Sony Pixel Power calrec Sony

October 01, 2018

02/10/2018

Former Scripps Research postdoctoral associate James P. Allison wins the 2018 Nobel Prize in Physiology or Medicine

October 01, 2018

Understanding how to shut off cancerous tumors' ability to hide from immune attack has given doctors new tools to fight cancers such as melanoma. For his discovery of how to reawaken immune system attacks on cancer, former Scripps Research postdoctoral associate James P. Allison, PhD, was awarded the Nobel Prize in Physiology or Medicine on Monday, alongside Japanese immunologist Tasuku Honjo, MD, PhD.

Advancing the concept of immunotherapies for cancer has been an undertaking, says Michael Oldstone, MD, professor at Scripps Research. Allison deserves a lot of credit for bringing that therapy from the bench into humans.

Allison trained as a postdoctoral researcher in the laboratory of noted Scripps Research immunologist Ralph Reisfeld, PhD, from 1974 to 1977. In addition to his legacy in advancing cancer therapeutics, Scripps Research scientists know him as a determined scientist and skilled mentor.

The birth of a new therapy

Allison's innovative focus on optimizing the immune response, rather than specifically targeting tumors, proved revolutionary, says Wendy Havran, PhD, a professor in the Scripps Research Department of Immunology and Microbiology, who worked as a postdoctoral researcher under Allison at the University of California, Berkeley. Checkpoint blockade immunotherapy has saved numerous lives and provides hope to many cancer patients, she says.

In the 1970s, immunologists including Oldstone worked at the Scripps Clinic and Research Foundation, predecessor of Scripps Research. They focused on basic science, characterizing how the immune system recognized pathogens. They hoped to understand not only how the immune system recognized attackers, but also why the immune system sometimes becomes overzealous and attacks the body's own cells.

Argyrios Theofilopoulos, MD, a professor at Scripps Research, recalls the intensity of the work happening on the Scripps Research campus at that time, and the steps Reisfeld and Allison were taking to advance the field.

The institute was very famous already for our work on immunological aspects of diseases, Theofilopoulos says. At that time we knew nothing about T cell receptors. They were trying to identify the peptides that were presented to T cells, and thereby identify the T cell receptor.

In 1974, Allison accepted a position working with Reisfeld, an expert on major histocompatibility complex, critical to discernment of self versus attacker. Their work focused on the interaction among proteins called human leukocyte antigens and T cells. By 1977, Allison and a colleague, G. N. Callahan, reported in a letter to the journal Nature that they had found evidence that the immune system was prevented from attacking cancer cells due to an association between pathogenic markers and additional proteins.

Finding the factors that cloaked cancer from immune attack, then developing techniques to suppress the cloaking system, eventually led to the development of checkpoint-blockade cancer immunotherapies such as ipilimumab (Yervoy). It has inspired a new generation of immunologists focused on making more types of cancer visible to immune attack, among them, immunologist Mark Sundrud, PhD, associate professor at Scripps Research in Florida.

This highlights the life-changing implications of understanding how the immune system works at a fundamental level, Sundrud says.

Training the next generation of researchers

Oldstone remembers Allison as a postdoctoral researcher with incredible potential, saying, He was very smart and very determined. Interestingly, Allison's colleagues at the time included Rafi Ahmed, PhD, who has advanced cancer immunotherapies at Emory University, and Robert Schreiber, PhD, who has pioneered cancer immunoediting at Washington University School of Medicine in St. Louis.

Scripps Research has a long history of training postdoctoral researchers for impactful careers in science. Postdocs come from all over the world to improve human health in an environment that fosters collaboration, creativity, and scientific excellence, says Ryan Wheeler, director of the Career, International and Postdoctoral Services Office at Scripps Research.

After leaving Scripps Research, Allison moved to UC Berkeley, and went on to become Head of Immunology at Sloan-Kettering in New York. Today he is with M.D. Anderson in Texas, where he is currently Chair of Immunology.

Havran says her work with Allison continues to inspire her.

Jim took an unexpected basic science discovery, funded by grants from the National Institutes of Health, saw the implications, and was able to translate it to the clinic to treat cancer patients, she says. It is every researchers dream.

Immunology & Microbiology Awards and honors
LINK: https://www.scripps.edu/news-and-events/press-room/2018/20181001-allis...
See more stories from scripps

Most recent headlines

05/01/2027

Worlds first 802.15.4ab-UWB chip verified by Calterah and Rohde & Schwarz to be demoed at CES 2026

Worlds first 802.15.4ab-UWB chip verified by Calterah and Rohde & Schwarz to be ...

09/10/2026

Dolby Expands Dolby OptiView Platform with New Capabilities at IBC 2026

September 10 2026, 06:00 (PDT) Dolby Expands Dolby OptiView Platform with New Capabilities at IBC 2026 New Sports Intelligence helps providers better unders...

07/10/2026

Dalet Flex LTS Delivers Smarter Media Operations from Ingest to Distribution

Dalet, a leading technology and service provider for media-rich organizations, today announced the latest Long-Term Supported (LTS) release of Dalet Flex. Build...

11/09/2026

IBC 2026: Calrec Launches Type RT Console and Apex M6 Modular I/O Platform

Calrec will introduce two new products at IBC2026 (Stand 8.C47, RAI Amsterdam, September 11-14): the Type RT broadcast production console and the Apex M6 Modula...

11/09/2026

IBC 2026: Grass Valley Launches AVORA All-in-One Live Production Platform

Grass Valley has announced AVORA, a standalone all-in-one live production solution launching at IBC2026 (Booth 9.A01 and IBC Future Tech Zone, Stand 14.C49, Sep...

11/09/2026

IBC 2026: CAMB.AI Launches Streaming SDK and Dashboard for Multilingual Live Broadcasting

CAMB.AI is introducing its Streaming SDK and Streaming Dashboard at IBC2026, wit...

11/09/2026

IBC 2026: EVS Launches XT-S Software-Defined Multi-Application Server

EVS has announced XT-S, a software-defined server platform that runs multiple live production applications on a common hardware foundation. The platform debuts ...

11/09/2026

IBC 2026: EKT Showcases Linux-Based ATSC 3.0 Converter Box

EKT is demonstrating a new Linux-based ATSC 3.0 set-top box at IBC2026. The second-generation product moves away from Android to reduce memory costs, with Linux...

11/09/2026

IBC 2026: Sennheiser Group to Showcase Wireless, Monitoring, and Broadcast Workflow

The Sennheiser Group will exhibit at IBC2026 (Hall 8, Booth D50, September 11-14...

11/09/2026

Ludacris Joins Chris Stapleton and Cindy Blackman Santana for Monday Night Footballs In the Air Tonight Open

ESPN's Monday Night Football will open its 2026-27 season with a new renditi...

11/09/2026

Dalet Integrates NVIDIA Synthetic Content Detection into Dalet Flex

Dalet has announced an integration of NVIDIA's Synthetic Video Detector AI model into Dalet Flex, enabling media organizations to identify potentially AI-ge...

11/09/2026

IBC 2026: MC-IF Demonstrates VVC Capabilities

The Media Coding Industry Forum (MC-IF) will demonstrate Versatile Video Coding (VVC) capabilities at IBC2026 (Hall 2, Stand 2.B13), as the codec moves toward c...

11/09/2026

IBC 2026: Sony to Demonstrate Live, News, Cinema, and Immersive Production

Sony will exhibit at IBC2026 (Hall 13, September 11-14), demonstrating products across live production, news, cinema, and immersive and spatial content workflow...

11/09/2026

Wave Central Named Recipient of 2026 Technology and Engineering Emmy for FPV Drone Systems

Wave Central, a Domo Broadcast Company, has been named a recipient of a 2026 Tec...

11/09/2026

IBC 2026: SNS Validates EVO Compatibility With Avid Media Composer 2026.8, Adds Browser-Based Upload to Outpost

Studio Network Solutions (SNS) is bringing a pair of workflow updates to IBC2026...

11/09/2026

IBC 2026: iodyne to Demo Pro Mini Smart Drive Across Four Partner Booths

iodyne will co-exhibit with Hedge at IBC2026 (Booth 7.A36, September 11-14) and appear across three additional partner booths, marking the first public demonstr...

11/09/2026

SVG GameDay, Ep. 30: Freelance Graphics Operator Corinne Yamada - Philly-Based Graphics Creation

In-venue and creative video staffers at the professional and collegiate level ha...

11/09/2026

CBS Sports Goes HDR Across Its Entire NFL Package, Heads to Rio in Week 3

The network will phase in HDR crew by crew while expanding Next Gen Stats integration, SkyDry availability, and onsite studio shows...

11/09/2026

IBC 2026: CAMB.AI Unveils the World's First Multilingual Broadcasting Agent Powered by NVIDIA

CAMB.AI is introducing its new Streaming SDK and Streaming Dashboard at IBC2026,...

11/09/2026

Netflix Goes Down Under With NBC Sports, NEP for NFL From Melbourne

Massive host operation at Melbourne Cricket Ground featured 54 cameras, 25,000 ST 2110 flows, REMI studio production in Stamford, and global distribution to mor...

11/09/2026

FOX Sports Homogenizes Coverage With Upscaled Game Tech, Seamless Integration With Studio Shows in L.A.

Production Anywhere Remote Kit (PARK) & AR-fueled Stage B are two key pieces to ...

11/09/2026

Get to Know This Fall and Winter's Filmmakers Through These 36 Sundance Institute-Supported Films

By Ramona Flume and Lucy Spicer There's a particular kind of magic that hap...

11/09/2026

Film Festival Watch: 8 Sundance Institute-Supported Films to See at the 2026 Toronto International Film Festival

By Jessica Herndon The fall film season is kicking off, and Sundance Institute-...

11/09/2026

Positive Grid announce the Spark Pedal

Spark series gains compact modelling stompbox Positive Grid's Spark amps have become a popular part of the company's line-up, offering a convenient ...

11/09/2026

Rapid Flow release omniGRID

New flagship sequencing plug-in revealed Rapid Flow have just launched a new 16-track sequencer plug-in which they say has been designed for total rhythmic...

11/09/2026

Rohde & Schwarz unveils the air-cooled R&STM1 medium-power UHF transmitter at IBC 2026

Rohde & Schwarz unveils the air-cooled R&S TM1 medium-power UHF transmitter at I...

11/09/2026

TV Usage Kicks Usual Summer Slowdown, Fueled by World Cup and Streaming in Nielsen's July Gauge Reports

FIFA World Cup 2026 and Peacock's Love Island USA' Power NBCU-Versant ...

11/09/2026

Atomos Debuts New HDR Monitors at IBC2026

Share Copy link Facebook X Linkedin Bluesky Email...

11/09/2026

Calrec to Unveil Type RT Compact Console at IBC2026

Share Copy link Facebook X Linkedin Bluesky Email...

11/09/2026

Lightware Launches LARA 2 with New Architecture for More...

Lightware has announced the launch of LARA (Lightware Advanced Room Automation) 2.0, a major upgrade to its built-in room automation platform, introducing impro...

11/09/2026

MusiMap launches latest technology unlocking new commerci...

10 September 2026 - MusiMap, the B2B music intelligence company that is transforming how companies can harness the emotional power of music to reach consumers a...

11/09/2026

Matrox Video Integrates Matrox ORIGIN with NVIDIA Holosca...

Matrox Video today announced an integration between Matrox ORIGIN and NVIDIA Holoscan for Media, enabling Matrox ORIGIN media services to be provisioned, config...

11/09/2026

Net Insight brings cloud-native live media orchestration...

Net Insight today announced that its cloud-native live media orchestration is now available through Oracle Cloud Marketplace, providing broadcasters, production...

11/09/2026

Calrec to Unveil Type RT Compact Console at IBC 2026

Share Copy link Facebook X Linkedin Bluesky Email...

11/09/2026

Biggest functionality boost yet makes Buttons the perfect...

Version 1.8 will bring advanced routing control, new workflow tools, boosted control panel flexibility and ease of integration into IP networks...

11/09/2026

Ikegami Announces Four New UNICAM XE Series Cameras

Ikegami announces four additions its UNICAM XE range of 4K-UHD cameras with the introduction of the UHK-X700VN, UHK-X750VN, UHK-X600VN and UHK-X650VN. Developed...

11/09/2026

DHD Launches New MX3 Consoles - Modular to the Core

DHD.audio has chosen IBC2026 as the launch venue for a major new addition to its broadcast sound production platform: the MX3 console range. MX3 retains the mod...

11/09/2026

Sony To Showcase Latest Production Technology At IBC2026

Share Copy link Facebook X Linkedin Bluesky Email...

11/09/2026

EKT To Feature New Linux-Based ATSC 3.0 STB At IBC2026

Share Copy link Facebook X Linkedin Bluesky Email...

11/09/2026

Jimmy Kimmel Shifts Political Interview to YouTube Over FCC Worries

Share Copy link Facebook X Linkedin Bluesky Email...

11/09/2026

Remembering 9/11: 25 Years of TV Tech Coverage

Share Copy link Facebook X Linkedin Bluesky Email...

11/09/2026

Tiger Group To Auction Equipment from a National Broadcasting Studio

Share Copy link Facebook X Linkedin Bluesky Email...

11/09/2026

Grass Valley Launches AVORA at IBC2026

Share Copy link Facebook X Linkedin Bluesky Email...

11/09/2026

Survey: Low Latency for Live Streaming Is Industrys Top Challenge

Share Copy link Facebook X Linkedin Bluesky Email...

11/09/2026

Atomos Debuts New HDR Monitors at 2026 IBC Show

Share Copy link Facebook X Linkedin Bluesky Email...

11/09/2026

Grass Valley Launches AVORA at IBC2026 Bringing All in On...

New standalone solution gives production teams everything they need to create, produce and deliver live content from one flexible system. Grass Valley today an...

11/09/2026

Wave Central a Domo Broadcast Company Named Recipient of...

Recognition honors the development of FPV drone camera systems for live sports broadcast coverage Wave Central, a Domo Broadcast Company that develops advanced...

11/09/2026

Teradek Launches Bolt 7 A Unified Wireless System for Zer...

Teradek, the industry leader in zero-delay wireless video solutions, announced the launch of Bolt 7, which now includes a unified wireless video and data system...

11/09/2026

ACT Pixel Academy Announces Autumn Courses

The ACT Entertainment tvONE and Green Hippo Pixel Academy has released its autumn course schedule, with hands-on training dates in September, October and Novemb...

11/09/2026

Scientists discover a new way that a disease-linked protein comes apart

LA JOLLA, CA-Transthyretin amyloid disease (ATTR) is a progressive, life-threatening condition caused when the protein transthyretin (TTR) breaks apart and aggr...