Scripps Florida Scientists Offer New Insight into Neuron Changes Brought About by Aging JUPITER, FL, January 22, 2013 How aging affects communication between neurons is not well understood, a gap that makes it more difficult to treat a range of disorders, including Alzheimer's and Parkinson's disease.
A new study from the Florida campus of The Scripps Research Institute (TSRI) offers insights into how aging affects the brain's neural circuitry, in some cases significantly altering gene expression in single neurons. These discoveries could point the way toward a better understanding of how aging affects our cognitive ability and new therapeutic targets for the treatment of neurodegenerative disease.
Although we don't know exactly why, we do know there is a signaling imbalance as we age, and we've captured these changes at the single neuron level, said Sathyanarayanan V. Puthanveettil, a TSRI assistant professor who led the work. If we could identify the underpinnings of this mechanism, we may be able to target the specific mechanism to affect or reverse the aging process in human neurons.
To record the electrical and physiological properties of single neurons, the scientists created a new method and applied it to the marine snail Aplysia californica, a widely used animal model. Many Aplysia gene expression signatures have counterparts in the human genome.
Using this methodology, which was published in the Journal of Visualized Experiments, the scientists were then able to focus on neuron R15, a burst firing neuron that is implicated in the regulation of water content and reproduction, showing how its response to the neurotransmitter acetylcholine and gene expression changed with age.
In a study published in the journal PLOS ONE, the team described specific changes in burst firing and action potentials which play a central role in cell-to-cell communication during the aging of R15, suggesting that changes in the response to acetylcholine during aging has been conserved during evolution in organisms from snails to mammals.
In another study, published in published in BMC Genomics, the team revealed unexpected information about gene expression during R15 aging.
Aging brings bidirectional changes in the gene expression, said Puthanveettil. Some gene expression goes up; some goes down. This was surprising, particularly that some gene expression went up something you don't necessarily associate with aging.
The study also noted that more than 1,000 DNA sequences are regulated differently in mature versus old R15 neurons. Among the specific biological pathways that are altered are networks involved in: cell signaling and skeletal muscular system development; cell death and survival; cellular function maintenance and embryonic development; and neurological diseases and developmental and hereditary disorders.
To confirm these findings, Puthanveettil and his colleagues also isolated and examined three other Aplysia neurons. Interestingly, while all the neurons showed changes in gene expression with age, these changes weren't necessarily similar among the neurons. Also the magnitude of change was specific to individual neurons.
The scientists are now investigating how and why aging affects neurons differently.
The first author of the Journal of Visualized Experiments study, Aplysia Ganglia Preparation for Electrophysiological and Molecular Analyses of Single Neurons, is Komol Akhmedov of TSRI. Other authors include Beena M. Kadakkuzha, also of TSRI. For more information, see http://www.jove.com/video/51075/aplysia-ganglia-preparation-for-electrophysiological-molecular
The first authors of the PLOS ONE study, Decreased response to acetylcholine during aging of Aplysia neuron R15, are Komol Akhmedov and Valerio Rizzo of TSRI. Other authors include Beena M. Kadakkuzha of TSRI, Christopher J. Carter and Neil S. Magoski of Queens University, Canada, and Tom R Capo of the University of Miami. For more information, see http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3874043/
The first author of the BMC Genomics study, Age-Associated Bidirectional Modulation of Gene Expression in Single Identified R15 Neuron of Aplysia, is Beena M Kadakkuzha of TSRI. Other authors include Komolitdin Akhmedov, Mohammad Fallahi and Anthony C Carvalloza of TSRI and Tom R Capo of the University of Miami. For more information, see http://www.biomedcentral.com/1471-2164/14/880/abstract
The studies were supported by the National Institutes of Health (grant Number 1 R21 MH096258), the Whitehall Foundation and the State of Florida.
About The Scripps Research Institute
The Scripps Research Institute (TSRI) is one of the worlds largest independent, not-for-profit organizations focusing on research in the biomedical sciences. TSRI is internationally recognized for its contributions to science and health, including its role in laying the foundation for new treatments for cancer, rheumatoid arthritis, hemophilia, and other diseases. An institution that evolved from the Scripps Metabolic Clinic founded by philanthropist Ellen Browning Scripps in 1924, the institute now employs about 3,000 people on its campuses in La Jolla, CA, and Jupiter, FL, where its renowned scientists including three Nobel laureates work toward their next discoveries. The institutes graduate program, which awards PhD degrees in biology and chemistry, ranks among the top ten of its kind in the nation. For more information, see www.scripps.edu.
# # #
For information:
Office of Communications
Tel: 858-784-2666
Fax: 858-784-8136
press@scripps.edu
Most recent headlines
04/08/2024
Dalet, a leading technology and service provider for media-rich organizations, is excited to announce Santiago Solanas as its new Chief Executive Officer (CEO)....
03/06/2024
Dalet, a leading technology and service provider for media-rich organizations, a...
07/05/2024
PORTSMOUTH, N.H. New findings from Hub Entertainment Research provides extensive data showing that the majority of consumers will opt for lower cost ad-supporte...
07/05/2024
NEW YORK The Library of American Broadcasting Foundation (LABF) has announced th...
07/05/2024
CBS News has named Lindsey Reiser an anchor and correspondent for CBS News 24/7, the network's live, streaming news service. Reiser, who was most recently a...
07/05/2024
NEEDHAM, Mass. After more than two years of decline, worldwide tablet shipments posted modest year-over-year growth of 0.5% in the first quarter of 2024 (1Q24),...
07/05/2024
ESPN is reporting that April was a record-setting month as the network delivered its best April prime time audience on record, dating back more than 30 years....
07/05/2024
WASHINGTON, D.C. The National Association of Broadcasters (NAB) has announced that Kirsten Donaldson has joined NAB as vice president of public policy. Donaldso...
07/05/2024
The Bulls are back home again this week from May 7-12! Don't miss out on any...
06/05/2024
By Ilyse McKimmie
Now, more than ever
That's a phrase so often used in the last few years that I've come to dread seeing it in notes like this one. A...
06/05/2024
alt= class=wp-image-12099 data-lazy-src=/wp-content/uploads/2024/05/Blog-Exabyte-Storage-Demand-960x540-1.jpg/> Demand for storage solutions has reached unprece...
06/05/2024
Around the world, Asian and Pacific Islander (API) artists continue to impact mu...
06/05/2024
Spotify is making it easier for booklovers to count down the days, hours, minutes, and seconds until a new audiobook releases. With Countdown Pages for audioboo...
06/05/2024
Get Ready to join Dan Hong as he hits the streets in his ultimate culinary journ...
06/05/2024
In this video, cinematographer Simon Rowling welcomes viewers behind the scenes as he lights a daytime-interior scene inside a coffee shop. Shooting on Panavisi...
06/05/2024
L3Harris is well positioned to support the complex and multifaceted nature of special operations forces in all domains through our agile and responsive technolo...
06/05/2024
OAKVILLE, Ontario As part of Emergency Preparedness Week, Alert Ready, Canadas national public alerting system, will be distributing a test alert to Canadians i...
06/05/2024
NEW ROCHELLE, N.Y. Horowitz Research has released a new study on the viewing and media habits of U.S. Hispanic/Latine audiences that shows a dramatic decline in...
06/05/2024
RE:Vision Effects Autograph 2024.4 released! 50% Off Through May 9th
Brie Clayton May 6, 2024
0 Comments
New game-changing motion graphics & VFX featu...
06/05/2024
NBC has renewed Night Court for a third season. The courtroom comedy was on the network from 1984 to 1992, and NBC rebooted it in early 2023....
06/05/2024
ABC has revealed its summer schedule. The Bachelorette gets going Monday, July 8, with Jenn Tran the star in season 21. Celebrity Family Feud starts up Tuesday,...
06/05/2024
It's almost go-time for the Holly Springs Salamanders! The season opener is ...
06/05/2024
Tonight on Skeem Saam: Kobus busts Pretty in a compromising positionDon't miss Monday, 6 May's riveting episode of South African soapie Skeem Saam on SA...
06/05/2024
Tonight on House of Zwide: Bra Zakes and Sphamandla agree to leave Tembisa and n...
06/05/2024
RT has announced details of its coverage across digital, TV and Radio in the ru...
06/05/2024
For years, radio stations have used on-premises servers to broadcast content and manage automation, traffic, and billing systems. As technology continues to adv...
06/05/2024
06 May 2024
AI and Big Data Take the Centre Stage in Central Asia at Beetech 20...
06/05/2024
FIRST LOOK AT JIM PARSONS & MAYIM BIALIK REPRISING THEIR ROLES FROM THE BIG BAN...
06/05/2024
NBC Sports and Churchill Downs Extend Historic Partnership, Kentucky Derby to Be...
06/05/2024
Beverly Hills Aerials, LIV Golf Make Australian-Broadcast History by Flying Live...
06/05/2024
Back to All News
Watch the Trailer for A Part of You - Felicia Maxime, Edvin Ry...
06/05/2024
Leadership in 12G-SDI for low impact migration to 4k production...
06/05/2024
Press release - 6 May 2024 07:31
STATEMENT CONCERNING EUTELSAT GROUP'S GROUND NETWORK Facebook
LinkedIn
Twitter
Download as PDF
Paris, 06 May 2024 ...
06/05/2024
Tyngsboro, Mass. - May 6, 2024 - Join us at InfoComm 2024 to experience the latest advancements in live production technology. From June 12-14, 2024, at the Las...
06/05/2024
To champion global movements to protect and advance equality for LGBTQ+ communities, Apple is introducing a new Apple Watch Pride Edition Braided Solo Loop, ava...
06/05/2024
Actress Matseliso Mohale has joined Muvhango'Talented actress Matseliso Mohale has joined SABC2's soapie Muvhango' as Vhangani's lover and a c...
06/05/2024
Tonight on Smoke and Mirrors: Leroy refuses to give up fighting to bury MthethoDon't miss Monday, 6 May's riveting episode of South African soapie Smoke...
06/05/2024
Intrinsic, a software and AI robotics company at Alphabet, has integrated NVIDIA AI and Isaac platform technologies to advance the complex field of autonomous r...
06/05/2024
Cybersecurity experts at the RSA Conference this week will be on the hunt for ways to secure their operations in the era of generative AI.
They'll find man...
06/05/2024
1) What is the rationale of the transaction? What is the benefit for SES shareholders?
This combination creates a stronger and more competitive multi-orbit ope...
05/05/2024
A special evening performance by multiplatinum singer Becky G will provide a memorable conclusion to TeievisaUnivision's Casa Cultura upfront event on May 1...
05/05/2024
Giant media buyer Publicis is telling network sales executives that it does not think Nielsen's new panel-plus-big-data currency is ready for this upfront....
05/05/2024
WASHINGTON Glenn Kirschner, legal analyst at NBC News, blasted the media for referring to the New York trial of former President Donald Trump as a hush-money ...
05/05/2024
Catchy Comedy's weekend marathon sees The Beverly Hillbillies on the weekend of May 4-5. The event kicks off Saturday, May 4 at 11 a.m. ET, and runs through...
05/05/2024
NBC Sports has the 150th Kentucky Derby Saturday, May 4. The coverage begins at 2:30 p.m. ET on NBC and Peacock and the feature race at Churchill Downs in Louis...
05/05/2024
Back to All News
Netflix Announces New Comedy Series Roosters, Starring Jeroen ...
05/05/2024
Back to All News
Showdown Alert: Baki Hanma VS Kengan Ashura' Drops Electr...
04/05/2024
NEW YORK As the Asian Pacific American Heritage Month kicks off in May, Nielsen has released an extensive new report diving into their media habits with data sh...
04/05/2024
PHILADELPHIA As National Military Appreciation Month gets underway, Comcast has announced several new initiatives to help veterans, service members, and their f...
Scripps Florida Scientists Offer New Insight into Neuron Changes Brought About by Aging JUPITER, FL, January 22, 2013 How aging affects communication between neurons is not well understood, a gap that makes it more difficult to treat a range of disorders, including Alzheimer's and Parkinson's disease.
