UK Biobank is broadening scientists' access to high-quality genomic data and analysis by making its massive dataset available in the cloud alongside NVIDIA GPU-accelerated analysis tools.
Used by more than 25,000 registered researchers around the world, UK Biobank is a large-scale biomedical database and research resource with deidentified genetic datasets, along with medical imaging and health record data, from more than 500,000 participants across the U.K.
Regeneron Genetics Center, the high-throughput sequencing center of biotech leader Regeneron, recently teamed up with UK Biobank to sequence and analyze the exomes - all protein-coding portions of the genome - of all the biobank participants.
The Regeneron team used NVIDIA Clara Parabricks, a software suite for secondary genomic analysis of next-generation sequencing data, during the exome sequencing process.
UK Biobank has released 450,000 of these exomes for access by approved researchers, and is now providing scientists six months of free access to Clara Parabricks through its cloud-based Research Analysis Platform. It was developed by bioinformatics platform DNAnexus, which lets scientists use Clara Parabricks running on NVIDIA GPUs in the AWS cloud.
As demonstrated by Regeneron, GPU acceleration with Clara Parabricks achieves the throughputs, speed and reproducibility needed when processing genomic datasets at scale, said Dr. Mark Effingham, deputy CEO of UK Biobank. There are a number of research groups in the U.K. who were pushing for these accelerated tools to be available in our platform for use with our extensive dataset.
Regeneron Exome Research Accelerated by Clara Parabricks Regeneron's researchers used the DeepVariant Germline Pipeline from NVIDIA Clara Parabricks to run their analysis with a model specific to the genetic center's workflow.
Its researchers identified 12 million coding variants and hundreds of genes associated with health-related traits - certain genes were associated with increased risk for liver disease and eye disease, and others were linked to lower risk of diabetes and asthma.
The unique set of tools the researchers used for high-quality variant detection is available to UK Biobank registered users through the Research Analysis Platform. This capability will allow scientists to harmonize their own exome data with sequenced exome data from UK Biobank by running the same bioinformatics pipeline used to generate the initial reference dataset.
Cloud-Based Platform Improves Equity of Access Researchers deciphering the genetic codes of humans - and of the viruses and bacteria that infect humans - can often be limited by the computational resources available to them.
UK Biobank is democratizing access by making its dataset open to scientists around the world, with a focus on further extending use by early-career researchers and those in low- and middle-income countries. Instead of researchers needing to download this huge dataset to use on their own compute resources, they can instead tap into UK Biobank's cloud platform through a web browser.
We were being contacted by researchers and clinicians who wanted to access UK Biobank data, but were struggling with access to the basic compute needed to work with even relatively small-scale data, said Effingham. The cloud-based platform provides access to the world-class technology needed for large-scale exome sequencing and whole genome sequencing analysis.
Researchers using the platform pay only for the computational cost of their analyses and for storage of new data they generate from the biobank's petabyte-scale dataset, Effingham said.
Using Clara Parabricks on DNAnexus helps reduce both the time and cost of this genomic analysis, delivering a whole exome analysis that would take nearly an hour of computation on a 32-vCPU machine in less than five minutes - while also reducing cost by approximately 40 percent.
Exome Sequencing Provides Insights for Precision Medicine For researchers studying links between genetics and disease, exome sequencing is a critical tool - and the UK Biobank dataset includes nearly half a million participant exomes to work with.
The exome is approximately 1.5 percent of the human genome, and consists of all the known genes and their regulatory elements. By studying genetic variation in exomes across a large, diverse population, scientists can better understand the population's structure, helping researchers address evolutionary questions and describe how the genome works.
With a dataset as large as UK Biobank's, it is also possible to identify the specific genetic variants associated with inherited diseases, including cardiovascular disease, neurodegenerative conditions and some kinds of cancer.
Exome sequencing can even shed light on potential genetic drivers that might increase or decrease an individual's risk of severe disease from COVID-19 infection, Effingham said. As the pandemic continues, UK Biobank is adding COVID case data, vaccination status, imaging data and patient outcomes for thousands of participants to its database.
Get started with NVIDIA Clara Parabricks on the DNAnexus-developed UK Biobank Research Analysis Platform. Learn more about the exome sequencing project by registering for this webinar, which takes place Feb. 17 at 8am Pacific.
Subscribe to NVIDIA healthcare news here.
Main image shows the freezer facility at UK Biobank where participant samples are stored. Image courtesy of UK Biobank.
North America Stories
13/06/2026
Share
Copy link
Facebook
X
Linkedin
Bluesky
Email...
13/06/2026
Share
Copy link
Facebook
X
Linkedin
Bluesky
Email...
12/06/2026
YES Network and The Gotham Sports App will air seven Athletes Unlimited Softball...
12/06/2026
The United Football League will host its FAST Innovation Suite at the 2026 United Bowl presented by Credit One Bank on Saturday, June 13 at 3:00 p.m. ET at Audi...
12/06/2026
PTZOptics and LayerJot will present live demonstrations at InfoComm 2026 showing how natural-language AI prompting, robotic camera control, and on-device comput...
12/06/2026
MultiDyne Video and Fiber Optic Systems will exhibit at InfoComm 2026, featuring...
12/06/2026
Ateme has announced that Eurovision Services is using Ateme's software-based frame-rate conversion technology for international live event workflows. The de...
12/06/2026
Bitmovin and Simplestream have announced a partnership with Xperi to simplify the launch of OTT streaming services on TiVo OS smart TVs and devices. The collabo...
12/06/2026
Net Insight has announced that a multinational technology company is deploying a...
12/06/2026
MLB Players Inc., the business arm of the MLB Players Association, has announced a partnership with Athletes First to develop and sell brand partnerships across...
12/06/2026
Guntermann and Drunck (G&D) and VuWall have announced the CommandKeyboard-Advanc...
12/06/2026
Comcast Smart Solutions announces a new smart technology deployment with Major L...
12/06/2026
Elevation Worship completed the initial leg of its Elevation Nights 2026 tour ...
12/06/2026
AJA Video Systems has announced KONA IP25 support for Colorfront Transkoder and ...
12/06/2026
Audinate Group Limited (ASX: AD8) will exhibit at InfoComm 2026 (Booth C7321, Ce...
12/06/2026
Pac-12 Commissioner Teresa Gould has announced the appointment of Scott Adametz as Chief Technology Officer. The Pac-12 describes the hire as the first CTO appo...
12/06/2026
Grass Valley has announced AMPP Edge Live, a production system combining Grass Valley hardware, NVIDIA Blackwell GPU acceleration, and AMPP OS in a single platf...
12/06/2026
At one time a trailblazer with the launch of the Longhorn Network, the Universit...
12/06/2026
Ratings Roundup is a rundown of recent rating news and is derived from press rel...
12/06/2026
Chyron has announced PAINT 10.4, an update to its illustrated replay and sports ...
12/06/2026
SVP, Production Mark Gross: With the new schedule, with not having every Sunday night, it's given us an opportunity to take a step back and reimagine what ...
12/06/2026
For Televisa Technical Engineering Manager Roberto N nez Ibarra and the small team of 12 technicians and two production personnel at the IBC things are already ...
12/06/2026
Share
Copy link
Facebook
X
Linkedin
Bluesky
Email...
12/06/2026
Share
Copy link
Facebook
X
Linkedin
Bluesky
Email...
12/06/2026
AJA Announces KONA IP25 Integration with Colorfront Software
Brie Clayton June 12, 2026
0 Comments
Collaboration enables uncompressed SMPTE ST 2110 I/O ...
12/06/2026
URSA Cine 12K LF Used to Create Visuals for STUTS' K-Arena Concert
Brie Clayton June 12, 2026
0 Comments
Organic visuals projected on a giant scre...
12/06/2026
MTI FILM Acquires Mango New Edit, Expanding its Global Post-Production Services ...
12/06/2026
AI Point Tracking Speeds Up Complex VFX Tracks in Mocha Pro
Jessie Electa Petrov June 12, 2026
0 Comments
The 2026.5 release adds automatic point trac...
12/06/2026
Bitmovin, a provider of video streaming solutions, has partnered with Simplestream, a provider of OTT and broadcast solutions, and technology provider Xperi, to...
12/06/2026
Leostream Corporation, creator of the world-leading Leostream Remote Desktop Access Platform, today announced Jigsaw24, a leading B2B IT solutions provider wit...
12/06/2026
Share
Copy link
Facebook
X
Linkedin
Bluesky
Email...
12/06/2026
Share
Copy link
Facebook
X
Linkedin
Bluesky
Email...
12/06/2026
Share
Copy link
Facebook
X
Linkedin
Bluesky
Email...
12/06/2026
Share
Copy link
Facebook
X
Linkedin
Bluesky
Email...
12/06/2026
Share
Copy link
Facebook
X
Linkedin
Bluesky
Email...
12/06/2026
AgentPerf from Artificial Analysis, the industry's first agentic AI benchmark, gives developers, enterprises and infrastructure providers a clear way to com...
12/06/2026
Back to All News
Netflix Unveils First-Look Images from Villaflor, Santiago Mitre's New Film
Entertainment
12 June 2026
GlobalArgentina
Link copied to ...
12/06/2026
Back to All News
Cross the Boundaries of the Real World into the Spirit Realm i...
12/06/2026
A fentanyl countermeasure that adapts to combat future black-market drugs Scripps Research scientists developed a vaccine that teaches the immune system to rapi...
11/06/2026
The immense size of the tourney and its Atlantic-spanning operation also disting...
11/06/2026
Nielsen has released a new soccer fandom consumer research report, The Fans Behind The Game: FIFA World Cup 2026 Edition, examining the soccer audience in the...
11/06/2026
Telemundo will launch its FIFA World Cup 2026 coverage on Thursday, June 11 with...
11/06/2026
FuboTV Inc. has announced a distribution agreement with NBCUniversal. Fubo customers can now stream Telemundo and Universo, with NBC Sports Network (NBCSN), NBC...
11/06/2026
DAZN has announced its in-app features for FIFA World Cup 2026 coverage in Spain...
11/06/2026
Roblox has released the 2026 Roblox Digital Expression Report: Wave 4 - Sports D...
11/06/2026
FIFA has unveiled DNA, the Official FIFA World Cup 2026 Anthem, performed by A...
11/06/2026
ESPN will provide English- and Spanish-language news and information coverage of FIFA World Cup 2026 across its U.S. media platforms from June 11 through July 1...
11/06/2026
The latest product of the outstanding RIT Sports Network program, this recent grad from Long Island is carving out a promising path in broadcast engineering
In...
11/06/2026
DAZN has announced a multi-year agreement to make DSPORTS channels available to ...
UK Biobank is broadening scientists' access to high-quality genomic data and analysis by making its massive dataset available in the cloud alongside NVIDIA GPU-accelerated analysis tools.
