIH will support research into how air pollution could lead to the development of Alzheimer's disease.
