Sony Pixel Power calrec Sony

April 16, 2025

17/04/2025

A better way to predict a patient's risk of coronary artery disease Scripps Research scientists developed a model that more accurately identifies patients at risk of coronary artery disease and can inform tailored treatment.

April 16, 2025

LA JOLLA, CA Coronary artery disease (CAD) is the leading cause of death in the United States. Although effective preventative treatments exist, these measures are often underutilized, in part because people don't know they're at risk of CAD until it's too late.

Now, scientists at the Scripps Research Translational Institute have developed a machine learning model that more accurately estimates a patient's risk of CAD compared to the standard clinical practice, which is based primarily on age. The findings, published in Nature Medicine on April 16, 2025, leveraged data that spanned 10 years. Their new model is personalized and integrates factors including genetics, lifestyle and medical history, enabling clinicians to provide patients with advice and preventative treatment tailored to their individual needs.

I think more precise and personalized risk prediction could motivate patients to engage in early prevention, says senior author Ali Torkamani, PhD, professor and director of Genomics and Genome Informatics at the Scripps Research Translational Institute. Our model first predicts the risk that a person will develop CAD, and then it provides information to allow personalized intervention.

CAD is caused by a buildup of plaque in the heart's arteries, which then blocks blood supply. Many people don't realize they have CAD until they experience a heart attack, but the disease is cumulative the earlier treatment begins, the more effective it will be.

We tend to observe bad outcomes for CAD in patients who are in their mid-50s and older, but the disease actually begins to develop much earlier, sometimes even while people are teenagers. Theres a lot of room for us to take action, says first author Shang-Fu Shaun' Chen, a former doctoral student in Torkamani's group.

To enable more accurate CAD risk prediction, Torkamani's team set out to create a model that incorporates factors beyond age, including genetic predisposition, lifestyle and medical history. They used data from the UK Biobank to train a machine learning model to recognize factors associated with CAD. Then, they tested the model on longitudinal data from a different cohort of individuals within the Biobank to see whether it could predict their risk of developing CAD over the course of 10 years based on their baseline data.

The model started with around 2,000 predictive features that could factor into CAD risk, but the team eventually whittled this list down to 53 risk factors. These included physical measurements, blood biomarkers, family medical history, mental illness, sleep duration and the presence of specific gene variants.

The new model outperformed the standard clinical model and enabled the prediction of two times as many CAD events. After 10 years of follow-up, 62.9% of individuals that the model categorized as being at highest risk had developed CAD, compared to only 0.3% of individuals in the lowest risk group.

The new model is personalized and integrates factors including genetics, lifestyle and medical history, enabling clinicians to provide patients with advice and preventative treatment tailored to their individual needs. Credit: Scripps Research Compared to traditional clinical tools, the new model improved risk classification for approximately one in four individuals helping to better identify those truly at risk while avoiding unnecessary concern for those who are not, said Chen.

The model's accuracy was partially due to its better ability to predict CAD in groups of people who are usually categorized as low risk, such as younger individuals and women.

Our model can pick up individuals who would be considered at low risk of CAD due to their age, but who are actually high risk due to their underlying genetics, says Torkamani.

Though the model's accuracy depended on the inclusion of multiple factors, the team showed that genetic predisposition was by far the strongest predictor of CAD risk. This included not only genetic predisposition for CAD itself, but also for related conditions such as high blood pressure, high cholesterol and diabetes.

The higher your genetic risk for one of those traits high cholesterol levels or high blood pressure levels or high diabetes risk the greater benefit you get from intervening on that particular aspect through medication or lifestyle changes, says Torkamani.

When the team validated the model using the National Institutes of Health All of Us dataset which includes more diverse populations than the UK Biobank they showed it was able to predict CAD risk equally well for people with European, African and Hispanic ancestries.

Now, the researchers are planning a long-term clinical trial to test whether informing patients of their risk of CAD can help prevent the disease.

We think the most important thing is for patients to be aware of their individual risks so that they can receive the appropriate treatments and make lifestyle changes, says Chen.

In addition to Torkamani and Chen, authors of the study, Meta-Prediction of Coronary Artery Disease Risk, include Hossein J. Sadaei, Ahmed Khattab, Corneliu Henegar, Nathan E. Wineinger and Evan D. Muse of Scripps Research; Sang Eun Lee of University of Ulsan College of Medicine; Jun-Bean Park of Seoul National University Hospital; and Jei-Fu Chen of Memorial Sloan Kettering Cancer Center.

This work was supported by funding from the National Institutes of Health (R01HG010881 and UM1TR004407) and the Scripps Research HPC team, including JC Ducom and Lisa Dong.

Heart Disease Torkamani, Ali
LINK: https://www.scripps.edu/news-and-events/press-room/2025/20250416-torka...
See more stories from scripps

Most recent headlines

05/01/2027

Worlds first 802.15.4ab-UWB chip verified by Calterah and Rohde & Schwarz to be demoed at CES 2026

Worlds first 802.15.4ab-UWB chip verified by Calterah and Rohde & Schwarz to be ...

04/08/2026

Dalet Announces Commercial Availability of Dalia, Bringing Media-Aware Agentic AI to Enterprise Productions

Dalet, a leading technology and service provider for media-rich organizations, t...

04/07/2026

Detective Conan: Fallen Angel of the Highway Opens in Dolby Cinemas Across Japan, Presented in Dolby Atmos and Dolby ...

April 7 2026, 19:00 (PDT) Detective Conan: Fallen Angel of the Highway Opens in...

01/06/2026

Dolby Sets the New Standard for Premium Entertainment at CES 2026

January 6 2026, 05:30 (PST) Dolby Sets the New Standard for Premium Entertainment at CES 2026 Throughout the week, Dolby brings to life the latest innovatio...

02/05/2026

Dalet Flex LTS Delivers Smarter Search, Faster Editing, and an AI-Ready Foundation for Modern Media

Dalet, a leading technology and service provider for media-rich organizations, t...

01/05/2026

NBCUniversal's Peacock to Be First Streamer to Integrate Dolby's Full Suite of Premium Picture and Sound Innovations

January 5 2026, 18:30 (PST) NBCUniversal's Peacock to Be First Streamer to ...

09/04/2026

ENCO to Showcase New aiTrack Capabilities at 2026 NAB Show

Share Copy link Facebook X Linkedin Bluesky Email...

09/04/2026

LTN Unveils Network Enhancements in Advance of C-Band Changes

Share Copy link Facebook X Linkedin Bluesky Email...

09/04/2026

FOR-A Buys Tamura Corp. Information Equipment Business

Share Copy link Facebook X Linkedin Bluesky Email...

09/04/2026

Imagine Showcases Expanded Multiviewer Portfolio at 2026...

Purpose Built Monitoring From Live Production to Master Control to OTT, Across On Prem and Cloud Environments At the 2026 NAB Show (April 19-22, Las Vegas Con...

09/04/2026

Harmonic Extends Hybrid Streaming Leadership with AI and...

Purpose Built Monitoring From Live Production to Master Control to OTT, Across On Prem and Cloud Environments At the 2026 NAB Show (April 19-22, Las Vegas Con...

09/04/2026

LTN unveils network enhancements as broadcaster satellite...

New advances meet surge in demand for broadcast-grade IP migration as C-band spectrum auctions approach LTN announces major enhancements to its purpose-built g...

09/04/2026

Hitomi Broadcast Expands Sales Team with Nicola Milburn

Hitomi Broadcast has expanded its sales team with the addition of Nicola Milburn as Technical Sales Manager. In this role, Nicola will work with customers and p...

09/04/2026

Layercake and Ceeblue Announce Strategic Integration to D...

Revolutionary combined solution brings sub-second latency, resilient delivery, and workflow orchestration to global broadcasters and digital platforms Layercak...

09/04/2026

BIA Increases 2026 Local Ad Forecast to $184.5 Billion

Share Copy link Facebook X Linkedin Bluesky Email...

09/04/2026

Yospace surpasses 10 billion ads stitched in a single mon...

Yospace exceeded 10 billion dynamically stitched ads in a single month, reaching 11.6 billion as ad-supported streaming surged. Driven by a packed global sports...

09/04/2026

Bitmovin Expands Live Encoding and Observability Solution...

Bitmovin has expanded its Live Encoding and Observability solutions to provide true end to end, real time insights across live streaming workflows, from encodin...

09/04/2026

Leyra Powers the Launch of Icelandic Broadcaster RUVs Str...

Leyra has announced the launch of Icelandic public broadcaster R V's streaming service on Samsung and LG Smart TVs. R V is the first public broadcaster to d...

09/04/2026

3Play Media Launches AI Dubbing Solution for YouTube Crea...

3Play Media, a global leader in video accessibility and localization, today announced an AI Dubbing solution purpose-built for YouTube creators. The company, wh...

09/04/2026

Big Blue Marble Recognized as AWS Managed Services Provid...

Big Blue Marble, a provider of broadcast-grade, cloud-native video solutions, has been recognized as an Amazon Web Services (AWS) Managed Services Provider (MSP...

09/04/2026

PDC Cleeng and Urban Zoo partner to launch new global str...

The Professional Darts Corporation (PDC) has officially launched its revamped global streaming service, PDC TV, in collaboration with Cleeng and sports technolo...

09/04/2026

Cleeng launches industry first cross-platform AI agents t...

Cleeng, the Subscriber Retention Management (SRM ) pioneer, today announced a raft of new AI agents for its AI Assistant to accelerate decision-making and autom...

09/04/2026

Hearst Taps Merzigo to Expand Presence on YouTube, Facebook

Share Copy link Facebook X Linkedin Bluesky Email...

09/04/2026

Fox Jumps Into Prediction Markets with Kalshi Integration

Share Copy link Facebook X Linkedin Bluesky Email...

09/04/2026

NAB Show: Kokusai Denki To Feature New, Affordable 4K Broadcast Camera

Share Copy link Facebook X Linkedin Bluesky Email...

09/04/2026

Corus Taps Appear for IP-First Operations

Share Copy link Facebook X Linkedin Bluesky Email...

09/04/2026

2026 NAB Show Exhibitor Insights: Big Blue Marble

Share Copy link Facebook X Linkedin Bluesky Email...

09/04/2026

FCC Extends Audible Crawl Rule Waiver for 18 Months

Share Copy link Facebook X Linkedin Bluesky Email...

09/04/2026

Pliant Technologies Showcases Expanded Accessories at NAB...

New Charging, Connectivity, and Mounting Solutions Now Available LAS VEGAS, APRIL 8, 2026 Pliant Technologies will highlight a range of new accessories at th...

09/04/2026

Media Links Brings Ultra Resilient IP Transport Proven at...

As live production continues its shift to IP, the challenge is no longer adoption it's reliability. At NAB Show 2026 (Booth W2033), Media Links will demon...

09/04/2026

QuickLink Launches StudioPro Town Hall at 2026 NAB Show

QuickLink, a leading provider of award-winning video production and remote guest contribution solutions, launches its new AI-powered add-on for its StudioPro p...

09/04/2026

The Hive Group Releases White Paper on the FCC Upper C-Ba...

The Hive Group has published a new white paper, No Safe Harbor: Why the FCC's Upper C-Band Auction Demands Early Action from Broadcasters ahead of NAB Sho...

09/04/2026

Saranyu Technologies Renews VisualOn Optimizer VoD Subscr...

Saranyu Technologies today announced the renewal of its Optimizer VoD subscription with VisualOn. The announcement coincides with NAB Show 2026, taking place Ap...

09/04/2026

Brian Fenton Joins RT Sunday Game GAA Panel for 2026 Championship

RT Sport has announced Brian Fenton will join its Sunday Game GAA punditry panel for the 2026 Championship, featuring across video, audio, online including the...

09/04/2026

Time for some fresh air: Tracks & Trails is back

Doireann N Ghlac in returns as presenter, with the first episode airing this Friday at 8.30pm on RT One and RT Player The beloved walking series Tracks & T...

09/04/2026

Strength and Destiny Collide: Samson: A Tyndalston Story' Arrives in the Cloud

A timeless story of grit, faith and rebellion takes center stage as Samson: A Ty...

09/04/2026

April 08, 2026

New technique for synthesizing branched molecules could accelerate the development of future medicines Scripps Research chemists solve a longstanding problem in...

08/04/2026

SVG College Sports Media Awards 2026: Entry Deadline is Monday, April 13

The deadline to enter the 18th Annual SVG College Sports Media Awards in association with NACDA is rapidly approaching! Submit your entries to this year's c...

08/04/2026

SVG Campus Shot Callers: Trever Sheets, Senior Director, ACC Network, Virginia Tech

The Pittsburgh product helps lead more than 100 annual ESPN broadcasts as part o...

08/04/2026

SVG Sit-Down: Harmonic's Jean Macher on Turning Live Sports Content Into a Smarter Monetization Engine

Dynamic ad insertion, AI-based technologies, programmatic advertising are some o...

08/04/2026

Announcing the 2026 Fellows for the Sundance Institute Cultural Impact Residency on Sundance Collab

Seven Fellows Selected for Second Year of Residency in Honor of Social Justice L...

08/04/2026

From Tokyo to the World: Watch Bad Bunny's Billions Club Live Concert on Spotify

On March 7, Bad Bunny made history with his first-ever performance in Asia, taki...

08/04/2026

De Tokio para el mundo: Mira el concierto Billions Club Live de Bad Bunny en Spotify

El 7 de marzo, Bad Bunny hizo historia con su primera presentaci n en Asia, subi...

08/04/2026

Tube Lab from Fuse Audio Labs

New channel strip plug-in revealed The latest plug-in to be added to the Fuse Audio Labs line-up emulates a selection of vintage hardware units, combining c...

08/04/2026

Blue Cat Audio release Axiom 2.3

Guitar & bass multi-effects software overhauled Blue Cat Audio's flagship guitar and bass multi-effects software has recently received a significant upd...

08/04/2026

Merging Technologies launch Pyramix 16

PanNoir mixer integration, Dolby Atmos Renderer & more Merging Technologies have just launched Pyramix 16, the latest major update to their renowned DAW sof...

08/04/2026

Updating QUARTZ Router Module Firmware Over-The-Air

Applicable Products Part number Description QUARTZ-22-LTE (EU) Dual Port Dual SIM LTE Router (EU) QUARTZ-COMPACT-11-LTE (EU) Single Port Compact LTE ...

08/04/2026

YEP September 2025 Newsletter (2)

The September 19, 2025 YEP Newsletter highlights a group visit to the Academy Museum of Motion Pictures, where participants explored exhibits showcasing the art...

08/04/2026

Proven On Orbit: L3Harris Congratulates Missile Defense Agency for Receiving Top Defense Honor for HBTSS

The L3Harris HBTSS satellite is proven on orbit, successfully demonstrating trac...

08/04/2026

From Earth to Mars: Resilient Communications Powering the Space Economy

Image Credit: NASA. Artist rendering of a space communications satellite in orbit, representative of the resilient, multiband infrastructure supporting mission ...