May 24, 2022
25/05/2022
May 24, 2022
LA JOLLA, CA The National Institute of Neurological Disorders and Stroke (NINDS), part of the National Institutes of Health (NIH), has awarded the first $4 million tranche of funding for a large, phase three clinical trial of an experimental stroke drug invented at Scripps Research.
The award, totaling approximately $20 million in direct funds over 6 years, will fund an international, multi-center clinical trial of the experimental treatment 3K3A-APC in about 1,400 patients led by the Keck School of Medicine of the University of Southern California (USC). The trial will focus on patients who experience the most common form of stroke ( ischemic stroke), which is caused by the blockage of blood flow usually from a blood clot in vessels serving the brain. The trial will determine whether 3K3A-APC can hasten recovery and improve outcomes for these patients when added to standard clot-busting treatment.
I'm very encouraged to see that NINDS is supporting the testing of 3K3A-APC at this scale ischemic stroke is a major disorder, and any new and effective treatment has the potential to preserve life and otherwise improve outcomes for a very large patient population, says John Griffin, PhD, a professor in the Department of Molecular Medicine at Scripps Research whose lab invented 3K3A-APC.
Americans suffer ischemic strokes at the rate of roughly 700,000 per year, and although the clot-busting drug tPA has improved outcomes since its introduction in 1996, these vascular events remain a common cause of death and severe disability, particularly among the elderly.
3K3A-APC has demonstrated strong brain-protecting effects in animal models of stroke. In a recent phase 2 clinical trial, 3K3A-APC, in conjunction with tPA or surgical clot removal, showed promising signs of tolerability and improved imaging markers in patients.
3K3A-APC is a modified version of a natural human protein called Activated Protein C (APC). While the latter has powerful brain cell-protecting properties, it also has a strong anticoagulant effect. Griffin and his colleagues slightly modified APC to 3K3A-APC to remove virtually all the anticoagulant effect and reduce the risk of brain bleeding a risk that is already elevated by the use of tPA.
Griffin collaborated in many groundbreaking studies of 3K3A-APC with Berislav Zlokovic, MD, PhD, director of Zilkha Neurogenetic Institute at the Keck School of Medicine. Zlokovic co-founded ZZ Biotech, the Houston-based company that now sponsors its clinical development. The FDA last summer gave 3K3A-APC development a Fast Track designation, speeding up its application review process.
The new trial, due to begin next year, will be conducted under the supervision of stroke clinician Patrick Lyden, MD, professor of physiology, neuroscience and neurology at the medical school
3K3A-APC is also currently being studied in a phase 2 trial, as a potential treatment for patients with ALS (amyotrophic lateral sclerosis), based on earlier studies suggesting that its brain cell-protecting properties may enable it to slow or stop ALS progression.
Molecular Medicine Griffin, John
LINK: | https://www.scripps.edu/news-and-events/press-room/2022/20220524-griff... |
See more stories from scripps |
Most recent headlines
04/08/2024
Dalet Appoints Santiago Solanas as CEO to Lead Next Era of Growth and Innovation
Dalet, a leading technology and service provider for media-rich organizations, is excited to announce Santiago Solanas as its new Chief Executive Officer (CEO)....
03/06/2024
Dalet and Veritone Reach Agreement to Distribute, Transact and Monetize Media Archives
Dalet, a leading technology and service provider for media-rich organizations, a...
28/04/2024
Mediahaus delivers the first SRT live-streaming sports production over 5G with URSA Broadcast G2
Mediahaus delivers the first SRT live-streaming sports production over 5G with U...
18/04/2024
First Look: Tom Durant Pritchard joins the cast of crime drama Miss Scarlet for its fifth series
Tom Durant Pritchard as Alexander Blake Thursday 18 April 2024 Tom Durant Prit...
18/04/2024
Alone Australia goes from strength to strength
Alone Australia goes from strength to strength 18 April, 2024 Media releases The program again delivers for SBS with significant uplifts in digital BVOD vi...
18/04/2024
L3Harris to Expand and Modernize Solid Rocket Motor Manufacturing in Virginia
ORANGE COUNTY, Va., April 18, 2024 - L3Harris Technologies [NYSE:LHX] has entered into an agreement with Orange County, Virginia, to fund the expansion and mode...
18/04/2024
Achieving Air Dominance by Advancing Imaging & Designating EO/IR Capabilities
L3Harris Sky Warden multi-mission aircraft, equipped with the WESCAM MX-15 and WESCAM MX-20 EO/IR sensor systems, was selected for USSOCOMs Armed Overwatch prog...
18/04/2024
US Space Force Extends Partnership with L3Harris to Enhance Space Domain Awareness
MELBOURNE, Fla., April 18, 2024 - L3Harris Technologies (NYSE:LHX) has received ...
18/04/2024
2024 NAB Show Attendance Topped 61,000
LAS VEGAS The National Association of Broadcasters is reporting that more than 61,000 people attended the 2024 NAB Show, where artificial intelligence and the c...
18/04/2024
How today's storage and memory decisions underpin future creativity
Ann Keefe, Regional Director - UK and Ireland at Kingston Technology, explains how storage and memory decisions made now are underpinning creativity in the futu...
18/04/2024
Krisha Marcano Announced as Dean of Theater for Boston Conservatory at Berklee
Krisha Marcano Announced as Dean of Theater for Boston Conservatory at Berklee The theater educator, choreographer, and performer will join Boston Conservator...
18/04/2024
Escape Studios obtains UKVI licence to support international students
The newly acquired UKVI licence enables Escape Studios to recruit and retain international students By Matthew Corrigan Published: April 18, 2024 The newl...
18/04/2024
NAB 2024 popular among first time visitors
Attendees from more than 163 countries were present, including 34 delegation buying groups from around the world By Matthew Corrigan Published: April 18, 202...
18/04/2024
Dyn Media and NEP Germany pioneer new frontier in remote...
In August 2023, Dyn Media launched as a new broadcaster in European sports, aimed at giving sports beyond football the exposure and viewership they deserve. The...
18/04/2024
Hitomi partners with ES Broadcast Hire for US rentals
Hitomi Broadcast, market leader in audio/video alignment and latency tools based in the UK, has signed a partnership deal with global broadcast rental specialis...
18/04/2024
Screen Australia and Dynamic Television announce new Scripted Initiative
18 04 2024 - Media release Screen Australia and Dynamic Television announce new Scripted Initiative Savage River Screen Australia and Los Angeles-based telev...
18/04/2024
Vislink's DragonFly V - The Company's Smallest-Ever Transmitter Debuted at NAB 2024
Vislink's DragonFly V - The Company's Smallest-Ever Transmitter Debuted ...
18/04/2024
MediaSilo to Offer Camera to Cloud with Atomos
MediaSilo to Offer Camera to Cloud with Atomos Brie Clayton April 17, 2024 0 Comments Integration between MediaSilo and Atomos Cloud Studio unlocking ...
18/04/2024
MultiDyne Updates its SilverBULLET Series to Serve More Fiber-Optic Links
MultiDyne Updates its SilverBULLET Series to Serve More Fiber-Optic Links Brie Clayton April 17, 2024 0 Comments MultiDyne Fiber Optic Solutions intro...
18/04/2024
Cinedeck Partners with Paramount to Revolutionize Content Delivery Process
Cinedeck Partners with Paramount to Revolutionize Content Delivery Process Brie Clayton April 17, 2024 0 Comments Cinedeck, a pioneer in integrated de...
18/04/2024
Unreal for video adding rocks and foliage
Unreal for video adding rocks and foliage Graham Quince April 17, 2024 0 Comments Welcome to my series on learning Unreal Engine for After Effects u...
18/04/2024
Best Budget Beginner-Friendly 4k Drone
Best Budget Beginner-Friendly 4k Drone Sean Alami April 17, 2024 0 Comments Potensic Atom 4k 3 axis Gimbal Drone, ideal drone for beginners. Some con...
18/04/2024
Race or Just Have Fun at Rocky Mount Mills for a Good Cause, Not Your Run of the Mill 5K
Rocky Mount Mills will be overflowing with runners, families and friends, all fo...
18/04/2024
Berklee's Yoon-Ji Lee Receives Guggenheim Fellowship
Berklee's Yoon-Ji Lee Receives Guggenheim Fellowship Lee, an assistant professor of composition, creates music based on unconventional and nonlinear struc...
18/04/2024
Ben Sherwood, Former ABC President, Named CEO at The Daily Beast
Ben Sherwood, former president of Disney ABC Television Group, has been named CEO and publisher at The Daily Beast. Joanna Coles, former chief content officer a...
18/04/2024
Ping Pong for the Masses: Bringing an Old Sport to a Brand New Audience With World Table Tennis
Ping pong for the masses: Bringing an old sport to a brand new audience with Wor...
18/04/2024
Fanatical Fans: IMG on Bringing the World of Table Tennis to a New Global Audience for WTT
Fanatical fans: IMG on bringing the world of table tennis to a new global audien...
18/04/2024
Netflix Follows Dallas Cowboys Cheerleaders in New Series
Back to All News Netflix Follows Dallas Cowboys Cheerleaders in New SeriesPlay Video Play Video Entertainment 18 April 2024 GlobalUnited States Link copie...
18/04/2024
Chinese-Language Revenge Thriller Series The Resurrected' Marks International Film Stars Shu Qi and Sinje Lee's Debut on Netflix
Back to All News Chinese-Language Revenge Thriller Series The Resurrected'...
18/04/2024
'The Witcher' Season 4 Begins Production in the UK and Netflix Announces Fifth and Final Season
Back to All News The Witcher Season 4 Begins Production in the UK and Netflix A...
18/04/2024
2024-04-18
Apple has reduced its overall greenhouse gas emissions by more than 55 percent since 2015, the company shared today in its 2024 Environmental Progress Report. T...
18/04/2024
Prison Journalism: April's experiences of black boudoir
Prison Journalism: April's experiences of black boudoirThabo Mthembu was incarcerated in Pollsmoor Prison from 2014 to 2019. Read Thabo's story by Tha...
18/04/2024
Prison Journalism: Can gangsterism and violence be reduced in prison?
Prison Journalism: Can gangsterism and violence be reduced in prison?Dean Mashimbwe, a Zimbabwean migrant residing in Cape Town, was incarcerated at Pollsmoor C...
18/04/2024
Software-making music: How DJs are doing it
Software making music: How DJs are doing itSoftware plays a big part in music production, recording, and performances. Here's what DJs are using, and how yo...
18/04/2024
Tonight on House of Zwide: Zanele later blindsides an unwitting Faith into meeting with Zola
Tonight on House of Zwide: Zanele later blindsides an unwitting Faith into meeti...
18/04/2024
Debut author stuns with international bestselling thriller Anna O'
Debut author stuns with international bestselling thriller Anna O'Matthew Blake burst onto the book scene with his bestseller Anna O', a deliciously d...
18/04/2024
Up to No Good: No Rest for the Wicked' Early Access Launches on GeForce NOW
It's time to get a little wicked. Members can now stream No Rest for the Wicked from the cloud. It leads six new games joining the GeForce NOW library of m...
18/04/2024
Skeem Saam: Wednesday's episode, 17 April 2024 [video]
Skeem Saam: Wednesday's episode, 17 April 2024 [video]Missed an episode of Skeem Saam? No problem! Watch the latest episode of your favourite South African ...
18/04/2024
Watch: Trailers for the best Afrikaans movies ever made
Watch: Trailers for the best Afrikaans movies ever madeDon't know what to watch? Here are some of the best Afrikaans movie trailers ever made, including Too...
18/04/2024
Thales secures three major contracts to modernize the Portuguese railway infrastructure
Facebook Twitter LinkedIn Thales alongside partners SISINT and CONECTICABO...
18/04/2024
RT Prime Time experiment reveals disturbing content recommended to 13 year old TikTok users in Ireland
In response to growing concerns raised regarding the adverse impact of TikTok co...
18/04/2024
Remembering Alf McCarthy and Larry Masterson
We were saddened to learn this morning of the passing of our friend and former colleague, Alf McCarthy who died yesterday. We remember Alf as a popular present...
18/04/2024
NVIDIA Honors Partners of the Year in Europe, Middle East, Africa
NVIDIA today recognized 18 partners in Europe, the Middle East and Africa for their achievements and commitment to driving AI adoption. The recipients were hon...
17/04/2024
Sundance Institute Launches RFI and RFP Process to Explore Host Locations for the Sundance Film Festival in 2027 and Beyond
Opening today, the exploration is aimed at selecting a location that will preser...
17/04/2024
Spotify's Michael Krause Talks Industry Trends Ahead of Our Music and Podcasting Summits in Germany
On April 18 and 19, experts from across the audio industry-including artists, pu...
17/04/2024
Spotify Brings Entrepreneurs and Trailblazers Together to Talk the Future of Tech in the UK
With its particular combination of talent, ambition, culture, and, of course, wo...
17/04/2024
NextGen Partners With Howard University Professor Nikole Hannah-Jones on Student Podcasting Course
At Spotify, we want to equip student creators with the tools and resources neede...
17/04/2024
Strengthening Australian Industry Capability Through Sovereign Sustainment Support
L3Harris Communications Australia Field Service support continues to grow with a...
17/04/2024
L3Harris Team Aligns 10 Mirrors for NASA's Roman Telescope
An optical technician lays on a diving board suspended between NASAs Nancy Grace Roman Space Telescopes primary and secondary mirrors. The photo is a projected ...