Sony Pixel Power calrec Sony

October 01, 2018

02/10/2018

Former Scripps Research postdoctoral associate James P. Allison wins the 2018 Nobel Prize in Physiology or Medicine

October 01, 2018

Understanding how to shut off cancerous tumors' ability to hide from immune attack has given doctors new tools to fight cancers such as melanoma. For his discovery of how to reawaken immune system attacks on cancer, former Scripps Research postdoctoral associate James P. Allison, PhD, was awarded the Nobel Prize in Physiology or Medicine on Monday, alongside Japanese immunologist Tasuku Honjo, MD, PhD.

Advancing the concept of immunotherapies for cancer has been an undertaking, says Michael Oldstone, MD, professor at Scripps Research. Allison deserves a lot of credit for bringing that therapy from the bench into humans.

Allison trained as a postdoctoral researcher in the laboratory of noted Scripps Research immunologist Ralph Reisfeld, PhD, from 1974 to 1977. In addition to his legacy in advancing cancer therapeutics, Scripps Research scientists know him as a determined scientist and skilled mentor.

The birth of a new therapy

Allison's innovative focus on optimizing the immune response, rather than specifically targeting tumors, proved revolutionary, says Wendy Havran, PhD, a professor in the Scripps Research Department of Immunology and Microbiology, who worked as a postdoctoral researcher under Allison at the University of California, Berkeley. Checkpoint blockade immunotherapy has saved numerous lives and provides hope to many cancer patients, she says.

In the 1970s, immunologists including Oldstone worked at the Scripps Clinic and Research Foundation, predecessor of Scripps Research. They focused on basic science, characterizing how the immune system recognized pathogens. They hoped to understand not only how the immune system recognized attackers, but also why the immune system sometimes becomes overzealous and attacks the body's own cells.

Argyrios Theofilopoulos, MD, a professor at Scripps Research, recalls the intensity of the work happening on the Scripps Research campus at that time, and the steps Reisfeld and Allison were taking to advance the field.

The institute was very famous already for our work on immunological aspects of diseases, Theofilopoulos says. At that time we knew nothing about T cell receptors. They were trying to identify the peptides that were presented to T cells, and thereby identify the T cell receptor.

In 1974, Allison accepted a position working with Reisfeld, an expert on major histocompatibility complex, critical to discernment of self versus attacker. Their work focused on the interaction among proteins called human leukocyte antigens and T cells. By 1977, Allison and a colleague, G. N. Callahan, reported in a letter to the journal Nature that they had found evidence that the immune system was prevented from attacking cancer cells due to an association between pathogenic markers and additional proteins.

Finding the factors that cloaked cancer from immune attack, then developing techniques to suppress the cloaking system, eventually led to the development of checkpoint-blockade cancer immunotherapies such as ipilimumab (Yervoy). It has inspired a new generation of immunologists focused on making more types of cancer visible to immune attack, among them, immunologist Mark Sundrud, PhD, associate professor at Scripps Research in Florida.

This highlights the life-changing implications of understanding how the immune system works at a fundamental level, Sundrud says.

Training the next generation of researchers

Oldstone remembers Allison as a postdoctoral researcher with incredible potential, saying, He was very smart and very determined. Interestingly, Allison's colleagues at the time included Rafi Ahmed, PhD, who has advanced cancer immunotherapies at Emory University, and Robert Schreiber, PhD, who has pioneered cancer immunoediting at Washington University School of Medicine in St. Louis.

Scripps Research has a long history of training postdoctoral researchers for impactful careers in science. Postdocs come from all over the world to improve human health in an environment that fosters collaboration, creativity, and scientific excellence, says Ryan Wheeler, director of the Career, International and Postdoctoral Services Office at Scripps Research.

After leaving Scripps Research, Allison moved to UC Berkeley, and went on to become Head of Immunology at Sloan-Kettering in New York. Today he is with M.D. Anderson in Texas, where he is currently Chair of Immunology.

Havran says her work with Allison continues to inspire her.

Jim took an unexpected basic science discovery, funded by grants from the National Institutes of Health, saw the implications, and was able to translate it to the clinic to treat cancer patients, she says. It is every researchers dream.

Immunology & Microbiology Awards and honors
LINK: https://www.scripps.edu/news-and-events/press-room/2018/20181001-allis...
See more stories from scripps

Most recent headlines

03/06/2024

Dalet and Veritone Reach Agreement to Distribute, Transact and Monetize Media Archives

Dalet, a leading technology and service provider for media-rich organizations, a...

28/04/2024

Mediahaus delivers the first SRT live-streaming sports production over 5G with URSA Broadcast G2

Mediahaus delivers the first SRT live-streaming sports production over 5G with U...

29/03/2024

Dalet to Demo AI-Enabled Production, Automation and Monetization at NAB Show

PARIS Dalet has announced that during the 2024 NAB Show (booth #W1713), attendees can experience firsthand Dalet's collaborative, AI-enabled workflows that ...

29/03/2024

DirecTV Inks Deal to Carry 2024 Colorado Rockies Games

DENVER AND EL SEGUNDO, Calif. DirecTV has announced a new agreement with Major League Baseball that will allow Colorado Rockies fans to see this season's ga...

29/03/2024

S&P: Media, Telecom M&A Plunges to 13-Month Low

S&P Global Market Intelligence has released new data showing that dealmaking in the North America for media and telecom companies remains in the doldrums....

29/03/2024

NAB Show: Pebble Launches PRIMA Software Platform

EPSOM, Surrey, UK The automation, content management, and integrated channel specialist Pebble, has announced that it will be launching a new software platform ...

29/03/2024

Gray Television to Air Arena Football League Local Games

ATLANTA Gray Television Inc. has inked a multi-year agreement with the Arena Football League to bring Saturday arena football games over-the-air to local audien...

29/03/2024

Muvhango: Thursday's episode, 28 March 2024 [VIDEO]

Muvhango: Thursday's episode, 28 March 2024 [VIDEO]Stay up to date with the latest episodes of your favourite South African soapie on The South African webs...

29/03/2024

Gqeberha: The Empire - Thursday's episode, 28 March 2024 [VIDEO]

Gqeberha: The Empire - Thursday's episode, 28 March 2024 [VIDEO]Stay up to date with the latest episodes of your favourite South African soapie on The South...

29/03/2024

My Brother's Keeper: Thursday's episode, 28 March 2024 [VIDEO]

My Brother's Keeper: Thursday's episode, 28 March 2024 [VIDEO]Stay up to date with the latest episodes of your favourite South African soapie on The Sou...

29/03/2024

Umkhokha: The Curse - Thursday's episode, 28 March 2024 [VIDEO]

Umkhokha: The Curse - Thursday's episode, 28 March 2024 [VIDEO]Stay up to date with the latest episodes of your favourite South African soapie on The South ...

29/03/2024

Skeem Saam: Thursday's episode, 28 March 2024 [VIDEO]

Skeem Saam: Thursday's episode, 28 March 2024 [VIDEO]Missed an episode of Skeem Saam? No problem! Watch the latest episode of your favourite South African s...

29/03/2024

House of Zwide: Thursday's episode, 28 March 2024 [VIDEO]

House of Zwide: Thursday's episode, 28 March 2024 [VIDEO]Stay up to date with the latest episode of South African soapie House of Zwide on The South African...

28/03/2024

No votes for all

Out of an estimated 20,000 journalists in Pakistan, less than one thousand are women according to a recent Gender Disparity Report published by the Internationa...

28/03/2024

Give Me the Backstory: Get to Know 8 Women Filmmakers With Shorts at the 2024 Sundance Film Festival

A still from Jasmin Baumgartner's Bye Bye, Bowser, which screened as part ...

28/03/2024

The Best Shared Storage For Video Production

alt= class=wp-image-12214 data-lazy-src=/wp-content/uploads/2024/03/Best-Shared-Storage-EVO-logo-960x540-1.jpg/> Embarking on a cinematic journey or crafting a ...

28/03/2024

Future-Proofing the B-52

L3Harris is upgrading critical electronic warfare systems to ensure the iconic aircrafts spectrum superiority for decades to come....

28/03/2024

Supporting the RCAF for more than 25 Years with L3Harris' WESCAM MX-Series

L3Harris' WESCAM MX-Series EO/IR systems have supported the RCAF for more than 25 years....

28/03/2024

ENCO to Add AI News Anchor to Qimera Virtual Production Set

NOVI, Mich. During the 2024 NAB Show, ENCO will be showcasing an AI-driven virtual anchor delivering live news from a realistic 3D virtual news set....

28/03/2024

Johan de Nysschen Named President and CEO of ARRI Americas

MUNICH ARRI has announced that Johan de Nysschen has been put in charge of the ARRI Americas team as president and CEO ARRI Americas Inc....

28/03/2024

Fubo Inks Carriage Deal with YES Network

NEW YORK The YES Network and FuboTV have reached a multi-year carriage agreement that will allow Fubo to launch YES in its Pro base channel plan in time for YES...

28/03/2024

Dalet to Demo AI-Enabled Production, Automation and Monetization at NAB 2024

PARIS Dalet has announced that during its 2024 NAB showcase (booth #W1713), attendees can experience firsthand Dalet's collaborative, AI-enabled workflows t...

28/03/2024

Blackmagic Design Used on 2024 Oscar Nominated Films

Blackmagic Design Used on 2024 Oscar Nominated Films Brie Clayton March 28, 2024 0 Comments Blackmagic Design congratulates the many film professional...

28/03/2024

Arkona to Introduce BLADE//master Control and Orchestration Service at NAB 2024

Arkona to Introduce BLADE//master Control and Orchestration Service at NAB 2024 Brie Clayton March 28, 2024 0 Comments New option for BLADE//runner ke...

28/03/2024

Join Maxon for NAB 2024

Join Maxon for NAB 2024 Brie Clayton March 28, 2024 0 Comments Maxon returns to NAB with presentations by artists from around the world and demos of t...

28/03/2024

Boston Conservatory to Present Center Stage Production of A Midsummer Night's Dream at The Huntington

Boston Conservatory to Present Center Stage Production of A Midsummer Night'...

28/03/2024

The 4K cameras giving audiences an astronaut's view of Earth

TVBEurope meets Charles Black, founder and CEO of Sen, which has sent a payload of 4K cameras to the ISS to livestream images of Earth to audiences around the w...

28/03/2024

2024 Big Night In Raises $145k to Support Triangle Arts Councils

Capitol Broadcasting and WRAL-TV once again proudly supported our local arts community with the broadcast of Big Night in for the Arts Thursday, March 7, 2024. ...

28/03/2024

JIC, MRC Announce Accord On Roles In Judging Measurement Companies

With more companies offering different approaches to measuring television viewing and campaign effectiveness, two of the groups that evaluate potential media bu...

28/03/2024

Hulu Added to Disney Plus App for Bundle Subscribers

The Walt Disney Co. said that it launched Hulu on Disney Plus, which makes Hulu programming available via the Disney Plus app....

28/03/2024

GroupM To Double Ad Spending On Women's Sports Programming

Giant media buyer GroupM said it plans to double its media spending on women's sports....

28/03/2024

Scripps Renews State Farm As Sponsor of Friday Night WNBA on Ion

Scripps Sports said that State Farm has signed a new multi-year agreement to continue as the title sponsor of Ion's Friday night WNBA telecasts....

28/03/2024

Elisabeth Moss, Kerry Washington Sign On for Imperfect Women' on Apple TV Plus

Elisabeth Moss and Kerry Washington will star in, and executive produce, Imperfe...

28/03/2024

Telemundo Station Group Addresses Climate Change With Month-Long Initiative

Telemundo Station Group launches the month-long climate change initiative Our Planet Thursday, March 28. The multiplatform campaign ends on Earth Day, April 22,...

28/03/2024

Circle City Broadcasting Renews Nielsen Ratings Deal

Nielsen said that Circle City Broadcasting, owner of WISH-TV in Indianapolis, has renewed its local TV measurement deal....

28/03/2024

Lionsgate Extends Deal With Seth Rogen's Point Grey Pictures

Lionsgate Television said it extended its deal with Point Grey Pictures, the production company led by Seth Rogen, Evan Goldberg and James Weaver....

28/03/2024

Ariana DeBose Back as Tonys Host

Ariana DeBose returns as host of the Tony Awards Sunday, June 16, on CBS and Paramount Plus. It is her third consecutive time hosting, and it will be the 77th T...

28/03/2024

The Steve Wilkos Show' Renewed for Season 18

The Steve Wilkos Show has been renewed for its 18th season in national syndication, Tracie Wilson, executive VP, NBCUniversal Syndication Studios & E! News, sai...

28/03/2024

Sinclair Selects Embrace as Its Media Orchestration Engine

PARIS Embrace, a developer of advanced automation and orchestration software solutions, has announced that Sinclair Broadcast Group has selected Embrace's P...

28/03/2024

Nielsen and Circle City Broadcasting Renew Local TV Measurement Deal

NEW YORK Nielsen has a multi-year renewal with Circle City Broadcasting, Indianas only locally owned and operated broadcast and digital news media network, for ...

28/03/2024

JVC to Demo Its First Ever 40x Zoom PTZ Camera Series at 2024 NAB Show

LAS VEGAS JVC Professional Video has announced that it will debut its new KY-PZ540 Series PTZ Cameras with 40x zoom at 2024 NAB Show (Booth C4720)....

28/03/2024

Brightcove Launches Cloud Playout 2.0

BOSTON Brightcove has announced the launch of Cloud Playout 2.0, a platform that the company said will offer customers new ways to create linear channels, monet...

28/03/2024

NBC Sports Chicago to Air First-Ever Animated Real-Time Local Sports Telecast

The Chicago Blackhawks and NBC Sports Chicago have announced a collaboration with the NHL to bring fans the first-ever local animated real-time sports telecast....

28/03/2024

The Best News Coverage is Real, Live, Balanced, Professional

The Best News Coverage is Real, Live, Balanced, Professional Andy Marken March 28, 2024 0 Comments Hero image source News of the World, Perfect Wo...

28/03/2024

DJ Sbu makes shock return to SABC radio after almost a decade

DJ Sbu makes shock return to SABC radio after almost a decadeRevered radio host, media personality, philanthropist, and businessman DJ Sbu will finally be back ...

28/03/2024

Smoke and Mirrors: Thursday's episode, 28 March 2024 [VIDEO]

Smoke and Mirrors: Thursday's episode, 28 March 2024 [VIDEO]Stay up to date with the latest episodes of your favourite South African soapie on The South Afr...

28/03/2024

VEON Pays Back Outstanding Balance and Cancels its Revolving Credit Facility

28 Mar 2024 VEON Pays Back Outstanding Balance and Cancels its Revolving Credit Facility Amsterdam, 28 March 2024, 09.30 CET - VEON Ltd. (Nasdaq: VEON, Euronex...

28/03/2024

TNT Sports Gets Its College Game On for March Madness Audio

TNT Sports Gets Its College Game On for March Madness Audio Marching bands, crowds make up for lack of court FX and wired players By Dan Daley, Audio Editor ...

28/03/2024

Cosm/ESPN Deal Will Bring NBA, NHL, Tennis, College Football, and More to Shared Reality' Venues

Cosm/ESPN Deal Will Bring NBA, NHL, Tennis, College Football, and More to Share...

28/03/2024

MLB 2024: The Famous Group, Miami Marlins Team Up for AI-Powered Intro for All 2024 Home Games

MLB 2024: The Famous Group, Miami Marlins Team Up for AI-Powered Intro for All 2...