Former Scripps Research postdoctoral associate James P. Allison wins the 2018 Nobel Prize in Physiology or Medicine
October 01, 2018
Understanding how to shut off cancerous tumors' ability to hide from immune attack has given doctors new tools to fight cancers such as melanoma. For his discovery of how to reawaken immune system attacks on cancer, former Scripps Research postdoctoral associate James P. Allison, PhD, was awarded the Nobel Prize in Physiology or Medicine on Monday, alongside Japanese immunologist Tasuku Honjo, MD, PhD.
Advancing the concept of immunotherapies for cancer has been an undertaking, says Michael Oldstone, MD, professor at Scripps Research. Allison deserves a lot of credit for bringing that therapy from the bench into humans.
Allison trained as a postdoctoral researcher in the laboratory of noted Scripps Research immunologist Ralph Reisfeld, PhD, from 1974 to 1977. In addition to his legacy in advancing cancer therapeutics, Scripps Research scientists know him as a determined scientist and skilled mentor.
The birth of a new therapy
Allison's innovative focus on optimizing the immune response, rather than specifically targeting tumors, proved revolutionary, says Wendy Havran, PhD, a professor in the Scripps Research Department of Immunology and Microbiology, who worked as a postdoctoral researcher under Allison at the University of California, Berkeley. Checkpoint blockade immunotherapy has saved numerous lives and provides hope to many cancer patients, she says.
In the 1970s, immunologists including Oldstone worked at the Scripps Clinic and Research Foundation, predecessor of Scripps Research. They focused on basic science, characterizing how the immune system recognized pathogens. They hoped to understand not only how the immune system recognized attackers, but also why the immune system sometimes becomes overzealous and attacks the body's own cells.
Argyrios Theofilopoulos, MD, a professor at Scripps Research, recalls the intensity of the work happening on the Scripps Research campus at that time, and the steps Reisfeld and Allison were taking to advance the field.
The institute was very famous already for our work on immunological aspects of diseases, Theofilopoulos says. At that time we knew nothing about T cell receptors. They were trying to identify the peptides that were presented to T cells, and thereby identify the T cell receptor.
In 1974, Allison accepted a position working with Reisfeld, an expert on major histocompatibility complex, critical to discernment of self versus attacker. Their work focused on the interaction among proteins called human leukocyte antigens and T cells. By 1977, Allison and a colleague, G. N. Callahan, reported in a letter to the journal Nature that they had found evidence that the immune system was prevented from attacking cancer cells due to an association between pathogenic markers and additional proteins.
Finding the factors that cloaked cancer from immune attack, then developing techniques to suppress the cloaking system, eventually led to the development of checkpoint-blockade cancer immunotherapies such as ipilimumab (Yervoy). It has inspired a new generation of immunologists focused on making more types of cancer visible to immune attack, among them, immunologist Mark Sundrud, PhD, associate professor at Scripps Research in Florida.
This highlights the life-changing implications of understanding how the immune system works at a fundamental level, Sundrud says.
Training the next generation of researchers
Oldstone remembers Allison as a postdoctoral researcher with incredible potential, saying, He was very smart and very determined. Interestingly, Allison's colleagues at the time included Rafi Ahmed, PhD, who has advanced cancer immunotherapies at Emory University, and Robert Schreiber, PhD, who has pioneered cancer immunoediting at Washington University School of Medicine in St. Louis.
Scripps Research has a long history of training postdoctoral researchers for impactful careers in science. Postdocs come from all over the world to improve human health in an environment that fosters collaboration, creativity, and scientific excellence, says Ryan Wheeler, director of the Career, International and Postdoctoral Services Office at Scripps Research.
After leaving Scripps Research, Allison moved to UC Berkeley, and went on to become Head of Immunology at Sloan-Kettering in New York. Today he is with M.D. Anderson in Texas, where he is currently Chair of Immunology.
Havran says her work with Allison continues to inspire her.
Jim took an unexpected basic science discovery, funded by grants from the National Institutes of Health, saw the implications, and was able to translate it to the clinic to treat cancer patients, she says. It is every researchers dream.
Immunology & Microbiology Awards and honors
Most recent headlines
05/01/2027
Worlds first 802.15.4ab-UWB chip verified by Calterah and Rohde & Schwarz to be ...
07/10/2026
Dalet, a leading technology and service provider for media-rich organizations, today announced the latest Long-Term Supported (LTS) release of Dalet Flex. Build...
06/09/2026
June 9 2026, 23:00 (PDT) Dolby and MagentaTV Bring Fans Closer to the FIFA Worl...
20/08/2026
Share
Copy link
Facebook
X
Linkedin
Bluesky
Email...
20/08/2026
Share
Copy link
Facebook
X
Linkedin
Bluesky
Email...
20/08/2026
Share
Copy link
Facebook
X
Linkedin
Bluesky
Email...
20/08/2026
Share
Copy link
Facebook
X
Linkedin
Bluesky
Email...
20/08/2026
IPC Expands Brazilian Presence with New Channel Partner CCATech
Industry veterans Carlos Abrah o and Bruno Lopes strengthen local support and expand IPCs prese...
20/08/2026
Zixi Enters Mauritius Market Through Strategic Deployment with MTC Jockey Club
Worlds Oldest Horse Racing Club in the Southern Hemisphere Selects Zixis Softwar...
20/08/2026
LA JOLLA, CA-Scripps Research assistant professor Tiantian Liu has received a five-year NIAID DP2 award from the National Institute of Allergy and Infectious Di...
20/08/2026
Audiences reveal appetite for multicultural Australia on-screen 20 August 2026
Dr Georgie McClean, Dr Rebecca Huntley (L-R)
By Dr Georgie McClean and Dr Rebec...
20/08/2026
How Mavis Studio Is Expanding Live Production Teaching at Sussex
Brie Clayton August 19, 2026
0 Comments
Hero image displays a student about to mix be...
20/08/2026
Vertical Unscripted Series Legal Queens Captured with Blackmagic Design
Brie Clayton August 19, 2026
0 Comments
Reality TV veteran Eric Gardner create...
19/08/2026
As the cost of IP nears price parity with traditional SDI, Reynolds argues that ...
19/08/2026
A private 5G bubble was chosen instead of traditional broadcast RF for the race ...
19/08/2026
(L-R) Rafael Manuel and Isabel Sicat attend the Filipi ana premiere during the 2026 Sundance Film Festival at The Ray Theatre on January 23, 2026, in Park Cit...
19/08/2026
Studio owners invited to have their say on rates cuts
The Music Producers Guild (MPG) are inviting UK-based studios to take part in an in-depth survey that ...
19/08/2026
Vintage-inspired desktop interface revealed
Harrison's latest hardware offering sees them head into the world of audio interfaces, delivering a 10-in/12...
19/08/2026
Granular effect remains locked to scale and tempo
Described as your dream granular effect , Minimal Audio's latest creation is capable of turning any s...
19/08/2026
First polyphonic SWAM instrument incoming
Audio Modeling's latest physical-modelling orchestral instrument is just around the corner, and is now availab...
19/08/2026
World Cup Games Generate 84 Billion Minutes Across FOX, Fox Sports 1 and NBCU...
19/08/2026
July brought typical peak-holiday drops in viewership, driven primarily by viewers stepping away from screens and a visible decline in reach across both traditi...
19/08/2026
Share
Copy link
Facebook
X
Linkedin
Bluesky
Email...
19/08/2026
Henry joins BCE as the company accelerates its commercial strategy and expands its international presence across the media, broadcast and technology markets. He...
19/08/2026
iWedia, a leading provider of software solutions for connected TV devices, today announced a major milestone in Android platform optimization with the successfu...
19/08/2026
NTP Technology announces that ST 2110-30 audio-over-IP connectivity with AES67 and RAVENNA capabilities is now available for the brand's world-class audio i...
19/08/2026
Net Insight has been selected to provide its Nimbra platform by the service provider Big Blue Marble, formerly ORS Group, as the core media transport solution f...
19/08/2026
LiveU has supported Coventry City FC and several other top-flight UK football clubs through one of their most demanding live production challenges of the year, ...
19/08/2026
Nature Seekers Documentary Shot with Blackmagic URSA Cine 12K LF
Brie Clayton August 18, 2026
0 Comments
Filming endangered turtles required camera...
19/08/2026
Neyrinck Brings D-Control Consoles Back to Life on Apple Silicon with D-Control ...
19/08/2026
Share
Copy link
Facebook
X
Linkedin
Bluesky
Email...
19/08/2026
Share
Copy link
Facebook
X
Linkedin
Bluesky
Email...
19/08/2026
Share
Copy link
Facebook
X
Linkedin
Bluesky
Email...
19/08/2026
Share
Copy link
Facebook
X
Linkedin
Bluesky
Email...
19/08/2026
Share
Copy link
Facebook
X
Linkedin
Bluesky
Email...
19/08/2026
Riedel Communications today announced that Edith Cowan University (ECU) in Perth, Australia, implemented a comprehensive communications infrastructure that brin...
19/08/2026
QuickLink, a leading provider of award-winning video production and remote guest contribution solutions, will spotlight a major leap forward in remote guest con...
19/08/2026
Integrated platform melds media asset management, playout automation and newsroom workflows
EMAM, PlayBox Neo and SNEWS have officially launched Nuvex, a conne...
19/08/2026
Screen Australia releases the Private Investment Toolkit to strengthen screen in...
19/08/2026
Do Aussies truly value local content? Unpacking Screen Currency 2026 with Deirdr...
19/08/2026
There's an early Christmas gift for Bookish fans, as UKTV confirms the re-commission of the hit U&alibi drama, created by and starring Mark Gatiss. Viewers ...
19/08/2026
Wednesday 19 August 2026
Sky gives sports fans the chance to watch multiple liv...
19/08/2026
On Saturday September 5 Katie Taylor will step into the ring for the fight of her life against Flora Pili in front of 80,000 fans in Croke Park. A legendary fig...
18/08/2026
SportStream 2026, a free three-day virtual event, will take place September 15-17. One registration provides access to all three days of live programming and on...
18/08/2026
BeckTV will introduce BeckFlow to the European market at IBC2026, demonstrated on the Providius stand (10.F53).
BeckFlow is a web-based schematic documentation...
18/08/2026
Boland Communications will introduce a SMPTE ST 2110 input option for its 4K monitors at IBC2026, along with a new 55-inch super-narrow bezel display for video ...
18/08/2026
Dolby Laboratories and the Seattle Seahawks have announced a partnership integrating Dolby OptiView into the Seahawks' live streaming coverage, making the S...
18/08/2026
For BMG Executive Producer of Sports Production, Graham Taylor, producing live s...
18/08/2026
TMRW Sports has appointed Rufus Hack as President of Golf, a newly created role in which he will lead the company's golf businesses including TGL presented ...
Former Scripps Research postdoctoral associate James P. Allison wins the 2018 Nobel Prize in Physiology or Medicine 
