A better way to predict a patient's risk of coronary artery disease Scripps Research scientists developed a model that more accurately identifies patients at risk of coronary artery disease and can inform tailored treatment.
April 16, 2025
LA JOLLA, CA Coronary artery disease (CAD) is the leading cause of death in the United States. Although effective preventative treatments exist, these measures are often underutilized, in part because people don't know they're at risk of CAD until it's too late.
Now, scientists at the Scripps Research Translational Institute have developed a machine learning model that more accurately estimates a patient's risk of CAD compared to the standard clinical practice, which is based primarily on age. The findings, published in Nature Medicine on April 16, 2025, leveraged data that spanned 10 years. Their new model is personalized and integrates factors including genetics, lifestyle and medical history, enabling clinicians to provide patients with advice and preventative treatment tailored to their individual needs.
I think more precise and personalized risk prediction could motivate patients to engage in early prevention, says senior author Ali Torkamani, PhD, professor and director of Genomics and Genome Informatics at the Scripps Research Translational Institute. Our model first predicts the risk that a person will develop CAD, and then it provides information to allow personalized intervention.
CAD is caused by a buildup of plaque in the heart's arteries, which then blocks blood supply. Many people don't realize they have CAD until they experience a heart attack, but the disease is cumulative the earlier treatment begins, the more effective it will be.
We tend to observe bad outcomes for CAD in patients who are in their mid-50s and older, but the disease actually begins to develop much earlier, sometimes even while people are teenagers. Theres a lot of room for us to take action, says first author Shang-Fu Shaun' Chen, a former doctoral student in Torkamani's group.
To enable more accurate CAD risk prediction, Torkamani's team set out to create a model that incorporates factors beyond age, including genetic predisposition, lifestyle and medical history. They used data from the UK Biobank to train a machine learning model to recognize factors associated with CAD. Then, they tested the model on longitudinal data from a different cohort of individuals within the Biobank to see whether it could predict their risk of developing CAD over the course of 10 years based on their baseline data.
The model started with around 2,000 predictive features that could factor into CAD risk, but the team eventually whittled this list down to 53 risk factors. These included physical measurements, blood biomarkers, family medical history, mental illness, sleep duration and the presence of specific gene variants.
The new model outperformed the standard clinical model and enabled the prediction of two times as many CAD events. After 10 years of follow-up, 62.9% of individuals that the model categorized as being at highest risk had developed CAD, compared to only 0.3% of individuals in the lowest risk group.
The new model is personalized and integrates factors including genetics, lifestyle and medical history, enabling clinicians to provide patients with advice and preventative treatment tailored to their individual needs. Credit: Scripps Research Compared to traditional clinical tools, the new model improved risk classification for approximately one in four individuals helping to better identify those truly at risk while avoiding unnecessary concern for those who are not, said Chen.
The model's accuracy was partially due to its better ability to predict CAD in groups of people who are usually categorized as low risk, such as younger individuals and women.
Our model can pick up individuals who would be considered at low risk of CAD due to their age, but who are actually high risk due to their underlying genetics, says Torkamani.
Though the model's accuracy depended on the inclusion of multiple factors, the team showed that genetic predisposition was by far the strongest predictor of CAD risk. This included not only genetic predisposition for CAD itself, but also for related conditions such as high blood pressure, high cholesterol and diabetes.
The higher your genetic risk for one of those traits high cholesterol levels or high blood pressure levels or high diabetes risk the greater benefit you get from intervening on that particular aspect through medication or lifestyle changes, says Torkamani.
When the team validated the model using the National Institutes of Health All of Us dataset which includes more diverse populations than the UK Biobank they showed it was able to predict CAD risk equally well for people with European, African and Hispanic ancestries.
Now, the researchers are planning a long-term clinical trial to test whether informing patients of their risk of CAD can help prevent the disease.
We think the most important thing is for patients to be aware of their individual risks so that they can receive the appropriate treatments and make lifestyle changes, says Chen.
In addition to Torkamani and Chen, authors of the study, Meta-Prediction of Coronary Artery Disease Risk, include Hossein J. Sadaei, Ahmed Khattab, Corneliu Henegar, Nathan E. Wineinger and Evan D. Muse of Scripps Research; Sang Eun Lee of University of Ulsan College of Medicine; Jun-Bean Park of Seoul National University Hospital; and Jei-Fu Chen of Memorial Sloan Kettering Cancer Center.
This work was supported by funding from the National Institutes of Health (R01HG010881 and UM1TR004407) and the Scripps Research HPC team, including JC Ducom and Lisa Dong.
Heart Disease Torkamani, Ali
Most recent headlines
06/10/2025
France T l visions, France's leading broadcaster, has received the 2025 EBU ...
04/09/2025
Monumental Sports & Entertainment (MSE), in collaboration with Dalet, has been a...
07/08/2025
July 8 2025, 22:30 (PDT) Tata Motors & Dolby Bring Dolby Atmos to Harrier.ev, R...
11/07/2025
PARK CITY, UTAH, July 11, 2025 - The nonprofit Sundance Institute announced today the 11 producers chosen for its annual Producers Labs, returning to Ucross Fou...
11/07/2025
If you've ever wondered what might be playing in Clark Kent's headphones...
11/07/2025
L3Harris Technologies President of Intelligence, Surveillance and Reconnaissance Jason Lambert and General Manager of L3Harris Waco facility Sean Ling held a ce...
11/07/2025
ARLINGTON, Va. WETA, the flagship public media station in the national capital area, has launched WETA+, a new streaming service tailored for the local Washingt...
11/07/2025
The Federal Communications Commission has emerged as one of the central players in the broadcast TV landscape in 2025, with its deregulatory policies sparking h...
11/07/2025
Calrec will introduce usability, customization and system enhancements across its entire range of Argo consoles during IBC2025, Sept. 12-15, at the RAI Amsterda...
11/07/2025
LONDON Encompass Digital Media said it will support live and on-demand viewing of the 2025 FIFA Club World Cup across multiple global regions for sports enterta...
11/07/2025
Two-thirds of broadcast engineers reaped the benefits of a pay raise within the last year....
11/07/2025
CARY, N.C. SmallHD has launched the Quantum 27, a new 26.5-inch Quantum-Dot OLED monitor designed to deliver postproduction image quality in a compact, set-frie...
11/07/2025
The Federal Communications Commission's Enforcement Bureau and Tegna have entered into a consent decree that will settle an investigation into the accidenta...
11/07/2025
WASHINGTON Following news in early July that Paramount had settled President Donald Trump's lawsuit, Sens. Edward J. Markey (D-Mass.) and Ben Ray Luj n (D-N...
11/07/2025
Model/Actriz Performs Lead Single Cinderella on The Late Show with Stephen Colbe...
11/07/2025
Behind the Mic: Amazon Prime Preps for First Season of NBA Action; MSG Networks ...
11/07/2025
SVG New Sponsor Spotlight: Suite Studios' Craig Hering on Adapting to Client...
11/07/2025
2025 SVG Content Management Forum Breaks Down AI's Impact, Continued Transit...
11/07/2025
A Journey HOME: University of Nebraska's HuskerVision Goes IP Leaders from the HuskerVision and Lawo share their IP learnings By SVG Staff
Friday, July 1...
11/07/2025
CMSI, Remote Picture Labs, Ace ESPN's Cloud-Based Editing Efforts for Wimble...
11/07/2025
Netflix Enters the Live-Boxing-Production Ring for Round 2 With Historic Taylor-...
11/07/2025
Back to All News
Too Hot to Handle: Italy Is Coming on July 18 Only on Netflix
Entertainment
11 July 2025
GlobalItaly
Link copied to clipboard
July 11, 20...
11/07/2025
Back to All News
Netflix Will Release Death Inc. Seasons 1, 2 and 3
Entertainment
11 July 2025
GlobalSpain
Link copied to clipboard
Season 1
Season 2
Se...
11/07/2025
AI and Multimedia Authenticity Standards Collaboration launches two papers to guide the future of AI integration, today at the AI for Good Global Summit
The...
11/07/2025
Ceramics - the humble mix of earth, fire and artistry - have been part of a global conversation for millennia.
From Tang Dynasty trade routes to Renaissance pa...
10/07/2025
The current holder of the prestigious Thomson Foundation Young Journalist of the Year Award has been forced to stop reporting over fears for her safety in Afgha...
10/07/2025
Spotify is turning up the volume on Australian music with a multipronged initiative designed to highlight the dominance of Australian artists on the global stag...
10/07/2025
This is not a drill: Oasis is back on the road-marking its first live performanc...
10/07/2025
The music industry depends on fresh ideas, bold voices, and emerging talent. Yet across the U.K., too many young musicians lack the space to develop their craft...
10/07/2025
NEW YORK - July 10, 2025 - Nielsen, the global leader in audience measurement, data and analytics, today announced that it appointed Richard Pacheco as head of ...
10/07/2025
Local newscasts don't exist in a vacuum. News directors and station management constantly evaluate what's working, what isn't and perhaps most impor...
10/07/2025
Lawo has announced that Stuttgart Media University (Hochschule der Medien, HdM) has comprehensively modernized its central recording studio after selecting an I...
10/07/2025
The Society of Motion Picture and Television Engineers (SMPTE) has opened early-bird registration for the Media Technology Summit, which will take place in a ne...
10/07/2025
NASHVILLE, Tenn. TNDV Television has launched Aspiration 35, a new version of its 40-foot Aspiration truck reimagined for cinematic multicamera productions....
10/07/2025
BURBANK, Calif. Key Code Education, a provider of instructor-led postproduction training, is growing its curriculum with new programs for beginner and intermedi...
10/07/2025
HACKENSACK, N.J. Actus Digital will demonstrate how broadcasters can transform compliance monitoring from a necessary expense into a strategic revenue driver at...
10/07/2025
The Federal Register has published a summary of the Federal Communications Commission's Public Notice seeking comments on its ownership rules that lists a d...
10/07/2025
Back to All News
Netflix Presents the Official Trailer for SuperestarPlay Video
Play Video
Entertainment
10 July 2025
GlobalSpain
Link copied to clipboard...
10/07/2025
In the race to understand our planet's changing climate, speed and accuracy are everything. But today's most widely used climate simulators often strugg...
10/07/2025
As one of the world's largest emerging markets, Indonesia is making strides toward its Golden 2045 Vision - an initiative tapping digital technologies and...
10/07/2025
10 Jul 2025
VEON and Cohen Circle Secure Investor Commitments for Kyivstar Listing Kyiv, New York, Dubai, and Philadelphia - July 10, 2025 - VEON Ltd. (Nasdaq:...
10/07/2025
5G for all? What the DFL's use of Easy5G and RefCam could mean for events in...
10/07/2025
Save the Date: PGA TOUR Studios Welcomes SVG Remote Production Summit on Oct 14-...
10/07/2025
Cloud on the Road: How Remote-Production-Service Providers Are Adapting to a New...
10/07/2025
Seattle Kraken's Ryan Schaber on the NHL Team Taking Live Game Productions I...
10/07/2025
FOX Sports Reboots Small Control Room in Los Angeles as Hub for Vertical-First P...
10/07/2025
SVG Sit-Down: MSE's Zach Leonsis, ViewLift's Rick Allen Go Deep on Joint...
10/07/2025
Thursday 10 July 2025
The Very Small Creatures
Jaime's Treetop Tales
Emerald
BooSnoo! Christmas Mashup
Pip & Posy's Spooktacular Party
The Very Sm...
10/07/2025
Thursday 10 July 2025
Brand new rewards are coming to Sky customers, with free ...
A better way to predict a patient's risk of coronary artery disease Scripps Research scientists developed a model that more accurately identifies patients at risk of coronary artery disease and can inform tailored treatment. 
