Intarcia and Calibr Announce Collaboration and In-Licensing Deal Aimed At Delivering a Next Generation Combination Product For Diabetes & Obesity
15/06/2017
Collaboration aims to develop a novel peptide therapeutic derived from Calibr's Stapled-Peptide Technology Platform that can be combined with ITCA 650, Intarcia's late stage investigational GLP-1 therapy for Type 2 Diabetes.
The Calibr deal expands Intarcia's existing combination product strategy and pipeline that is targeting diabetes, obesity and other potential indications.
Intarcia's Medici Drug Delivery SystemTM will be leveraged to optimize the combination therapy and then deliver it in a once- or twice-yearly mini-pump.
Boston, MA, and San Diego, CA, January 9, 2017 Intarcia Therapeutics, Inc. and the California Institute for Biomedical Research (Calibr) today announced a strategic research collaboration focused on the development of a novel peptide therapeutic leveraging Calibr's Stapled-Peptide Platform Technology. Intarcia plans to develop and administer this novel therapy in combination with Exenatide (a GLP-1 receptor agonist and active agent in Intarcia's ITCA 650 product), by leveraging its proprietary Medici Drug Delivery SystemTM.
Under the terms of the agreement, Calibr will receive an upfront grant of Intarcia equity, with additional shares vesting over key development milestones, as well as undisclosed cash payments on achievement of predetermined regulatory and sales milestones. In addition to the milestone payments, Calibr will be eligible to receive tiered royalties on product sales.
Kurt Graves, Chairman, President and CEO of Intarcia Therapeutics, commented: We are committed to disruptive innovation leveraging our proprietary Medici Drug Delivery SystemTM and we now have several combination products in our pipeline that we believe we can uniquely optimize and deliver in a once- or twice-yearly mini-pump. We're excited to advance a combination program with Calibr that is targeting significant advances for patients suffering from type 2 diabetes and obesity..
This collaboration is another example of Calibr's drive to work with innovative partners who are committed to making a difference in human health , said Matt Tremblay, Ph.D., Calibr's Chief Operating Officer. We look forward to working with Intarcia to leverage our peptide technology platform to create transformative new medicines.
About the Medici Drug Delivery System
Intarcia's novel technology platform, the Medici Drug Delivery System, is a proprietary subcutaneous delivery system comprised of three unique technologies:
A stabilization technology that allows for proteins, peptides, antibody fragments, and other highly potent small molecules to be stabilized at or above human body temperatures for up to three years or more
A matchstick-sized osmotic mini-pump that is placed just under the dermal layer of skin to deliver a continuous and consistent flow of medication
A placement technology including proprietary tools designed to provide an optimal user experience
Once a drug is approved, a trained healthcare professional can place the small device in an in-office procedure. Once in place under the skin, water from the extracellular fluid enters the pump device at one end by diffusing through a semi-permeable membrane directly into an osmotic engine that expands to drive a piston at a controlled rate. This allows the drug within the pump to be released in a steady, consistent fashion at the other end of the device. Each osmotic mini-pump is designed to hold an appropriate volume of drug to treat a patient for up to a full year.
About ITCA 650
ITCA 650 is designed as a twice-yearly therapy for the chronic treatment of type 2 diabetes. The investigational therapy employs Intarcia's innovative technology platform, the Medici Drug Delivery System . In its Phase 3 clinical trials for type 2 diabetes, ITCA 650 was evaluated while delivering a continuous and consistent drug therapy in a three-month initiation dose, followed by consecutive six-month doses. Exenatide, the active agent in ITCA 650, is a glucagon-like peptide-1 (GLP-1) receptor agonist that is currently marketed globally as twice-daily and once-weekly self-injection therapies for type 2 diabetes. All four of the global Phase 3 clinical trials for ITCA 650 in type 2 diabetes were successfully completed, and the New Drug Application (NDA) was submitted to the U.S. Food and Drug Administration (FDA) on November 21, 2016. If approved, ITCA 650 would be the first and only injection-free GLP-1 receptor agonist therapy. Once-yearly mini-pumps at the 60mcg/day maintenance dose are also in development.
About Intarcia Therapeutics, Inc.
Intarcia Therapeutics, Inc. is a biopharmaceutical company developing therapies to enhance treatment outcomes by optimizing and improving the efficacy, continuous administration and tolerability of drug therapies. Delivering medicines for six-month periods of time, and potentially for up to a year and beyond, may improve outcomes by addressing patient adherence and persistence issues with prescribed drug therapies, which are very poor in most chronic diseases. Intarcias drug development expertise and competitive edge are brought to life within the Medici Drug Delivery System , the innovative science and technology platform from which Intarcia plans to launch its pipeline of disruptively innovative drugs. Intarcia continues to research and develop treatments utilizing the Medici Drug Delivery System for major chronic disorders such as diabetes, obesity, HIV prevention, autoimmune, and other serious diseases. For more information on the Company, please visit www.intarcia.com. Follow us on Twitter @intarcia.
About the California Institute for Biomedical Research, Calibr
The California Institute for Biomedical Resea
LINK: | http://www.scripps.edu/news/press/2017/20170109intarcia_calibr.html... |
See more stories from scripps |
Most recent headlines
04/08/2024
Dalet Appoints Santiago Solanas as CEO to Lead Next Era of Growth and Innovation
Dalet, a leading technology and service provider for media-rich organizations, is excited to announce Santiago Solanas as its new Chief Executive Officer (CEO)....
03/06/2024
Dalet and Veritone Reach Agreement to Distribute, Transact and Monetize Media Archives
Dalet, a leading technology and service provider for media-rich organizations, a...
14/05/2024
Gary Heelas Joins TSL as Principal Engineer
LOS ANGELES Gary Heelas has joined TSL as principal engineer in the company's U.S. office, the company announced....
14/05/2024
Gray Television Inks AAPB Deal for Summer Baseball
ATLANTA Gray Television Inc. has announced an agreement to bring select American Association of Professional Baseball (AAPB) games to free, over-the-air local t...
14/05/2024
Adsmovil Expands Nuestra.TV Distribution
MIAMI, Fla. Adsmovil has expanded access to its free, ad-supported, streaming TV service, Nuestra.TV to include Apple TV, Android TV, Smart TVs, Android media p...
14/05/2024
Roku Lands Exclusive Rights to Package of MLB Games
SAN JOSE, Calif. In another important example of how high-profile sports rights are shifting to streaming, Roku has secured the exclusive multi-year rights for ...
14/05/2024
Arkona Presents a Sneak Peek into the Future of Live Prod...
arkona technologies GmbH, provider of IP core infrastructure solutions for Tier-1 broadcast productions, has announced that it will be supporting its growing gl...
14/05/2024
TAG Teams with Techex at MPTS to Demonstrate Best-of-Bree...
TAG Video Systems, the leader in software-based IP end-to-end workflow monitoring, deep probing, and real-time visualization, has revealed highlights of its MPT...
14/05/2024
Blaze Audio Acquires Cornered Audios Commercial Install L...
Blaze Audio, a Copenhagen-based global leader specialising in pro audio solutions tailored for the installed sound market, has today announced it has acquired t...
14/05/2024
GBICS Offers Exclusive Free Bespoke Samples at MPTS 2024
GBICS, a pioneer in multi-vendor optical networking solutions, announces its presence at the upcoming Media Production and Technology Show (MPTS), happening on ...
14/05/2024
Glensound brings the latest in IP audio to CABSAT 2024
Glensound, industry leader in high quality audio systems, is showcasing the latest additions to its extensive portfolio of networked audio products at CABSAT. A...
14/05/2024
Marshall Cameras Deliver Efficient and Innovative Hybrid...
S&L Integrated Systems, a leader in audio-visual technology solutions, has recently transformed courtroom experiences throughout Georgia and the surrounding reg...
14/05/2024
Broadcast Bionics showcases the future of podcast technol...
Visit UK software company Broadcast Bionics in London this May at the Media Production & Technology Show (MPTS), Olympia London on Wednesday 15th and Thursday 1...
14/05/2024
Miami-Based DJ Creates Unique Mixes in His Studio With KR
Miami-based DJ, Music Producer, and Music Business Entrepreneur Christian Tian Jimenez has always enjoyed making music. From producing and mastering in his ho...
14/05/2024
Rohde and Schwarz showcases operational efficiency at MPT...
Rohde & Schwarz will showcase its media technologies portfolio at the Media Production & Technology Show (stand M40, MPTS, London, 15 16 May) and demonstrate ...
14/05/2024
International OB provider DVB Production in Slovenia is f...
DVB Production, a major supplier of outside broadcast (OB) services in Slovenia and Central Europe, has integrated Calrec's all-IP Argo S audio console and ...
14/05/2024
Custom Consoles Announces Latest-Generation M-Desk Techni...
Custom Consoles will highlight major refinements to its M-Desk Technical HA heavy duty height-adjustable desk workstation on stand J26 at The Media Production &...
14/05/2024
Leader to Highlight Latest Test and Measurement Innovatio...
Leader Electronics Corporation, globally active innovator of broadcast-quality test and measurement instrumentation, will highlight three latest-generation test...
14/05/2024
IBC2024 Primed to Lead Innovation Explore Trends and Fost...
IBC2024 is now open for registration, with the global media and entertainment (M&E) industry set to converge on the RAI Amsterdam on 13-16 September. The event ...
14/05/2024
Vidzemes TV Latvia Expands with PlayBox Neo Channel-in-a-...
Latvian free-to-air broadcaster Vidzemes TV has chosen PlayBox Neo Channel-in-a-Box playout to expand the technical facilities at its studio headquarters in Val...
14/05/2024
Avid Presents - Meet the Sound Team Behind True Detective: Night Country
Avid Presents - Meet the Sound Team Behind True Detective: Night Country Brie Clayton May 13, 2024 0 Comments There's nothing quite like the sound...
14/05/2024
Rethinking Media Archiving with Object Storage
Rethinking Media Archiving with Object Storage Brie Clayton May 13, 2024 0 Comments Media producers today need to maintain online access to all conten...
14/05/2024
Liquid Morphing Motion in After Effects
Liquid Morphing Motion in After Effects Graham Quince May 13, 2024 0 Comments I'm not too sure if it is liquid motion but it's probably the b...
14/05/2024
Why APSC Lenses Might Be All You Need
Why APSC Lenses Might Be All You Need Sean Alami May 13, 2024 0 Comments Exploring the big impact of small sensors: Dive into how APSC lenses offer ci...
14/05/2024
Intelligent Video Effects with Film Impact in Adobe Premiere Pro Transitions
Intelligent Video Effects with Film Impact in Adobe Premiere Pro Transitions Colin Smith May 13, 2024 0 Comments This tutorial is part 2 of a detail...
14/05/2024
Shawne Merriman Turns on Lights Out Sports Streamer
Former NFL linebacker Shawne Merriman has soft-launched Lights Out Sports, a free ad-supported sports streaming service....
14/05/2024
Stars Are Back for Upfronts, More Dollars May Follow as Well
Television companies expect this year's upfront to be stronger than last year's....
14/05/2024
PJ Gallagher explores Ireland's fight for mental wellness in new RT documentary, PJ Gallagher: Changing My Mind
Comedian PJ Gallagher turns mental health warrior in PJ Gallagher: Changing My M...
13/05/2024
Entry opens for EU Award for Investigative Journalism 2024
Journalists from the Western Balkans and T rkiye can now submit their investigative stories published in 2023 for the EU Award for Investigative Journalism 2024...
13/05/2024
Sundance Film Festival: London 2024 Announces Repertory Shorts Programme, Three Repertory Features And Three Public Talks
Tickets on sale now London, 13 May 2024 - Today Picturehouse and the nonprofit ...
13/05/2024
In Their Own Words: Audiobooks To Explore During Asian and Pacific Islander Heritage Month
May is Asian and Pacific Islander Heritage Month (APIHM), a time to reflect and ...
13/05/2024
Eurovision 2024: Swiss Singer Nemo Took the Crown, but There's More Talent To Celebrate
From C line Dion to ABBA, the Eurovision Song Contest has served as a launchpad ...
13/05/2024
Eurovision delivers strong Total TV audiences for SBS, with more than 2.2 million Australians tuning in
Eurovision delivers strong Total TV audiences for SBS, with more than 2.2 millio...
13/05/2024
L3Harris and Azerbaijan Airlines Advancing Pilot Training Capabilities in the Caspian Sea Region with Cutting-Edge Boeing 787-9 Full Flight Simulator
L3Harris is pleased to announce that it has secured a contract with Azerbaijan A...
13/05/2024
PBS Stations to Gain Access to Nielsen Local Dashboards
ARLINGTON, Va. PBS has received a significant grant from the Corporation for Public Broadcasting (CPB) to provide PBS Member Stations with Nielsen Local Dashboa...
13/05/2024
IBC2024 Now Open for Registration, Adds New AI Tech Zone
LONDON IBC2024, the broadcast industry's second largest international trade show, is now open for registration. Organizers said exhibition space reservation...
13/05/2024
CNBC: Sinclair Considering Selling Some Broadcast Stations
Sinclair Broadcast Group is reportedly considering selling more than 30% of its broadcast stations according to CNBC....
13/05/2024
Three New Shows on NBC's Fall Schedule
NBC has shared its fall schedule, with three new series set to premiere: Drama Brilliant Minds, with Zachary Quinto; comedy St. Denis Medical, with Wendi McLend...
13/05/2024
Animated Show Housebroken' Will Not Return on Fox
Animated comedy Housebroken will not see season three on Fox. The network said it was pleased with the show's creative, but viewer response wasn't stron...
13/05/2024
Tributes Flow for KTLA Entertainment Reporter Sam Rubin, Dead at 64
Tributes flowed in Hollywood today after KTLA in Los Angeles reported that longtime morning-news entertainment reporter, Sam Rubin, had died Friday at age 64....
13/05/2024
CBS Sports to Use 5G-Connected Cameras to Cover PGA Championship
T-Mobile announced today that it is deploying its 5G Advanced Network Solutions (ANS) to enhance the fan experience as well as CBS Sports' live coverage of ...
13/05/2024
The Film and TV Charity launches fund for Black and Global Majority professionals
Funding will be awarded in three rounds over two years, with applications for th...
13/05/2024
IBC2024 opens for registration and announces new AI tech zone
This years show features an expanded venue including a new AI tech Zone and a second Content Everywhere area By Matthew Corrigan Published: May 13, 2024 T...
13/05/2024
David Loving Named KHOU-KTBU Houston General Manager
David Loving srtarts as president and general manager of KHOU-KTBU Houston May 20. He comes from WOI-KCWI Des Moines, where he was the general manager. Both duo...
13/05/2024
Rick Sallinger, KCNC Denver Reporter, Has Died
Rick Sallinger, KCNC Denver reporter, died of natural causes May 9 in the Denver area. He was 74....
13/05/2024
ABC Renews Idol,' Shark Tank,' Dancing With the Stars,' Others
In advance of its upfront presentation, ABC has renewed American Idol for season eight, The Bachelor for season 29, Celebrity Jeopardy! for season three, Celebr...
13/05/2024
Gordon Ramsay, Fox Launch Bite Food Entertainment Platform
Fox Entertainment and Gordon Ramsay said they have launched Bite, a food brand and entertainment business featuring digital content, live events and consumer pr...
13/05/2024
Doctor Who' Showrunner on What New Doctor Brings to Show
The 15th Doctor in Doctor Who history steps onstage with the show debuting on Disney Plus May 10. It is Ncuti Gatwa, who played Eric Effiong in Sex Education. H...
13/05/2024
Drug Discovery, STAT! NVIDIA, Recursion Speed Pharma R&D With AI Supercomputer
Described as the largest system in the pharmaceutical industry, BioHive-2 at the Salt Lake City headquarters of Recursion debuts today at No. 35, up more than 1...
13/05/2024
SVG Sit-Down: Blackmagic Design's Dan May Explores Addition of Instant-Replay to Davinci Resolve Solution
SVG Sit-Down: Blackmagic Design's Dan May Explores Addition of Instant-Repla...