UK Biobank is broadening scientists' access to high-quality genomic data and analysis by making its massive dataset available in the cloud alongside NVIDIA GPU-accelerated analysis tools.
Used by more than 25,000 registered researchers around the world, UK Biobank is a large-scale biomedical database and research resource with deidentified genetic datasets, along with medical imaging and health record data, from more than 500,000 participants across the U.K.
Regeneron Genetics Center, the high-throughput sequencing center of biotech leader Regeneron, recently teamed up with UK Biobank to sequence and analyze the exomes - all protein-coding portions of the genome - of all the biobank participants.
The Regeneron team used NVIDIA Clara Parabricks, a software suite for secondary genomic analysis of next-generation sequencing data, during the exome sequencing process.
UK Biobank has released 450,000 of these exomes for access by approved researchers, and is now providing scientists six months of free access to Clara Parabricks through its cloud-based Research Analysis Platform. It was developed by bioinformatics platform DNAnexus, which lets scientists use Clara Parabricks running on NVIDIA GPUs in the AWS cloud.
As demonstrated by Regeneron, GPU acceleration with Clara Parabricks achieves the throughputs, speed and reproducibility needed when processing genomic datasets at scale, said Dr. Mark Effingham, deputy CEO of UK Biobank. There are a number of research groups in the U.K. who were pushing for these accelerated tools to be available in our platform for use with our extensive dataset.
Regeneron Exome Research Accelerated by Clara Parabricks Regeneron's researchers used the DeepVariant Germline Pipeline from NVIDIA Clara Parabricks to run their analysis with a model specific to the genetic center's workflow.
Its researchers identified 12 million coding variants and hundreds of genes associated with health-related traits - certain genes were associated with increased risk for liver disease and eye disease, and others were linked to lower risk of diabetes and asthma.
The unique set of tools the researchers used for high-quality variant detection is available to UK Biobank registered users through the Research Analysis Platform. This capability will allow scientists to harmonize their own exome data with sequenced exome data from UK Biobank by running the same bioinformatics pipeline used to generate the initial reference dataset.
Cloud-Based Platform Improves Equity of Access Researchers deciphering the genetic codes of humans - and of the viruses and bacteria that infect humans - can often be limited by the computational resources available to them.
UK Biobank is democratizing access by making its dataset open to scientists around the world, with a focus on further extending use by early-career researchers and those in low- and middle-income countries. Instead of researchers needing to download this huge dataset to use on their own compute resources, they can instead tap into UK Biobank's cloud platform through a web browser.
We were being contacted by researchers and clinicians who wanted to access UK Biobank data, but were struggling with access to the basic compute needed to work with even relatively small-scale data, said Effingham. The cloud-based platform provides access to the world-class technology needed for large-scale exome sequencing and whole genome sequencing analysis.
Researchers using the platform pay only for the computational cost of their analyses and for storage of new data they generate from the biobank's petabyte-scale dataset, Effingham said.
Using Clara Parabricks on DNAnexus helps reduce both the time and cost of this genomic analysis, delivering a whole exome analysis that would take nearly an hour of computation on a 32-vCPU machine in less than five minutes - while also reducing cost by approximately 40 percent.
Exome Sequencing Provides Insights for Precision Medicine For researchers studying links between genetics and disease, exome sequencing is a critical tool - and the UK Biobank dataset includes nearly half a million participant exomes to work with.
The exome is approximately 1.5 percent of the human genome, and consists of all the known genes and their regulatory elements. By studying genetic variation in exomes across a large, diverse population, scientists can better understand the population's structure, helping researchers address evolutionary questions and describe how the genome works.
With a dataset as large as UK Biobank's, it is also possible to identify the specific genetic variants associated with inherited diseases, including cardiovascular disease, neurodegenerative conditions and some kinds of cancer.
Exome sequencing can even shed light on potential genetic drivers that might increase or decrease an individual's risk of severe disease from COVID-19 infection, Effingham said. As the pandemic continues, UK Biobank is adding COVID case data, vaccination status, imaging data and patient outcomes for thousands of participants to its database.
Get started with NVIDIA Clara Parabricks on the DNAnexus-developed UK Biobank Research Analysis Platform. Learn more about the exome sequencing project by registering for this webinar, which takes place Feb. 17 at 8am Pacific.
Subscribe to NVIDIA healthcare news here.
Main image shows the freezer facility at UK Biobank where participant samples are stored. Image courtesy of UK Biobank.
North America Stories
19/05/2026
Champaign, IL - March 16, 2026 Cobalt Digital, the leading designer and manufa...
19/05/2026
CHAMPAIGN, Ill. April 16, 2026 - Cobalt Digital today announced a partnership ...
19/05/2026
Las Vegas - April 18, 2026 Cobalt Digital, the leading designer and manufactur...
19/05/2026
LAS VEGAS April 18, 2026 - Advanced HDR by Technicolor and Cobalt Digital are ...
19/05/2026
LAS VEGAS - May 4, 2026 - Cobalt Digital, the leading designer and manufacturer of signal processing products, and a founding partner in the openGear initiativ...
19/05/2026
London - 11 May 2026 Cobalt Digital, the leading designer and manufacturer of award-winning signal processing products, and a founding partner in the openGear...
19/05/2026
Share
Copy link
Facebook
X
Linkedin
Bluesky
Email...
19/05/2026
Share
Copy link
Facebook
X
Linkedin
Bluesky
Email...
19/05/2026
Grass Valley has entered into a three-year enterprise agreement with Phoenix Broadcast Solutions as the Singapore-based company expands its live production oper...
19/05/2026
Clear-Com supported Musikal Perahu Kertas, a large-scale musical theater production in Indonesia adapted from the acclaimed novel by Dee Lestari, through the d...
19/05/2026
Actus Digital, a LiveU company, and a leading provider of intelligent media monitoring and broadcast compliance platforms, announced today that METEO CONSULT ha...
19/05/2026
Globecast, a leading provider of managed services for the broadcast and media industry, today announced the completion of a major renovation of its Singapore fa...
19/05/2026
Following a major upgrade to its Connecticut remote production centre with the installation of three 60-fader Argo S consoles in 2023, RPS has switched one of t...
19/05/2026
PlayBox Technology today announced the launch of Celebro Play, a browser-based media orchestration platform designed specifically for broadcast facilities and p...
19/05/2026
Share
Copy link
Facebook
X
Linkedin
Bluesky
Email...
19/05/2026
Share
Copy link
Facebook
X
Linkedin
Bluesky
Email...
19/05/2026
Share
Copy link
Facebook
X
Linkedin
Bluesky
Email...
19/05/2026
Share
Copy link
Facebook
X
Linkedin
Bluesky
Email...
19/05/2026
LYNX Technik, provider of modular signal processing solutions for broadcast, post, and professional AV will showcase its latest signal processing solutions at B...
19/05/2026
Media Links, a leading developer and manufacturer of IP media transport solutions, has announced the integration of its Xscend platform with Skyline Communicat...
19/05/2026
Collaboration expands regional partner ecosystem as Media Links showcases IP media transport solutions on stand 4M4-4 and alongside Clearcast Asia on stand
Me...
19/05/2026
Company Highlights Labor-Saving Control and Custom Branding Opportunities Designed to Increase Integrator Profitability
LynTec, a leading manufacturer of ele...
19/05/2026
Mago Studio Moves AI Video Beyond Prompts with New Production-Focused Tools
Brie Clayton May 18, 2026
0 Comments
New Capabilities Bring Controllable, ...
19/05/2026
It May be Time to Stop and Take an AI Breather
Brie Clayton May 19, 2026
0 Comments
If the rock you stay on starts to roll, jump clean. Or you'll...
18/05/2026
Despite a bumpy start to the year, the provider of event-production support and ...
18/05/2026
Daktronics has partnered with the University of North Carolina to manufacture and install 11 LED displays totaling more than 10,000 square feet and more than 14...
18/05/2026
CBS LA has announced a multi-year partnership with the Los Angeles Rams, covering exclusive local broadcasts of Rams preseason games, weekly year-round programm...
18/05/2026
Skyline Communications has announced an integration between its DataMiner xOps p...
18/05/2026
eCLUTCH, the hybrid esports platform powered by iKOMG, has announced an expansion of its distribution across Europe, MENA, Africa, and Asia, along with new cont...
18/05/2026
Behind The Mic provides a roundup of recent news regarding on-air talent, includ...
18/05/2026
With 22 games this season, the production team looks forward to tweaking and enhancing the coverage
After 8,660 days off the air, the WNBA returned to NBC yest...
18/05/2026
(L-R) Midori Francis and Natalie Erika James attend the Saccharine premiere during the 2026 Sundance Film Festival at The Ray Theatre on January 22, 2026, in ...
18/05/2026
The Australian Defence Force uses L3Harris T4 and T7 robots for explosive ordnan...
18/05/2026
Continued investment across Europe and Germany is expanding local teams and improving access to stock, regional expertise, and specialist broadcast support.
CV...
18/05/2026
Agentic AI inference at one-tenth the cost per token with NVIDIA Vera Rubin NVL7...
17/05/2026
Back to All News
Oasis Premieres on Netflix June 19
Entertainment
17 May 2026
GlobalSpain
Link copied to clipboard
Summer, sunshine, the beach, parties. T...
16/05/2026
Boris FX Continuum Pairs AI Precision and Advanced Creative Controls
Jessie Electa Petrov May 16, 2026
0 Comments
The 2026.5 release adds automatic de...
16/05/2026
Share
Copy link
Facebook
X
Linkedin
Bluesky
Email...
16/05/2026
Share
Copy link
Facebook
X
Linkedin
Bluesky
Email...
16/05/2026
Share
Copy link
Facebook
X
Linkedin
Bluesky
Email...
16/05/2026
Share
Copy link
Facebook
X
Linkedin
Bluesky
Email...
15/05/2026
Seattle Sounders FC and Seattle Reign FC, in partnership with RAVE Foundation an...
15/05/2026
Dan Brumm has served as sound designer on Bluey, the Australian children's t...
15/05/2026
The Professional Audio Manufacturers Alliance (PAMA) and Shure Incorporated are accepting applications for the 6th annual Mark Brunner Professional Audio Schola...
15/05/2026
Netflix has announced an expanded NFL schedule for 2026 and beyond under a four-year partnership extension with the NFL through the 2029-30 season. Each season,...
15/05/2026
Ateme is supporting TVRI (Televisi Republik Indonesia) with a contribution and d...
15/05/2026
Concacaf has announced the launch of a new website and mobile app built on Deltatre's FORGE platform. Concacaf.com and the mobile app, available on iOS and ...
15/05/2026
Eutelsat has announced the launch of QBC Business Economic Channel by Qatar Media Corporation, broadcasting in 4K/UHD via Eutelsat's 7/8 West video neighbo...
15/05/2026
Major League Soccer has announced four original content series timed to the 2026...
UK Biobank is broadening scientists' access to high-quality genomic data and analysis by making its massive dataset available in the cloud alongside NVIDIA GPU-accelerated analysis tools.
